scholarly journals Programmed DNA Elimination in Vertebrates

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Jeramiah J. Smith ◽  
Vladimir A. Timoshevskiy ◽  
Cody Saraceno
Keyword(s):  
Germ Cells ◽  
Genome Rearrangement ◽  
The Body ◽  
Annual Review ◽  
Publication Date ◽  
Vertebrate Species ◽  
Vertebrate Lineage ◽  
Dna Elimination ◽  
Dna Loss ◽  
Dna Silencing

Over the last few decades, an increasing number of vertebrate taxa have been identified that undergo programmed genome rearrangement, or programmed DNA loss, during development. In these organisms, the genome of germ cells is often reproducibly different from the genome of all other cells within the body. Although we clearly have not identified all vertebrate taxa that undergo programmed genome loss, the list of species known to undergo loss now represents ∼10% of vertebrate species, including several basally diverging lineages. Recent studies have shed new light on the targets and mechanisms of DNA loss and their association with canonical modes of DNA silencing. Ultimately, expansion of these studies into a larger collection of taxa will aid in reconstructing patterns of shared/independent ancestry of programmed DNA loss in the vertebrate lineage, as well as more recent evolutionary events that have shaped the structure and content of eliminated DNA. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 9 is February 16, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Immunosensation: Neuroimmune Cross Talk in the Skin

2021 ◽  
Vol 39 (1) ◽  
Author(s):  
Masato Tamari ◽  
Aaron M. Ver Heul ◽  
Brian S. Kim
Keyword(s):  
Immune System ◽  
Host Immunity ◽  
The Body ◽  
Annual Review ◽  
Publication Date ◽  
Protective Behaviors ◽  
Evolutionarily Conserved ◽  
Structural Barrier ◽  
Thermal Stimuli ◽  
Antimicrobial Immunity

Classically, skin was considered a mere structural barrier protecting organisms from a diversity of environmental insults. In recent decades, the cutaneous immune system has become recognized as a complex immunologic barrier involved in both antimicrobial immunity and homeostatic processes like wound healing. To sense a variety of chemical, mechanical, and thermal stimuli, the skin harbors one of the most sophisticated sensory networks in the body. However, recent studies suggest that the cutaneous nervous system is highly integrated with the immune system to encode specific sensations into evolutionarily conserved protective behaviors. In addition to directly sensing pathogens, neurons employ novel neuroimmune mechanisms to provide host immunity. Therefore, given that sensation underlies various physiologies through increasingly complex reflex arcs, a much more dynamic picture is emerging of the skin as a truly systemic organ with highly coordinated physical, immunologic, and neural functions in barrier immunology. Expected final online publication date for the Annual Review of Immunology, Volume 39 is April 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

The Spectrum of Helicobacter-Mediated Diseases

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Karen Robinson ◽  
John C. Atherton
Keyword(s):  
The Body ◽  
Deficiency Anemia ◽  
Effective Vaccine ◽  
Annual Review ◽  
Vitamin B ◽  
Publication Date ◽  
Ulcer Disease ◽  
Human Carcinogen ◽  
The Past ◽  
H Pylori

Helicobacter pylori is the leading cause of peptic ulcer disease. The infection has been implicated in more than 75% of duodenal ulcer cases and 17% of gastric ulcer cases. H. pylori has been classified as a human carcinogen, since it is the main cause of distal gastric adenocarcinoma and B cell mucosa-associated lymphoid tissue lymphoma. Evidence also links H. pylori with extragastric conditions including iron deficiency anemia, idiopathic thrombocytopenic purpura, and vitamin B12 deficiency. Studies indicate that H. pylori may be protective against other conditions of the gastrointestinal tract (e.g., reflux esophagitis and related pathologies) and elsewhere in the body (e.g., asthma). The infection is asymptomatic in the vast majority of cases; more serious outcomes occur in only 10–15% of infected individuals. Despite extensive research over the past 3 decades, there is no effective vaccine, and the circumstances leading to disease development remain unclear. In addition, there is now a growing prevalence of antimicrobial resistance in H. pylori. This review discusses these important issues. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 16 is January 25, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Generating and Using Transcriptomically Based Retinal Cell Atlases

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Karthik Shekhar ◽  
Joshua R. Sanes
Keyword(s):  
Expression Patterns ◽  
Retinal Disease ◽  
Cell Types ◽  
Retinal Cell ◽  
Annual Review ◽  
Publication Date ◽  
Vertebrate Species ◽  
Retinal Cells ◽  
Vision Science ◽  
The Brain

It has been known for over a century that the basic organization of the retina is conserved across vertebrates. It has been equally clear that retinal cells can be classified into numerous types, but only recently have methods been devised to explore this diversity in unbiased, scalable, and comprehensive ways. Advances in high-throughput single-cell RNA-sequencing (scRNA-seq) have played a pivotal role in this effort. In this article, we outline the experimental and computational components of scRNA-seq and review studies that have used them to generate retinal atlases of cell types in several vertebrate species. These atlases have enabled studies of retinal development, responses of retinal cells to injury, expression patterns of genes implicated in retinal disease, and the evolution of cell types. Recently, the inquiry has expanded to include the entire eye and visual centers in the brain. These studies have enhanced our understanding of retinal function and dysfunction and provided tools and insights for exploring neural diversity throughout the brain. Expected final online publication date for the Annual Review of Vision Science, Volume 7 is September 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Vitamin A and Vitamin E: Will the Real Antioxidant Please Stand Up?

2021 ◽  
Vol 41 (1) ◽  
Author(s):  
William S. Blaner ◽  
Igor O. Shmarakov ◽  
Maret G. Traber
Keyword(s):  
Retinoic Acid ◽  
Vitamin E ◽  
Vitamin A ◽  
Expression Profiles ◽  
Transcriptional Regulator ◽  
The Body ◽  
Annual Review ◽  
Antioxidant Vitamin ◽  
Publication Date ◽  
Apparent Contradiction

Vitamin A, acting through its metabolite, all- trans-retinoic acid, is a potent transcriptional regulator affecting expression levels of hundreds of genes through retinoic acid response elements present within these genes. However, the literature is replete with claims that consider vitamin A to be an antioxidant vitamin, like vitamins C and E. This apparent contradiction in the understanding of how vitamin A acts mechanistically within the body is a major focus of this review. Vitamin E, which is generally understood to act as a lipophilic antioxidant protecting polyunsaturated fatty acids present in membranes, is often proposed to be a transcriptional regulator. The evaluation of this claim is another focus of the review. We conclude that vitamin A is an indirect antioxidant, whose indirect function is to transcriptionally regulate a number of genes involved in mediating the body's canonical antioxidant responses. Vitamin E, in addition to being a direct antioxidant, enables the increase of peroxidized lipids that alter both metabolic pathways and gene expression profiles within tissues and cells. However, there is little compelling evidence that vitamin E has a direct transcriptional mechanism like that of vitamin A. Thus, we propose that the term antioxidant not be applied to vitamin A, and we discourage the use of the term transcriptional mediator when discussing vitamin E. Expected final online publication date for the Annual Review of Nutrition, Volume 41 is September 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Transmission of Respiratory Viral Diseases to Health Care Workers: COVID-19 as an Example

2022 ◽  
Vol 43 (1) ◽  
Author(s):  
Amanda M. Wilson ◽  
Darrah K. Sleeth ◽  
Camie Schaefer ◽  
Rachael M. Jones
Keyword(s):  
Health Care ◽  
Infectious Diseases ◽  
Health Care Workers ◽  
Control Strategies ◽  
Respiratory Viruses ◽  
The Body ◽  
Annual Review ◽  
Publication Date ◽  
Indirect Contact ◽  
Care Workers

Health care workers (HCWs) can acquire infectious diseases, including coronavirus disease 2019 (COVID-19), from patients. Herein, COVID-19 is used with the source–pathway–receptor framework as an example to assess evidence for the role of aerosol transmission and indirect contact transmission of viral respiratory infectious diseases. Evidence for both routes is strong for COVID-19 and other respiratory viruses, but aerosol transmission is likely dominant for COVID-19. Key knowledge gaps about transmission processes and control strategies include the distribution of viable virus among respiratory aerosols of different sizes, the mechanisms and efficiency by which virus deposited on the facial mucous membrane moves to infection sites inside the body, and the performance of source controls such as face coverings and aerosol containment devices. To ensure that HCWs are adequately protected from infection, guidelines and regulations must be updated to reflect the evidence that respiratory viruses are transmitted via aerosols. Expected final online publication date for the Annual Review of Public Health, Volume 43 is April 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development

2021 ◽  
Vol 62 (1) ◽  
Author(s):  
Tatsuki Fukami ◽  
Tsuyoshi Yokoi ◽  
Miki Nakajima
Keyword(s):  
Phase I ◽  
Drug Disposition ◽  
Current Knowledge ◽  
Drug Efficacy ◽  
The Body ◽  
Annual Review ◽  
Publication Date ◽  
Oxidation Reactions ◽  
Oxidation Reduction ◽  
Phase I Enzymes

Most clinically used drugs are metabolized in the body via oxidation, reduction, or hydrolysis reactions, which are considered phase I reactions. Cytochrome P450 (P450) enzymes, which primarily catalyze oxidation reactions, contribute to the metabolism of over 50% of clinically used drugs. In the last few decades, the function and regulation of P450s have been extensively studied, whereas the characterization of non-P450 phase I enzymes is still incomplete. Recent studies suggest that approximately 30% of drug metabolism is carried out by non-P450 enzymes. This review summarizes current knowledge of non-P450 phase I enzymes, focusing on their roles in controlling drug efficacy and adverse reactions as an important aspect of drug development. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 62 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Touch and Social Interaction

2021 ◽  
Vol 50 (1) ◽  
Author(s):  
Asta Cekaite ◽  
Marjorie H. Goodwin
Keyword(s):  
Social Interaction ◽  
Online Publication ◽  
Social Life ◽  
The Body ◽  
Sense Making ◽  
Annual Review ◽  
Publication Date ◽  
Instructional Environments ◽  
The World ◽  
Interaction Order

Our understanding of touch as a basic and complex sense is informed by phenomenological perspectives on our corporeal “being-in-the-world” and the notion of intercorporeality (Merleau-Ponty 1964) as well as by sociological perspectives on social life as organized and accomplished through corporeal participation and the interaction order (Goffman 1983). Intercorporeality involves sense-making of oneself and copresent others as body subjects, active in (re)producing a corporeal interaction order that is understood as tactile as well as visual and sonorous. In our review of contemporary ethnographic work, we direct our attention to touch and social interaction and discuss ( a) ritualized supportive interchanges; ( b) moves of compassion that calm a distressed child; ( c) forms of control that socialize the body and gain attention, in particular to create multisensorial, instructional environments; and ( d) forms of touch during care and bodywork in medical and therapeutic contexts. Expected final online publication date for the Annual Review of Anthropology, Volume 50 is October 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Brain Repair by Cell Replacement via In Situ Neuronal Reprogramming

2021 ◽  
Vol 55 (1) ◽  
Author(s):  
Hao Qian ◽  
Xiang-Dong Fu
Keyword(s):  
Treatment Strategies ◽  
The Body ◽  
Annual Review ◽  
Publication Date ◽  
Medical Problems ◽  
Brain Repair ◽  
The Central Nervous System ◽  
Aging Societies ◽  
The Brain

Neurodegenerative diseases, characterized by progressive neural loss, have been some of the most challenging medical problems in aging societies. Treatment strategies such as symptom management have little impact on dis-ease progression, while intervention with specific disease mechanisms may only slow down disease progression. One therapeutic strategy that has the potential to reverse the disease phenotype is to replenish neurons and re-build the pathway lost to degeneration. Although it is generally believed that the central nervous system has lost the capability to regenerate, increasing evidence indicates that the brain is more plastic than previously thought, containing perhaps the biggest repertoire of cells with latent neurogenic programs in the body. This review focuses on key advances in generating new neurons through in situ neuronal reprogramming, which is tied to fun-damental questions regarding adult neurogenesis, cell source, and mecha-nisms for neuronal reprogramming, as well as the ability of new neurons to integrate into the existing circuitry. Expected final online publication date for the Annual Review of Genetics, Volume 55 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

IL-17 in the Pathogenesis of Disease: Good Intentions Gone Awry

2021 ◽  
Vol 39 (1) ◽  
Author(s):  
Saikat Majumder ◽  
Mandy J. McGeachy
Keyword(s):  
Chronic Disease ◽  
Autoimmune Diseases ◽  
Family Member ◽  
Immunology Volume ◽  
Online Publication ◽  
The Body ◽  
Annual Review ◽  
Publication Date ◽  
Disease Pathogenesis ◽  
Founding Family

The IL-17 family is an evolutionarily old cytokine family consisting of six members (IL-17A through IL-17F). IL-17 family cytokines signal through heterodimeric receptors that include the shared IL-17RA subunit, which is widely expressed throughout the body on both hematopoietic and nonhematopoietic cells. The founding family member, IL-17A, is usually referred to as IL-17 and has received the most attention for proinflammatory roles in autoimmune diseases like psoriasis. However, IL-17 is associated with a wide array of diseases with perhaps surprisingly variable pathologies. This review focuses on recent advances in the roles of IL-17 during health and in disease pathogenesis. To decipher the functions of IL-17 in diverse disease processes it is useful to first consider the physiological functions that IL-17 contributes to health. We then discuss how these beneficial functions can be diverted toward pathogenic amplification of deleterious pathways driving chronic disease. Expected final online publication date for the Annual Review of Immunology, Volume 39 is April 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Seq Your Destiny: Neural Crest Fate Determination in the Genomic Era

2021 ◽  
Vol 55 (1) ◽  
Author(s):  
Shashank Gandhi ◽  
Marianne E. Bronner
Keyword(s):  
Nervous System ◽  
Neural Crest ◽  
Cell Lineage ◽  
Cell Types ◽  
The Body ◽  
Annual Review ◽  
Publication Date ◽  
Developmental Potential ◽  
Migratory Patterns ◽  
Modern Genomic

Neural crest stem/progenitor cells arise early during vertebrate embryogenesis at the border of the forming central nervous system. They subsequently migrate throughout the body, eventually differentiating into diverse cell types ranging from neurons and glia of the peripheral nervous system to bones of the face, portions of the heart, and pigmentation of the skin. Along the body axis, the neural crest is heterogeneous, with different subpopulations arising in the head, neck, trunk, and tail regions, each characterized by distinct migratory patterns and developmental potential. Modern genomic approaches like single-cell RNA- and ATAC-sequencing (seq) have greatly enhanced our understanding of cell lineage trajectories and gene regulatory circuitry underlying the developmental progression of neural crest cells. Here, we discuss how genomic approaches have provided new insights into old questions in neural crest biology by elucidating transcriptional and posttranscriptional mechanisms that govern neural crest formation and the establishment of axial level identity. Expected final online publication date for the Annual Review of Genetics, Volume 55 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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