Dithranol creams for psoriasis

1979 ◽  
Vol 17 (14) ◽  
pp. 53-54
Keyword(s):  
Salicylic Acid ◽  
Adverse Effects ◽  
Therapeutic Effect ◽  
Normal Skin ◽  
Inactive Compound ◽  
Topical Corticosteroids

Dithranol is a valuable agent in the treatment of chronic discoid psoriasis. Properly used it can clear the lesions in most patients without any of the adverse effects of the strong topical corticosteroids.1 Dithranol inactivates various enzymes, binds with DNA, and inhibits mitosis, but the basis for the therapeutic effect is not fully understood.2 The main drawbacks of dithranol preparations, which often make patients reluctant to treat themselves, are dose-related irritancy, especially affecting normal skin, and staining of skin, clothing and bedclothes. To reduce the spread to normal skin, dithranol is usually applied accurately to psoriatic plaques in a stiff base (Zinc and Salicylic Acid Paste BPC). The salicylic acid in this preparation appears to prevent oxidation of the dithranol to an inactive compound.2

scholarly journals Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study

2021 ◽  
pp. 2021063
Author(s):  
Surabhi Dayal ◽  
Satbir Singh ◽  
Priyadarshini Sahu
Keyword(s):  
Salicylic Acid ◽  
Adverse Effects ◽  
Comparative Study ◽  
Clinical Efficacy ◽  
Trichloroacetic Acid ◽  
Acne Vulgaris ◽  
Efficacy And Safety ◽  
Inflammatory Lesions ◽  
Treatment Groups ◽  
Proven Efficacy

Background: Both salicylic acid (SA) and trichloroacetic acid (TCA) have proven efficacy with goodsafety profiles in the treatment of acne vulgaris. Objectives: This study compared the clinical efficacy and safety of 25% TCA and 30% SA peels in thetreatment of mild and moderate acne vulgaris. Methods: Patients with mild or moderate acne vulgaris were randomized into 2 groups of 25 personseach, and treated with either the TCA peel or the SA peel at 2-week intervals for 12 weeks. Evaluationof active acne was done by individual lesion counts (comedones, papules and pustules) and calculationof the Michaelsson acne score (MAS). Results: Both peels led to significant decrease in individual lesion counts and MAS compared to baselinevalues, without significant differences between the treatment groups. Thus, the peels had equivalentefficacy against acne vulgaris. The TCA peel was better in treating non-inflammatory lesions,while the SA peel was better for inflammatory lesions, but the differences were not significant. Noserious adverse effects were recorded, but more patients in the TCA peel group experienced burningand stinging sensations. Conclusion: The efficacy of 25% TCA is comparable to that of 30% SA in mild-to-moderate acnevulgaris, but safety and tolerability were better with the SA peel than TCA peel.

Foliar application of sodium nitroprusside and salicylic acid alleviates the adverse effects of alkaline soil on roses

2021 ◽  
Vol 86 (1) ◽  
pp. 78-87
Author(s):  
M. Moazam Babasheikhali ◽  
◽  
Z. Jabbarzadeh ◽  
J. Amiri ◽  
M. Barin ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Adverse Effects ◽  
Sodium Nitroprusside ◽  
Foliar Application ◽  
Alkaline Soil

Nanomedicine

2015 ◽  
pp. 64-89
Author(s):  
Roy Gaurab ◽  
Shetti Dattatrya ◽  
Yadav Amit ◽  
Kundu Gopal C
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Therapeutic Effect ◽  
21St Century ◽  
Delivery Systems ◽  
Imaging Agents ◽  
Life Threatening

Nanomedicine, an offshoot of nanotechnology, is considered as one of the most promising technologies of the 21st century. Due to their minute size, nanomedicines can easily target difficult-to-reach sites with improved solubility and bioavailability and reduced adverse effects. They also act as versatile delivery systems, carrying both chemotherapeutics and imaging agents to targeted sites. Hence, nanomedicine can be used to achieve the same therapeutic effect at smaller doses than their conventional counterparts and can offer impressive resolutions for various life-threatening diseases. Although certain issues have been raised about the potential toxicities of nanomaterials, it is anticipated that the advances in nanomedicine will furnish clarifications to many of modern medicine's unsolved problems. This chapter aims to provide a comprehensive and contemporary survey of various nanomedicine products along with the major risks and side effects associated with the nanoparticles.

scholarly journals Mitigating the adverse effects of deficit fertigation on strawberry yield, quality and phytochemical compounds by salicylic acid and putrescine treatments

2020 ◽  
pp. 1-14
Author(s):  
Mohammadreza Asghari ◽  
Feridoun Ahmadi ◽  
Ramin Hajitagilou
Keyword(s):  
Salicylic Acid ◽  
Adverse Effects ◽  
Production Systems ◽  
Water Shortage ◽  
Crop Productivity ◽  
Fruit Growth ◽  
Growth Stages ◽  
Positive Effects ◽  
Yield And Quality ◽  
Phytochemical Compounds

BACKGROUND: For global water shortage concerns and high cost of mineral nutrients it is necessary to decrease the amount of nutrient solutions in greenhouse production systems. Deficit fertigation may negatively affect the crop productivity and phytohormones can mitigate the adverse effects of stresses. OBJECTIVE: We studied the effects of deficit fertigation in combination with salicylic acid (SA) and putrescine (PUT) on strawberry fruit yield and quality. METHODS: Strawberry plants were fertilized with a complete nutrient solution of 220 (control), 180 (mild deficit fertigation) and/or 140 mL/dD (severe deficit fertigation), and treated with PUT (at 0 and 2 mM) and/or SA (at 0 and 2 mM) and the combinations of these treatments during growth stages. Fruit growth, quality parameters, yield and phytochemical compounds were evaluated at harvest. RESULTS: Mild deficit fertigation (MDF) (140 mL/d) significantly enhanced the yield and quality of the fruit, and both PUT and SA, enhanced the positive effects of MDF on crop productivity. SA and PUT decreased the negative effects of DF on crop yield and fruit growth. CONCLUSIONS: The results of this study indicate that it is possible to substantially enhance the quality and productivity of strawberries with a MDF regime, and PUT and SA treatments.

Mitigation of drought stress by foliar application of salicylic acid and potassium in mungbean (Vigna radiata L.)

2016 ◽  
Vol 39 (2) ◽  
Author(s):  
Sadia Majeed ◽  
Muhammad Akram ◽  
Muhammad Latif ◽  
Muhammad Ijaz ◽  
Mubshar Hussain
Keyword(s):  
Salicylic Acid ◽  
Drought Stress ◽  
Adverse Effects ◽  
Vigna Radiata ◽  
Foliar Application ◽  
Growth And Yield ◽  
Flowering Stage ◽  
Stress Control ◽  
Formation Stage ◽  
Effects Of Drought

An experiment was conducted to investigate the mitigation of drought stress by foliar application of salicylic acid and potassium in mung bean. Treatments comprised of three drought stress (control, drought stress at flowering stage and drought stress at flowering and pod formation stages) and foliar application salicylic acid (100 ppm) alone and in combination with potassium (1%). Irrigation missing at flowering stage, affected less the growth and yield as compared with irrigation missing at both flowering and pod formation stage. Exogenous application of salicylic acid and potassium could mitigate the adverse effects of drought stress significantly.

Vesiculo-erosive Oral Mucosal Disease—Management with Topical Corticosteroids: (2) Protocols, Monitoring of Effects and Adverse Reactions, and the Future

2005 ◽  
Vol 84 (4) ◽  
pp. 302-308 ◽  
Author(s):  
M.A. González-Moles ◽  
C. Scully
Keyword(s):  
Disease Management ◽  
Adverse Effects ◽  
Treatment Failure ◽  
Adverse Reactions ◽  
Evidence Based ◽  
Oral Medicine ◽  
Topical Corticosteroids ◽  
Mucosal Disease ◽  
The Future

Although topical corticosteroids (TCs) are the most widely used drugs in oral medicine, and specifically in the treatment of vesiculo-erosive oral mucosal disease, there are few evidence-based data for the correct use of these drugs. In this review, we outline the most widely used protocols, the most common reasons for treatment failure, and the adverse effects documented in the literature.

scholarly journals Prevalence of Misuse of Topical Corticosteroid among Dermatology Outpatients

2020 ◽  
Vol 58 (231) ◽  
Author(s):  
Shristi Shrestha ◽  
Smita Joshi ◽  
Sajana Bhandari
Keyword(s):  
Adverse Effects ◽  
Confidence Interval ◽  
Topical Corticosteroid ◽  
Binary Data ◽  
Cross Sectional Study ◽  
Point Estimate ◽  
Care Hospital ◽  
Cross Sectional ◽  
Topical Corticosteroids ◽  
Number Of Patients

Introduction: Topical corticosteroids misuse has become one of the burning issues in many countries across the globe. They are known to cause a myriad of adverse effects which include local effects commonly and systemic effects rarely. In dermatology practice, one of the common problems we see these days are steroid-induced and steroid aggravated dermatoses. So, this study was done to find the prevalence of misuse of topical corticosteroid among dermatology outpatients. Methods: A descriptive cross-sectional study was done in the outpatient department of dermatology at atertiary care hospital for 18 months. Ethical clearance was obtained from the Institutional Review Committee of NMCTH (Reference no. 029-076/077). Convenient sampling was done. Statistical Package for the Social Sciences (SPSS) version 16 was used to tabulate the data and analyze the results. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Out of 19464 patients, 614 (3.15%) (2.91%-3.39% at 95% Confidence Interval) gave a history of applying steroid containing creams. Among them, 220 (35.8%) belonged to the age group 21-30 years. Dermatophytoses were the skin disease where TCS was most commonly misused followed by melasma in 425 (69.2%) and 115 (18.7%) respectively. Beclomethasone was the steroid preparation that was misused in the maximum number of patients in 271 (44.1%). Some form of adverse effects was seen in 554 (88.6%) patients. Conclusions: Non-prescription sale of topical corticosteroids is the major cause of topical corticosteroids abuse in Nepal. Creating awareness among the prescribers as well as the patients is the current need.

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