scholarly journals Reproduction and longevity A Mendelian randomization study of gonadotropin-releasing hormone and ischemic heart disease

2018 ◽  
Author(s):  
C M Schooling ◽  
Jack C M Ng
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Genetic Variants ◽  
Evolutionary Biology ◽  
Causal Effect ◽  
Gonadotropin Releasing Hormone ◽  
Ischemic Heart ◽  
P Value ◽  
Releasing Hormone ◽  
Reproductive Axis

BackgroundAccording to well-established evolutionary biology theory reproduction trades-off against longevity, implying that upregulating the reproductive axis might drive major diseases. We assessed whether the central driver of reproduction gonadotropin-releasing hormone 1 (GnRH1) had a causal effect on the leading cause of global morbidity and mortality, i.e. ischemic heart disease (IHD). As a contrast we similarly examined the role of GnRH2 because it is more a driver of female sexual behavior.MethodsWe applied strong (p-value <5×10−6) and independent genetic predictors of GnRH1 and GnRH2 to an extensively genotyped IHD case (n=76,014) - control (n=264,785) study using multiplicative random effects inverse variance weighted (IVW), weighted median, MR-Egger and MR-PRESSO estimates.ResultsGnRH1, predicted by 11 genetic variants, was positively associated with IHD (IVW odds ratio (OR) 1.04 per effect size, 95% confidence interval (CI) 1.01 to 1.08), but GnRH2, predicted by 15 genetic variants, was not (IVW OR 0.98, 95% CI 0.95 to 1.02).ConclusionsGnRH1 is a potential IHD genetic target. Apart from demonstrating a central tenet of evolutionary biology in humans, our study suggests that existing treatments and environmental factors targeting GnRH1, its drivers or consequences could be re-purposed to prevent and treat IHD. Given, the importance of reproduction to the human species, many such exposures likely exist.

scholarly journals Comprehensive Study of Acute Myocardial Infarctions Triggers

2020 ◽  
Author(s):  
Kamal Khademvatani ◽  
Amin Sedokani ◽  
Sima Masudi ◽  
Parisa Nejati ◽  
Mir Hossein Seyed-Mohammadzad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Health Care Systems ◽  
Ischemic Heart ◽  
Clinical Event ◽  
P Value ◽  
Cross Sectional

AbstractAimMyocardial infarction (MI) is one of the most important cardiovascular diseases. A trigger is an external stimulus, potential to create a pathological change leading to a clinical event. In addition to classic risk factors of ischemic heart disease and myocardial infarction, MI triggers play critical roles in the incidence of acute MI.Methods and ResultsThis is a cross-sectional study of 254 patients with the first acute myocardial infarction referring to Seyedoshohada heart center of Urmia, Iran were enrolled in the study within one year of study. After 48h of hospitalization and, treatment, and cardiac caring, the patients were provided with the questionnaire to collecting the history of the disease ad triggers. In addition to laboratory and paraclinical data, the analysis of the study was performed. Out of 220 (86.4%) patients with STEMI and 34 (13.6%) patients with NSTEMI, there were significant differences (P-value <0.05) in AMI triggers with LVEF (0.03), gender (0.027), residency and living area (0.039), occupation (0.002), smoking (0.008), abnormal serum TG levels (0.018) and the season of AMI occurrence (0.013). The mean age for AMI patients was 60.4±12.97 years old with a mean BMI of 26.65±4.35 kg/m2.ConclusionIn addition to classic risk factors of ischemic heart disease and myocardial infarction, health care systems and physicians must pay more attention to triggers that may induce an acute myocardial infarction in people with predisposing factors especially in the male sex, stressful and hand working jobs, and psychological and mental tension patients.

Genetic variants in SUSD2 are associated with the risk of ischemic heart disease

2020 ◽  
Vol 14 (4) ◽  
pp. 470-481
Author(s):  
Caroline S. Bruikman ◽  
Nawar Dalila ◽  
Julian C. van Capelleveen ◽  
Jeffrey Kroon ◽  
Jorge Peter ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Genetic Variants ◽  
Ischemic Heart

scholarly journals Effects of copper and zinc on ischemic heart disease and myocardial infarction: a Mendelian randomization study

2018 ◽  
Vol 108 (2) ◽  
pp. 237-242 ◽  
Author(s):  
Hanish P Kodali ◽  
Brian T Pavilonis ◽  
C Mary Schooling
Keyword(s):  
Sensitivity Analysis ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Genome Wide Association Study ◽  
Mendelian Randomization ◽  
Dietary Factors ◽  
Ischemic Heart ◽  
P Value ◽  
Copper And Zinc ◽  
A Genome

ABSTRACTBackgroundDespite great progress in prevention and control, ischemic heart disease (IHD) remains a leading cause of global morbidity and mortality. Diet plays a key role in IHD, but a comprehensive delineation of the role of dietary factors in IHD is not yet quite complete.ObjectiveThe aim of this study was to test the long-standing hypothesis that copper is protective and zinc harmful in IHD.DesignWe used separate-sample instrumental variable analysis with genetic instruments (Mendelian randomization). We obtained single nucleotide polymorphisms (SNPs) from a genome wide association study, strongly (P value < 5 × 10−8) and independently associated with erythrocyte copper and zinc. We applied these genetic predictors of copper and zinc to the largest, most extensively genotyped IHD case (n ≤ 76014)-control (n ≤ 264785) study, based largely on CARDIoGRAMplusC4D 1000 Genomes and the UK Biobank SOFT CAD, to obtain SNP-specific Wald estimates for the effects of copper and zinc on IHD, which were combined through the use of inverse variance weighting. Sensitivity analysis included use of the MR-Egger method, and reanalysis including SNPs independently associated with erythrocyte copper and zinc at P value < 5 × 10−6.ResultsGenetically instrumented copper was negatively associated with IHD (OR: 0.94; 95% CI: 0.90, 0.98). Genetically instrumented zinc was positively associated with IHD (OR: 1.06; 95% CI: 1.02, 1.11). Sensitivity analysis via MR-Egger gave no indication of unknown pleiotropy; less strongly associated SNPs gave similar results for copper.ConclusionGenetic validation of a long-standing hypothesis suggests that further investigation of the effects, particularly of copper, on IHD may provide a practical means of reducing the leading cause of mortality and morbidity.

scholarly journals (Frequency of CYP2C19 Gene Polymorphisms (SNP) and its Impact on Clinical Outcome in Ischemic Heart Disease Patients Taking Clopidogrel after percutaneous coronary intervention (PCI

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Ahmed Shawky, Mokhtar Elzawahry, Hussein Sabet, Khaled Barak
Keyword(s):  
Heart Disease ◽  
Clinical Outcome ◽  
Ischemic Heart Disease ◽  
Coronary Intervention ◽  
Ischemic Heart ◽  
P Value ◽  
Loss Of Function ◽  
Multicenter Studies ◽  
Non Invasive ◽  
Cyp2c19 Gene

Clopidogrel an oral thienopyridine derivative capable of inhibiting platelet activation. Clopidogrel is prodrug that is converted into an active drug by hepatic cytochrome CYP2C19, CYP2C19*2 and CYP2C19*3 polymorphic alleles are considered to be important loss- of- function alleles resulting in diminished response to clopidogrel. our study aimed to detect frequency of CYP2C19 gene polymorohisms and its impact on clinical outcome in ischemic heart disease patients taking clopidogrel. Matrial and methods: blood samples were collected from 102 ischemic heart disease patients and the frequency alleles was determined by PCR and all patients were followed by clinical assessment and invasive and non- invasive cardiac investigations .Results:. frequency of CYP2C19*1 was 49%, CYP2C19*2 was 15% and CYP2C19*3 was 1%, CYP2C19*17 was 34%, patients with recurrent ischemic attacks 37patients (35.8%), from those patients, 10 patients were normal metabolizer (27%), and 27 patients were abnormal metabolizers(73%) with p- value 0.047 to myocardial infarction and 0.020 to unstable angina. Conclusion:. Asignificance relation was found between CYP2C19polymorphism and recurrent ischemic attacks in this study and multicenter studies are required to confirm this results.

scholarly journals Relationship Between Ischemic Heart Disease and Sexual Satisfaction

2015 ◽  
Vol 8 (1) ◽  
pp. 263 ◽  
Author(s):  
Leila Ghanbari Afra ◽  
Mohsen Taghadosi ◽  
Hamid Reza Gilasi
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Sexual Satisfaction ◽  
Linear Regression Analysis ◽  
Ischemic Heart ◽  
P Value ◽  
Chi Square ◽  
Convenience Sample ◽  
Significant Difference ◽  
Threatening Condition

<p><strong>AIM:</strong> Ischemic heart disease is a life-threatening condition. Considerable doubts exist over the effects of this disease on patients’ sexual activity and satisfaction. The aim of this study was to evaluate the relationship between ischemic heart disease and sexual satisfaction.</p> <p><strong>METHODS:</strong> In a retrospective cohort study, the convenience sample of 150 patients exposure with ischemic heart disease and 150 people without exposure it was drawn from Shahid Beheshti hospital, Kashan, Iran. Sampling was performed from March to September 2014. We employed the Larson’s Sexual Satisfaction Questionnaire for gathering the data. Data were analyzed using descriptive statistics and Chi-square, t-test and linear regression analysis.</p> <p><strong>RESULTS:</strong> The means of sexual satisfaction in patients exposure with ischemic heart disease and among the subjects without exposure it were 101.47±13.42 and 100.91±16.52, respectively. There was no significant difference between the two groups regarding sexual satisfaction. However, sexual satisfaction was significantly correlated with gender and the use of cardiac medications (P value &lt; 0.05).</p> <p><strong>CONCLUSION:</strong> The level of sexual satisfaction in patients with exposure ischemic heart disease is similar to the people without exposure it. Moreover, the men and the patients who do not receive cardiac medications have higher levels of sexual satisfaction. Nurses who are providing care to patients with ischemic heart disease need to pay closer attention to patient education about sexual issues.</p>

scholarly journals Association of Diabetes and Hypertension as risk factors with Ischemic Heart Disease among patients visiting a Public Sector Tertiary Care Hospital of Karachi, Pakistan

2021 ◽  
Vol 10 (4) ◽  
pp. 215-219
Author(s):  
Zulfiqar Ali Shaikh ◽  
Javeria Shamim ◽  
Akmal Khurshid Bhatti ◽  
Sahar Soomro ◽  
Zareen Kiran ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Family History ◽  
Public Sector ◽  
Ischemic Heart Disease ◽  
Sedentary Lifestyle ◽  
Tertiary Care ◽  
Ischemic Heart ◽  
P Value ◽  
Care Hospital

Background: Ischemic Heart Disease (IHD) is a leading cause of morbidity and mortality worldwide. IHD results from myocardial ischemia, and occurs whenever perfusion outgrows the demand. Though lethal, but can be prevented by modification of predisposing conditions, most important are diabetes and hypertension. Almost fifty percent of IHD patients are found hypertensive with or without being diabetic. The objective of the study was to determine association of diabetes and hypertension as risk factors for IHD patients Methods: This was a hospital-based cross-sectional study that included 199 IHD patients of 35-70 years age, visiting Civil Hospital Karachi, a tertiary care public sector hospital, from September 2017 to January 2018 by using non-probability convenient sampling technique. The patients were approached in the hospital and briefed about the purpose of the study. A pre-tested, structured close ended questionnaire was used to collect the data. Data entry and analysis were done by using SPSS version 20.0. A p-value of <0.05 was considered as statistically significant. Results: Out of 199 participants, 156 (78%) were males while 43 (22%) were females; 119 60%) were 56-65 years of age. Family history of ischemic heart diseases was unremarkable in 126 (63%) patients. In total, 122 (61%) were diabetic; among them, 24 were of less than 40years and 98 of more than 40years of age. The older age of the diabetics had a direct association with the risk of IHD (p-value <0.05). About 83% had a non-significant family history for diabetes; and 83% of the total study participants were having a sedentary lifestyle. Out of 199, 166 (83%) had never checked their blood pressures earlier. The lifestyle, diet, addiction, and duration of hypertension had a strong association with IHD (p-value <0.05). Conclusion: IHD occurs more frequently in males of 56-65 years age, with insignificant family history for IHD and diabetes. The IHD is associated with hypertension and diabetes along with sedentary lifestyle, unhealthy diet and smoking/tobacco addiction.

scholarly journals ISCHEMIC HEART DISEASE

2016 ◽  
Vol 23 (12) ◽  
pp. 442-1448
Author(s):  
Shahadat Hussain Ch ◽  
Anwaar Ul Hassan ◽  
Shafqat Nazir
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Premenopausal Women ◽  
Ischemic Heart ◽  
P Value ◽  
Cross Sectional ◽  
Younger Age ◽  
Artery Disease ◽  
Disease Study

Objectives: To find out distribution of cardiovascular risk factors for women inestablished coronary artery disease. Study Design: Retrospective cross sectional descriptivestudy. Place and Duration of Study: Private clinic of consultant cardiologist at Bahawalpur fromJune 2013 to December 2015. Methodology: Total 6345 patients were registered and only 820female patients were diagnosed cases of ischemic heart disease selected for analysis of theircardiovascular risk factors. Results: The overall mean age of women was 57.75±11.28 years,weight was 66.3±15.14 kilogram, height was 153.77±7.87 cm, body mass index (BMI) was27.89±6 kg/m2 and body surface area (BSA) was 1.76±0.28 m2. Significantly high frequencyof obesity was found in premenopausal women as compared to other group i.e. 56.5% with pvalue <0.0001. BMI was also high in premenopausal women 32.13±7.91 then perimenopausalwomen, postmenopausal women and women with hysterectomy 28.06±6.93, 27.84±5.51 and27.33±6.03 respectively. The overall weight is also more in premenopausal group as comparedto postmenopausal, perimenopasaul and hysterectomy group i.e. 77.54±21.18, 66.46±13.66,66.07±16.33 and 64.41±15.31 respectively and P Value was <0.0001. There was no differencefound when DM, HTN and smoking compared within these four group. Smoking, CVA and PCI orCABG were 13(1.5%), 30(3.7%) and 13(1.5%) women respectively. Conclusion: Hypertensionand DM are most common risk factor in women with IHD. Weight, BMI and different class ofobesity are more common in younger age group as compare to older age. Smoking, PCI andCABG are very less frequent in women in this area.

scholarly journals Correlation between Inflammatory Marker and Glycemic Control in Patients with Ischemic Heart Disease

2018 ◽  
Vol 33 (2) ◽  
pp. 100-105
Author(s):  
Mohsin Ahmed ◽  
Md Mesbahul Islam ◽  
Mohammad Arifur Rahman ◽  
Khandaker Abu Rubaiyat ◽  
CM Khudrate E Khuda ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Disease ◽  
Glycemic Control ◽  
Ischemic Heart Disease ◽  
Inflammatory Marker ◽  
Ischemic Heart ◽  
P Value ◽  
Continuous Variables ◽  
Positive Correlation ◽  
The Relationship

Background: Recent evidence suggests that inflammatory markers and poor glycemic control are significantly associated with the development of cardiovascular complications. The purpose of this study was to determine the association between inflammatory marker (CRP) and glycemic status (HbA1c) in ischemic heart disease patients. Method: This cross sectional study was performed on 668 patients of ischemic heart disease in the Department of Cardiology, Dhaka Medical College Hospital, Dhaka, who underwent Coronary angiogram from January 2017 to December 2017. CRP value were divided into normal (<6 mg/L), borderline (6-10 mg/L) and high (>10 mg/L) and HbA1c was divided <6.5% and ≥6.5%. After performed Coronary angiography the extent of disease was divided into insignificant CAD of (<50% stenosis), significant CAD considered as >50% stenosis and single vessel, double vessel, triple vessel CAD and normal coronaries. The relationship between CRP with HbA1c was analyzed by Chi square test. ANOVA test was used to analyze the continuous variables, shown with mean and standard deviation. Pearson’s correlation coefficient was used to test the relationship between CRP and HbA1c in CAD patients. p value <0.05 was considered as statistically significant. Result: Most (65.0%) of the patients belonged to age 41-60 years. The mean age was found 51.4±10.7 years. Majority (82.3%) of patients were male. Among risk factors, highest (40.0%) patients had hypertension followed by 209 (31.3%) diabetes mellitus and 204 (30.5%) smoker. Positive correlation was found (r=0.220, p= 0.001) between HbA1c with CRP in CAD patients. High CRP was found 138(38.4%) in <6.5% HbA1c and 187(60.5%) in ≥6.5 percent HbA1c. The difference was statistically significant (p<0.05). Multi variable logistic regression was found high HbA1c, high CRP and diabetes mellitus were statistically significant (p<0.05) in severe CAD (Double and triple vessel) patient. Conclusion: Positive correlation was found between serum levels of CRP and HbA1c in CAD patients. Thus, aiming at good glycemic control and estimation of serum CRP levels will possibly be of help in planning early intervention, thereby preventing further complications which in turn may help preserve cardiac functions in ischemic heart disease patients. Bangladesh Heart Journal 2018; 33(2) : 100-105

scholarly journals Patient’s Information Toward Some Modifiable Risk Factors of Ischemic Heart Disease

2020 ◽  
pp. 27-39
Author(s):  
Bayan Omar Sharif ◽  
Aras Hamad Rasul ◽  
Osman Ibrahim Mahmud ◽  
Farman Nuri Abdulla
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Demographic Data ◽  
Internal Consistency Reliability ◽  
Ischemic Heart ◽  
P Value ◽  
Modifiable Risk Factors ◽  
Dietary Regimen ◽  
Patient’S Information

Ischemic heart disease (IHD), , is the condition of heart problems, caused by narrowed coronary arteries that supply oxygenated blood to the heart muscle. There is a shortage of study of bachelor students. The goal of this research was directed to assess level of patient’s information toward some modifiable risk factors of IHD at Rania teaching hospital in Kurdistan region of Iraq during the period of (20th October 2019 - 10th February 2020). A non- probability purposive sample of (143) patients; the study instrument was constructed of total (42) items for the purpose of data collection. The content validity of the instrument was determined through a panel of (12) experts. Reliability of the instrument was determined through the use of internal consistency reliability (split half) approach which was estimated as r = (0.83) the data were collected through the use of interview technique (face to face approach), the computer files is used to organizing and coding it. The data analyzed by Statistical approaches which includes: descriptive and inferential statistical and chi- square, data analysis (SPSS version 25). The outcome showed that most of the sample rang from the age (25-40) years and most of them were male from urban, more than half of them were unemployed but nearly half of them were graduated from primary school. 32.2% of them diagnosed by cardiovascular disease. However more than half of them had a high level of information about IHD as a general, and the TV was the first source of their information but more than half of them were overweight, 65% did not do regular exercise, 52.4% were relatively stressful. Also, the study demonstrated that there is no significant association between socio demographic data and level of patient’s information toward some modifiable risk factors of IHD, with age, gender, educational level and occupation with IHD, at p value greater than 0.05. The study recommended to ministry of health and directorate of health in Rania city to develop and supervise the center of dietary regimen and halls of exercise for the people to implement their information and practice it

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