Influence of Nutrient Channels on Development of Engineered Cartilage Properties

2007 ◽  
Author(s):  
Liming Bian ◽  
Kenneth W. Ng ◽  
Eric G. Lima ◽  
Gerard A. Ateshian ◽  
Clark T. Hung
Keyword(s):  
Mechanical Properties ◽  
Central Region ◽  
Material Properties ◽  
Large Diameter ◽  
Inhomogeneous Material ◽  
Diffusion Distance ◽  
Diffusion Limitations ◽  
Spatially Inhomogeneous ◽  
Nutrient Diffusion ◽  
Engineered Cartilage

It has been shown that chondrocyte-seeded agarose constructs of large dimensions develop spatially inhomogeneous material properties with stiffer outer edges and a softer central core [1]. This axial (depth-dependent) inhomogeneity was observed for constructs with relatively large diameter (4mm) and thickness (2.3mm) and suggests nutrient diffusion limitations to the central region of the constructs. Our previous study also showed that by reducing the thickness of the agarose construct (to 1mm) more homogenous construct properties can be obtained as a result of the reduced diffusion distance [2]. In this study we hypothesized that more homogeneous constructs of better mechanical properties could be achieved by creating channels running through the depth of the thick constructs (2.3mm), thereby facilitating nutrient diffusion into the central region of the constructs.

Cytocompatibility and Material Properties of Poly-carbonate Urethane/Carbon Nanofiber Composites for Neural Applications

2003 ◽  
Vol 774 ◽  
Author(s):  
Janice L. McKenzie ◽  
Michael C. Waid ◽  
Riyi Shi ◽  
Thomas J. Webster
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanofibers ◽  
Material Properties ◽  
Carbon Nanofiber ◽  
Scar Tissue ◽  
Tissue Response ◽  
Positive Interactions ◽  
Weight Percentage ◽  
Poly Carbonate

AbstractCarbon nanofibers possess excellent conductivity properties, which may be beneficial in the design of more effective neural prostheses, however, limited evidence on their cytocompatibility properties exists. The objective of the present in vitro study was to determine cytocompatibility and material properties of formulations containing carbon nanofibers to predict the gliotic scar tissue response. Poly-carbonate urethane was combined with carbon nanofibers in varying weight percentages to provide a supportive matrix with beneficial bulk electrical and mechanical properties. The substrates were tested for mechanical properties and conductivity. Astrocytes (glial scar tissue-forming cells) were seeded onto the substrates for adhesion. Results provided the first evidence that astrocytes preferentially adhered to the composite material that contained the lowest weight percentage of carbon nanofibers. Positive interactions with neurons, and, at the same time, limited astrocyte functions leading to decreased gliotic scar tissue formation are essential for increased neuronal implant efficacy.

The Effect of Heat Treatment on Mechanical Properties of Car Interior Fabric Used for Injection Molding

2012 ◽  
Vol 532-533 ◽  
pp. 234-237
Author(s):  
Wei Lai Chen ◽  
Ding Hong Yi ◽  
Jian Fu Zhang
Keyword(s):  
Mechanical Properties ◽  
Heat Treatment ◽  
High Temperature ◽  
Injection Molding ◽  
High Temperatures ◽  
Material Properties ◽  
Injection Molding Process ◽  
Molding Process ◽  
Composite Fabrics

The purpose of this paper is to study the effect of high temperature in injection molding process on mechanical properties of the warp-knitted and nonwoven composite fabrics (WNC)used in car interior. Tensile, tearing and peeling properties of WNC fabrics were tested after heat treatment under120, 140,160,180°C respectively. It was found that, after 140°C heat treatment, the breaking and tearing value of these WNC fabrics are lower than others. The results of this study show that this phenomenon is due to the material properties of fabrics. These high temperatures have no much effect on peeling properties of these WNC fabrics. It is concluded that in order to preserve the mechanical properties of these WNC fabrics, the temperature near 140°C should be avoided possibly during injection molding process.

Evaluating Mechanical Properties of Ceramics by Relative Methods

2007 ◽  
Vol 336-338 ◽  
pp. 2406-2410
Author(s):  
Yi Wang Bao ◽  
Xiao Xue Bu ◽  
Yan Chun Zhou ◽  
Li Zhong Liu
Keyword(s):  
Mechanical Properties ◽  
Material Properties ◽  
Ceramic Coatings ◽  
Relative Method ◽  
Tempered Glass ◽  
Theoretic Analysis ◽  
Surface Strength ◽  
Indirect Approach ◽  
Before And After ◽  
The Relationship

A relative method, defined as indirect approach to evaluate the material properties via the relationship between unknown properties and a known property, is proposed to estimate some properties that could not be measured by the traditional methods for ceramics. Experiments and theoretic analysis based on the relative method were carried out in this study to estimate the properties in following aspects: determining the temperature dependence of elastic modulus of some machineable ceramics by comparing the deflections; obtaining the modulus and strength of ceramic coatings supported by substrates, from the variation in properties of the rectangular beam samples before and after coating; estimating the residual stresses in tempered glass by comparing the change in the surface strength after strengthening.

The Effect of Cross-Linking on Nano-Mechanical Properties of Polyamide

2016 ◽  
Vol 699 ◽  
pp. 37-42 ◽  
Author(s):  
Martin Ovsik ◽  
David Manas ◽  
Miroslav Manas ◽  
Michal Stanek ◽  
Martin Reznicek
Keyword(s):  
Mechanical Properties ◽  
Surface Layer ◽  
Material Properties ◽  
Basic Material ◽  
Nanoindentation Test ◽  
Cross Linking ◽  
Indentation Hardness ◽  
Depth Sensing ◽  
Nanomechanical Properties ◽  
Radiation Crosslinking

Radiation crosslinking of polyamidu 6 (PA 6) is a well-recognized modification of improving basic material characteristics. Radiation, which penetrated through specimens and reacted with the cross-linking agent, gradually formed cross-linking (3D net), first in the surface layer and then in the total volume, which resulted in considerable changes in specimen behaviour. This research paper deals with the possible utilization of irradiated PA6. The material already contained a special cross-linking agent TAIC (5 volume %), which should enable subsequent cross-linking by ionizing β – radiation (15, 30 and 45 kGy). The effect of the irradiation on mechanical behavior of the tested PA 6 was investigated. Material properties created by β – radiation are measured by nanoindentation test using the DSI method (Depth Sensing Indentation). Hardness increased with increasing dose of irradiation at everything samples; however results of nanoindentation test shows increasing in nanomechanical properties of surface layer. The highest values of nanomechanical properties were reached radiation dose of 45 kGy, when the nanomechanical values increased by about 95%. These results indicate advantage cross-linking of the improved mechanical properties.

Hydrogen’s Peculiar Effect on Material Properties: Do We Need to Be Concerned About Hydrogen Transport in Pipelines?

2021 ◽  
Author(s):  
Erling Østby ◽  
Bjørn-Andreas Hugaas ◽  
Agnes Marie Horn
Keyword(s):  
Mechanical Properties ◽  
Material Properties ◽  
Reliable Data ◽  
Hydrogen Gas ◽  
Decision Makers ◽  
Hydrogen Transport ◽  
Offshore Pipelines ◽  
Vast Number ◽  
Technical Aspects ◽  
Controversial Topic

Abstract Considering the vast number of articles that have been published during the last 150 years related to hydrogen embrittlement and the multiple attempts to explain the governing mechanisms, it is evident that hydrogen’s effect on mechanical properties in steel is still a controversial topic. This little atom has even by some authors been referred to as the “little devil”. We do not intend to explore this particular description of hydrogen any further. However, we would like to shed some light on the key technical aspects we believe need to be further scrutinized and understood to ensure that the decision-makers have sufficiently reliable data available to decide whether hydrogen gas can be safely transported in new or existing offshore pipelines at an acceptable cost.

Tissue-Engineered Cartilage in Three-Dimensional Cultured Chondrocytes by Ultrasound Stimulation and Collagen Sponge as Scaffold

2009 ◽  
Author(s):  
Toshihiko Shiraishi ◽  
Ietomo Matsunaga ◽  
Shin Morishita ◽  
Ryohei Takeuchi ◽  
Tomoyuki Saito ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Three Dimensional ◽  
Collagen Sponge ◽  
Cartilage Tissue ◽  
Mechanical Environment ◽  
Ultrasound Stimulation ◽  
Scaffold Structure ◽  
Matrix Production ◽  
Engineered Cartilage ◽  
Cultured Chondrocytes

This paper describes the effects of ultrasound stimulation on chondrocytes in three-dimensional culture in relation to the production of regenerative cartilage tissue, using collagen sponges as a carrier and supplementation with hyaluronic acid (used in the conservative treatment of osteoarthritis). It has been shown that cell proliferation and matrix production can be facilitated by considering the mechanical environment of the cultured chondrocytes and the mechanical properties of the scaffold structure used in the culture and of the stimulation used.

scholarly journals Characterization of scar tissue biomechanics during adult murine flexor tendon healing

2021 ◽  
Author(s):  
Antonion Korcari ◽  
Alayna E Loiselle ◽  
Mark R Buckley
Keyword(s):  
Mechanical Properties ◽  
Material Properties ◽  
Healing Process ◽  
Tendon Healing ◽  
Scar Tissue ◽  
Element Analysis ◽  
Material Quality ◽  
Treatment Regimens ◽  
Tangent Moduli ◽  
Experimental Findings

Tendon injuries are very common and result in significant impairments in mobility and quality of life. During healing, tendons produce a scar at the injury site, characterized by abundant and disorganized extracellular matrix and by permanent deficits in mechanical integrity compared to healthy tendon. Although a significant amount of work has been done to understand the healing process of tendons and to develop potential therapeutics for tendon regeneration, there is still a significant gap in terms of assessing the direct effects of therapeutics on the functional and material quality specifically of the scar tissue, and thus, on the overall tendon healing process. In this study, we focused on characterizing the mechanical properties of only the scar tissue in flexor digitorum longus (FDL) tendons during the proliferative and remodeling healing phases and comparing these properties with the mechanical properties of the composite healing tissue. Our method was sensitive enough to identify significant differences in structural and material properties between the scar and tendon-scar composite tissues. To account for possible inaccuracies due to the small aspect ratio of scar tissue, we also applied inverse finite element analysis (iFEA) to compute mechanical properties based on simulated tests with accurate specimen geometries and boundary conditions. We found that the scar tissue linear tangent moduli calculated from iFEA were not significantly different from those calculated experimentally at all healing timepoints, validating our experimental findings, and suggesting the assumptions in our experimental calculations were accurate. Taken together, this study first demonstrates that due to the presence of uninjured stubs, testing composite healing tendons without isolating the scar tissue overestimates the material properties of the scar itself. Second, our scar isolation method promises to enable more direct assessment of how different treatment regimens (e.g., cellular ablation, biomechanical and/or biochemical stimuli, tissue engineered scaffolds) affect scar tissue function and material quality in multiple different types of tendons.

Elasto-Plastic Hemispherical Contact Models for Various Mechanical Properties

2005 ◽  
Author(s):  
John J. Quicksall ◽  
Robert L. Jackson ◽  
Itzhak Green
Keyword(s):  
Mechanical Properties ◽  
Elastic Modulus ◽  
Material Properties ◽  
Poisson’S Ratio ◽  
Carbon Steels ◽  
Poisson's Ratio ◽  
Aluminum Bronze ◽  
Contact Models ◽  
Element Technique ◽  
Malleable Cast

This work uses the finite element technique to model the elasto-plastic deformation of a hemisphere contacting a rigid flat for various material properties typical of aluminum, bronze, copper, titanium and malleable cast iron. Additionally, this work conducted parametric FEM tests on a generic material in which the elastic modulus and Poisson’s ratio are varied independently while the yield strength is held constant. A larger spectrum of material properties are covered in this work than in most previous works. The results are compared to two previously formulated elasto-plastic models simulating the deformation of a hemisphere in contact with a rigid flat. Both of the previously formulated models use carbon steel mechanical properties to arrive at empirical formulations implied to pertain to various materials. While both models considered several carbon steels with varying yield strengths, they did not test materials with varying Poisson’s ratio or elastic modulus. The previously generated elasto-plastic models give fairly good predictions when compared to the FEM results for various material properties from the current work, except that one model produces more accurate predictions overall, especially at large deformations where other models neglect important trends due to decreases in “hardness” with increasing deformation.

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