Carbohydrate Influences Plasma Interleukin-6 but Not C-Reactive Protein or Creatine Kinase Following a 32-Km Mountain Trail Race

2006 ◽  
Vol 16 (1) ◽  
pp. 36-46 ◽  
Author(s):  
Mary P. Miles ◽  
Erin E. Walker ◽  
Stephen B. Conant ◽  
Shelly P. Hogan ◽  
Jessy R. Kidd
Keyword(s):  
Creatine Kinase ◽  
Interleukin 6 ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
C Reactive Protein ◽  
Blood Samples ◽  
Reactive Protein ◽  
Ad Libitum ◽  
Voluntary Intake ◽  
Exercise Induced

Attenuation of exercise-induced interleukin-6 (IL-6) responses by carbohydrate (CHO) has been demonstrated in studies comparing controlled doses (≥ 0.9 g · kg−1 · h−1) to placebo, but not in studies of voluntary intake. This study sought to determine if attenuation of the IL-6 response during a 32.2-km mountain trail race occurs for high compared to low ad libitum CHO intakes. IL-6, C-reactive protein (CRP), and creatine kinase activity (CK) were analyzed from blood samples collected 12 h pre-, 0, 4, and 24 h post-race. Subjects were grouped into low (n = 14, 0.4 ± 0.1 g · kg−1· h−1) and high (n = 18, 0.8 ± 0.2 g · kg−1 · h−1) CHO intake groups. IL-6 0 h post-race (P < 0.05) was higher in the low (40.2 ± 22.7 pg · mL−1) compared to the high CHO group (32.7 ± 22.1 pg · mL−1). CRP and CK both increased post-race, but no differences were observed between groups. Attenuation of exercise-induced IL-6 is apparent across a range of CHO intakes.

scholarly journals An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

2010 ◽  
Vol 81 (1) ◽  
Author(s):  
B. Nevill ◽  
A. Leisewitz ◽  
A. Goddard ◽  
P. Thompson
Keyword(s):  
Creatine Kinase ◽  
Protein Concentration ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Activity Levels ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Wide Range ◽  
A Prospective Study ◽  
Time Point

The extent of trauma in a patient can be difficult for a clinician to quantify. A prospective study was performed on 2 groups of dogs undergoing either ovariohysterectomy or hemilaminectomy. The serum activity of creatine kinase and serum concentration of C-reactive protein were evaluated preoperatively and then at 4, 6, 8, 12, 24 and 48 hours postoperatively in both groups. The results were compared statistically both within and between the 2 groups. A wide range of results was found at each time point for both analytes although there were no significant differences for either analyte between the 2 surgical groups preoperatively. Thereafter there were significant differences in creatine kinase activity levels between the 2 groups. C-reactive protein concentration results were very similar in the 2 groups with no statistical difference at any time point. The results of this study suggest that the evaluation of CK and CRP at any one time point in a traumatised animal is of limited value. However, the evaluation of the trend of these 2 analytes, even over a relatively short time period, may allow for useful prognostication in clinical cases.

Cholesterol fractions, C-reactive protein and creatine kinase activity in plasma of female athletes

2008 ◽  
Vol 52 (-1) ◽  
pp. 88-91 ◽  
Author(s):  
Elżbieta Hübner-Woźniak ◽  
Marzena Malara ◽  
Joanna Okęcka-Szymańska ◽  
Konrad Witek
Keyword(s):  
Creatine Kinase ◽  
Kinase Activity ◽  
Female Athletes ◽  
Creatine Kinase Activity ◽  
C Reactive Protein ◽  
Reactive Protein

Plasma creatine kinase activity and exercise-induced muscle damage in older men

1991 ◽  
Vol 23 (9) ◽  
pp. 1028???1034 ◽  
Author(s):  
THOMAS G. MANFREDI ◽  
ROGER A. FIELDING ◽  
KEVIN P. O??REILLY ◽  
CAROL N. MEREDITH ◽  
HO YONG LEE ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Kinase Activity ◽  
Older Men ◽  
Creatine Kinase Activity ◽  
Exercise Induced ◽  
Plasma Creatine Kinase ◽  
Plasma Creatine Kinase Activity

scholarly journals Evaluation of Serum Interleukin-6 and C-Reactive Protein Levels among Women During Term Labour

2020 ◽  
pp. 69-76
Author(s):  
Ubongabasi A. James ◽  
John O. Imaralu ◽  
Ijeoma Esiaba
Keyword(s):  
Interleukin 6 ◽  
Venous Blood ◽  
University Teaching ◽  
Enzyme Linked Immunosorbent Assay ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Blood Samples ◽  
Reactive Protein ◽  
Significant Difference ◽  
Term Labour

Aims: To determine the serum concentrations of C-reactive protein (CRP) and interleukin 6 (IL-6) as well as level of leukocytosis, as inflammatory contributory factors in women with uncomplicated term pregnancies before, during and after labour. Study Design:  This is a cross-sectional study. Place and Duration of Study: The study was carried out in the Department of Obstetrics and Gynaecology of Babcock University Teaching Hospital (BUTH) and Department of Biochemistry, Babcock University, Ogun State Nigeria between June 2019 and February 2020. Methodology: 45 venous blood samples were obtained from 34 selected women and grouped into three; prenatal (≥ 32 weeks, n = 18), labour (4 to 6 cm dilation, n = 12) and postnatal (≤ 24 hour postpartum, n = 15). Sixteen blood samples were also obtained from the umbilical cord. Levels of CRP and IL-6 were determined by Enzyme Linked Immunosorbent Assay (ELISA) techniques and the leukocyte count, by hematologic method. Differences in statistical mean were evaluated by one way analysis of variance (ANOVA) with Bonferroni post hoc comparison. The level of significance was set at P < 0.05. Results: Concentration of serum IL-6 was significantly high during labour (1354.79 ± 189.16 pg/mL) compared to the prenatal (14.94 ± 4.86 pg/mL, P < .001) and postnatal (13.17 ± 3.06 pg/mL, P < .001) periods. The low level of CRP observed during active labour compared to the prenatal and postnatal periods did not reach significant difference. The levels of these inflammatory markers were low in the cord blood. Leukocyte counts (P = .011) as well as neutrophils (P = .014) and MID cell fractions (P = .004) were significantly higher during the postnatal period. Conclusion: The high levels of serum IL-6 observed in this study supports human term labour as an inflammatory event not associated with increased leukocytosis.

PSV-B-28 Late-Breaking: Development and validation of a Total Inflammation Index™ for identifying inflammation in Labrador Retrievers using a pressure walkway

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 383-384
Author(s):  
Jessica L Varney ◽  
Craig N Coon
Keyword(s):  
Creatine Kinase ◽  
Gait Analysis ◽  
Interleukin 6 ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Low Grade ◽  
C Reactive Protein ◽  
Inflammatory Biomarker ◽  
Reactive Protein ◽  
Labrador Retrievers

Abstract The objective of this trial was to develop an index system to identify inflammation in Labrador Retrievers using a pressure walkway system. Gait analysis data can be difficult to interpret between treatment groups or for identifying low grade inflammation. To calculate the Total Inflammation Index™, the distance away from the ideal score was calculated for four parameters for each dog, including gait lameness score, total pressure index, step/stride ratio, and hind reach. These values were equally weighted and added together to produce the Total Inflammation Index™. For validation, the Total Inflammation Index™ values were compared to biomarker data for inflammation including cartilage oligomeric matrix protein, interleukin-6, creatine kinase, and c-reactive protein. Forty Labrador Retrievers (20 male/20 female) were used in this trial. All dogs were passed over the pressure walkway (Gait4Dogs; CIR Systems, Inc) to obtain gait analysis at baseline, 24h prior to the first 5km run, 24h after the first 5km run, 24h prior to the final 16km run, and 24h after the final 16km run. All biomarkers and the Total Inflammation Index™ were both significantly lower at the pre-exercise timepoints and elevated after post-exercise timepoints (P &lt; 0.01). The Total Inflammation Index™ had significant correlation between timepoints and all biomarkers, including cartilage oligomeric matrix protein (P &lt; 0.01), interleukin-6 (P &lt; 0.05), creatine kinase (P &lt; 0.01), and c-reactive protein (P &lt; 0.05). The Total Inflammation Index™ appears to be a valid assay to evaluate generalized inflammation in Labrador Retrievers, and is in agreement with inflammatory biomarker values.

Effects of Oral Supplementation With Plant Superoxide Dismutase Extract on Selected Redox Parameters and an Inflammatory Marker in a 2,000-m Rowing-Ergometer Test

2011 ◽  
Vol 21 (2) ◽  
pp. 124-134 ◽  
Author(s):  
Anna Skarpanska-Stejnborn ◽  
Lucja Pilaczynska-Szczesniak ◽  
Piotr Basta ◽  
Ewa Deskur-Smielecka ◽  
Donata Woitas-Slubowska ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Placebo Group ◽  
Inflammatory Marker ◽  
Thiobarbituric Acid ◽  
Creatine Kinase Activity ◽  
C Reactive Protein ◽  
Sod Activity ◽  
Blood Samples ◽  
Reactive Protein ◽  
Rowing Ergometer

The aim of this study was to investigate the effect of plant superoxide dismutase extract (GliSODin) supplementation on the balance of oxidants and antioxidants in the serum and erythrocytes of competitive rowers. The double-blinded study included 19 members of the Polish rowing team who were participating in a preparatory camp. Subjects were randomly assigned to the supplemented group (n = 10), who received 2 capsules (500 mg) of GliSODin extract once daily for 6 weeks, or the placebo group (n = 9). At the beginning and end of the study, subjects performed a 2,000-m maximum-effort test on a rowing ergometer. Blood samples were taken from the antecubital vein before each exercise test, 1 min after completing the test, and after a 24-hr restitution period. The following redox parameters were assessed in erythrocytes: superoxide dismutase (SOD) activity, glutathione peroxidase activity, and concentrations of thiobarbituric-acid-reactive substances. In addition, creatine kinase activity and total antioxidant capacity were measured in plasma samples, lactate levels were determined in capillary blood samples, and C-reactive protein and lactate dehydrogenase concentrations were measured in serum. After supplementation, SOD activity was significantly higher (p = .0037) in the supplemented group than the placebo group, and C-reactive protein was significantly (p = .00001) lower in athletes receiving GliSODin than those in the placebo group. In conclusion, supplementation with an extract rich in SOD activity promoted antioxidant status and protected against increased inflammation in the serum of professional rowers but had no effect on oxidative damage induced by exhaustive exercise.

scholarly journals Serum Interleukin-6 Expression Level and Its Clinical Significance in Patients with Dermatomyositis

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Min Yang ◽  
Xiaomin Cen ◽  
Qibing Xie ◽  
Chuan Zuo ◽  
Guixiu Shi ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Lupus Erythematosus ◽  
Interleukin 6 ◽  
Expression Level ◽  
C Reactive Protein ◽  
Laboratory Findings ◽  
Blood Samples ◽  
Reactive Protein ◽  
Normal Controls ◽  
Group Serum

Objective. To analyze serum interleukin-6 (IL-6) expression level and its clinical significance in patients with dermatomyositis.Methods. Blood samples from 23 adult patients with dermatomyositis (DM), 22 with systemic lupus erythematosus (SLE), 22 with rheumatoid arthritis (RA), 16 with Sjögren's syndrome (SS), and 20 healthy controls were collected. The IL-6 concentration was detected by chemiluminescence immunoassay. Correlations between IL-6 expression levels and clinical features or laboratory findings in patients with DM were investigated.Results. IL-6 expression level of DM patients was significantly higher than that of normal controls, significantly lower than that of RA patients, and slightly lower than that of SLE or SS patients with no significant differences. The incidence of fever was significantly higher in the IL-6 elevated group. Serum ferritin (SF) and C-reactive protein (CRP) were positively correlated with IL-6.Conclusions. IL-6 plays a less important role in DM than in RA. IL-6 monoclonal antibodies may have poor effect in patients with DM.

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