Effect of length changes on sensitivity of helical artery strips to adenosine

1986 ◽  
Vol 64 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Duane H. Foley
Keyword(s):  
Coronary Artery ◽  
Femoral Artery ◽  
Vasoactive Agents ◽  
Experimental Conditions ◽  
Isolated Artery ◽  
Length Changes ◽  
The Mean ◽  
Vascular Beds ◽  
The Relationship ◽  
Strip Length

The relationship between length and the responses of helical strips of rabbit femoral and coronary arteries to vasoactive agents was investigated by conducting concentration–response determinations at the length for maximum active force (Lmax) and a shorter length. The mean effective dose (ED50) values for norepinephrine (NE) were smaller when femoral artery strips were set at Lmax, in comparison to the values at the shorter length. Maximal relaxation of femoral artery strips by adenosine was greater when the strips were set at Lmax. However, adenosine ED50 values were smaller at Lmax only in groups of strips in which responses at Lmax were obtained prior to those at the shorter length. Experiments with coronary artery strips did not demonstrate consistent relationships between strip length and ED50 values for acetylcholine (ACh) or adenosine. The results of experiments with artery strips from normotensive and those from one-kidney, one-clip hypertensive rabbits were similar. Thus, the femoral artery data indicate that helical artery strip preparations may exhibit length-dependent sensitivity to a vasodilator agent as well as vasoconstrictor agents under certain experimental conditions. However, the coronary artery data suggest that length may not affect sensitivity of isolated artery preparations from all vascular beds in the same manner.

Estimation of fat content of beef carcasses in a commercial classification system

1983 ◽  
Vol 101 (3) ◽  
pp. 513-516 ◽  
Author(s):  
B. L. McIntyre ◽  
W. J. Ryan
Keyword(s):  
Fat Content ◽  
Experimental Conditions ◽  
Commercial Use ◽  
Beef Carcasses ◽  
Wide Range ◽  
Fat Thickness ◽  
The Mean ◽  
Thickness Measurements ◽  
The Relationship ◽  
Two Sides

SUMMARYA total of 25 steer carcasses from a wide range of breeds and carcass weight and fatness were used to examine the relationship between a range of fat thickness measurements and the dissected fat content of beef carcasses. Fat thickness measurements included those on the hot carcass suitable for ‘commercial’ use and others on the cold carcass commonly used in research.The mean of the measurements of fat thickness from the two sides of the hot carcass between the 12th and 13th ribs (12H) gave the most accurate prediction of carcass fat content (FPCT). The relationship was described by the equation FPCT = 14·61 + 1·85 (12H) (R2 = 0·92; S.E. of prediction of individual FPCT at the mean= ±2·17%).The mean of four fat thickness measurements made on the quartered surface between the 10th and 11th ribs of the cold carcass was the next most accurate predictor (S.E. = 2·28%) of fat content. Fat thickness measurements made on the hot carcass between the 10th and 11th ribs were the least satisfactory.Although the hot carcass measurements between the 12th and 13th ribs were made under commercial conditions and included a wide range of types of cattle the prediction of fat content from these measurements had a marginally lower standard error than the prediction based on measurements made under experimental conditions.

scholarly journals INVESTIGATING THE RELATIONSHIP BETWEEN SERUM PENTRAXIN3 LEVEL AND ANGIOGRAPHIC FINDINGS IN PATIENTS WITH CORONARY ANGIOGRAPHY

2018 ◽  
Vol 11 (3) ◽  
pp. 424
Author(s):  
Habib Heybar ◽  
Ahmadreza Assareh ◽  
Sommayeh Jalali
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Level ◽  
Coronary Angiography ◽  
Serum Levels ◽  
Specific Marker ◽  
The Mean ◽  
Artery Disease ◽  
The Relationship ◽  
Angiographic Findings

 Objective: Pentraxin3 (PTX3) is an inflammatory single-phase mononuclear polysorbate glycoprotein, synthesized by endothelial, macrophages, and mildew cells; based on reports and research findings, it is also believed to be synthesized in the tissue of atherosclerotic lesions of arterial arteries. Therefore, PTX3 can be considered as a more specific marker for atherosclerosis. The present study examines the relationship between PTX3 serum levels and coronary angiography findings.Methods: A total of 100 patients with stable cardiac status under elective coronary angiography were studied. Meanwhile, serum levels of PTX3 were measured, along with coronary angiography, in these patients. Finally, the relationship between the serum level of this marker and the severity of the angiographic findings of these individuals was compared and contrasted.Results: out of 100 patients examined in the present study, 57 subjects (57.6%) were male and 42 subjects (42.4%) were female. The mean age of participants turned out to be 53±9.16, and the mean serum level of PTX3 was 5.91±12.5. The mean serum level of PTX3 turned out to be lower in patients with normal angiography than in those with coronary artery disease (p<0.0001). Smoking and age did not affect the mean serum levels of this marker. Furthermore, a higher serum level of PTX3 was associated with a higher syntax score in the angiography (p<0.0001).Conclusion: Serum levels of PTX3 can have a predictive value in the diagnosis of coronary artery disease in patients with stable cardiovascular symptoms.

An investigation into the relationship between the metabolism of pyruvate in bull spermatozoa and fertility

1956 ◽  
Vol 48 (2) ◽  
pp. 153-159 ◽  
Author(s):  
G. Glew
Keyword(s):  
Metabolic Response ◽  
Conception Rate ◽  
Low Fertility ◽  
High Fertility ◽  
Practical Application ◽  
Experimental Conditions ◽  
Conception Rates ◽  
The Mean ◽  
Dairy Bulls ◽  
The Relationship

1. Two hundred and ninety-one samples of semen from seventy-four dairy bulls in use at seven artificial insemination centres and one bull-rearing centre were tested and graded according to the type of metabolic response under the experimental conditions described by Melrose & Terner (1953).2. Conception rates of bulls were obtained from the breeding records based on not less than 150 first inseminations. Since the mean conception rates of centres varied, the fertility of each bull was assessed in relation to the mean conception rate of the centre at which the bull was standing. Bulls were considered of ‘high’ fertility when their conception rates were above, and of ‘low’ fertility when their conception rates were below a dividing line 5% below the mean conception rate of the centre.3. A highly significant relationship (P < 0·001) was found between the groups of the metabolic responses and the fertility levels of the bulls. The practical application of the test in the assessment of the potential fertility of individual bulls is discussed.

scholarly journals SYNTAX and Coronary Artery Calcium Score Predict Atherosclerotic Plaque Formation in the Ascending Aorta

2021 ◽  
Vol 24 (6) ◽  
pp. E996-E1004
Author(s):  
Ismail Haberal ◽  
Mehmet Balli ◽  
Esra Ertürk tekin ◽  
Ayhan Uysal ◽  
Sadiye Deniz Ozsoy ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Atherosclerotic Plaque ◽  
Calcium Score ◽  
Plaque Formation ◽  
Aortic Calcification ◽  
Syntax Score ◽  
Atherosclerotic Plaque Formation ◽  
The Mean ◽  
Cabg Patients ◽  
The Relationship

Background: There is no study about the relationship between the complexity of coronary artery disease (SYNTAX SCORE; SS), and coronary artery calcium (CAC) score, accompanied with aortic calcium score (ACS) levels. The objective of this study was to investigate the relationship between the preoperative SS and CAC scores accompanying ACS in isolated CABG patients and their postoperative clinical results. Methods: This study included 130 consecutive CABG patients. The mean age of the patients was 62.3 ± 8.62 years (range: 47-84 years). SS was measured using coronary angiography by an experienced cardiologist. We investigated the ACS accompanied with CAC scores using a multidetector computed tomography (MDCT) in the same session, preoperatively. Measurements of the CAC score and ACS were measured by an experienced radiologist, who was unaware of the study in the same session. In order to investigate aortic wall pathology in patients with positive aortic calcification, we provided aortic tissue samples prior to the proximal anastomosis of bypass grafts using No:11 scalpel. Results: Overall median SS was 39 ± 7.2 (range: 15-41). CAC score was zero in 34 patients (26.1%). For the patients with a CAC score of zero, the median SS was 32 ± 9.4. There was no evidence of aortic calcification or plaque formation in 62 patients (47.6%). In these patients, the median SS was 35.6 ± 11.3. No significant difference was found when both groups were compared and for those patients with a calcific score of zero (P = .85). The median CAC score and ACS were 238 ± 122 AU (range: 0-1238 AU) and 112 ± 40 AU (range: 0-730 AU), respectively (P = .0033). For patients with a CAC score and ACS ≥400 AU, the mean SYNTAX score was ≥ 37. SS was correlated with CAC score (R:0.585; P < .0001). SYNTAX was correlated with ACS (R:0.557; P < .001). In multivariate analysis of SS (OR 1.053, 95% CI: 1.003–1.106, P = .039), gender (OR 0.189, 95% CI: 0.053–0.678, P = 0.011), age (OR 1.454, 95% CI: 1.256–1.632, P = .012), and diabetes mellitus (OR 0.341, 95% CI: 1.006–1.124, P = .014) were independent predictors for CAC score and aortic calcification. Conclusions: CAC score and ACS are strongly correlated with the complexity of coronary arteries in CABG patients. The total CAC score (≥ 400 AU) was independently associated with the degree of SS (>37). To prevent MACCE and mortality in CABG patients, we suggest the measurement of CAC score accompanied with ACS using MDCT as a non-invasive method. Highlight points: • Atherosclerotic plaque formation in aorta and coronary arteries are the main risk factors for stroke and infarction in CABG operations. •SYNTAX score value and aortic atherosclerosis levels are directly correlated. •SYNTAX score may predict the complications due to atherosclerosis during heart surgery.

Articulatory Behavior Pre and Post Full-Mouth Tooth Extraction and Alveoloplasty

1980 ◽  
Vol 23 (3) ◽  
pp. 630-645 ◽  
Author(s):  
Gerald Zimmermann ◽  
J.A. Scott Kelso ◽  
Larry Lander
Keyword(s):  
Control Subject ◽  
High Speed ◽  
Tooth Extraction ◽  
Kinematic Parameters ◽  
Experimental Conditions ◽  
Mean Values ◽  
Articulatory Movements ◽  
The Mean ◽  
Experimental Subjects ◽  
Normal Speech

High speed cinefluorography was used to track articulatory movements preceding and following full-mouth tooth extraction and alveoloplasty in two subjects. Films also were made of a control subject on two separate days. The purpose of the study was to determine the effects of dramatically altering the structural dimensions of the oral cavity on the kinematic parameters of speech. The results showed that the experimental subjects performed differently pre and postoperatively though the changes were in different directions for the two subjects. Differences in both means and variabilities of kinematic parameters were larger between days for the experimental (operated) subjects than for the control subject. The results for the Control subject also showed significant differences in the mean values of kinematic variables between days though these day-to-day differences could not account for the effects found pre- and postoperatively. The results of the kinematic analysis, particularly the finding that transition time was most stable over the experimental conditions for the operated subjects, are used to speculate about the coordination of normal speech.

Multi-Center Calibration of the Second Reference Material for Thromboplastin, Rabbit, Plain, Coded CRM 149R

1991 ◽  
Vol 65 (03) ◽  
pp. 263-267 ◽  
Author(s):  
A M H P van den Besselaar ◽  
R M Bertina
Keyword(s):  
Reference Material ◽  
Standard Error ◽  
Standard Errors ◽  
Sensitivity Index ◽  
Long Term Stability ◽  
Significant Bias ◽  
The Mean ◽  
The Relationship ◽  
International Sensitivity Index

SummaryIn a collaborative trial of eleven laboratories which was performed mainly within the framework of the European Community Bureau of Reference (BCR), a second reference material for thromboplastin, rabbit, plain, was calibrated against its predecessor RBT/79. This second reference material (coded CRM 149R) has a mean International Sensitivity Index (ISI) of 1.343 with a standard error of the mean of 0.035. The standard error of the ISI was determined by combination of the standard errors of the ISI of RBT/79 and the slope of the calibration line in this trial.The BCR reference material for thromboplastin, human, plain (coded BCT/099) was also included in this trial for assessment of the long-term stability of the relationship with RBT/79. The results indicated that this relationship has not changed over a period of 8 years. The interlaboratory variation of the slope of the relationship between CRM 149R and RBT/79 was significantly lower than the variation of the slope of the relationship between BCT/099 and RBT/79. In addition to the manual technique, a semi-automatic coagulometer according to Schnitger & Gross was used to determine prothrombin times with CRM 149R. The mean ISI of CRM 149R was not affected by replacement of the manual technique by this particular coagulometer.Two lyophilized plasmas were included in this trial. The mean slope of relationship between RBT/79 and CRM 149R based on the two lyophilized plasmas was the same as the corresponding slope based on fresh plasmas. Tlowever, the mean slope of relationship between RBT/79 and BCT/099 based on the two lyophilized plasmas was 4.9% higher than the mean slope based on fresh plasmas. Thus, the use of these lyophilized plasmas induced a small but significant bias in the slope of relationship between these thromboplastins of different species.

Evaluation of the Efficacy of ST2 and NT-proBNP in the Diagnosis and Prediction of Short- Term Prognosis in Heart Failure with Reduced Ejection Fraction

2017 ◽  
Vol 9 (04) ◽  
Author(s):  
Shivananda B Nayak ◽  
Dharindra Sawh ◽  
Brandon Scott ◽  
Vestra Sears ◽  
Kareshma Seebalack ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Cardiac Biomarkers ◽  
Double Blind Study ◽  
Short Term ◽  
Double Blind ◽  
Reduced Ejection Fraction ◽  
The Mean ◽  
Design And Methods ◽  
The Relationship

Purpose: i) To determine the relationship between the cardiac biomarkers ST2 and NT-proBNP with ejection fraction (EF) in heart failure (HF) patients. ii) Assess whether a superiority existed between the aforementioned cardiac markers in diagnosing the HF with reduced EF. iii) Determine the efficacy of both biomarkers in predicting a 30-day cardiovascular event and rehospitalization in patients with HF with reduced EF iv) To assess the influence of age, gender, BMI, anaemia and renal failure on the ST2 and NT-proBNP levels. Design and Methods: A prospective double-blind study was conducted to obtain data from a sample of 64 cardiology patients. A blood sample was collected to test for ST2 and NT-proBNP. An echocardiogram (to obtain EF value), electrocardiogram and questionnaire were also obtained. Results: Of the 64 patients enrolled, 59.4% of the population had an EF less than 40%. At the end of the 30- day period, 7 patients were warded, 37 were not warded, one died and 17 were non respondent. Both biomarkers were efficacious at diagnosing HF with a reduced EF. However, neither of them were efficacious in predicting 30-day rehospitalization. The mean NT-proBNP values being: not rehospitalized (2114.7486) and 30 day rehospitalization (1008.42860) and the mean ST2 values being: not rehospitalized (336.1975), and 30-day rehospitalization. (281.9657). Conclusion: Neither ST2 or NT-proBNP was efficacious in predicting the short- term prognosis in HF with reduced EF. Both however were successful at confirming the diagnosis of HF in HF patients with reduced EF.

scholarly journals Correlation between fundus autofluorescence and visual function in patients with cone-rod dystrophy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Satoru Kanda ◽  
Takumi Hara ◽  
Ryosuke Fujino ◽  
Keiko Azuma ◽  
Hirotsugu Soga ◽  
...  
Keyword(s):  
Visual Field ◽  
Significant Relationship ◽  
Fundus Autofluorescence ◽  
Univariate Analysis ◽  
Retrospective Chart Review ◽  
Mean Deviation ◽  
Wide Field ◽  
The Mean ◽  
The Relationship ◽  
Field Imaging

AbstractThis study aimed to investigate the relationship between autofluorescence (AF) signal measured with ultra-wide field imaging and visual functions in patients with cone-rod dystrophy (CORD). A retrospective chart review was performed for CORD patients. We performed the visual field test and fundus autofluorescence (FAF) measurement and visualized retinal structures with optical coherence tomography (OCT) on the same day. Using binarised FAF images, we identified a low FAF area ratio (LFAR: low FAF/30°). Relationships between age and logMAR visual acuity (VA), central retinal thickness (CRT), central choroidal thickness (CCT), mean deviation (MD) value, and LFAR were investigated. Thirty-seven eyes of 21 CORD patients (8 men and 13 women) were enrolled. The mean patient age was 49.8 years. LogMAR VA and MD were 0.52 ± 0.47 and − 17.91 ± 10.59 dB, respectively. There was a significant relationship between logMAR VA and MD (p = 0.001). LogMAR VA significantly correlated with CRT (p = 0.006) but not with other parameters. Conversely, univariate analysis suggested a significant relationship between MD and LFAR (p = 0.001). In the multivariate analysis, LFAR was significantly associated with MD (p = 0.002). In conclusion, it is useful to measure the low FAF area in patients with CORD. The AF measurement reflects the visual field deterioration but not VA in CORD.

Heart Rate and Neurological Outcomes in Patients Undergoing Targeted Temperature Management

2020 ◽  
pp. 088506662098250
Author(s):  
Chad M. Conner ◽  
William H. Perucki ◽  
Andre Gabriel ◽  
David M. O’Sullivan ◽  
Antonio B. Fernandez
Keyword(s):  
Heart Rate ◽  
Positive Association ◽  
Targeted Temperature Management ◽  
Temperature Management ◽  
Neurological Outcomes ◽  
Neurologic Outcomes ◽  
Resuscitation Guidelines ◽  
The Mean ◽  
The Impact ◽  
The Relationship

Introduction: There is a paucity of data evaluating the impact of heart rate (HR) during Targeted Temperature Management (TTM) and neurologic outcomes. Current resuscitation guidelines do not specify a HR goal during TTM. We sought to determine the relationship between HR and neurologic outcomes in a single-center registry dataset. Methods: We retrospectively studied 432 consecutive patients who completed TTM (33°C) after cardiac arrest from 2008 to 2017. We evaluated the relationship between neurologic outcomes and HR during TTM. Pittsburgh Cerebral Performance Categories (CPC) at discharge were used to determine neurological recovery. Statistical analysis included chi square, Student’s t-test and Mann-Whitney U. A logistic regression model was created to evaluate the strength of contribution of selected variables on the outcome of interest. Results: Approximately 94,000 HR data points from 432 patients were retrospectively analyzed; the mean HR was 82.17 bpm over the duration of TTM. Favorable neurological outcomes were seen in 160 (37%) patients. The mean HR in the patients with a favorable outcome was lower than the mean HR of those with an unfavorable outcome (79.98 bpm vs 85.67 bpm p < 0.001). Patients with an average HR of 60-91 bpm were 2.4 times more likely to have a favorable neurological outcome compared to than HR’s < 60 or > 91 (odds ratio [OR] = 2.36, 95% confidence interval [CI] 1.61-3.46, p < 0.001). Specifically, mean HR’s in the 73-82 bpm range had the greatest rate of favorable outcomes (OR 3.56, 95% CI 1.95-6.50), p < 0.001. Administration of epinephrine, a history of diabetes mellitus and hypertension all were associated with worse neurological outcomes independent of HR. Conclusion: During TTM, mean HRs between 60-91 showed a positive association with favorable outcomes. It is unclear whether a specific HR should be targeted during TTM or if heart rates between 60-91 bpm might be a sign of less neurological damage.

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