Simulated Tests of Large Animal Impacts

2001 ◽  
Author(s):  
Brian Herbst ◽  
Stephen Forrest ◽  
Steven E. Meyer ◽  
Davis Hock
Keyword(s):  
Failure Modes ◽  
Field Research ◽  
Large Animal ◽  
Injury Patterns ◽  
Front Seat ◽  
Test Procedures ◽  
Vehicle Collisions ◽  
Static Test ◽  
Occupant Protection ◽  
Large Animals

Abstract Front seat occupants can be catastrophically injured in vehicle collisions with large animals such as elk, cattle or moose. This paper will discuss general injury patterns observed in these impacts, as well as the general vehicle motions and interactions with the animals. Some manufacturers (i.e. Saab and Volvo) have developed tests and incorporated design considerations to deal with this injury threat. Primary failure modes will be identified from field research and discussed. Quasi-static test procedures will be documented. Additionally, insights gained from the failure modes in both field accidents and test vehicles were used to modify vehicles with simple alterations. The vehicles were then tested using the quasi-static procedure and demonstrated significant improvements in occupant protection and roof crush resistance.

Research on seismic behavior of special-shaped CFST column to H-section steel beam joint

2021 ◽  
pp. 136943322110073
Author(s):  
Yu Cheng ◽  
Yuanlong Yang ◽  
Binyang Li ◽  
Jiepeng Liu
Keyword(s):  
Finite Element ◽  
Finite Element Model ◽  
Seismic Behavior ◽  
Failure Modes ◽  
Joint Stiffness ◽  
Load Ratio ◽  
Element Model ◽  
Steel Tube ◽  
Steel Beam ◽  
Static Test

To investigate the seismic behavior of joint between special-shaped concrete-filled steel tubular (CFST) column and H-section steel beam, a pseudo-static test was carried out on five specimens with scale ratio of 1:2. The investigated factors include stiffening types of steel tube (multi-cell and tensile bar) and connection types (exterior diaphragm and vertical rib). The failure modes, hysteresis curves, skeleton curves, stress distribution, and joint shear deformation of specimens were analyzed to investigate the seismic behaviors of joints. The test results showed the connections of exterior diaphragm and vertical rib have good seismic behavior and can be identified as rigid joint in the frames with bracing system according to Eurocode 3. The joint of special-shaped column with tensile bars have better seismic performance by using through vertical rib connection. Furthermore, a finite element model was established and a parametric analysis with the finite element model was conducted to investigate the influences of following parameters on the joint stiffness: width-to-thickness ratio of column steel tube, beam-to-column linear stiffness ratio, vertical rib dimensions, and axial load ratio of column. Lastly, preliminary design suggestions were proposed.

scholarly journals Review: Tissue Engineering of Small-Diameter Vascular Grafts and Their In Vivo Evaluation in Large Animals and Humans

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 713
Author(s):  
Shu Fang ◽  
Ditte Gry Ellman ◽  
Ditte Caroline Andersen
Keyword(s):  
Animal Models ◽  
Vascular Grafts ◽  
Small Diameter ◽  
Large Animal ◽  
Large Animal Models ◽  
Graft Outcome ◽  
Limited Success ◽  
Large Animals

To date, a wide range of materials, from synthetic to natural or a mixture of these, has been explored, modified, and examined as small-diameter tissue-engineered vascular grafts (SD-TEVGs) for tissue regeneration either in vitro or in vivo. However, very limited success has been achieved due to mechanical failure, thrombogenicity or intimal hyperplasia, and improvements of the SD-TEVG design are thus required. Here, in vivo studies investigating novel and relative long (10 times of the inner diameter) SD-TEVGs in large animal models and humans are identified and discussed, with emphasis on graft outcome based on model- and graft-related conditions. Only a few types of synthetic polymer-based SD-TEVGs have been evaluated in large-animal models and reflect limited success. However, some polymers, such as polycaprolactone (PCL), show favorable biocompatibility and potential to be further modified and improved in the form of hybrid grafts. Natural polymer- and cell-secreted extracellular matrix (ECM)-based SD-TEVGs tested in large animals still fail due to a weak strength or thrombogenicity. Similarly, native ECM-based SD-TEVGs and in-vitro-developed hybrid SD-TEVGs that contain xenogeneic molecules or matrix seem related to a harmful graft outcome. In contrast, allogeneic native ECM-based SD-TEVGs, in-vitro-developed hybrid SD-TEVGs with allogeneic banked human cells or isolated autologous stem cells, and in-body tissue architecture (IBTA)-based SD-TEVGs seem to be promising for the future, since they are suitable in dimension, mechanical strength, biocompatibility, and availability.

scholarly journals Large Animal Models of Vascularized Composite Allotransplantation: A Review of Immune Strategies to Improve Allograft Outcomes

2021 ◽  
Vol 12 ◽  
Author(s):  
Abraham J. Matar ◽  
Rebecca L. Crepeau ◽  
Gerhard S. Mundinger ◽  
Curtis L. Cetrulo ◽  
Radbeh Torabi
Keyword(s):  
Animal Models ◽  
Ex Vivo ◽  
Solid Organ Transplantation ◽  
Tolerance Induction ◽  
Large Animal ◽  
Solid Organ ◽  
Large Animal Models ◽  
Large Animals ◽  
And Function ◽  
Made In

Over the past twenty years, significant technical strides have been made in the area of vascularized composite tissue allotransplantation (VCA). As in solid organ transplantation, the allogeneic immune response remains a significant barrier to long-term VCA survival and function. Strategies to overcome acute and chronic rejection, minimize immunosuppression and prolong VCA survival have important clinical implications. Historically, large animals have provided a valuable model for testing the clinical translatability of immune modulating approaches in transplantation, including tolerance induction, co-stimulation blockade, cellular therapies, and ex vivo perfusion. Recently, significant advancements have been made in these arenas utilizing large animal VCA models. In this comprehensive review, we highlight recent immune strategies undertaken to improve VCA outcomes with a focus on relevant preclinical large animal models.

Severe Unintentional Injuries to Ohio Children: What We Should Be Addressing at Well-Child Visits

2018 ◽  
Vol 57 (9) ◽  
pp. 1092-1099
Author(s):  
Victoria M. Wurster Ovalle ◽  
Wendy J. Pomerantz ◽  
Michael A. Gittelman
Keyword(s):  
Causes Of Death ◽  
Motor Vehicle ◽  
Motor Vehicle Collisions ◽  
Injury Patterns ◽  
National Data ◽  
Unintentional Injuries ◽  
Severe Injuries ◽  
Vehicle Collisions ◽  
The Mean ◽  
Significant Injury

This was a retrospective study examining severe injuries to Ohio children in order to provide pediatricians with targeted injury talking points at well visits. We included children ≤14 years old from the Ohio Trauma Acute Care Registry with severe unintentional injuries from January 1, 2003, to December 31, 2012. There were 45 347 patients; 611 died, and the mean age was 6.8 years. Fractures/dislocations were common (46.6%), and many injuries occurred at home (49.1%). In children ≤2 years old, the leading causes of injury were falls and burns/fire; falls and motor vehicle collisions (MVCs) predominated above this age. Leading causes of death were MVCs, drowning, and suffocation. We concluded that national data may not always reflect state-specific injury patterns. In Ohio, though falls and MVCs were the most common mechanisms, fire and drowning also caused significant injury. Given limited time to discuss injury prevention, pediatricians should concentrate on statewide injuries.

Pendulum Animal Impact Testing

2009 ◽  
Author(s):  
Stephen Forrest ◽  
John Paul Sodusta ◽  
Brian Herbst ◽  
Steven E. Meyer
Keyword(s):  
Real World ◽  
Impact Testing ◽  
Front Seat ◽  
Test Vehicle ◽  
Roof Structure ◽  
Pendulum Test ◽  
Large Animals ◽  
Serious Injuries ◽  
Roof Deformation

When vehicles collide with large animals, such as cattle, moose, elk or horses, the front seat occupants can be seriously or fatally injured; primarily due to roof deformation. In order to protect the front occupants in these accidents, it is necessary to understand the forces and energy involved in the interaction between the animal and the vehicle roof structure. The authors have developed a pendulum test incorporating an animal dummy to generate similar roof deformation to that experienced in real world animal impact accidents. The energy absorbed by the vehicle roof structure in the accident can then be determined by comparing the accident vehicle roof deformation to the pendulum test vehicle roof deformation. Ultimately, alternative roof structural designs are evaluated to demonstrate that a roof can perform well in this type of accident mode and reduce the risk for serious injuries to the occupants.

scholarly journals A systematic evaluation on reporting quality of modern studies on pulmonary heart valve implantation in large animals

2020 ◽  
Vol 31 (4) ◽  
pp. 437-445
Author(s):  
Marcelle Uiterwijk ◽  
Annemijn Vis ◽  
Iris de Brouwer ◽  
Debora van Urk ◽  
Jolanda Kluin
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Animal Experiments ◽  
Reporting Quality ◽  
Systematic Evaluation ◽  
Large Animal Model ◽  
Large Animal ◽  
Before And After ◽  
Large Animals

Abstract OBJECTIVES Before new heart valves can be implanted safely in humans, animal experiments have to be performed. These animal experiments have to be clearly designed, analysed and reported to assess the accuracy and importance of the findings. We aimed to provide an overview of the reporting and methodological quality of preclinical heart valve research. METHODS We conducted a systematic literature search on biological and mechanical pulmonary valve implantations in large animals. We used the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines to score the quality of reporting in each article. We compared the scores before and after the introduction of the ARRIVE guidelines (2010). RESULTS We screened 348 articles, of which 31 articles were included. The included articles reported a mean of 54.7% adequately scored ARRIVE items (95% confidence interval 52.2–57.3%). We did not identify a difference in reporting quality (54.7% vs 54.8%) between articles published before and after 2010. We found an unclear (lack of description) risk of selection bias, performance bias and detection bias. CONCLUSIONS The reporting quality of studies that implanted bioprosthetic or mechanical valves in the pulmonary position in the large animal model is not on the desired level. The introduction of the ARRIVE guidelines in 2010 did not improve the reporting quality in this field of research. Hereby, we want to emphasize the importance of clearly describing the methods and transparently reporting the results in animal experiments. This is of great importance for the safe translation of new heart valves to the clinic. Clinical trial registration number PROSPERO (CRD42019147895).

Evaluation of Motor Vehicle Seatbelt Retractor Locking Devices

2004 ◽  
Author(s):  
Davis Hock ◽  
Steven E. Meyer ◽  
Brian Herbst ◽  
Stephen Forrest ◽  
David A. Renfroe ◽  
...  
Keyword(s):  
Motor Vehicle ◽  
Inertial Sensor ◽  
Wide Spectrum ◽  
Field Research ◽  
Velocity Sensor ◽  
Occupant Protection ◽  
Long Duration ◽  
Vehicle Acceleration ◽  
Current Production ◽  
Injury Potential

The seemingly never-ending increase in popularity of the more rollover-prone Sport Utility Vehicle type vehicles (SUVs) has provided an increased focus and urgency on rollover occupant protection. Field research has made clear that traditional, contemporary motor vehicle seatbelt retractors often fail to restrain occupants as expected. Various researchers have documented laboratory tests results and cited numerous real-world case studies describing these circumstances. These studies have typically focused on the response of the retractor’s inertial acceleration sensing lockup device. This device has been shown to allow surprising amounts of seatbelt spool out during long duration accident sequences with resulting multi-directional vehicle acceleration pulses such as those seen in typical rollover crashes. Further, increased injury potential has been discussed and attributed to such webbing spool out. One commonly implemented design countermeasure, or redundancy, to the retractor’s inertial sensor is a webbing velocity sensor intended to lock up the retractor independent of vehicle acceleration. This paper reports laboratory test data evaluating a wide spectrum of webbing velocity sensor designs found in current production vehicles. This study evaluates their relative performance, corresponding injury potential and occupant protection aspects of these designs.

scholarly journals Intratracheal aerosolization of viral vectors to newborn pig airways

BioTechniques ◽  
2020 ◽  
Vol 68 (5) ◽  
pp. 235-239
Author(s):  
Ashley L Cooney ◽  
Patrick L Sinn
Keyword(s):  
Gene Therapy ◽  
Animal Models ◽  
Endotracheal Tube ◽  
Viral Vectors ◽  
Small Animal ◽  
Large Animal ◽  
Large Animal Models ◽  
Airway Diseases ◽  
Efficient Delivery ◽  
Large Animals

Gene therapy for airway diseases requires efficient delivery of nucleic acids to the airways. In small animal models, gene delivery reagents are commonly delivered as a bolus dose. However, large animal models are often more relevant for the transition from preclinical studies to human trials. Aerosolizing viral vectors to the lungs of large animals can maximize anatomical distribution. Here, we describe a technique for aerosolization of viral vectors to the airways of newborn pigs. Briefly, a pig is anesthetized and intubated with an endotracheal tube, and a microsprayer is passed through the endotracheal tube. A fine mist is then sprayed into the distal trachea. Widespread and uniform distribution of transgene expression is critical for developing successful lung gene therapy treatments.

Comparative Study on the Effects of Infill Walls on Reinforced Concrete Frame Structures

2015 ◽  
Vol 730 ◽  
pp. 81-84
Author(s):  
Huan Jin
Keyword(s):  
Finite Element ◽  
Failure Modes ◽  
Shear Failure ◽  
Frame Structure ◽  
Frame Structures ◽  
Reinforced Concrete Frame ◽  
Element Analysis ◽  
Infill Walls ◽  
Finite Element Program ◽  
Static Test

Based on the quasi-static test of single-layer, two-bay RC frame model, using DIANA finite element program, a finite element Macro-model of masonry-infilled frame structure was established, and nonlinear finite element analysis of frame structures filled with different masonry materials was conducted. As a result of the existence of infill walls, the failure modes of frame structure have been changed, and which is easy to cause shear failure at the top of frame columns. If masonry materials of infill walls are different, the effects of infill panels on frame structures will be different. Comparative analysis shows that the influence of clay bricks is the largest, followed by autoclaved bricks’ influence, while aerated concrete blocks’ influence is the smallest. Therefore, to avoid the associated failure mechanism caused by infill walls, lightweight masonry materials are suggested to be used in actual engineering.

scholarly journals A Novel Approach to Drug Delivery for Hepatities C Virus (HCV) for High Immune Responses

2008 ◽  
Vol 2 (2) ◽  
Author(s):  
W. T. Chen ◽  
C. Zhang
Keyword(s):  
Immune Responses ◽  
High Strength ◽  
Azomethine Ylides ◽  
Enzyme Linked Immunosorbent Assay ◽  
Large Animal ◽  
Testing Environment ◽  
Large Animal Models ◽  
Novel Approach ◽  
Large Animals

Hepatities C Virus (HCV) is a significant health problem worldwide due to the lack of effective vaccines. HCV plasmid DNA (pDNA) vaccine represents a promising means to induce a Th1-biased cell-mediated response which tends to be associated with HCV clearance. However, the immune responses induced by naked pDNA vaccine in large animals as well as in humans are usually too weak to show sufficient protection against new infections. Therefore, it is interesting to look for new ways to deliver HCV pDNA vaccine. In this research, carbon nanotube (CNT) is used as a carrier to deliver the pDNA vaccine of HCV to induce high immune responses, because CNT has some excellent properties such as high strength and good biocompatibility. One of the key approaches to make this idea work is to treat CNT so that it can bind with HCV pDNA with good stability. An approach called 1, 3-dipolar cycloaddition of azomethine ylides was modified. We analyzed the complex of f-CNTs combined with pDNA vaccines expressing HCV E2 protein by using Enzyme-linked immunospot (ELISPOT) or Enzyme-linked immunosorbent assay (ELISA) assay in vitro. The result showed that the CNT approach can induce stronger protective immune responses than the needle delivery of naked pDNA vaccine. We have also found an optimal way to treat CNT in light of the highest immune response in the same testing environment. The success of this research will warrant testing HCV vaccine in large animal models and human clinical trials.

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