Metabolic effects of somatotropin in rats acclimated to adverse environments

1961 ◽  
Vol 16 (2) ◽  
pp. 243-246 ◽  
Author(s):  
Henry B. Hale ◽  
Roy B. Mefferd
Keyword(s):  
Uric Acid ◽  
Mineral Metabolism ◽  
Synergistic Effects ◽  
Barometric Pressure ◽  
Metabolic Effects ◽  
Male Rats ◽  
Sodium Potassium ◽  
Cold Environments ◽  
Metabolic Functions ◽  
Calcium Phosphorus

Effects of somatotropin (STH, growth hormone) in low dosage on metabolic functions were determined in adult male rats acclimated to hot, neutral or cold environments or to low barometric pressure. Urinary determinations (24-hour, fasting) provided the means for evaluating nitrogen and mineral metabolism. The interplay between STH and environmental factors thus received some clarification. STH had certain effects in normal rats which were clearly heat- or altitude-mimetic. In combination, STH and heat had synergistic effects on urea, phosphate and the calcium/phosphorus ratio; and STH and altitude acted synergistically on phosphate and the sodium/potassium and calcium/phosphorus ratios. STH and cold had antagonistic effects on urea, uric acid and the uric acid/creatinine ratio, but synergism was evident in the sodium/potassium ratio. The effects of STH during the initial stage of recovery from heat, altitude or cold were also studied. While some of the recovery reactions were augmented by STH, others were blocked or at least diminished, and there were instances where STH had normalizing effects. Submitted on October 6, 1960

Factorial Study of Environmentally-Induced Metabolic Changes in Rats

1958 ◽  
Vol 194 (3) ◽  
pp. 469-475 ◽  
Author(s):  
Henry B. Hale ◽  
Roy B. Mefferd
Keyword(s):  
Amino Acids ◽  
Body Weight ◽  
Uric Acid ◽  
Chronic Exposure ◽  
Urine Volume ◽  
Ground Level ◽  
Barometric Pressure ◽  
Metabolic Effects ◽  
Body Weight Change ◽  
Metabolic Functions

Metabolic effects of chronic exposure to combinations of adverse environmental influences were studied in rats. During exposures lasting 12 weeks, rats were subjected to the barometric pressure equivalent to 18,000 feet altitude at temperatures ranging from 5° to 34°C. Controls at the various temperatures were held at ground level (700 ft. above sea level). Biweekly observations showed that metabolic functions (water, electrolyte and nitrogen) were influenced primarily by the thermal factors, but altitude effects could also be distinguished. Observations are reported for survival, body weight change, water and food intake, urine volume and the urinary excretion of Na, K, PO4, Mg, Ca, urea, uric acid, creatinine, taurine and 10 amino acids.

Effects of adrenocorticotropin on temperature- and pressure-dependent metabolic functions

1959 ◽  
Vol 197 (6) ◽  
pp. 1291-1296 ◽  
Author(s):  
Henry B. Hale ◽  
Roy B. Mefferd
Keyword(s):  
Barometric Pressure ◽  
Male Rats ◽  
Short Term ◽  
Metabolic Functions ◽  
Metabolic States ◽  
Environmental Extremes ◽  
Temperature And Pressure ◽  
Hot Environments ◽  
Low Dosage

Effects of adrenocorticotropin (ACTH) in low dosage on metabolic aspects were determined in adult male rats acclimated to cold, neutral or hot environments or to low barometric pressure. Urinary determinations provided the means for indirectly assessing metabolic states. The metabolic aspects studied were Na, K, Ca, P, Mg, urea, uric acid, creatinine, creatine, taurine, ß-alanine, glycine, α-alanine, valine, methionine, serine, threonine, tyrosine, glutamic acid, aspartic acid, lysine, arginine, histidine, glucose, glucuronic acid, phenolic acids and coproporphyrin. Additionally, fecal determinations were made for coproporphyrin, protoporphyrin and deuteroporphyrin. The interplay between endocrine and environmental factors and their importance to metabolic states during short-term and long-term exposures to environmental extremes thus received some clarification. With the low dosage employed, ACTH had a ‘restraining’ influence on nonspecific metabolic responses.

Effects of somatotropin in rats acutely exposed to adverse environments

1961 ◽  
Vol 16 (1) ◽  
pp. 123-126 ◽  
Author(s):  
Henry B. Hale ◽  
Roy B. Mefferd
Keyword(s):  
Uric Acid ◽  
Urinary Excretion ◽  
Barometric Pressure ◽  
Metabolic Effects ◽  
Subcutaneous Injections ◽  
Suggestive Evidence ◽  
Temperature And Pressure ◽  
Induced Changes ◽  
Neutral Conditions ◽  
Adverse Environments

Metabolic effects of acute (24-hr.) exposure to low barometric pressure (380 mm Hg), heat (35°C), or cold (2°C) were determined in fasting rats which had received subcutaneous injections of somatotropin (0.5 mg/100 gm b.wt.) 24 hours before and immediately before exposure. Comparison was made with rats exposed to the same conditions without pretreatment with somatotropin and with controls held under neutral conditions of temperature and pressure (24°C, 750 mm Hg). Somatotropin modified environmentally induced changes in 24-hour urinary excretion of urea, uric acid and phosphate and the urinary Na/K, Ca/P and uric acid/creatinine ratios. Suggestive evidence was thus obtained to support the hypothesis that somatotropin contributes to homeostasis. Submitted on October 26, 1959

METABOLIC EFFECTS OF THREE TESTOSTERONE DERIVATIVES INCLUDING 17α-ETHYL-19-NORTESTOSTERONE

1957 ◽  
Vol 16 (1) ◽  
pp. 28-40 ◽  
Author(s):  
R. R. McSWINEY ◽  
F. T. G. PRUNTY
Keyword(s):  
Nitrogen Retention ◽  
Urinary Calcium ◽  
Plasma Calcium ◽  
Metabolic Effects ◽  
Calcium Balance ◽  
Sodium Potassium ◽  
The Third ◽  
Calcium Phosphorus ◽  
Derivatives Of ◽  
Plasma Phosphorus

SUMMARY 1. The protein anabolic properties of three derivatives of testosterone have been investigated. 2. 17α-methyl-Δ5-androstene-3β: 17β-diol and 17α-methyl androstane-3α: 17β-diol produced nitrogen retention in doses approaching those reported as androgenic by other investigators. 3. The third compound, 17α-ethyl-19-nortestosterone (17-ENT), which was studied in greatest detail, produced nitrogen retention in moderate dosage. Other metabolic effects were a fall in urinary calcium and, usually, a fall in faecal calcium. Phosphorus balance agreed with that calculated from nitrogen and calcium balance. Plasma calcium showed no consistent variation, while plasma phosphorus fell. 17-ENT also brought about marked changes in weight, and in fluid, sodium, potassium and chloride balances which are probably due partly to the retention of nitrogen and corresponding intracellular fluid, and partly to increased sweating. When given to two patients with osteoporosis due to prolonged steroid therapy, and receiving prednisone, the compound appeared to aid the restoration of a positive calcium balance. 17-ENT was found to have definite androgenic effects, but their intensity requires further study.

A Multichannel Continuous-Flow Analyzer

1966 ◽  
Vol 12 (3) ◽  
pp. 120-136 ◽  
Author(s):  
Ralph E Thiers ◽  
Jean Bryan ◽  
Katherine Oglesby
Keyword(s):  
Carbon Dioxide ◽  
Uric Acid ◽  
Total Protein ◽  
Continuous Flow ◽  
Data Handling ◽  
Operating Characteristics ◽  
Sodium Potassium ◽  
Sample Handling ◽  
Calcium Phosphorus ◽  
Channel Analyzer

Abstract A 10-channel analyzer is described with which sodium, potassium, chloride, carbon dioxide, calcium, phosphorus, total protein, albumin, albumin blank, and uric acid levels may be determined simultaneously. Operating at the rate of 60 specimens per hour, the instrument uses less than 1 ml. of serum for all 10 determinations. The results appear on 5 two-pen recorders. The report describes the instrument, its operating characteristics, modification of the sampler module to enable sampling from test tubes, a manual system of rapid data-handling, and the system employed for nearly anaerobic sample-handling.

Applicability of the Ektachem 400 analyzer for assaying analytes in miscellaneous body fluids.

1988 ◽  
Vol 34 (12) ◽  
pp. 2534-2539 ◽  
Author(s):  
D A Georgewill ◽  
G A Graham ◽  
I Schoen
Keyword(s):  
Carbon Dioxide ◽  
Cerebrospinal Fluid ◽  
Uric Acid ◽  
Protein Concentration ◽  
Pericardial Fluid ◽  
Vitreous Fluid ◽  
Sodium Potassium ◽  
Clinical Specimens ◽  
Wide Range ◽  
Calcium Phosphorus

Abstract The Ektachem analyzer, a slide-film chemistry technology, demonstrated applicability to non-serum, non-urine stimulated and actual clinical specimens having a wide range of protein concentration and pH. The simulated specimens studied had pH and protein that ranged from 2 to 9 and 0 to 88 g/L, respectively. Actual patients' specimens studied, which had protein concentrations ranging from 0.1 to 60 g/L, included peritoneal fluid, vitreous fluid, synovial fluid, pericardial fluid, and cerebrospinal fluid. The analytes studied included glucose, urea nitrogen, uric acid, creatinine, calcium, phosphorus, sodium, potassium, chloride, and carbon dioxide.

Profile of Admission Chemical Data by Multichannel Automation: An Evaluative Experiment

1966 ◽  
Vol 12 (3) ◽  
pp. 137-143 ◽  
Author(s):  
D Jean Bryan ◽  
Judith L Wearne ◽  
Alberto Viau ◽  
A Wendell Musser ◽  
Fred W Schoonmaker ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Uric Acid ◽  
Total Protein ◽  
Chemical Data ◽  
Routine Laboratory ◽  
Carbon Dioxide Content ◽  
Sodium Potassium ◽  
Clinical Chemical ◽  
Hospital Patients ◽  
Calcium Phosphorus

Abstract In an experiment comparing the clinical chemical data obtained for incoming hospital patients from samples of blood submitted to the routine laboratory and from samples analyzed automatically, a multichannel analyzer was employed. The constituents determined, chosen on the basis of the frequency with which they were ordinarily requested, were glucose, urea, sodium, potassium, chloride, carbon dioxide content, calcium, phosphorus, total protein, albumin, and uric acid. In a significant fraction of the patients admitted at three different hospitals the profile of admission chemical determinations indicated abnormal values which had not been sought by the physician and which often were of direct help to him and benefit to the patient.

Vitamin D Provision in High-Yield Dairy Cows During the Winter Housing Period

2014 ◽  
Vol 1 (1) ◽  
pp. 42-46
Author(s):  
L. Yuskiv ◽  
V. Vlizlo
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase Level ◽  
Mineral Metabolism ◽  
Physiological State ◽  
Blood Parameters ◽  
Postnatal Period ◽  
High Yield ◽  
Oral Supplementation ◽  
Calcium Phosphorus ◽  
Vitamin D 3

Aim. To investigate the vitamin D status in highly productive cows during winter housing period and effect of cholecalciferol by various ways of vitamin D 3 injection to cows in last days of gestation and after calving. Methods. Enzyme-linked immunoassay, spectrophotometry. Results. It has been stated that intramuscular injection of cholecalciferol into cows caused increase of the vitamin D 3 active metabolite – 25-OHD 3 , calcium, phosphorus and magnesium levels together with decrease of alkaline phosphatase level in pre- and post-natal periods. Oral supplementation makes little infl uence on the studied blood parameters of cows. Conclusions. Extrabuccal administration and oral supplementation of cholecalciferol in winter housing period to high-yield cows in the last days of gestation and after calving is accompanied by increased levels of its metabolites and their effect on mineral metabolism in the postnatal period. The nature of these changes depends on the mode of vitamin D administration and the physiological state of the cows.

scholarly journals Metabolic Effects of Recurrent Genetic Aberrations in Multiple Myeloma

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 396
Author(s):  
Timon A. Bloedjes ◽  
Guus de Wilde ◽  
Jeroen E. J. Guikema
Keyword(s):  
Multiple Myeloma ◽  
Cell Metabolism ◽  
Chromosomal Rearrangements ◽  
Chromosomal Translocations ◽  
Metabolic Effects ◽  
Aberrant Expression ◽  
Metabolic Functions ◽  
Complex Chromosomal Rearrangements ◽  
Cancer Cell Metabolism ◽  
The Many

Oncogene activation and malignant transformation exerts energetic, biosynthetic and redox demands on cancer cells due to increased proliferation, cell growth and tumor microenvironment adaptation. As such, altered metabolism is a hallmark of cancer, which is characterized by the reprogramming of multiple metabolic pathways. Multiple myeloma (MM) is a genetically heterogeneous disease that arises from terminally differentiated B cells. MM is characterized by reciprocal chromosomal translocations that often involve the immunoglobulin loci and a restricted set of partner loci, and complex chromosomal rearrangements that are associated with disease progression. Recurrent chromosomal aberrations in MM result in the aberrant expression of MYC, cyclin D1, FGFR3/MMSET and MAF/MAFB. In recent years, the intricate mechanisms that drive cancer cell metabolism and the many metabolic functions of the aforementioned MM-associated oncogenes have been investigated. Here, we discuss the metabolic consequences of recurrent chromosomal translocations in MM and provide a framework for the identification of metabolic changes that characterize MM cells.

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