Correlation between plasma fibronectin level and experimental rat heat stress mortality

1985 ◽  
Vol 59 (3) ◽  
pp. 706-709 ◽  
Author(s):  
D. A. DuBose ◽  
J. McCreary ◽  
L. Sowders
Keyword(s):  
Heat Stress ◽  
Mortality Rate ◽  
Reticuloendothelial System ◽  
Mortality Rates ◽  
Plasma Fibronectin ◽  
Survival Group ◽  
The Relationship

Reticuloendothelial system (RES) clearance function correlates with the mortality rate associated with stresses that can induce shock. Likewise, experimental rat heat stress (ERHS) mortality rate is altered by modulation of RES function. Since plasma fibronectin (PF) in many instances appears to mediate in vivo phagocytosis by the RES, the relationship between mean plasma fibronectin level (MPFL) and ERHS mortality was examined. A comparison of MPFLs prior to ERHS revealed that rats which ultimately comprised the survival group had a MPFL of 269.0 +/- 11.2 micrograms/ml, whereas that of the nonsurvivors was 252.9 +/- 11.9 micrograms/ml. Both groups had elevated MPFLs up to 12 h following ERHS. However, after this time, MPFL began to decline. The decline was more severe for the nonsurvivors, with MPFLs at 15, 18, and 20.3 h significantly (P less than 0.01) lower than the values for the survival group. Even the lowest MPFL (256.0 +/- 30.7 micrograms/ml) noted for the survival group was still significantly (P less than 0.01) higher than the value (159.3 +/- 13.3 micrograms/ml) determined for agonal samples collected from nonsurvivors. Furthermore, grouping rats according to their preheat PF level demonstrated that rats with levels exceeding 300 micrograms/ml had significantly (P less than 0.05) reduced mortality rates (12.5 vs. 51.3%) compared with rats with levels below this value. It was concluded that elevated PF levels prior to ERHS correlated with thermotolerance.

scholarly journals Mortality rates in pediatric septic shock

2017 ◽  
Vol 56 (5) ◽  
pp. 304 ◽  
Author(s):  
Desy Rusmawatiningtyas ◽  
Nurnaningsih Nurnaningsih
Keyword(s):  
Intensive Care Unit ◽  
Septic Shock ◽  
Intensive Care ◽  
Mortality Rate ◽  
Fluid Overload ◽  
Pediatric Intensive Care ◽  
Developed Countries ◽  
Mortality Rates ◽  
Study Cohort ◽  
Survival Group

Background Septic shock remains a major cause of morbidity and mortality in children admitted to the intensive care unit. Recent investigations from developed countries have reported mortality rates of 20-30%. Few studies have reported mortality rates from pediatric septic shock in intensive care settings in developing countries with limited resources.  Objective  To determine the current mortality rates for pediatric patients with septic shock in a developing country.Methods A retrospective study was conducted in the Pediatric Intensive Care Unit (PICU) at DR. Sardjito General Hospital. Medical records and charts were reviewed and recorded for diagnoses of septic shock, from November 1st, 2011 to June 30th, 2014. Results  A database of all PICU admissions was assembled, and cases with diagnoses of septic shock were reviewed. The final data consisted of 136 patients diagnosed with septic shock. Septic shock was defined as a clinical suspicion of sepsis, manifested by hyperthermia or hypothermia, and accompanied by hypoperfusion  The overall mortality rate for the study cohort was 88.2%.  The median age of patients was 16 months, with 52.2% males. Median initial PRISM III and PELOD scores were 10 and 22, respectively. The median length of PICU stay was 4 days. A total of 48.5% of the subjects were in need of crystalloid and colloid fluid at a median amount of 40 mL/kg. The median time required to complete the initial resuscitation was 60 minutes. Mechanical ventilator support in the first 24 hours was required in 79.4% of the cases. Fluid overload of > 10% (FO>10%) was found in 58.8% of the subjects.Conclusion The mortality rate in pediatric septic shock in our hospital is very high. There is a higher incidence of fluid overload in the non-survival group .

scholarly journals The Relationship between Birth Weight Discordance and Adverse Infant Mortality among Monozygotic and Dizygotic Twins in Japan, 1995–2008

2020 ◽  
Vol 23 (1) ◽  
pp. 55-60
Author(s):  
Yoko Imaizumi
Keyword(s):  
Birth Weight ◽  
Mortality Rate ◽  
Infant Mortality ◽  
Age Groups ◽  
Mortality Rates ◽  
Vital Statistics ◽  
Infant Mortality Rate ◽  
Infant Deaths ◽  
Mz Twins ◽  
The Relationship

AbstractUsing vital statistics in Japan (1995–2008), 154,578 live-born twin pairs (128,236 monozygotic [MZ] and 180,920 dizygotic [DZ]) were identified. The proportion of severe discordance among live-born twin births was twice as high in Japanese than Caucasian infants. There were 1858 MZ and 1620 DZ infant deaths. Computation of the relationship between infant mortality rate and birth weight discordance among the twins was performed. Discordance levels were classified into seven groups: <5%, five groups from 5–9% to 25–29%, and ≥30%.The mortality rate was significantly higher in MZ than DZ twins for discordances except at 5–9% and 10–14%. The lowest rate for MZ twins was at 5–9% (7.5 per 1000 live twins) and significantly increased from 10–14% (9.4) to ≥30% (83.4), while the lowest rate for DZ twins was at <5% (6.7), which significantly increased at 10–14% (8.0) and from 25–29% (12.1) to ≥30% (35.5). The relationship was also computed in two gestational age groups (<28 and ≥28 weeks). For births at <28 weeks, three discordances (after 20–24%) in MZ twins were associated with adverse mortality rate. For births at ≥28 weeks, the same relationship was obtained after 10–14% in MZ and after 20–24% in DZ twins. The relationship from 2002 to 2008 showed that the mortality rates significantly increased after 10–14% for both types of twins. In conclusion, five discordance levels in MZ and three levels in DZ twins were associated with adverse mortality rates.

Catabolism of Fibrinogen and its Derivatives

1977 ◽  
Vol 38 (04) ◽  
pp. 0809-0822 ◽  
Author(s):  
Laurence A. Sherman
Keyword(s):  
Experimental Data ◽  
Molecular Weight ◽  
Degradation Products ◽  
Reticuloendothelial System ◽  
Hepatic Uptake ◽  
Low Molecular Weight ◽  
Cell Membrane Binding ◽  
Relationship Of ◽  
The Relationship

SummaryAlthough the site and manner of normal catabolism of most of the fibrinogen pool is uncertain, certain pathways have been defined for various fibrinogen derivatives. Several organs, including the kidneys and reticuloendothelial system (RES) have been directly implicated as catabolic sites for various fibrinogen derivatives. The catabolic sites are not the same for different derivatives. These differences in catabolism are probably in part related to biochemical differences between fibrinogen and its various derivatives. Fibrinogen itself may be catabolized in endothelial cells, although little experimental data is available. RES uptake of intact fibrinogen does not occur, and removal of sialic acid does not result in the rapid hepatic uptake seen with other desialop rote ins. In contrast, a variety of studies have shown that fibrin is taken up by the RES by at least 2 mechanisms. The first is phagocytosis of microparticulate fibrin. The second involves a RES cell membrane binding of soluble fibrin which remains soluble in the blood, when complexed to fibrinogen or degradation products. Fibrinogen degradation products alone may in part also be cleared in the RES. Fragments D and E appear to be catabolized in the kidney, although both the intrarenal site of catabolism and the means of cellular uptake is unknown. It is clear that normally there is no urinary excretion of D and E. Another fibrinogen derivative, low molecular weight clottable fraction 1–8, is derived in vivo from intact fibrinogen. 1–8 is found normally in the blood and has a shorter t ½ than fibrinogen although much longer than D and E. While originally thought to be the result of limited plasmin degradation, 1–8 may be the result of another type of proteolysis. The sites of both 1–8 formation and degradation are unknown. Catabolism via fibrin, 1–8, or D and E appears to be only a small percent of normal turnover, albeit of much greater significance in disease. The relationship of these pathways to the as yet unknown catabolic site for the bulk of normal fibrinogen remains to be determined.

scholarly journals Coarse woody habitat does not predict largemouth bass young of year mortality during the open-water season

2019 ◽  
Vol 76 (6) ◽  
pp. 998-1005 ◽  
Author(s):  
Jacob P. Ziegler ◽  
Colin J. Dassow ◽  
Stuart E. Jones ◽  
Alexander J. Ross ◽  
Christopher T. Solomon
Keyword(s):  
Mortality Rate ◽  
Freshwater Fish ◽  
Largemouth Bass ◽  
Micropterus Salmoides ◽  
Open Water ◽  
Mortality Rates ◽  
In Situ Tests ◽  
Coarse Woody Habitat ◽  
The Relationship

Littoral structure is often assumed to provide refuge to young of year (YOY) freshwater fish species, but empirical in situ tests of this relationship are lacking. We estimated mortality rates of YOY largemouth bass (Micropterus salmoides) over the open-water season in 13 lakes in northern Wisconsin and Michigan using repeated snorkel surveys. Our goal was to test the hypothesis that mortality rate is negatively related to the abundance of littoral coarse woody habitat, which ranged from 3 to 1500 pieces of wood per kilometre of shoreline in these lakes. Instantaneous mortality rates were well-constrained and ranged from 0.04 to 0.19 among the 13 lakes. Mortality was not related to coarse woody habitat abundance. Our results suggest that the relationship between coarse woody habitat and YOY mortality might not be as strong or universal as is often assumed.

scholarly journals Aplikasi Korelasi Kanonikal Pada Faktor – Faktor Yang Mempengaruhi Angka Kematian Ibu Dan Bayi Di Provinsi Jawa Timur

2017 ◽  
Vol 4 (1) ◽  
pp. 5
Author(s):  
Endang Yuswatiningsih
Keyword(s):  
Mortality Rate ◽  
Infant Mortality ◽  
Maternal Mortality ◽  
Canonical Correlation ◽  
Correlation Method ◽  
Mortality Rates ◽  
Infant Mortality Rate ◽  
Strong Positive Correlation ◽  
Independent Variables ◽  
The Relationship

The purpose of this study was to analyze the relationship between maternal and infant mortality by influenced factors and the factors most closely associated with maternal and infant mortality rates in the province of East Java in 2012. This research uses canonical correlation method that aims to determine the relationship between two variables and identify the dimensions between two groups of variables. The results showed that the variable factors that affect maternal mortality and infant mortality has a strong positive correlation to variable maternal mortality and infant mortality rate. Highest impact of the independent variables for maternal mortality is pregnancy, postpartum maternal, neonatal visits, visiting the baby and toddler care was the infant mortality rate is the delivery by the shaman, neonatal visits and infant visits.;Keywords : canonical correlation, maternal mortality rates, infant mortality rates.

Ultrastructural Correlations between Clonal Human Tumor Colonies and in Vivo Neoplasms

1982 ◽  
Vol 40 ◽  
pp. 210-211
Author(s):  
M.J. Murphy ◽  
R.R. Price ◽  
J.C. Sloman
Keyword(s):  
Cultured Cells ◽  
Human Tumor ◽  
Cell Type ◽  
Tumor Mass ◽  
Initial Cell ◽  
Cloning Assay ◽  
Human Tumor Cloning ◽  
The Relationship

The in vitro human tumor cloning assay originally described by Salmon and Hamburger has been applied recently to the investigation of differential anti-tumor drug sensitivities over a broad range of human neoplasms. A major problem in the acceptance of this technique has been the question of the relationship between the cultured cells and the original patient tumor, i.e., whether the colonies that develop derive from the neoplasm or from some other cell type within the initial cell population. A study of the ultrastructural morphology of the cultured cells vs. patient tumor has therefore been undertaken to resolve this question. Direct correlation was assured by division of a common tumor mass at surgical resection, one biopsy being fixed for TEM studies, the second being rapidly transported to the laboratory for culture.

Do Extra-Platelet Sources Contribute to the Plasma Level of Thrombospondin?

1988 ◽  
Vol 59 (02) ◽  
pp. 273-276 ◽  
Author(s):  
J Dawes ◽  
D A Pratt ◽  
M S Dewar ◽  
F E Preston
Keyword(s):  
Platelet Count ◽  
Background Concentration ◽  
Serum Concentrations ◽  
Bone Marrow Depression ◽  
Serial Sampling ◽  
Control Serum ◽  
Platelet Release ◽  
Highly Correlated ◽  
The Relationship

SummaryThrombospondin, a trimeric glycoprotein contained in the platelet α-granules, has been proposed as a marker of in vivo platelet activation. However, it is also synthesised by a range of other cells. The extraplatelet contribution to plasma levels of thrombospondin was therefore estimated by investigating the relationship between plasma thrombospondin levels and platelet count in samples from profoundly thrombocytopenic patients with marrow hypoplasia, using the platelet-specific α-granule protein β-thromboglobulin as control. Serum concentrations of both proteins were highly correlated with platelet count, but while plasma β-thromboglobulin levels and platelet count also correlated, there was no relationship between the number of platelets and thrombospondin concentrations in plasma. Serial sampling of patients recovering from bone marrow depression indicated that the plasma thrombospondin contributed by platelets is superimposed on a background concentration of at least 50 ng/ml probably derived from a non-platelet source, and plasma thrombospondin levels do not simply reflect platelet release.

Accumulation of Macromolecular Particles in the Reticuloendothelial System (RES) Mediated by Platelet Aggregation and Disaggregation

1969 ◽  
Vol 22 (03) ◽  
pp. 496-507 ◽  
Author(s):  
W.G van Aken ◽  
J Vreeken
Keyword(s):  
Platelet Aggregation ◽  
Degradation Products ◽  
Reticuloendothelial System ◽  
Caproic Acid ◽  
Carbon Particles ◽  
Carbon Clearance ◽  
Aggregation And Disaggregation ◽  
Platelet Aggregates

SummaryCarbon particles cause platelet aggregation in vitro and in vivo. Prior studies established that substances which modify thrombocyte aggregation also influence the rate at which carbon is cleared from the blood.This study was performed in order to elucidate the mechanism by which the carbon-platelet aggregates specifically accumulate in the RES.Activation of fibrinolysis by urokinase or streptokinase reduced the carbon clearance rate, probably due to generated fibrinogen degradation products (FDP). Isolated FDP decreased the carbon clearance and caused disaggregation of platelets and particles in vitro. Inhibition of fibrinolysis by epsilon-amino-caproic acid (EACA), initially accelerated the disappearance of carbon and caused particle accumulation outside the RES, predominantly in the lungs. It is supposed that platelet aggregation and locally activated fibrinolysis act together in the clearance of particles. In the normal situation the RES with its well known low fibrinolytic activity, becomes the receptor of the particles.

Dose Requirement for Replacement Therapy in Hemophilia A

1979 ◽  
Vol 42 (03) ◽  
pp. 825-831 ◽  
Author(s):  
Jean-Pierre Allain
Keyword(s):  
Clinical Effect ◽  
Hemophilia A ◽  
Clinical Results ◽  
Severe Hemophilia ◽  
Dose Requirement ◽  
Viii Level ◽  
The Relationship ◽  
In Vivo Recovery ◽  
Different Doses

SummaryIn order to determine the correlation between different doses of F. VIII and their clinical effect,. 70 children with severe hemophilia A were studied after treatment with single doses of cryoprecipitate. The relationship between plasma F. VIII levels or doses calculated in u/ kg of body weight and clinical results followed an exponential curve. Plasma F. VIII levels of 0.35 and 0.53 u/ml corresponded to 95 and 99% satisfactory treatment, respectively. Similar clinical results were obtained with 20 and 31 u/kg. When the in vivo recovery of F. VIII after lyophilized cryoprecipitate was 0.015 u/ml for each u/kg injected, plasma F. VIII levels of 0.30 and 0.47 u/ml respectively were achieved. Since home treatment is largely based on single infusions of F. VIII, it is suggested that moderate and severe hemorrhages be treated with a dose which will provide a plasma F. VIII level of 0.5 u/ml.

Initial Report of Off-Pump Coronary Artery Bypass Surgery as Sole Therapy for Moderate Ischemic Mitral Regurgitation: Operative and Intermediate-Term Outcome

2005 ◽  
Vol 8 (2) ◽  
pp. 89 ◽  
Author(s):  
Kevin M. Harris ◽  
Avinash Reddy ◽  
Dorothee Aepplii ◽  
Betsy Wilson ◽  
Robert W. Emery
Keyword(s):  
Coronary Artery ◽  
Mortality Rate ◽  
Mitral Regurgitation ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Mortality Rates ◽  
Off Pump ◽  
Moderate Ischemic Mitral Regurgitation ◽  
Pump Coronary Artery Bypass

Background: Patients undergoing on-pump coronary artery bypass surgery (CAB) with coexistent moderate ischemic mitral regurgitation (IMR) have a significant mortality rate compared to patients without MR. The mortality rate is elevated both perioperatively (0%-12% mortality), as well as over a 1- and 2-year postoperative period (15%-25%). It is thought that some patients are best served by off-pump CAB (OPCAB); however, outcomes have not been reported for such patients with coexistent moderate IMR. Methods: We reviewed the independent database of patients undergoing OPCAB between 1995 and 2002 to find 989 patients, 17 (1.7%) of whom had moderate or moderately severe MR. Patients were contacted and clinical and echocardiographic data were obtained. Results: The patient group consisted of 11 men and 6 women (age, 65 15 years). The study group had a PA pressure of 52 14, creatinine of 1.6 0.7, and left ventricular ejection fraction of 43 18. Nine patients (53%) had advanced New York Heart Association (class III-IV) heart failure. Mortality rates perioperatively and at 1, 2, and 3 years were 0%, 6.25% (1/16), 12.5% (2/16), and 38% (4/8), respectively. At the time of this report, no patient had returned for a reparative procedure. Conclusion: In patients felt to be best served by OPCAB with ischemic MR, operative and intermediate mortality rates are remarkably similar to those previously reported for on-pump series. These data underscore the continued need to understand which patients undergoing CAB require mitral valve problems to be addressed at the time of surgery.

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