scholarly journals Association of long-term exposure to PM2.5 with hypertension prevalence and blood pressure in China: a cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e050159
Author(s):  
Jiali Song ◽  
Yan Gao ◽  
Shuang Hu ◽  
Emanuela Medda ◽  
Guigang Tang ◽  
...  

ObjectiveEvidence of the effects of long-term fine particulate matter (PM2.5) exposure on hypertension and blood pressure is limited for populations exposed to high levels of PM2.5. We aim to assess associations of long-term exposure to PM2.5 with hypertension prevalence and blood pressure, and further explore the subpopulation differences and effect modification by participant characteristics in these associations in China.MethodsWe analysed cross-sectional data from 883 827 participants aged 35–75 years in the China Patient-Centred Evaluative Assessment of Cardiac Events Million Persons Project. Data from the monitoring station were used to estimate the 1-year average concentration of PM2.5. The associations of PM2.5 exposure with hypertension prevalence and blood pressure were investigated by generalised linear models, with PM2.5 included as either linear or spline functions.ResultsThe 1-year PM2.5 exposure of the study population ranged from 8.8 to 93.8 µg/m3 (mean 49.2 µg/m3). The adjusted OR of hypertension prevalence related to a 10 μg/m3 increase in 1-year PM2.5 exposure was 1.04 (95% CI, 1.02 to 1.05). Each 10 μg/m3 increment in PM2.5 exposure was associated with increases of 0.19 mm Hg (95% CI, 0.10 to 0.28) and 0.13 mm Hg (95% CI, 0.08 to 0.18) in systolic blood pressure and diastolic blood pressure, respectively. The concentration–response curves for hypertension prevalence and systolic blood pressure showed steeper slopes at higher PM2.5 levels; while the curve for diastolic blood pressure was U-shaped. The elderly, men, non-current smokers and obese participants were more susceptible to the exposure of PM2.5.ConclusionsLong-term exposure to PM2.5 is associated with higher blood pressure and increased risk of hypertension prevalence. The effects of PM2.5 on hypertension prevalence become more pronounced at higher PM2.5 levels. These findings emphasise the need to reduce air pollution, especially in areas with severe air pollution.

2017 ◽  
Vol 124 (6) ◽  
pp. 1107-1120 ◽  
Author(s):  
Heloyse E. G. Nunes ◽  
Carlos A. S. Alves ◽  
Eliane C. A. Gonçalves ◽  
Diego A. S. Silva

This study aimed to determine which of four selected physical fitness variables, would be most associated with blood pressure changes (systolic and diastolic) in a large sample of adolescents. This was a descriptive and cross-sectional, epidemiological study of 1,117 adolescents aged 14–19 years from southern Brazil. Systolic and diastolic blood pressure were measured by a digital pressure device, and the selected physical fitness variables were body composition (body mass index), flexibility (sit-and-reach test), muscle strength/resistance (manual dynamometer), and aerobic fitness (Modified Canadian Aerobic Fitness Test). Simple and multiple linear regression analyses revealed that aerobic fitness and muscle strength/resistance best explained variations in systolic blood pressure for boys (17.3% and 7.4% of variance) and girls (7.4% of variance). Aerobic fitness, body composition, and muscle strength/resistance are all important indicators of blood pressure control, but aerobic fitness was a stronger predictor of systolic blood pressure in boys and of diastolic blood pressure in both sexes.


2017 ◽  
Vol 6 (4) ◽  
pp. 313
Author(s):  
Mega Lucyta Sari ◽  
Enny Probosari ◽  
Hartanti Sandi Wijayanti

Background: Hypertension is one of the major risk factors for cardiovascular disease. Decreased intake of omega-3 and increased intake of omega-6 can increase the risk of hypertension. Hypertension cases in Indonesia are highest in women especially aged 30 - 50 years. This study aimed to determine correlation of omega-3 and omega-6 intake with blood pressure in women aged 30-50 years.Method : This was an observational research with cross-sectional study design. Fifty four subjects were selecting using consecutive sampling. Intakes were assessed by food recall 2x24 hours. Blood pressure levels were measured by Sphygmomanometer. Data were analyzed by Chi Square and Fisher Exact.Result : Systolic and diastolic blood pressure mean were 115.92 ± 14.5 mmHg and 75 ± 7.45 mmHg, while omega-3 and omega-6 mean were of 3. 1.03 ± 0.52 g and 14.17 ± 5 , 8 g. More than one third of the subjects (37.9%) with pre-hypertension/hypertension had omega-3 intake less than 1.1 g and 52.7% of them had omega-6 intake less than 12 g.There was correlation of omega-6 intake with systolic blood pressure (p <0.05) but there were no correlation between omega-3 intake with systolic blood pressure, omega-3 and omega-6 intake with diastolic blood pressure (p >0,05). Conclusion: There was correlation of omega-6 intake with systolic blood pressure, there were no correlation between omega-3 intake with systolic blood pressure, omega-3 and omega-6 intake with diastolic blood pressure


2017 ◽  
Vol 6 (4) ◽  
pp. 385
Author(s):  
Aria Menad M ◽  
Aryu Candra Kusumastuti

Background : Hypertension is one of the degenerative diseases that has high prevalence an increase. One of the factors that influence blood pressure in hypertensive patients is protein, fat, potassium, and magnesium intake. The purpose of this study was to determine the relationship of protein, fat, potassium, and magnesium intake with blood pressure in elderly.Design : This cross-sectional study was conducted among 42 subjects (aged 60-80 years) of PWRI (Persatuan Wredatama Republik Indonesia) members rating South Semarang, Semarang. Food recall method was used to measure the intake of protein, fat, potassium and magnesium intake. Blood pressure was measured with a mercury sphygmomanometer. Rank- Spearman test was used on bivariate analysis. Results : On the results of this study as many as 83.3% of subjects hypertention. Protein intake (52.4% of subjects), fat intake (100% of subject) potassium intake (54.8%) and magnesium (95.2% of subjects) are lower than needs. Bivariate analysis shows that there were no correlation between protein, fat, potassium, and magnesium intake and systolic blood pressure and diastolic blood pressure. Conclusion : In there were correlation between protein, fat, potassium, and magnesium intake and systolic blood pressure and diastolic blood pressure. 


Author(s):  
Xiao Wu ◽  
Rachel C Nethery ◽  
M Benjamin Sabath ◽  
Danielle Braun ◽  
Francesca Dominici

AbstractObjectivesUnited States government scientists estimate that COVID-19 may kill tens of thousands of Americans. Many of the pre-existing conditions that increase the risk of death in those with COVID-19 are the same diseases that are affected by long-term exposure to air pollution. We investigated whether long-term average exposure to fine particulate matter (PM2.5) is associated with an increased risk of COVID-19 death in the United States.DesignA nationwide, cross-sectional study using county-level data.Data sourcesCOVID-19 death counts were collected for more than 3,000 counties in the United States (representing 98% of the population) up to April 22, 2020 from Johns Hopkins University, Center for Systems Science and Engineering Coronavirus Resource Center.Main outcome measuresWe fit negative binomial mixed models using county-level COVID-19 deaths as the outcome and county-level long-term average of PM2.5 as the exposure. In the main analysis, we adjusted by 20 potential confounding factors including population size, age distribution, population density, time since the beginning of the outbreak, time since state’s issuance of stay-at-home order, hospital beds, number of individuals tested, weather, and socioeconomic and behavioral variables such as obesity and smoking. We included a random intercept by state to account for potential correlation in counties within the same state. We conducted more than 68 additional sensitivity analyses.ResultsWe found that an increase of only 1 μg/m3 in PM2.5 is associated with an 8% increase in the COVID-19 death rate (95% confidence interval [CI]: 2%, 15%). The results were statistically significant and robust to secondary and sensitivity analyses.ConclusionsA small increase in long-term exposure to PM2.5 leads to a large increase in the COVID-19 death rate. Despite the inherent limitations of the ecological study design, our results underscore the importance of continuing to enforce existing air pollution regulations to protect human health both during and after the COVID-19 crisis. The data and code are publicly available so our analyses can be updated routinely.Summary BoxWhat is already known on this topicLong-term exposure to PM2.5 is linked to many of the comorbidities that have been associated with poor prognosis and death in COVID-19 patients, including cardiovascular and lung disease.PM2.5 exposure is associated with increased risk of severe outcomes in patients with certain infectious respiratory diseases, including influenza, pneumonia, and SARS.Air pollution exposure is known to cause inflammation and cellular damage, and evidence suggests that it may suppress early immune response to infection.What this study addsThis is the first nationwide study of the relationship between historical exposure to air pollution exposure and COVID-19 death rate, relying on data from more than 3,000 counties in the United States. The results suggest that long-term exposure to PM2.5 is associated with higher COVID-19 mortality rates, after adjustment for a wide range of socioeconomic, demographic, weather, behavioral, epidemic stage, and healthcare-related confounders.This study relies entirely on publicly available data and fully reproducible, public code to facilitate continued investigation of these relationships by the broader scientific community as the COVID-19 outbreak evolves and more data become available.A small increase in long-term PM2.5 exposure was associated with a substantial increase in the county’s COVID-19 mortality rate up to April 22, 2020.


2021 ◽  
Author(s):  
Lijun Gan ◽  
Dandan Sun ◽  
Yuntao Cheng ◽  
Deyang Wang ◽  
Fen Wang ◽  
...  

Abstract Background: There is no clear evidence for the target value of blood pressure control within 24 hours after Percutaneous coronary intervention (PCI). Therefore, our study was designed to explore the relationship between blood pressure within 24 hours after PCI and major adverse cardiac events (MACE) during 3-year follow-up. Methods: This study is a prospective study. The study initially collected information of 552 patients. The start and end times of the study are from January 1, 2017 to December 31, 2020. The independent variables of this study are the average systolic blood pressure and the average diastolic blood pressure within 24 hours after PCI. The dependent variable is the occurrence of MACE events in patients within 3 years after PCI. Results: A total of 514 subjects met the inclusion criteria. The average age of the study subjects is 61.92 ± 9.49 years old, of which 67.12% are male. 94 subjects had a MACE event within 3 years, and the occurrence rate was 18.29%. There is no significant non-linear or linear relationship between diastolic blood pressure and MACE events. There is a curvilinear relationship between the average systolic blood pressure within 24 hours of patients after PCI and MACE events within 3 years and the inflection point is 134. On the left side of the inflection point, the effect size and 95% CI are 1.22 and 1.04-1.43, respectively (P=0.017). The impact size and 95% CI at the right inflection point were 0.96 and 0.83-1.11, respectively (P=0.604). Conclusion: There is a non-linear relationship between systolic blood pressure and the occurrence of MACE events in 3 years, and its inflection point is 134mmHg. In the case of ensuring patient safety, we should control the patient's systolic blood pressure within 24 hours after surgery.


Author(s):  
MI Diah P ◽  
Banundari Rachmawati ◽  
Purwanto AP

The incidence of metabolic syndrome (MetS) is significantly increasing. The elevated serum uric acid (SUA) level is correlated with the metabolic risk of cardiovascular. The relationship between SUA levels and components of MetS has been inconsistent. The aim of this study was to know the correlation between SUA level and component of MetS by analyzng. This study was a cross-sectional design conducted on healthy people at the Medical Check Up (MCU) Clinic, Dr. Moewardi Hospital, Surakarta from June 2012 until February 2013. MetS was defined according to the 2005 International Diabetes Federation (IDF) criteria. The statistical analysis was done by Student’s T test, Pearson or Spearman correlation coefficients. The researchers considered p<0.05 as statistically significant with a 95% confidence interval. A total of 80 healthy subjects, (range 19–57 years) were enrolled into this study. MetS was diagnosed in 40 persons where men (62.5%) were more than women and the non-MetS in women (62.5%) were more than men. In this study, a positive correlation was found between SUA and systolic blood pressure, diastolic blood pressure and waist circumference (Pearson r=0.354, 0.495, 0.399, respectively, p<0.05) in women, but not in men. The SUA was positively correlated with systolic blood pressure, diastolic blood pressure and waist circumference, particularly in women. A long term study is needed to investigate the consequence of increasing the SUA level in metabolic disorders and hormonal influences as well.


Author(s):  
Paulo Renato Carvalho Alonso Rays ◽  
Honório Sampaio Menezes

Resumo: Hipertensão Arterial é definida como elevação da pressão arterial sistólica e diastólica acima de 140/90mmHg, respectivamente. Estima-se que mais de 50% dos pacientes acima de 60 anos tenham hipertensão, o que deixa essa população sob risco aumentado de doenças em órgãos alvo como coração, rins e cérebro, aumentando também a morbimortalidade desta população. Diversos estudos comprovam que a terapia anti-hipertensiva reduz o risco e a morbimortalidade cardiovascular, cerebral e renal. No presente trabalho foi realizado um estudo transversal, observacional, prospectivo, onde foram avaliadas as medidas da pressão arterial de 24 pacientes idosos do grupo de 70 pacientes hipertensos do ambulatório do Programa Saúde da Família da cidade de Mata, interior do RS. Foi utilizada estatística descritiva e distribuição por freqüência, além do teste “t” de Student para comparação de médias, com nível de significância de 5% para análise dos dados. A pressão sistólica variou entre 120 e 180mmHg, a diastólica entre 60 e 100mmHg. Em 17 (70,83%) dos pacientes não houve associação da hipertensão com outra doença crônica, em quatro (16,22%) havia associado diabete melito tipo II e três (12,50%) tinham dislipidemia. Predominou o sexo feminino em 75% (18) dos pacientes estudados. A pressão sistólica estava acima de 140mmHg em 10 (41,67%) dos pacientes entre os quais havia quatro (16,67%) com a diastólica acima de 90mmHg. Dois quintos dos idosos, mesmo sob tratamento ambulatorial, não apresentava controle da hipertensão arterial adequado. Palavras-chave: Hipertensão. Idoso. Controle. Abstract: Hypertension is defined as an elevation of systolic and diastolic blood pressure above 140/90mmHg. More than 50% of patients over 60 years have hypertension, which increases the risk of cerebrovascular, kidney and heart diseases in this population. The anti-hypertensive therapy reduces risks according several studies. This cross sectional hypertension study of the elderly patients over 60 years old analyzed blood pressure in two opportunities separated by two days. Twenty-four patients had the blood pressure measured among 70 patients. Results: the systolic blood pressure were between 120-190mmHg, the diastolic blood pressure between 60-100mmHg. Eighteen (75%) were women, 17 (70.83%) does not have other chronic diseases, four (16.22%) had diabetes type II, three (12.50%) were dislipidemic. In ten (41.67%) patients the systolic blood pressure was over 140mmHg and four (16.67%) had the diastolic blood pressure over 90mmHg. The hypertension was uncontrolled in two fifty of elderly patients. Keywords: Hypertension. Elderly. Control.


2020 ◽  
Vol 19 (1) ◽  
pp. 38-42
Author(s):  
Latifa Rachmawati ◽  
Suhartono Suhartono ◽  
Budiyono Budiyono

Latar belakang: Pestisida merupakanxsalahxsatuxbahan kimia yang berbahaya. Adanya kandungan bahan – bahan – bahan aktif pada pestisida yang masuk kedalam tubuh manusia dengan berbagai jalur dapat menganggu proses asetilkolin, yang dapat mengakibatkan gangguan pada tekanan darah. Desa Trayu memiliki pekerjaan dengan mayoritas sebagai petani penyemprot hortikultura denganxjumlah sebanyak 416 orang (41,06%), dimana seluruh petani masih aktif menggunakan pestisida. Tujuan penelitianxinixadalahxuntukxmengetahui beberapaxfaktorxyangxberhubunganxdenganxtekananxdarah petani penyemprot hortikultura dixDesa TrayuxKecamatanxSumowonoxKabupaten Semarang.Metode: Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross-sectional. Sampel penelitian berjumlah 66 orang diambil dengan menggunakan metode simple random sampling. Pengukuran tekanan darah dilakukan menggunakan tensimeter. Pengumpulan data dilakukan dengan wawancara menggunakan kuesioner. Analisis statistik menggunakan uji korelasi Rank Spearman pada α 95%.  Hasil: Responden rata – rata berumur 50 tahun, dengan tingkat pendidikan didominasi Sekolah Dasar, dimana untuk penggunaan pestisida di Desa Trayu mencapai 100%. Sebanyak 34 responden (51,51%)  memiliki tekanan darah sistolik tinggi dan 46 responden (69,69%) memiliki tekanan darah diastolik tinggi. Hasil menujukkanxbahwa tidakxadaxhubunganxantaraxmasaxkerjaxdenganxtekananxdarahxsistolik (p value = 0,408). Terdapat hubungan pada variabelxmasaxkerjaxdenganxtekananxdarah diastolik (pxvalue = 0,022).xTerdapat hubungan antara jumlah campuran pestisida dengan tekanan darah sistolik (p value = 0,001). Tidak ditemukan adanyaxhubunganxjumlah campuran pestisidaxdenganxtekananxdarahxdiastolik (p value = 0,238). Ada hubungan antara variabel frekuensi penyemprotan dengan tekanan darah sistolik (p value = 0,041) dan tekanan darah diastolik (p value = 0,006).Simpulan: Frekuensi penyemprotan berhubungan dengan tekanan darah petani penyemprot tanaman hortikulturaKata kunci: tekanan darah, pestisida, petani penyemprot, tanaman hortikultura.ABSTRACT Title: The Analysis Factors Related to Blood Pressure on Horticulture Spraying Farmers in Trayu Village, Subdistrict Sumowono, District SemarangBackground: Pesticides are a dangerous chemical. The composition of active ingredients in pesticides that enter the human body with various pathways can interfere with the process of acetylcholine, which can disturbing blood pressure. The highest occupation in Trayu Village is horticulture sprayer, the total is 416 people (41,06%), where all farmers are actively using pesticides. Thexpurposexofxthis research was to determine severalxfactorsxrelated to blood pressure.Method: This research was an observational analytic study with a cross-sectional design. The sample of this study was 66 people taken by simple random sampling method. Blood pressure was measured using tensimeter. Data collection were gathered by interview using a questionnaire. Statistical analysis using Rank Spearman test with α 95%.Result: The average respondent is 50 years, with an education level dominated by elementary school, meanwhile the use of pesticides in Trayu Village reaches 100%. There were 34 respondents (51,51%) had high systolic blood pressure and 46 respondents (69,69%) had high diastolic blood pressure. xThexresultsxshowxthere is no correlation between a work period and systolic pressure (pxvaluex= 0,408). Therexisxaxcorrelation work period with diastolicxbloodxpressurex(pxvaluex=x0,022). Therexisxan associationxbetweenxthexamount of pesticide mixture with systolic blood pressure (p value = 0,001). There was no correlation between the amount of pesticide mixture with diastolic blood pressure (p value = 0,238). There was no association btween the variable frequency of srpaying with systolic blood pressure (p value = 0,041) and diastolic blood pressure (p value = 0,006).Conclusion: The frequency of spraying associated with the blood pressure of horticulture spraying farmers.Keywords: blood pressure, pesticides, spraying farmers, horticulture plants


2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaoyun Lin ◽  
Xiqian Wang ◽  
Xin Li ◽  
Lili Song ◽  
Zhaowei Meng ◽  
...  

Objective. Both hyperuricemia and hypertension have important clinical implications, but their relationship in terms of gender and age is still a matter of debate. In this study, we aimed to explore gender- and age-specific differences in this association between hyperuricemia and hypertension in a Chinese population. Methods. A total of 78596 ostensibly healthy subjects (47781 men and 30815 women) were recruited. The association between hyperuricemia and hypertension was analyzed by multivariate logistic regression, and the analyses were stratified by gender and age. Results. Overall prevalence of hypertension and hyperuricemia was significantly higher in males than in females. Increasing trends of hypertension prevalence in both genders as well as hyperuricemia prevalence in females were found along with aging. However, males showed a reduced trend in hyperuricemia prevalence with aging. Higher hypertension and hyperuricemia prevalence was found in young and middle-aged men than in women, but not in elderly people older than 70 years. Significantly increased risk of hypertension from hyperuricemia was found only in men with an adjusted odds ratio of 1.131 (P<0.01), especially in the middle-aged male participants. However, such significant results were not found in women. Similarly, hyperuricemia was also an independent risk factor of increased systolic blood pressure and diastolic blood pressure in males, but not in females. Conclusion. We observed significantly higher overall prevalence of hyperuricemia and hypertension in men than in women. Men with hyperuricemia (particularly in middle age) had a significantly increased susceptibility of hypertension, while this significant association was not observed in women.


2021 ◽  
Vol 9 (2) ◽  
pp. 123-127
Author(s):  
Etisa Adi Murbawani ◽  
Etika Ratna Noer ◽  
Enny Probosari

Background: Hypertension is a highly prevalent health problem which incidence is greatest among the elderly. Hypertension may increase creatinine level and leads to other health problems like diabetes mellitus, kidney damage, and cardiovascular disease. Wrist circumference is a simple anthropometric measurement that can be used to identify hypertension and increasing level of serum creatinine.Objectives: To analyze the correlation of wrist circumference with blood pressure and creatinine level among the elderly.Materials and Methods: This was a cross-sectional study with a purposive sampling method. Subjects of this study were 84 women aged 60 years old or above at Unit Rehabilitasi Sosial Pucang Gading Semarang. The independent variable of this study was wrist circumference, and the dependent variables were systolic blood pressure, diastolic blood pressure, and creatinine level. The result was analyzed using the Spearman-rho test.Results: The participants of this research were 49% women aged 60-65 years old, with an average age was 65.5 years old. The prevalence of hypertension was 61.9%. Most hypertension incidence in this research was caused by high systolic blood pressure (50%), and the rest was caused by high diastolic blood pressure (3.9%) and both (46.1%). The level of creatinine was normal with an average level was 0.75 mg/dL. There was no correlation of wrist circumference with systolic blood pressure systolic (r=0.15; p=0.19), diastolic blood pressure (r=0.1; p=0.38), and creatinine serum (r=0.18; p=0.09) among elderly.Conclusions: There was no correlation of wrist circumference with blood pressure and creatinine level among the elderly.


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