Night shift work and lymphoma: results from an Italian multicentre case–control study

2022 ◽  
pp. oemed-2021-107845
Author(s):  
Pierluigi Cocco ◽  
Sara Piro ◽  
Federico Meloni ◽  
Andrea Montagna ◽  
Michele Pani ◽  
...  
Keyword(s):  
Shift Work ◽  
Night Shift ◽  
B Cell Lymphoma ◽  
Linear Increase ◽  
Night Shift Work ◽  
Lifetime Number ◽  
History Of ◽  
Study Participants ◽  
Incident Cases ◽  
Night Shifts

BackgroundNight shift work can disrupt circadian rhythm and cause chronic sleep deprivation, which might increase the risk of lymphoma through immunosuppression and oxidative stress.Material and methodsWe investigated the association between night shift work and risk of lymphoma subtypes in 867 incident cases and 774 controls, who participated in a multicentre Italian study between 2011 and 2017. Based on questionnaire information, occupational experts assessed the lifetime probability of night shift work, the total number of night shifts and years of night shift work among study participants. OR and 95% CI for lymphoma and its major subtypes associated with night shift work was calculated with logistic regression, adjusting by age, gender, education, study area, marital status and family history of haemolymphatic cancer.ResultsEver working night shifts was associated with an increase in the risk of chronic lymphocytic leukaemia (CLL) (OR 1.9, 95% CI 1.14 to 3.32), which was highest after a 15–34 years latency. However, there was not a linear increase in risk by probability of exposure, years of night shift work, nor lifetime number of night shifts whether under rotating or permanent work schedules. Risk of lymphoma overall, B cell lymphoma (BCL), its major subtypes other than CLL, and other less prevalent BCL subtypes combined did not show an association.ConclusionsWe found conflicting evidence of an association between night shift work and the risk of CLL. We did not observe an association with other lymphoma subtypes.

scholarly journals Rotating night shift work, exposure to light at night, and glomerular filtration rate: baseline results from a Chinese occupational cohort

2020 ◽  
Author(s):  
Shengkui Zhang ◽  
Yongbin Wang ◽  
Zhende Wang ◽  
Han Wang ◽  
Chao Xue ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Shift Work ◽  
Filtration Rate ◽  
Night Shift ◽  
Cumulative Number ◽  
Ambient Light ◽  
Light At Night ◽  
Night Shift Work ◽  
Night Shifts

Abstract Background The misalignment between the circadian clock and behavioral cycles has been implicated in pathogenesis of many diseases. However, whether the kidneys are also more prone to disease in the circumstances of chronic circadian rhythms disruption due to night shift work and light at night (LAN) is unclear. The main purpose of this study is to examine the association between rotating night shift work, exposure to light at night, and glomerular filtration rate among steelworkers in north China. Methods A total of 6869 participants, aged 22 to 60 years, were included in this study. Multivariable logistic regression was used to examine the association between night shift work, the brightness of bedroom ambient light at night (LAN), and estimated glomerular filtration rate (eGFR) with adjustment for potential confounders. The relationship between duration of night shift work (continuous), cumulative number of night shifts (continuous), and eGFR were also examined using restricted cubic spline models. Results Long duration of night shift work (≥29 years) had elevated odds of decreased eGFR (OR, 1.39, 95% CI 1.10–1.75) compared with day work after adjustment for potential confounders. Negative associations between duration of night shift work, cumulative number of night shifts, and eGFR (mL/min/1.73 m 2 ) were observed in RCS models. No significant associations were observed among the different brightness of bedroom ambient light levels: middle level (OR, 0.90, 95% CI 0.77–1.05), lightest level (OR, 0.94, 95% CI 0.75–1.17), and decreased eGFR compared with the darkest level. Conclusion The increased duration of night shift work and cumulative number of night shifts among night shift workers, but not the brightness of bedroom ambient LAN, are associated with a slight decline of renal function among steelworkers.

scholarly journals Night Shift Work Accelerates Menopausal Age in Health Workers

2021 ◽  
Vol 4 (1) ◽  
pp. 30
Author(s):  
Sri Ratna Dwiningsih ◽  
Samsulhadi Samsulhadi ◽  
Arif Tunjungseto ◽  
Monika Lijuwardi ◽  
Arsana Wiyasa
Keyword(s):  
Nutritional Status ◽  
Shift Work ◽  
Health Workers ◽  
Risk Group ◽  
Lymphoblastic Leukemia ◽  
Night Shift ◽  
Induction Phase ◽  
Night Shift Work ◽  
Increased Risk ◽  
History Of

Introduction: Earlier menopause has been associated with increased risk of cardiovascular disease, osteoporosis, shorter life expectancy and even cognitive decline. There are many factors that cause differences in the age of menopause in women, one of these environmental factors is a history of night shift work as a consequence of a job. It is not yet known whether female medical workers, with a history of night shifts, get earlier menopause.Methods: This case control study was conducted among 57 female night workers of the Dr. Soetomo General Academic Hospital. Data collection was conducted from December 2019 - March 2020. The study sample was postmenopausal health workers (nurse and midwife) and administrators. The instrument used in this study was a list of interview questions. The data was processed using SPSS software release 23.Results: The results show that from 45 children diagnosed with ALL, 53% are of the age ≤ 5 years old, with 58% males and 42% females. 13% of the patients are in the high risk group and 87% are in the standard risk group. Nutritional statuses of patients are 2% of them obese experienced remission after induction phase therapy, 56% normal with 80% of them experienced remission. 40% underweight with 89% of them experienced remission and 11% not experienced remission, 2% malnutrition and experienced remission. There is no correlation between the nutritional status of children with acute lymphoblastic leukemia with the outcome of induction phase (p = 0.798).Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes. 

scholarly journals Relationship between Night shift work, Eating Habits and BMI among Nurses in Lebanon

2020 ◽  
Author(s):  
Zeinab Samhat ◽  
Randa Attieh ◽  
Yonna Sacre
Keyword(s):  
Shift Work ◽  
Dietary Habits ◽  
Eating Habits ◽  
Night Shift ◽  
Cumulative Number ◽  
Anthropometric Measures ◽  
Cross Sectional ◽  
Night Shift Work ◽  
Validated Questionnaire ◽  
Night Shifts

Abstract Background: The objective of this cross-sectional study was to evaluate the relationships between night shift work, eating habits and body mass index (BMI) among Lebanese nurses. Methods: A total of 307 nurses were randomly selected from five hospitals located in Beirut. Data about demographic and professional characteristics, anthropometric measures, dietary habits and intakes were collected through a validated questionnaire. To study the relationship between night shift work, eating habits and BMI, chi-square test, t-test and logistic regressions were used.Results: The majority of nurses (78. 2%) had irregular meals timing with a significant decrease in the number of complete meals consumed during the day and an increase in the number of snacks consumed during night (p<0. 05). The most consumed snacks during night shifts were sweets and potato chips. The findings highlighted that BMI and waist circumference significantly increased with the number of years of work (r=0.175; p<0.05) and the cumulative number of night shifts hours over the entire work history (r=0.135/p< 0. 05). Conclusion: Night shift work is positively associated with abnormal eating patterns and BMI among Lebanese nurses. However the increase in BMI is not related to eating habits.

Differential effects of light at night and shift rotation pattern on the circadian system in night workers.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1556-1556
Author(s):  
Pedram Razavi ◽  
Eva S Schernhammer ◽  
Keyword(s):  
Shift Work ◽  
Night Shift ◽  
Circadian System ◽  
Activity Level ◽  
Melatonin Level ◽  
Consecutive Night ◽  
Light At Night ◽  
Night Shift Work ◽  
Single Night ◽  
Night Shifts

1556 Background: Light at night as in shift work suppresses nocturnal secretion of melatonin, a pineal hormone with oncostatic properties. Several studies have associated night shift work with higher risk of cancer, leading WHO in 2007 to classify rotating night shift work as “probably carcinogenic”. We conducted one of the most comprehensive studies, to date, to evaluate the effects of light and night shift work on melatonin measurements in the field. Methods: Study participants were 130 active nurses (84 current rotating night shift workers and 46 day shift workers) participating in NHS2. Each nurse wore a head-mounted light- and accelerometer for a 3-day study period, during which each spontaneous urine was collected for repeated urinary 6-sulfatoxymelatonin (melatonin) measurements. In addition, nurses were asked to fill out paper questionnaires and diaries. We used mixed models to evaluate the influence of light, activity and night shift work on urinary melatonin level adjusting, for age, lifestyle, and occupational history. We log-transformed main variables and report geometric means (GM [standard deviation]). Results: Greater levels of light were associated with lower melatonin (P < 0.0001), independent of activity level. An increase in light intensity from 10 to 100 lux was associated with a 12% decrease in geometric mean of melatonin level; however, this inverse association was only significant at night (Ptrend = 0.01). At night, each hour increase in exposure to ≥ 20 lux light lowered melatonin level by 5.7% (Ptrend < 0.0001). A single night shift affected the circadian system by lowering melatonin peak by 22% (day shift: GM = 17.57 [2.73]; night shift: GM = 13.64 [2.54]) and induced a phase shift (PS) of 0.9 hours, -changes that reset to normal by the next day. Two consecutive night shifts had a similar effect as a single shift. However, the effect was worse after three consecutive night shifts (GM = 10.11 [2.77]; PS = 2.2 hours). Conclusions: We found significant inverse associations of intensity and duration of exposure to light at night with urinary melatonin, independent of activity level. Three consecutive night shifts affected the circadian system more strongly than two consecutive, or a single night shift.

scholarly journals Night shift work and the risk of metabolic syndrome: Findings from an 8-year hospital cohort

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261349
Author(s):  
Wan-Ju Cheng ◽  
Chiu-Shong Liu ◽  
Kai-Chieh Hu ◽  
Yu-Fang Cheng ◽  
Kati Karhula ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Shift Work ◽  
Night Shift ◽  
Working Time ◽  
Health Examination ◽  
Long Term Effects ◽  
Time Data ◽  
Shift Workers ◽  
Night Shift Work ◽  
Night Shifts

Objectives Studies concerning the risk of metabolic syndrome associated with night work have shown inconsistent findings, due to imprecise working time data and cross-sectional design. We used register-based daily working time data to examine the risk of incident metabolic syndrome associated with night shift work. Methods Working time data collected between 2010 and 2018 of 5775 Taiwanese hospital workers were used to identify night shift workers and to calculate the number of night shifts. Metabolic syndrome was identified by annual occupational health examination results, which were linked to the working time data. Logistic regression models and generalized estimating equations were used to examine the association between night shift work and metabolic syndrome and the 5 components of metabolic syndrome. Results Night shift work is associated with a higher risk of developing metabolic syndrome (adjusted OR = 1.36, 95% CI = 1.04 to 1.78) and high waist circumference (adjusted OR = 1.27, 95% CI = 1.07 to 1.78) compared to day work. Among night shift workers, increased number of night shifts was associated with high blood pressure (adjusted OR = 1.15, 95% CI = 1.01 to 1.31). Conclusions Night shift work is associated with metabolic risk factors. Long-term effects of circadian rhythm disruption on metabolic disturbances needs to be further studied.

scholarly journals Occupational history of night shift work and Parkinson’s disease in Denmark

2015 ◽  
Vol 41 (4) ◽  
pp. 377-383 ◽  
Author(s):  
Eva S Schernhammer ◽  
Christina F Lassen ◽  
Line Kenborg ◽  
Beate Ritz ◽  
Jørgen H Olsen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Shift Work ◽  
Night Shift ◽  
Occupational History ◽  
Night Shift Work ◽  
History Of

scholarly journals Night Shift Work Affects Urine Metabolite Profiles of Nurses with Early Chronotype

Metabolites ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 45 ◽  
Author(s):  
Markus Rotter ◽  
Stefan Brandmaier ◽  
Marcela Covic ◽  
Katarzyna Burek ◽  
Johannes Hertel ◽  
...  
Keyword(s):  
Shift Work ◽  
Night Shift ◽  
Urine Samples ◽  
Acid Oxidation ◽  
Mixed Effect ◽  
Night Shift Work ◽  
Normalization Methods ◽  
Metabolite Profiles ◽  
Waking Up ◽  
Night Shifts

Night shift work can have a serious impact on health. Here, we assess whether and how night shift work influences the metabolite profiles, specifically with respect to different chronotype classes. We have recruited 100 women including 68 nurses working both, day shift and night shifts for up to 5 consecutive days and collected 3640 spontaneous urine samples. About 424 waking-up urine samples were measured using a targeted metabolomics approach. To account for urine dilution, we applied three methods to normalize the metabolite values: creatinine-, osmolality- and regression-based normalization. Based on linear mixed effect models, we found 31 metabolites significantly (false discovery rate <0.05) affected in nurses working in night shifts. One metabolite, acylcarnitine C10:2, was consistently identified with all three normalization methods. We further observed 11 and 4 metabolites significantly associated with night shift in early and late chronotype classes, respectively. Increased levels of medium- and long chain acylcarnitines indicate a strong impairment of the fatty acid oxidation. Our results show that night shift work influences acylcarnitines and BCAAs, particularly in nurses in the early chronotype class. Women with intermediate and late chronotypes appear to be less affected by night shift work.

Rotating night shift work and non-alcoholic fatty liver disease among steelworkers in China: a cross-sectional survey

2020 ◽  
Vol 77 (5) ◽  
pp. 333-339 ◽  
Author(s):  
Shengkui Zhang ◽  
Yongbin Wang ◽  
Zhende Wang ◽  
Han Wang ◽  
Chao Xue ◽  
...  
Keyword(s):  
Shift Work ◽  
Average Length ◽  
Night Shift ◽  
Average Frequency ◽  
Cumulative Number ◽  
Shift Workers ◽  
Alcoholic Fatty Liver ◽  
Night Shift Work ◽  
Cumulative Length ◽  
Night Shifts

ObjectivesIn a 24/7 society, the negative metabolic effects of rotating night shift work have been increasingly explored. This study aimed to examine the association between rotating night shift work and non-alcoholic fatty liver disease (NAFLD) in steelworkers.MethodsA total of 6881 subjects was included in this study. Different exposure metrics of night shift work including current shift status, duration of night shifts (years), cumulative number of night shifts (nights), cumulative length of night shifts (hours), average frequency of night shifts (nights/month) and average length of night shifts (hours/night) were used to examine the relationship between night shift work and NAFLD.ResultsCurrent night shift workers had elevated odds of NAFLD (OR, 1.23, 95% CI 1.02 to 1.48) compared with those who never worked night shifts after adjustment for potential confounders. Duration of night shifts, cumulative number of night shifts and cumulative length of night shifts were positively associated with NAFLD. Both the average frequency of night shifts (>7 nights/month vs ≤7 nights/month: OR, 1.24, 95% CI 1.06 to 1.45) and average length of night shifts (>8 hours/night vs ≤8 hours/night: OR, 1.27, 95% CI 1.08 to 1.51) were independently associated with overall NAFLD after mutually adjusting for the duration of night shifts and other potential confounders among night shift workers. No significant association was found in female workers between different exposure metrics of night shift work and NAFLD.ConclusionsRotating night shift work is associated with elevated odds of NAFLD in male steelworkers.

Rotating night shift work and risk of multiple sclerosis in the Nurses’ Health Studies

2019 ◽  
Vol 76 (10) ◽  
pp. 733-738 ◽  
Author(s):  
Kyriaki Papantoniou ◽  
Jennifer Massa ◽  
Elizabeth Devore ◽  
Kassandra L Munger ◽  
Tanuja Chitnis ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Shift Work ◽  
Proportional Hazards ◽  
Night Shift ◽  
Cox Proportional Hazards ◽  
Health Study ◽  
Work History ◽  
Night Shift Work ◽  
Increased Risk ◽  
History Of

ObjectivesNight shift work has been suggested as a possible risk factor for multiple sclerosis (MS). The objective of the present analysis was to prospectively evaluate the association of rotating night shift work history and MS risk in two female cohorts, the Nurses’ Health Study (NHS) and NHSII.MethodsA total of 83 992 (NHS) and 114 427 (NHSII) women were included in this analysis. We documented 579 (109 in NHS and 470 in NHSII) incident physician-confirmed MS cases (moderate and definite diagnosis), including 407 definite MS cases. The history (cumulative years) of rotating night shifts (≥3 nights/month) was assessed at baseline and updated throughout follow-up. Cox proportional hazards models were used to estimate HRs and 95% CIs for the association between rotating night shift work and MS risk adjusting for potential confounders.ResultsWe observed no association between history of rotating night shift work and MS risk in NHS (1–9 years: HR 1.03, 95% CI 0.69 to 1.54; 10+ years: 1.15, 0.62 to 2.15) and NHSII (1–9 years: HR 0.90, 95% CI 0.74 to 1.09; 10+ years: 1.03, 0.72 to 1.49). In NHSII, rotating night shift work history of 20+ years was significantly associated with MS risk, when restricting to definite MS cases (1–9 years: HR 0.88, 95% CI 0.70 to 1.11; 10–19 years: 0.98, 0.62 to 1.55; 20+ years: 2.62, 1.06 to 6.46).ConclusionsOverall, we found no association between rotating night shift work history and MS risk in these two large cohorts of nurses. In NHSII, shift work history of 20 or more years was associated with an increased risk of definite MS diagnosis.

scholarly journals Rotating Night Shift Work, Exposure to Light at Night, and Glomerular Filtration Rate: Baseline Results from a Chinese Occupational Cohort

2020 ◽  
Vol 17 (23) ◽  
pp. 9035
Author(s):  
Shengkui Zhang ◽  
Yongbin Wang ◽  
Ying Zhu ◽  
Xiaoming Li ◽  
Yang Song ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Shift Work ◽  
Filtration Rate ◽  
Night Shift ◽  
Mediation Effect ◽  
Ambient Light ◽  
Light At Night ◽  
Night Shift Work ◽  
Night Shifts

The misalignment between the circadian clock and behavioral cycles has been implicated in pathogenesis of many diseases. The main purpose of this study is to examine the association between rotating night shift work, exposure to light at night, and glomerular filtration rate among steelworkers in north China. A total of 6869 steelworkers, aged 22 to 60 years, were included in this study. Multivariable logistic regression was used to examine the association between night shift work, the brightness of bedroom ambient light at night (LAN), and estimated glomerular filtration rate (eGFR), with adjustment for potential confounders. Mediation analysis was performed to examine the mediation effect of potential mediators on the association of duration of night shifts and eGFR. Long duration of night shift work (≥29 years) had elevated odds of decreased eGFR (≤89 mL/min/1.73 m2) (odds ratio (OR), 1.37, 95% confidence interval (CI) 1.09–1.73) compared with day work after adjustment for potential confounders. The association between duration of night shifts and eGFR (continuous) was partially modified by diastolic blood pressure (average causal mediation effect (ACME), –0.077, 95% CI –0.134 to −0.030, p < 0.001). No significant associations were observed among the different brightness of bedroom ambient light levels: middle level (OR, 0.90, 95% CI 0.77–1.05), lightest level (OR, 0.94, 95% CI 0.75–1.18), and decreased eGFR compared with the darkest level. Long-term night-shift work, rather than the brightness of bedroom ambient LAN, is associated with early stage of renal dysfunction in steelworkers, and blood pressure may mediate the relationship between night shift work and decreased eGFR.

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