scholarly journals AB0436 CHANGES OF LYMPHOCYTE SUBSETS AND CLINICAL INDEXES IN PERIPHERAL BLOOD OF PATIENTS WITH ANTI-PHOSPHOLIPID SYNDROME

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1517.1-1517
Author(s):  
W. Niu ◽  
H. Y. Wen
Keyword(s):  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
Laboratory Data ◽  
Healthy Control Group ◽  
Control Group ◽  
Primary Antiphospholipid Syndrome ◽  
Significant Difference ◽  
Healthy Control ◽  
Adverse Pregnancy ◽  
Anti Phospholipid Syndrome

Background:Anti-phospholipid Syndrome (APS) is a non-inflammatory autoimmune disease, which can be divided into primary and secondary. Changes in lymphocyte numbers in APS are caused by disruption of the immune balance.Objectives:The levels of lymphocyte subsets in peripheral blood of patients with anti-phospholipid syndrome were observed and their clinical indexes were analyzed.Methods:53 patients with anti-phospholipid syndrome (APS) were collected as the case group and divided into two groups of A, B according to whether primary and 50 health examiners as the healthy control group. The levels of peripheral lymphocyte subsets and laboratory data [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), platelets (PLT)]levels in the three groups were analyzed. The measurement data is not subject to normal distribution using the Median-Quartile method for statistical description; multiple sample comparisons using the Kruskal-Wallis H test; p <0.05 as the difference is statistically significant.Results:(1) The rates of thrombosis and adverse pregnancy in the two case groups were significantly increased. In the two case groups, the ESR and CRP were higher than those in the healthy control group, and the CRP in group A was higher. (2) Compared with the healthy control group, the levels of CD8+T, CD4+T/CD8+T in case A group were increased,while the levels of total T,CD4+T, CD8+T,CD4+T/CD8+T,Th2 and Treg cells were decreased. However,there was no significant difference in Th17 cells level and Th17/Treg ratio compared with the healthy control group.Conclusion:APS patients were more prone to have thrombosis, adverse pregnancy and thrombocytopenia. The changes of lymphocyte subsets were seen in peripheral blood, and the primary and secondary had different directions and different degrees of manifestation.However, whether the secondary factors can aggravate the clinical indicators of APS is still unclear.References:[1]Simonin Laurent,Pasquier Elisabeth,Leroyer Christophe et al. Lymphocyte Disturbances in Primary Antiphospholipid Syndrome and Application to Venous Thromboembolism Follow-Up.[J].Clin Rev Allergy Immunol, 2017, 53: 14-27.doi:10.1007/s12016-016-8568-1.Disclosure of Interests:None declared

scholarly journals CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yan-Long Ren ◽  
Tao-Tao Li ◽  
Wei Cui ◽  
Li-Min Zhao ◽  
Na Gao ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
Takayasu’S Arteritis ◽  
Control Group ◽  
Takayasu's Arteritis ◽  
Cd8 T Lymphocyte ◽  
Healthy Control ◽  
Ifn Γ

AbstractInterferon-gamma (IFN-γ) is a cytokine involved in the pathogenesis of Takayasu’s arteritis (TAK). However, the source of IFN-γ in TAK patients is not fully clear. We aimed to investigate the source of IFN-γ in TAK. 60 TAK patients and 35 health controls were enrolled. The lymphocyte subsets of peripheral blood were detected by flow cytometry, cytokines were detected by Bio-plex. The correlation among lymphocyte subsets, cytokines and disease activity indexes was analyzed by person correlation. The level of serum IFN-γ in TAK patients was significantly increased (P < 0.05). The percentage of CD3+IFN-γ+ cells in peripheral blood CD3+ cells was significantly higher in TAK patients than that of healthy control group (P = 0.002). A higher proportion of CD3+CD8+IFN-γ+ cells/CD3+IFN-γ+ cells (40.23 ± 11.98% vs 35.12 ± 11.51%, P = 0.049), and a significantly lower CD3+CD4+IFN-γ+/ CD3+CD8+IFN-γ+ ratio (1.34 ± 0.62% vs 1.80 ± 1.33%, P = 0.027) were showed in the TAK group than that of control group. The CD3+CD8+IFN-γ+/CD3+IFN-γ+ ratio was positively correlated with CD3+IFN-γ+cells/ CD3+cells ratio (r = 0.430, P = 0.001), serum IFN-γ level (r = 0.318, P = 0.040) and IL-17 level (r = 0.326, P = 0.031). It was negatively correlated with CD3+CD4+IFN-γ+/CD3+IFN-γ+ ratio (r = − 0.845, P < 0.001). IFN-γ secreted by CD3+CD8 + T cells is an important source of serum IFN-γ in TAK patients.

CAT-21 A/T Gene Polymorphisms Associated with Breast Cancer Susceptibility

2021 ◽  
Vol 32 (2) ◽  
pp. 79-84
Author(s):  
Kevin Owen ◽  
Siti Syarifah ◽  
Mutiara Indah Sari
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Healthy Control Group ◽  
Control Group ◽  
Genotype Distribution ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Healthy Control

Background: Oxidative stress induced cancer cell formation. Gene polymorphism plays roles in carcinogen metabolism, antioxidant and DNA repairing pathway was susceptibility to oxidative stress. This study aim to determine the association between CAT-21 A/T polymorphism with breast cancer susceptibility. Methods: Case control study was conducted on 65 breast cancer patient and 65 healthy control group. The whole blood samples were isolated from 65 breast cancer patients in Haji Adam Malik General Hospital Medan and 65 healthy control group. The CAT-21A/T polymorphism was analyzed by PCR-RFLP procedure. PCR-RFLP product was electrophoresed and visualized in agarose 4%. Results:The AA CAT-21 genotype were lower in breast cancer (BC) than healthy control (HC) group (31/47.7% vs 40/61.5%), in the contrary AT+TT genotype was greater in BC than HC group (34/52.3% vs 25/38.5%) with (p=0.159, OR=1.755, CI=0.874–3.525). A allele CAT-21 were found lower in BC than HC group (89/68.5% vs 105/80.8%) then T allele were greater in BC than HC group (41/31.5% vs 25/19.2%) with (p=0.033, OR=1.935;CI=1.022-3.428). Conclusions: There was significant difference in allele distribution of CAT-21 A/T between case and control group but no in genotype distribution. In this population study showed that allele of CAT -21 A/T polymorphism could represent as a risk factor to breast cancer. Bangladesh J Medicine July 2021; 32(2) : 79-84

scholarly journals Evaluation of Cervical Dysfunctions in Temporomandibular Disorders

2021 ◽  
Author(s):  
Mustafa Çorum
Keyword(s):  
Neck Pain ◽  
Temporomandibular Disorders ◽  
Healthy Subjects ◽  
Healthy Control Group ◽  
Control Group ◽  
Pain Group ◽  
Pain Provocation ◽  
Significant Difference ◽  
Upper Cervical ◽  
Healthy Control

Objective: The purpose of this study is to investigate upper cervical segmental dysfunctions in female patients with chronic TMD with and without neck pain and to compare them with healthy subjects. Method: Patients admitted to our hospital with jaw pain were evaluated in this study, and a total of 152 patients and healthy subjects who met the inclusion criteria for the study were divided into 3 groups: TMD with neck pain (n = 94), TMD without neck pain (n = 28) and control (n = 30). Patients with myofascial pain (category I) or disc displacements (category II) were diagnosed based on the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) guidelines. Upper cervical segmental dysfunctions were identified using functional and pain provocation tests in patients with TMD and healthy subjects. Results: When patients with TMD were classified, there was a significant difference between TMD with neck pain (category I, 62.8%; category II, 37.2%) and TMD without neck pain (category I, 28.6%; category II, 71.4%) groups (p = 0.002). There was a statistically significant dysfunction [difference] in all upper cervical segments in favor of the TMD with neck pain group compared TMD without neck pain group and healthy control group (p < 0.05). 51.1% Occiput-C1, 81.9% C1-C2 and 53.2% C2-C3 segment dysfunction rates were detected in TMD with neck pain group. Conclusion: Upper cervical segmental dysfunction rate was higher in TMD group with neck pain than TMD without neck pain and healthy control group.

scholarly journals Th Cytokine Profile in Childhood-Onset Systemic Lupus Erythematosus

2021 ◽  
Author(s):  
Wei Quan ◽  
Jingnan An ◽  
Gang Li ◽  
Guanghui Qian ◽  
Meifang Jin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Peripheral Blood ◽  
Healthy Control Group ◽  
Control Group ◽  
Healthy Children ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Healthy Control

Abstract Background: Childhood-onset systemic lupus erythematosus (cSLE) is a kind of chronic inflammatory disease characterized by a highly abnormal immune system. This study aimed to detect expression of the Th cytokines IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-13, IL-17A, IL-17F, IL-21, IL-22, IFN-γ and TNF-α in the peripheral blood of children with cSLE; clinical symptoms; and a disease index and discuss the relationship between the Th cell cytokine regulatory network and onset of systemic lupus erythematosus (SLE) in children and disease outcome.Methods: A total of 33 children with cSLE and 30 healthy children were enrolled in this study. Children in the cSLE group were classified into the inactive cSLE group or active cSLE group according to their SLE disease activity index 2000 (SLEDAI-2K). Th cytokine profiles in peripheral blood of different groups were detected and analyzed.Results: The levels of IL-2, IL-10 and IL-21 in the cSLE group were significantly higher than those in the healthy control group (P < 0.05, P<0.01 and P<0.01, respectively). The expression of IL-2, IL-10 and IL-21 in the active cSLE group was significantly higher than that in the healthy control group (P<0.05, P<0.01 and P<0.05, respectively), but IL-22 expression was remarkably lower in the active cSLE group than in the healthy control group (P<0.001). IL-21 in the inactive SLE group was significantly higher than that in the healthy control group (P<0.05). The levels of IL-2 and IL-10 in the active cSLE group were significantly higher than those in the inactive cSLE group (P<0.01 and P<0.05). In-depth analysis showed that the expression levels of IL-2 (r=0.382, P=0.028), IL-6 (r=0.514, P=0.002) and IL-10 (r=0.429, P=0.016) were positively correlated with disease activity. Conclusion: This study provides a theoretical basis for the discovery of effective methods to regulate imbalance in T lymphocyte subsets in cSLE, which may open up potential new approaches for the diagnosis of cSLE.

scholarly journals High Level of Mir-142-3P Expression in Peripheral Blood of Patients with Ovarian Carcinoma

2021 ◽  
Author(s):  
Yasemin Gider ◽  
Xhariga Jabbarli ◽  
Gamze Uyaroglu ◽  
Seref Bugra Tuncer ◽  
Demet Akdeniz Odemis ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Late Stage ◽  
Peripheral Blood ◽  
Poor Prognosis ◽  
Expression Level ◽  
Healthy Control Group ◽  
Control Group ◽  
Healthy Controls ◽  
Healthy Control

Abstract Background The most common cancers detected in women are breast, thyroid, colorectal, uterine corpus, lung, and ovarian cancer. Ovarian cancer is responsible from more than 150.000 death annually worldwide. This cancer is detected in the late stage, and is characterised with poor prognosis, therefore most cases result with death. The fact that this cancer manifests itself in the late stage and is characterized by a poor prognosis, is caused death in the majority of cases. Therefore, the diagnosis and the treatment of the disease have to be improved for a better quality of life for patients. MicroRNAs are the noncoding RNAs in the length of 19–24 nucleotides which show suppressor effect on target genes. miRNAs are included in the pathology of various diseases including cancer. miRNAs being as the biomarker candidates in diagnosis, and their use in treatment as the inhibitors of the molecules mimicking the miRNA showed that they may be used as the new therapeutic target and agents. Methods We detected with our group in our prior study conducted with disconcordant ovarian cancer twins that many miRNA molecules were different in ovarian cancer compared with the molecules in healthy sibling. The expression level of miR-142-3p that was selected from the miRNAs detected in the previous study was compared, and investigated in a wider ovarian cancer group, and in healthy control group. miR-142-3p expression level was investigated using the real-time PCR method in the present study involving 147 patients, and 100 healthy control group. The differences in the expression levels of miR-142-3p detected in the peripheral blood lymphocytes of ovarian cancer patients, and healthy control were statisticaly evaluated. Results The expression level of miR-142-3p was detected to have increased 3.11 fold in ovarian cancer patients compared with the levels in healthy controls, and the difference was statistically significant (p:0.00). These results suggest that miR-142-3p that was found significantly increased in the peripheral blood samples of ovarian cancer patients compared with the healthy controls might be used as a sensitive, noninvasive biomarker in the early diagnosis, and treatment and follow up of ovarian cancer.

scholarly journals Chemerin rs17173608 Gene Polymorphism is not Associated with Type 2 Diabetes Mellitus: a Cross-sectional Study

Folia Medica ◽  
2019 ◽  
Vol 61 (1) ◽  
pp. 69-75
Author(s):  
Serdar Olt ◽  
Orhan Öznas ◽  
Haydar Bağış ◽  
Eda Tahir Turanlı
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Healthy Control Group ◽  
Control Group ◽  
Arms Pcr ◽  
Significant Difference ◽  
Healthy Control

Abstract Background: Previous studies have shown that chemerin has important roles in the development of obesity, insulin resistance, metabolic syndrome, polycystic ovary syndrome (PCOS) and T2DM. The main goal of our study was to investigate the role of Chemerin rs17173608 gene polymorphism in T2DM (type 2 diabetes mellitus). Materials and methods: 100 patients with T2DM and 50 healthy volunteers were included in the present study. DNA isolation from blood samples was performed with K1820-02 DNA Mini Kit. Chemerin gene polymorphism was detected by Tetra- Amplification Refractory mutation system polymerase chain reaction (T-ARMS-PCR). At the end of T-ARMS-PCR, samples were run using gel electrophoresis. Some samples were validated by sequence analysis. Results: In the genotype analysis, 18.0% of patients had TT genotype and 81.0% of TG genotype was detected. GG genotype was not detected in any patient. Genotype of 1 patient was unidentified. Genotype distribution of healthy control group was 12.0% TT genotype and 88.0% TG genotype. Similar to the T2DM group, the GG genotype was not detected in the control group. There was no statistically significant difference between T2DM group and healthy control group for TG and TT genotypes. Conclusion: To our knowledge, chemerin rs17173608 gene polymorphism has been investigated in T2DM for the first time herein. In the present study, the TT genotype ratios were higher in the T2DM subjects than in healthy subjects. G allele frequency in the T2DM group was lower than that in the control group. However, there was no statistically significant difference between the groups.

Important serum markers in malignant lymphoma

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22225-e22225
Author(s):  
S. Yavuz ◽  
M. Erkisi ◽  
I. Petekkaya ◽  
N. Basel
Keyword(s):  
Malignant Lymphoma ◽  
Peripheral Blood ◽  
Serum Markers ◽  
University Hospital ◽  
Healthy Control Group ◽  
Control Group ◽  
Host Immune System ◽  
Acute Phase Reactants ◽  
Healthy Control ◽  
Patient Groups

e22225 Background: In this study, 78 patients with new diagnosed, 21 patients with relapsed malignant lymphoma who applied to Cukurova University Hospital between March 2006 - 2008, and 36 age and sex matched healthy control group were evaluated and have been followed up. Methods: The aim of this study was to investigate if; any acute phase reactants or lymphocyte markers in peripheral blood have any predictive role concerning the treatment response, or disease progression. Results: Peripheral blood CD20 (+) lymphocyte levels were slightly higher in new diagnosed patients (12.09±13.79), than the control group (11.25 ±4. 79) but, much lower in relapsed patients (7.30±9.51, P= 0.038). After the chemotherapy (CT), CD20 (+) cell percentage decreased significantly only in new diagnosed patients (p<0.001). Pretreatment CD20 (+) cell levels were higher in responding patients than no responders (15. 42 ± 13.30 versus, 6.72 ± 5.24 p= 0.052). Peripheral blood CD 4 (+) cell levels were below the healthy control group (p= 0.01) and remained low after the CT. Interestingly, CD8 (+) cell levels increased in responders, after the CT (p= 0.046) in both patient groups. CD 56(+) lymphocyte levels were higher only in new diagnosed patients than healthy group (p= 0.05). Its level increased further after the CT (p= 0.044). Serum TNF α levels were higher in patient groups than control (p<0.001). Its level decreased following CT (p= 0.002). CRP levels were higher in both patient groups and remained high following the CT (p<0.001), regardless of the response status. Ferritin levels were also higher in patients groups (p<0.001). Pre-treatment serum ferritin levels were lower in responders, than no responders (236.65 ± 242.17 ng/ml versus 718.77 ± 645.24 ng/ml, p= 0.02). Serum prealbumine levels were lower in lymphoma patients than the healthy controls (p< 0.001). Its level was increased after treatment, especially in patients with recurrent disease (21.15± 5.89 versus 26.60 ± 7.29 mg/dl, p= 0.019). Conclusions: In conclusion, it was decided that; during the different stages of lymphoma progression, several mutations may occur, in the different components of the host immune system. Some of the immune responses would continue in spite of complete clinical remission, as some others would predict the response. No significant financial relationships to disclose.

Study on the Subtypes of Dendritic Cells and the Expression of T Cell Co-Stimulating Molecules (CD80, CD86, CD40) on Dendritic Cells and B Cells in the Peripheral Blood of SAA Patients.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3753-3753
Author(s):  
Zonghong Shao ◽  
Meifeng Tu ◽  
Hong Liu ◽  
Guangsheng He ◽  
Jun Shi ◽  
...  
Keyword(s):  
T Cell ◽  
B Lymphocytes ◽  
Normal Control ◽  
Peripheral Blood ◽  
Active Phase ◽  
Control Group ◽  
Control Groups ◽  
Significant Difference ◽  
Healthy Control ◽  
Cd40 Expression

Abstract Objective To detect the quantities of monocyte-derived dendritic cell precursors (pDC1) and plasmacytoid dendritic cell precursors (pDC2) in peripheral blood mononuclear cells (PBMC) of severe aplastic anemia (SAA) patients before and after immune suppressive therapy (IST), the ratio of their pDC1 to pDC2, and the expression of T-cell co-stimulating molecules (CD80, CD86, CD40) on dentritic cells (DC) and B cells surface in the SAA patients’ peripheral blood. Methods with three-color monoclonal antibody labeling technology, the quantities and ratio of pDC1 and pDC2 in PBMC were detected in 26 patients with SAA at active phase,13 patients with SAA at recovery phase and 15 normal control respectively by FACS. The aforementioned merits of 10 SAA patients were tested before and 2 months after IST by FACS. By FACS, the expression of CD80, CD86 and CD40 on DC and B lymphocytes were detected in 16 patients with SAA and 15 normal controls. Results The percentages of total pDC, pDC1, pDC2 and the ratio of pDC1/pDC2 of controls (healthy people) were(0.72±0.32)%,(0.41±0.18)%,(0.30±0.21)%, 1.58±0.69 respectively, and those of the patients with SAA at active phase were(0.96±0.92)%,(0.67±0.65)%,(0.32±0.30)%,2.70±1.63 respectively. The differences were significant [pDC1 (P<0.05); pDC1/pDC2 ratio (P<0.01)]. The aforementioned merits of recuperating SAA patients decreased to (0.77±0.48)%,(0.43±0.37)%,(0.34±0.34)%,1.78±1.29 respectively, which were not significantly different from those of normal control group. The aforementioned merits of 10 SAA patients were(0.87±0.98)%,(0.35±0.30)%,2.65±1.27 before IST, and(0.24±0.28)%,(0.14±0.14)%,2.16±0.82 after IST, with significant decreases of pDC1 and pDC2 (P<0.05). The percentages of CD80, CD86 and CD40 expression on DC in peripheral blood of healthy control were(1.61±2.37)%,(11.97±12.18)%,(0.56±1.26)% respectively, and those of SAA patients were(9.14±12.89)%,(29.84±9.56)%,(7.04±11.99)% respectively. There was a significant difference of CD86 expression (p<0.05) between SAA patient and normal control groups. The percentages of CD19, CD80, CD86 and CD40 expression on lymphocytes in peripheral blood of healthy control group were (9.38±3.18)%,(2.57±1.51)%,(1.86±1.11)%,(7.34±4.21)% respectively, and those of SAA patients were(11.12±9.02)%,(5.17±2.72)%,(5.98±3.84)%,(8.85±9.95)% respectively. There were significant differences of CD80 and CD86 expressions (P<0.05, P<0.01) between SAA and control groups. The percentages of CD80, CD86 and CD40 expression on B lymphocytes of control were(28.22±12.32)%, 8.04±2.27% and(81.6±22.45)% respectively, and those of SAA patients were(23.06±14.9)%,(20.46±11.1)%,(81.57±21.14)% respectively. There was a significant difference of CD86 expression (p<0.05) between patient and control groups. Conclusion The pDC subtypes were abnormal and the percentage of pDC1 increased in SAA patients, which were associated with the state of this illness. DC and B Lymphocytes in SAA up-regulated the expression of T cell co-stimulating molecules (CD86) that draw the T lymphocyte abnormally activated.

Taste Sensitivity to Phenylthiourea Among Leprosy and Filarial Patients in Coastal Andhra Pradesh

1972 ◽  
Vol 21 (4) ◽  
pp. 332-336
Author(s):  
B.R. Busi
Keyword(s):  
Healthy Subjects ◽  
Andhra Pradesh ◽  
Healthy Control Group ◽  
Taste Sensitivity ◽  
Control Group ◽  
Normal Individuals ◽  
Significant Difference ◽  
Leprosy Patients ◽  
Healthy Control

SummaryTaste blindness for PTC has been studied in (a) 416 leprosy patients and 424 healthy subjects, and (b) 261 filarial patients and 136 normal individuals of both sexes. A significant difference was found between leprosy patients and the healthy control group in the proportion of nontasters (χ2 = 4.096, for 1 DF, P〈0.05). No significant difference could be observed between the filariasis and the control group (χ2 = 0.605, for 1 DF, P〉0.30).

scholarly journals Study of the Levels of Advanced Glycation End Products in Sickle Cell Patients

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
N A Shalaby ◽  
R A Elgamal ◽  
M A Kenny ◽  
A A Sabrah
Keyword(s):  
Sickle Cell ◽  
Single Gene ◽  
Laboratory Data ◽  
Control Group ◽  
Compound Heterozygous ◽  
Red Cell Membrane ◽  
Pediatric Hematology ◽  
Significant Difference ◽  
Healthy Control ◽  
Organ Complications

Abstract Background Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and vaso-occlusion leading to reduced quality of life and life expectancy. SCD is caused by a point mutation in a single gene, which results in a mutant β-globin protein (HbS), in which the sixth amino acid is changed from glutamic acid to valine. In the homozygous and some compound heterozygous states, deoxygenated HbS molecules form polymers, which damage the red cell membrane and increase its rigidity. Aim of the Work to study the AGE levels in sickle cell patients and determine its relationship to the presence of SCD-related organ complications, in addition to exploring the association of AGE levels to other clinical and laboratory data. Patients and Methods This study was conducted on 40 Sickle cell patients, including sickle cell anemia (HbSS) and compound heterozygous states. In addition to 20 race, sex, and age matched healthy control subjects will also be included. They were recruited from patients attending Pediatric Hematology Clinic, Pediatric Hospital, Ain Shams University from September 2017 to September 2018. A verbal informed consent was taken from all patients. Results A statistically significant difference was found between SC patients and control group as regards their CBC data; including TLC, which showed a significant statistical difference being higher in patients group (P &lt; 0.001). Conclusion Plasma levels of pentosidine and CML are increased and associated with haemolysis and haemolysis-related organ complications in sickle cell patients, suggesting that AGEs might be implicated in vascular damage and chronic organ complications in SCD. Measurement of these AGEs might be useful in assessing disease severity and predicting organ complications in SCD.

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