Obesity in Osborne-Mendel and S 5B/Pl rats: effects of sucrose solutions, castration, and treatment with estradiol or insulin

1982 ◽  
Vol 243 (3) ◽  
pp. R347-R353 ◽  
Author(s):  
R. A. Schemmel ◽  
R. J. Teague ◽  
G. A. Bray
Keyword(s):  
Drinking Water ◽  
High Fat Diet ◽  
Sucrose Solution ◽  
Ovariectomized Rats ◽  
Immunoreactive Insulin ◽  
High Fat ◽  
Serum Free Fatty Acids ◽  
Protamine Zinc Insulin ◽  
Sucrose Solutions ◽  
Dietary Obesity

S 5B/Pl rats were tested for their susceptibility to develop obesity when 1) ovariectomized, 2) given injections of insulin, and 3) given a sucrose solution to drink instead of water. The results obtained in Osborne-Mendel rats susceptible to dietary obesity when fed a high-fat diet were compared to those obtained in the S 5B/Pl rats not susceptible to dietary obesity. When tested at the end of 10 wk, ovariectomized rats of both strains had gained 22% more weight than sham-operated controls. Replacement estradiol injections suppressed food intake in both strains with a concomitant loss in body weight. Osborne-Mendel rats tolerated at least 40 U of U-100 protamine zinc insulin/day and rapidly gained weight whereas S 5B/Pl rats given more than 2 U U-100 protamine zinc insulin/day died. Compared to female Osborne-Mendel rats drinking water, rats drinking a sucrose solution accumulated more body fat and had higher levels of serum immunoreactive insulin and lower levels of serum free fatty acids. The substitution of a sucrose solution for plain drinking water suppressed weight gain in S 5B/Pl rats.

Cardioprotective action of chia (Salvia hispanica L.) in ovariectomized rats fed a high fat diet

2021 ◽  
Vol 12 (7) ◽  
pp. 3069-3082
Author(s):  
Marcella Duarte Villas Mishima ◽  
Luiz Carlos Maia Ladeira ◽  
Bárbara Pereira da Silva ◽  
Renata Celi Lopes Toledo ◽  
Thomás Valente de Oliveira ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Mineral Content ◽  
Ovariectomized Rats ◽  
High Fat ◽  
Salvia Hispanica ◽  
Positive Effects ◽  
Biometric Parameters ◽  
Pump Activity ◽  
Salvia Hispanica L ◽  
Cardioprotective Action

The combination of ovariectomy with high fat diet consumption, in this study, affected biometric parameters, oxidative stress, mineral content and ATPase pump activity, while chia consumption had positive effects on these factors.

Aphagia and adipsia after kainic acid lesioning of the dorsomedial hypothalamic area

1983 ◽  
Vol 244 (3) ◽  
pp. R389-R399 ◽  
Author(s):  
L. L. Bellinger ◽  
F. E. Williams
Keyword(s):  
Kainic Acid ◽  
High Fat Diet ◽  
Water Deprivation ◽  
Sucrose Solution ◽  
Tap Water ◽  
Indirect Measurement ◽  
Chow Diet ◽  
High Fat ◽  
Hypothalamic Area ◽  
Hypothalamic Syndrome

Unlike rats which have electrolytic dorsomedial hypothalamic area lesions and are hypophagic and hypodipsic, the rats of the present study with dorsomedial hypothalamic area, kainic acid lesions (KAL) were postoperatively aphagic and adipsic. Subsequently, KAL rats rejected chow or a high-fat diet but ate a 30% sucrose-chow diet. Similarly the KAL rats were adipsic but drank a 30% sucrose solution. Slowly most of the KAL rats began to eat chow and drink tap water but remained hypophagic and hypodipsic. When tested for glucoprivic-induced feeding using 2-deoxy-D-glucose (200 or 400 mg/kg) the KAL rats, in contrast to the sham-operated controls, did not increase their food intake. During water deprivation the recovered KAL rats that would drink tap water ate, and following it they responded with an adequate increase in water consumption. During food deprivation the KAL rats, whether eating chow or sucrose-chow diet, drank, and subsequently the normally hypophagic rats actually ate more than the controls. Although the growth rate (linear and ponderal) of KAL rats was reduced compared with that of the controls, their body composition by indirect measurement was normal. The present data indicate that most of the dorsomedial hypothalamic syndrome results from damage to DMHA neurons and not to fibers of passage.

Bioavailability of Calcium from Chia (Salvia hispanica L.) in Ovariectomized Rats Fed a High Fat Diet

2020 ◽  
pp. 1-11
Author(s):  
Marcella Duarte Villas Mishima ◽  
Bárbara Pereira da Silva ◽  
Renata Celi Lopes Toledo ◽  
Neuza Maria Brunoro Costa ◽  
Hércia Stampini Duarte Martino
Keyword(s):  
High Fat Diet ◽  
Ovariectomized Rats ◽  
High Fat ◽  
Salvia Hispanica ◽  
Salvia Hispanica L

Exercise, dietary obesity, and growth in the rat

1977 ◽  
Vol 232 (1) ◽  
pp. R38-R44 ◽  
Author(s):  
G. C. Pitts ◽  
L. S. Bull
Keyword(s):  
Body Size ◽  
High Fat Diet ◽  
Treadmill Exercise ◽  
Rank Order ◽  
Live Weight ◽  
Exponential Model ◽  
Male Rats ◽  
High Fat ◽  
Dietary Obesity ◽  
Free Body

Four regimens: high-fat diet, exercised (I); chow, exercised (II); high-fat sedentary (III); and chow, sedentary (IV) were initiated in 35-day-old male rats. Growth was exponential in I and II and exponential progressing to rectilinear in III and IV. The exponential model predicted the decreasing rank order in asymptotic weight to be: III, IV, I, II. Body composition data (9 components) showed rank order in masses of fat and the fat-free body mass compartment (FFBM) to be the same as for asymptotic live weight. The rectilinear growth mode probably reflected fat accretion. High-fat diet increased and treadmill exercise decreased FFBM, the latter being reversible. These effects depended on regimen initiations by the 5-7th wk of age. During growth, masses of H2O, muscle, and skin increased as functions of body size; bone as a function of age; and heart, liver, gut, testevity, and diet. Growth in body size was expressed more precisely with FFBM, instead of live weight, as the index of size.

Diet, lighting, and food intake affect norepinephrine turnover in dietary obesity

1987 ◽  
Vol 252 (2) ◽  
pp. R402-R408 ◽  
Author(s):  
T. Yoshida ◽  
J. S. Fisler ◽  
M. Fukushima ◽  
G. A. Bray ◽  
R. A. Schemmel
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
High Fat Diet ◽  
Brown Fat ◽  
Light Cycle ◽  
High Fat ◽  
Interscapular Brown Adipose Tissue ◽  
Norepinephrine Turnover ◽  
Brown Adipose ◽  
Dietary Obesity

The effects of dietary fat content, lighting cycle, and feeding time on norepinephrine turnover in interscapular brown adipose tissue, heart, and pancreas, and on blood 3-hydroxybutyrate, serum glucose, insulin, and corticosterone have been studied in two strains of rats that differ in their susceptibility to dietary obesity. S 5B/Pl rats, which are resistant to dietary obesity, have a more rapid turnover of norepinephrine in interscapular brown adipose tissue and heart and a greater increase in the concentration of norepinephrine in brown fat when eating a high-fat diet than do Osborne-Mendel rats, which are sensitive to fat-induced obesity. Light cycle and feeding schedule are important modulators of sympathetic activity in heart and pancreas but not in brown fat. Rats of the resistant strain also have higher blood 3-hydroxybutyrate concentrations and lower insulin and corticosterone levels than do rats of the susceptible strain. A high-fat diet increases 3-hydroxybutyrate concentrations and reduces insulin levels in both strains. These studies show, in rats eating a high-fat diet, that differences in norepinephrine turnover, particularly in brown adipose tissue, may play an important role in whether dietary obesity develops and in the manifestations of resistance to this phenomenon observed in the S 5B/Pl rat.

Effects of chia (Salvia hispanica L.) on oxidative stress and inflammation in ovariectomized adult female Wistar rats

2019 ◽  
Vol 10 (7) ◽  
pp. 4036-4045 ◽  
Author(s):  
Bárbara Pereira da Silva ◽  
Renata Celi Lopes Toledo ◽  
Marcella Duarte Villas Mishima ◽  
Maria Eliza de Castro Moreira ◽  
Christiane Mileib Vasconcelos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adult Female ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Lipid Profiles ◽  
Ovariectomized Rats ◽  
High Fat ◽  
Salvia Hispanica ◽  
Female Wistar Rats ◽  
Salvia Hispanica L

The study investigated the influence of chia consumption on inflammation, oxidative stress, and lipid profiles in female ovariectomized rats fed a high-fat diet.

scholarly journals High-fat diet intake induces depressive-like behavior in ovariectomized rats

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Valter T. Boldarine ◽  
Amanda P. Pedroso ◽  
Nelson I. P. Neto ◽  
Ana P. S. Dornellas ◽  
Cláudia M. O. Nascimento ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Ovariectomized Rats ◽  
High Fat ◽  
Diet Intake

scholarly journals Effect of Keishibukuryogan on Genetic and Dietary Obesity Models

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Fengying Gao ◽  
Satoru Yokoyama ◽  
Makoto Fujimoto ◽  
Koichi Tsuneyama ◽  
Ikuo Saiki ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Rat Model ◽  
High Fat Diet ◽  
Blood Circulation ◽  
The Body ◽  
Kampo Medicine ◽  
High Fat ◽  
Scavenging Effect ◽  
Dietary Obesity ◽  
Mouse Obesity

Obesity has been recognized as one of the most important risk factors for a variety of chronic diseases, such as diabetes, hypertension/cardiovascular diseases, steatosis/hepatitis, and cancer. Keishibukuryogan (KBG, Gui Zhi Fu Ling Wan in Chinese) is a traditional Chinese/Japanese (Kampo) medicine that has been known to improve blood circulation and is also known for its anti-inflammatory or scavenging effect. In this study, we evaluated the effect of KBG in two distinct rodent models of obesity driven by either a genetic (SHR/NDmcr-cp rat model) or dietary (high-fat diet-induced mouse obesity model) mechanism. Although there was no significant effect on the body composition in either the SHR rat or the DIO mouse models, KBG treatment significantly decreased the serum level of leptin and liver TG level in the DIO mouse, but not in the SHR rat model. Furthermore, a lower fat deposition in liver and a smaller size of adipocytes in white adipose tissue were observed in the DIO mice treated with KBG. Importantly, we further found downregulation of genes involved in lipid metabolism in the KBG-treated liver, along with decreased liver TG and cholesterol level. Our present data experimentally support in fact that KBG can be an attractive Kampo medicine to improve obese status through a regulation of systemic leptin level and/or lipid metabolism.

Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice

2010 ◽  
Vol 61 (4) ◽  
pp. 355-363 ◽  
Author(s):  
Zsuzsa Iffiú-Soltész ◽  
Estelle Wanecq ◽  
Almudena Lomba ◽  
Maria P. Portillo ◽  
Federica Pellati ◽  
...  
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Weight Gain ◽  
Glucose Tolerance ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
High Fat
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