Background:The impact of rheumatic diseases on patients’sexual life has been gathering the attention of the scientific community over the last decade. The existing studies, especially related to fibromyalgia, are scarce.Objectives:To assess the prevalence of sexual dysfunction in women with fibromyalgia followed up at the Outpatient Clinic of the Medical Hospital in Russia.Methods:The main group consisted of 54 women aged from 18 to 55 who sequentially applied for rheumatologist consultation. All subjects fulfilled ACR 2016 Fibromyalgia criteria. The comparison group included 100 healthy women adjusted by age who came for a scheduled health check up and signed the informed consent form. The Female Sexual Function Index (FSFI), obtained by applying a 19-item questionnaire that assesses six domains (sexual desire, arousal, vaginal lubrication, orgasm, sexual satisfaction and pain) and Hospital Anxiety and Depression questionnaire (HADS) were used. The data are presented as means and standard deviations.Results:26 (48,1%) of the patients interviewed reported no sexual activity over the past 4 weeks. fibromyalgia patients reported no sexual activity during the previous 4 weeks. Fibromyalgia group had significantly lower values of all FSFI domains than those of the comparison group: desire 1.98±1.28 and 3.19±1.45; arousal 1.98±1.46 and 3.74±1.45; lubrification 2.35±2.25 and 4.37±1.32; orgasm 1.75±1.68 and 4.06±1.66; satisfaction 2.28±1.19 and 3.95±1.61; no pain 2.49±1.77 and 4.30±1.42. In General, total FSFI score was 12.86±10.97 on fibromyalgia group versus 23.55±8.24 in the healthy group (maximum possible being 36 points, p< 0.0001).We tried to see if sexual function was affected by psychological status or stile of life. We found that only arousal, lubrification, orgasm and satisfaction had minimal values for clinically expressed anxiety while all parameters of sexual dysfunction were reduced in women on fibromyalgia group with borderline and clinically significant depression. There was the best index of sexual function married patients compared to divorced women. Unexpectedly, the minimal scores for all FSFI domains were in the fibromyalgia subgroup of 8 women with body mass deficiency and 20 women with Overweight, while normal body mass index and obesity were protective factors in sexual function.Conclusion:Thus, a significant sexual function decrease was detected in female with fibromyalgia. The most severe dysfunction being associated with the abnormal anxiety, borderline and abnormal depression, divorced status, body mass deficiency and overweight.Disclosure of Interests:None declared