Quantitative studies of perception of thermal stimuli in the normal and neurogenic urinary bladder

1959 ◽  
Vol 14 (2) ◽  
pp. 204-206 ◽  
Author(s):  
Donald F. McDonald ◽  
Gerald P. Murphy
Keyword(s):  
Urinary Bladder ◽  
Saline Solution ◽  
Thermal Sensation ◽  
Human Beings ◽  
Temperature Changes ◽  
Quantitative Measurements ◽  
Quantitative Studies ◽  
Thermal Changes ◽  
The Mean ◽  
Thermal Stimuli

Quantitative measurements of the ability of human beings to perceive temperature changes in the urinary bladder were made using copper-constantan thermocouples connected to a continuous recording electronic potentiometer. Ten different thermal changes were induced by irrigation of the bladder with cold or warm saline solution. Each stimulus was presented to each subject 10 times, according to a table of random numbers. The subjects were asked to indicate whether they felt warmer or colder. The stimulus was maintained for less than 3 seconds. In 40 normal volunteers, the mean warm response was 93℉. The mean cool response was 87.5℉. The neutrality point where the two curves intersected was 89.4℉. Statistical evaluation established the validity of the differences. The thermal sensation of seven patients with varying levels of spinal cord trauma seemed to indicate that the afferent pathway for thermal bladder sensation involved S2,3,4cord segments. Submitted on December 5, 1958

scholarly journals On variability in the density of corticocortical and thalamocortical connections

2000 ◽  
Vol 355 (1393) ◽  
pp. 21-35 ◽  
Author(s):  
Jack W. Scannell ◽  
Simon Grant ◽  
Bertram R. Payne ◽  
Roland Baddeley
Keyword(s):  
Standard Deviation ◽  
Frequency Distribution ◽  
Negative Binomial ◽  
Distributed Data ◽  
Corticocortical Connections ◽  
Quantitative Measurements ◽  
Quantitative Studies ◽  
Thalamocortical Connections ◽  
The Mean ◽  
Connection Density

Variability is an important but neglected aspect of connectional neuroanatomy. The quantitative density of the ‘same’ corticocortical or thalamocortical connection may vary by over two orders of magnitude between different injections of the same tracer. At present, however, the frequency distribution of connection densities is unknown. Therefore, it is unclear what kind of sampling strategies or statistical methods are appropriate for quantitative studies of connectivity. Nor is it clear if the measured variability represents differences between subjects, or if it is simply a consequence of intra–individual differences resulting from experimental technique and the exact placement of tracers relative to local spatial and laminar variation in connectivity. W e used quantitative measurements of the density of a large number of corticocortical and thalamocortical connections from our own laboratories and from the literature. V ariability in the density of given corticocortical and thalamocortical connections is high, with the standard deviation of density proportional to the mean. The frequency distribution is close to exponential. Therefore, analysis methods relying on the normal distribution are not appropriate. W e provide an appendix that gives simple statistical guidance for samples drawn from exponentially distributed data. For a given corticocortical or thalamocortical connection density, between–individual standard deviation is 0.85 to 1.25 times the within–individual standard deviation. Therefore, much of the variability reported in conventional neuroanatomical studies (with one tracer deposited per animal) is due to within–individual factors. W e also find that strong, but not weak, corticocortical connections are substantially more variable than thalamocortical connections. We propose that the near exponential distribution of connection densities is a simple consequence of ‘patchy’ connectivity. W e anticipate that connection data will be well described by the negative binomial, a class of distribution that applies to events occurring in clumped or patchy substrates. Local patchiness may be a feature of all corticocortical connections and could explain why strong corticocortical connections are more variable than strong thalamocortical connections. This idea is supported by the columnar patterns of many corticocortical but few thalamocortical connections in the literature.

Comparative thermoregulatory responses of resting men and women

1978 ◽  
Vol 45 (6) ◽  
pp. 908-915 ◽  
Author(s):  
D. J. Cunningham ◽  
J. A. Stolwijk ◽  
C. B. Wenger
Keyword(s):  
Air Temperature ◽  
Thermal Sensation ◽  
Whole Body ◽  
Sweating Rate ◽  
Temperature Changes ◽  
Heat Flows ◽  
Thermoregulatory Responses ◽  
The Mean ◽  
Skin Temperatures ◽  
Central Drive

Three men and three women were exposed to transients of air temperature (range, 16--48 degrees C). Whole-body sweating rate, local tissue heat flows, and O2 consumption in the cold were linearly related to a weighted sum of tympanic and mean skin temperatures, called “central drive,” During changes in air temperature, changes in subjects' scaled estimates of thermal sensation and discomfort led changes in the physiological responses and central drive. Women's thermoregulatory responses were similar to the men's, but were shifted toward higher (warmer) values of central drive. This shift was about 0.3 degrees C for responses to heat and about 0.6 degrees C for responses to cold. With respect to the women, the mean thus showed delayed responses to the cold, and approached steady state in the cold more slowly.

Extracellular Proteins as Enterobacterial Thermometers

2003 ◽  
Vol 86 (1-2) ◽  
pp. 139-156 ◽  
Author(s):  
Robin J. Rowbury
Keyword(s):  
Thermal Stress ◽  
Heat Shock ◽  
Stress Responses ◽  
Direct Evidence ◽  
Experimental Studies ◽  
Extracellular Proteins ◽  
Temperature Changes ◽  
Induction Components ◽  
Cellular Components ◽  
Thermal Stimuli

Biological thermometers are cellular components or structures which sense increasing temperatures, interaction of the thermometer and the thermal stress bringing about the switching-on of inducible responses, with gradually enhanced levels of response induction following gradually increasing temperatures. In enterobacteria, for studies of such thermometers, generally induction of heat shock protein (HSP) synthesis has been examined, with experimental studies aiming to establish (often indirectly) how the temperature changes which initiate HSP synthesis are sensed; numerous other processes and responses show graded induction as temperature is increased, and how the temperature changes which induce these are sensed is also of interest. Several classes of intracellular component and structure have been proposed as enterobacterial thermometers, with the ribosome and the DnaK chaperone being the most favoured, although for many of the proposed intracellular thermometers, most of the evidence for their functioning in this way is indirect. In contrast to the above, the studies reviewed here firmly establish that for four distinct stress responses, which are switched-on gradually as temperature increases, temperature changes are sensed by extracellular components (extracellular sensing components, ESCs) i.e. there is firm and direct evidence for the occurrence of extracellular thermometers. All four thermometers described here are proteins, which appear to be distinct and different from each other, and on sensing thermal stress are activated by it to four distinct extracellular induction components (EICs), which interact with receptors on the surface of organisms to induce the appropriate responses. It is predicted that many other temperature-induced processes, including the synthesis of HSPs, will be switched-on following the activation of similar extracellular thermometers by thermal stimuli.

scholarly journals LPEATs Tailor Plant Phospholipid Composition through Adjusting Substrate Preferences to Temperature

2021 ◽  
Vol 22 (15) ◽  
pp. 8137
Author(s):  
Sylwia Klińska ◽  
Kamil Demski ◽  
Katarzyna Jasieniecka-Gazarkiewicz ◽  
Antoni Banaś
Keyword(s):  
Growth Regulation ◽  
Phylogenetic Analyses ◽  
Phospholipid Composition ◽  
Expression Ratio ◽  
Temperature Changes ◽  
Substrate Preferences ◽  
Thermal Changes ◽  
Biochemical Evaluation ◽  
Response To Temperature ◽  
Acyl Donors

Acyl-CoA:lysophosphatidylethanolamine acyltransferases (LPEATs) are known as enzymes utilizing acyl-CoAs and lysophospholipids to produce phosphatidylethanolamine. Recently, it has been discovered that they are also involved in the growth regulation of Arabidopsis thaliana. In our study we investigated expression of each Camelina sativa LPEAT isoform and their behavior in response to temperature changes. In order to conduct a more extensive biochemical evaluation we focused both on LPEAT enzymes present in microsomal fractions from C. sativa plant tissues, and on cloned CsLPEAT isoforms expressed in yeast system. Phylogenetic analyses revealed that CsLPEAT1c and CsLPEAT2c originated from Camelina hispida, whereas other isoforms originated from Camelina neglecta. The expression ratio of all CsLPEAT1 isoforms to all CsLPEAT2 isoforms was higher in seeds than in other tissues. The isoforms also displayed divergent substrate specificities in utilization of LPE; CsLPEAT1 preferred 18:1-LPE, whereas CsLPEAT2 preferred 18:2-LPE. Unlike CsLPEAT1, CsLPEAT2 isoforms were specific towards very-long-chain fatty acids. Above all, we discovered that temperature strongly regulates LPEATs activity and substrate specificity towards different acyl donors, making LPEATs sort of a sensor of external thermal changes. We observed the presented findings not only for LPEAT activity in plant-derived microsomal fractions, but also for yeast-expressed individual CsLPEAT isoforms.

Compare the Incidence of Surgical Site Infection after Appendectomy Wound Irrigation with Normal Saline and Imipenem Solutions

2021 ◽  
Vol 15 (8) ◽  
pp. 2184-2186
Author(s):  
Ahmad Shah ◽  
Nazeer Ahmad Sasoli ◽  
Farrukh Sami
Keyword(s):  
Surgical Site Infection ◽  
Wound Infection ◽  
Saline Solution ◽  
Abscess Formation ◽  
Site Infection ◽  
Wound Irrigation ◽  
Group I ◽  
Perforated Appendix ◽  
The Mean ◽  
Group Ii

Objective: To compare the incidence of surgical site infection after appendectomy wound irrigation with regular saline solution and imipenem solution. Study Design: Comparative randomized control trial Place and Duration of Study: Department of Surgery Unit-1, Sandeman Provincial Hospital Quetta from 1st September 2020 to 30th April 2021. Methodology: Eighty patients of both genders were presented in this study. Patients detailed demographics age, sex and body mass index were recorded after taking informed written consent. Patients underwent for appendectomy wound irrigation were included. Patients were equally divided into two equal groups, I and II. Group I had 40 patients and received imipenem and group II irrigated with saline solution with 40 patients. Outcomes were surgical site infection, deep abscess formation was observed post-operatively. Results: The mean age of the patients in group I was 26.11±2.03 years with mean BMI 23.61±3.32 kg/m2 and in group II mean age was 25.14±3.12 years with mean BMI 22.14±4.88 kg/m2. In group I, 32 (80%) patients had inflamed appendix, perforated appendix was in 7 (17.5%) and gangrenous appendix in 1 (2.5%) while in group II inflamed appendix in 34 (85%), perforated appendix in 4 (10%) and gangrenous appendix 2 (5%). Surgical site infection in group I was 3 (7.5%) and abscess formation in 2 (5%) cases while in group II SSI in 6 (15%) and abscess formation in 3 (7.5%) cases. Conclusion: Imipenem irrigation after appendectomy reduces wound infection. Healthcare costs and patient suffering due to infection can be reduced. Keywords: Imipenem solution, Wound irrigation with saline, Appendectomy wound infection

Quantitative studies of the reactions to horizontal angular accelerations in axolotls. I. The head-turning reflexes of normal animals

1977 ◽  
Vol 66 (1) ◽  
pp. 1-14
Author(s):  
K. Brandle
Keyword(s):  
Stimulus Intensity ◽  
Time Course ◽  
Maximum Velocity ◽  
Afferent Input ◽  
Head Turning ◽  
Mean Values ◽  
Quantitative Studies ◽  
The Mean ◽  
Negative Exponential ◽  
Total Angle

1. Artifically metamorphosed axolotls were exposed to both brief (impulse) and long-lasting horizontal angular accelerations on a turn-table. The animals responded with a head-turning reaction. 2. The general course of the reaction to impulse acceleration was independent of stimulus intensity. The velocity of the head movement first increased to a maximum exponentially and then decreased in a negative exponential manner. Stimulus intensity had a linear relationship to the mean maximum velocity and mean total angle covered by head-turning. The average velocity-time curves at various stimulus intensities differed only by a velocity factor. 3. During long-lasting constant accelerations the velocity of the head-turning increased to a maximum velocity in a sigmoid time-course and then decreased, first to a constant velocity, and then further. Mean values of the maximum velocity were correlated linearly with the stimulus intensity. 4. It was concluded that the head-turning reflexes in axolotls do not agree with the accepted movements of the vertebrate cupula and therefore are not a simple ‘copy’ of the afferent input. It is also suggested that the reaction threshold differes from that for the labyrinthine input.

scholarly journals The isotopic record at an alpine glacier and its implications for local climatic changes and isotopic homogenization processes

2001 ◽  
Vol 47 (156) ◽  
pp. 147-151 ◽  
Author(s):  
He Yuanqing ◽  
Wilfred H. Theakstone ◽  
Yao Tandong ◽  
Shi Yafeng
Keyword(s):  
Equilibrium Line Altitude ◽  
Temperature Variations ◽  
Alpine Glacier ◽  
Temperature Changes ◽  
Natural Factors ◽  
Air Temperatures ◽  
Regional Temperature ◽  
The Mean ◽  
A Site ◽  
The Relationship

AbstractStratigraphic variations of oxygen isotopes in the snow which accumulates during the winter at the Norwegian glacier Austre Okstindbreen are not entirely eliminated after 1–2 months of ablation in the following summer. The relationship between regional temperature changes and δ18O values in the snowpack is affected by many natural factors, but 1989/90 winter air temperatures were reflected in the snow which remained on Austre Okstindbreen at 1350 m a.s.l. in July 1990. There were many variations of δ18O values in the 4.1m of snow above the 1989 summer surface, but variations in the underlying firn were relatively small. Meltwater percolation modifies the initial variations of δ18O values in the snowpack. At a site below the mean equilibrium-line altitude on Austre Okstindbreen, increased isotopic homogenization within a 10 day period in July accompanied an increase of the mean δ18O value. Although the isotopic record at a temperate glacier is likely to be influenced by more factors than is that at polar glaciers, it can provide an estimate of the approximate trend of local temperature variations.

scholarly journals THE ASSAY OF HYPERTENSIN FROM THE ARTERIAL BLOOD OF NORMOTENSIVE AND HYPERTENSIVE HUMAN BEINGS

1952 ◽  
Vol 95 (6) ◽  
pp. 523-529 ◽  
Author(s):  
Joseph R. Kahn ◽  
Leonard T. Skeggs ◽  
Norman P. Shumway ◽  
Paul E. Wisenbaugh
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Normal Blood ◽  
Moderate Degree ◽  
Human Beings ◽  
Normal Blood Pressure ◽  
Arterial Blood ◽  
The Mean ◽  
Mean Concentration ◽  
Benign Group

Hypertensin has been assayed in the blood of patients with normal blood pressure and in those with essential hypertension in both the benign and malignant phases. 250 ml. samples of arterial blood were obtained, chemically purified, and concentrated to a volume of 1 ml. These extracts were then assayed in anesthetized rats. The concentrations of hypertensin in the blood of patients with the malignant phase of essential hypertension were found to be greatly increased. The concentrations of hypertensin found in patients with benign hypertension had a moderate degree of overlapping with those found in the normotensive group, but the mean concentration of hypertensin in the former group was twice that of the controls. Although these results are statistically significant, the amounts of hypertensin recovered in the benign group are so small that no conclusions can be drawn as to its effectiveness in producing vasoconstriction in these patients.

scholarly journals Comparative study on thermal comfort responses and sleep quality between Indonesian and Japanese students during summer in Japan

2021 ◽  
Vol 896 (1) ◽  
pp. 012074
Author(s):  
W Budiawan ◽  
K Tsuzuki ◽  
H Sakakibara
Keyword(s):  
Relative Humidity ◽  
Sleep Quality ◽  
Comparative Study ◽  
Thermal Comfort ◽  
Thermal Sensation ◽  
Temperate Climate ◽  
Japanese Students ◽  
The Mean

Abstract The comfort temperature and sleep quality of Indonesian residing in Japan during summer might be different from Japanese. As an extended previous research, this study aimed to compare the thermal comfort and sleep quality between Japanese and Indonesian students. Male Indonesian and Japanese students aged 20-35 years participated in this study. The participants completed a survey regarding thermal sensation before sleep. During sleep, actigraphy was used to monitor sleep. Additionally, the temperature and relative humidity of the participants’ bedrooms were recorded. The findings of this study indicated that Indonesian students’ bedroom temperature and relative humidity were not significantly different from those of Japanese students during the summer. Most of Indonesian students preferred neutral, like the Japanese students. According to a thermal comfort survey, Indonesians had the same sensation as Japanese (slightly comfortable). However, the Griffiths method revealed that the mean comfort temperature of Indonesian was higher than those of Japanese students. We also discovered that Indonesian students had shorter duration on bed and sleep minute than Japanese students. Furthermore, the sleep rate of Indonesian students was comparable to that of Japanese students. In conclusion, Indonesian students as tropical native became capable of adjusting to the hot and humid conditions in temperate climate, Japan.

scholarly journals Irreversible temperature gating in trpv1 sheds light on channel activation

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Ana Sánchez-Moreno ◽  
Eduardo Guevara-Hernández ◽  
Ricardo Contreras-Cervera ◽  
Gisela Rangel-Yescas ◽  
Ernesto Ladrón-de-Guevara ◽  
...  
Keyword(s):  
Trp Channels ◽  
Structural Information ◽  
Heat Absorption ◽  
Absorption Process ◽  
Open Probability ◽  
Temperature Changes ◽  
Trpv1 Channels ◽  
Channel Opening ◽  
Temperature Activation ◽  
Thermal Stimuli

Temperature-activated TRP channels or thermoTRPs are among the only proteins that can directly convert temperature changes into changes in channel open probability. In spite of a wealth of functional and structural information, the mechanism of temperature activation remains unknown. We have carefully characterized the repeated activation of TRPV1 by thermal stimuli and discovered a previously unknown inactivation process, which is irreversible. We propose that this form of gating in TRPV1 channels is a consequence of the heat absorption process that leads to channel opening.

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