ADDITION OF CONDUCTIVE ELEMENTS TO POLYMERIC SCAFFOLDS FOR MUSCLE TISSUE ENGINEERING
Cardiac and skeletal muscles are two tissues that would benefit from an electrically conductive scaffold to regenerate lost or lower functioning areas. By augmenting polymeric scaffolds with conductive elements, the contractile process for both muscles could increase. In this review, the components reviewed include polyaniline (PANi), gold (Au) nanoparticles, and carbon nanotubes (CNT). PANi has been combined with several polymers and increased the conductivity of the scaffolds. It is biocompatible, but increases mechanical properties and decreases scaffold elongation. Tissue engineering using nanoparticles is an emerging area and considerable research focuses on determining possible toxicity due to nanoparticle concentration. Contradicting data exists for both Au nanoparticles and CNT. Smaller Au nanoparticles damage cardiac tissue in vivo while larger ones do not. By comparison, in vitro data shows no harmful results for skeletal muscle cells. Data for CNT is just as diverse as the amount, orientation and further purification or functionalization could all play a role in determining biocompatibility. Future research should focus on establishing the conductivity level needed for each muscle tissue to ascertain the amount of conductive element needed so the most suitable one can be utilized.