Diethyl pyrocarbonate (an imidazole binding substance) inhibits rostral VLM CO2 sensitivity

1986 ◽  
Vol 61 (3) ◽  
pp. 843-850 ◽  
Author(s):  
E. E. Nattie
Keyword(s):  
Ventrolateral Medulla ◽  
Initial Slope ◽  
Rank Test ◽  
Co2 Response ◽  
Central Chemosensitivity ◽  
Diethyl Pyrocarbonate ◽  
Before And After ◽  
Wilcoxon Sign Rank ◽  
Chemosensitive Areas

Diethyl pyrocarbonate (DEPC) has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Administered via the cisterna magna DEPC inhibits central chemosensitivity in conscious rabbits, supporting the alphastat hypothesis for central chemoreceptor function. In this study I have applied DEPC via 1 X 3 mm cottonoid pledgets to each of the three ventrolateral medulla (VLM) chemosensitive areas in glomectomized, vagotomized, paralyzed, and servo-ventilated alpha-chloralose-urethan-anesthetized cats. CO2 responses measured by integrated phrenic nerve output were evaluated before and after DEPC application. A dose of 40 mmol/l applied to the rostral chemosensitive area increased the CO2 threshold (5.3%) and significantly decreased (P less than 0.03; Wilcoxon sign rank test) the initial slope (-43%) and the maximum (-41%) of the CO2 response. No significant effects were observed with DEPC application in the intermediate or caudal areas. Treatment with 40 mmol/l hydroxylamine immediately after DEPC in the rostral area prevented the effects supporting the interpretation that imidazole was the reactant with DEPC. The results are consistent with the hypothesis that imidazole-histidine is involved in the mechanism of central chemoreception and indicate that only the rostral area utilizes a DEPC inhibitable mechanism.

scholarly journals Pilot Study Efektifitas Media Video Animasi Terhadap Tingkat Depresi Pasien Kanker Serviks Diagnosa Awal

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Dwi Fitriyanti ◽  
Mardiyono Mardiyono ◽  
Yuriz Bakhtiar
Keyword(s):  
Cervical Cancer ◽  
Pilot Study ◽  
Intervention Group ◽  
Initial Diagnosis ◽  
Rank Test ◽  
Control Group ◽  
The World ◽  
Before And After ◽  
Wilcoxon Sign Rank ◽  
Depression Level

Cervical cancer is the cancer that most often attacks women after breastcancer throughout the world. Around the world every two minutes or everyhour a woman dies from cervical cancer. Every patient newly diagnosed withcervical cancer needs to know information about cervical cancer that canaffect the patient's psychological changes in the form of depression. Thepurpose of this study was to determine the effectiveness of education withanimation media to reduce the depression level of cervical cancer patientswith early diagnosis. The method of this research is a pilot study(preliminary study) or testing the feasibility of animation video media on thelevel of depression. Respondent samples in the animated video media trialincluded 10 intervention samples and 10 control samples. The results of theanimation video media research are feasible to be used in subsequent studiesin cervical cancer patients with an initial diagnosis of depression. Dataanalysis using the Wilcoxon Sign Rank Test showed that there was asignificant difference in the level of depression before and after being giveneducation using the animation video media in the intervention group with avalue of p = 0.005 while in the control group with a value p = 0.102. Theconclusion of this study is that the animation video media is feasible to beused in subsequent studies and can effectively be given to cervical cancerpatients with an initial diagnosis of depression.

scholarly journals Enamel Surface Roughness after Lingual Bracket Debonding: An In Vitro Study

Materials ◽  
2019 ◽  
Vol 12 (24) ◽  
pp. 4196
Author(s):  
Martina Eichenberger ◽  
Anna Iliadi ◽  
Despina Koletsi ◽  
George Eliades ◽  
Carlalberta Verna ◽  
...  
Keyword(s):  
Surface Roughness ◽  
In Vitro Study ◽  
Rank Test ◽  
Roughness Parameters ◽  
Signed Rank ◽  
Fine Diamond ◽  
Before And After ◽  
Signed Rank Test ◽  
Lingual Brackets

The aim of the present study was to quantitatively assess changes in enamel roughness parameters before and after lingual bracket debonding. The lingual surface of 25 sound premolars extracted for orthodontic reasons was studied by 3D optical interferometric profilometry before and after debonding of lingual brackets following enamel finishing (with fine diamond) and polishing (with 12- and 20-fluted carbide burs). The roughness parameters tested were the amplitude parameters Sa and Sz, the hybrid parameter Sdr, and the functional parameters Sc and Sv. The parameter differences (after debonding-reference) were calculated, and statistical analysis was performed via a Wilcoxon signed-rank test. Statistically significantly higher values were observed in all the surface roughness parameters of enamel surfaces after finishing and polishing, with the mostly affected parameter being the Sdr. Under the conditions of the present study, the finishing and polishing instruments used after debonding of lingual noncustomized brackets created a surface texture rougher than the control in all the tested roughness parameters.

scholarly journals PENGARUH PEMBERIAN MINUMAN KUNYIT ASAM TERHADAP INTENSITAS NYERI MENSTRUASI PADA REMAJA PUTRI

2020 ◽  
Vol 3 (1) ◽  
pp. 55-60
Author(s):  
Ika Nur Saputri ◽  
Dwi Handayani ◽  
Jurpia Yasara
Keyword(s):  
High School ◽  
Sample Selection ◽  
Rank Test ◽  
P Value ◽  
Acid Extract ◽  
Menstrual Pain ◽  
Natural Event ◽  
Before And After ◽  
Quasi Experimental ◽  
Wilcoxon Sign Rank

Menstruation is a natural and natural event, but in reality many women experience menstrual problems, including menstrual pain or dysmenorrhoea. Nonpharmacological menstrual pain management can be done by giving turmeric acid extract. This study aims to determine the effect of giving turmeric acid extract on the intensity of menstrual pain in adolescent girls in State High School 1 Serdang Bedagai Regency in 2020. The research method is quantitative. This type of research is a quasi-experimental design with one-group pretest-posttest design. The study population was 150 class X and XI students of State High School 1 Serdang Bedagai Regency as many as 150 people. The sample selection using purposive sampling as many as 36 people. The results of the study using Wilcoxon sign rank test showed p-value of 0,000 <0.05. The conclusion is there are differences before and after giving turmeric acid drink to the intensity of menstrual pain (dysmenorrhea). It is expected that schools can provide information to students about the use of turmeric acid as a non-pharmacological treatment in reducing menstrual pain.

scholarly journals PENGARUH REBUSAN BUNGA ROSELLA TERHADAP PENURUNAN TEKANAN DARAH (HIPERTENSI) PADA PASIEN DI WILAYAH KERJA PUKESMAS SUKAMERINDU BENGKULU

2019 ◽  
Vol 26 (2) ◽  
pp. 53-60
Author(s):  
Vellyza Colin ◽  
Buyung Keraman ◽  
Evan Aditya Pratama
Keyword(s):  
Public Health ◽  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Health Center ◽  
Rank Test ◽  
P Value ◽  
Wilcoxon Sign Rank Test ◽  
Before And After ◽  
Wilcoxon Sign Rank ◽  
Sign Rank Test

The Effect of Rosella Stew to Decreasing of Blood Pressure (Hypertension) in Patients at Working Area of  Sukamerindu Public Health Center BengkuluABSTRAKPengaruh rebusan bunga rosella terhadap penurunan tekanan darah (Hipertensi) pada pasien diwilayah kerja Puskesmas Sukamerindu Bengkulu. Hipertensi adalah peningkatan tekanan darah sistolik lebih dari 140 mmHg dan diastolik lebih dari 90 mmHg. Penelitian ini bertujuan untuk mempelajari pengaruh rebusan bunga rosella digunakan untuk menurunkan tekanan darah oleh sebagian masyarakat. Penelitian ini merupakan penelitian kuantiatif dengan desain pra exsprimental. Populasi dalam penelitian ini pasien hipertensi yang berobat di Puskesmas Sukamerindu Kota Bengkulu pada bulan Januari-Desember 2018 sebanyak 52 orang dewasa yang terkena hipertensi. Teknik pengambilan sample dengan total sampling dengan kriteria inkulasi dan ekslusi sehingga sample yang diambil 30 orang yang memenuhi kriteria dalam pemberian rebusan bunga rosella dan 22 orang yang tidak memenuhi kriteria dalam pemberian bunga rosella untuk penurunan tekanan darah hipertensi. Pengumpulan data dalam penelitian ini menggunakan data sekunder dengan melihat cacatan dokumentasi di Poli Umum Di Puskesmas Sukamerindu Bengkulu.Hasil penelitian didapatkan: uji statistik Wilcoxon Sign Rank Test Hasil tekanan darah sistolik sebelum dan sesudah perlakuan didapatkan nilai  Z = -4,293 dengan p=value=0,0000,05 berarti signifikan, maka Ho ditolak dan Ha diterima. Jadi Ada pengaruh pemberian rebusan bunga rosella terhadap penurunan tekanan darah sistolik pada pasien diwilayah kerja Puskesmas Sukamerindu Kota Bengkulu. Hasil tekanan darah diastol sebelum dan sesudah perlakuam didapatkan nilai  Z = -3,075 dengan p=value=0,0020,05 berarti signifikan, maka Ho ditolak dan Ha diterima. Jadi Ada pengaruh pemberian rebusan bunga rosella terhadap penurunan tekanan darah diastolik pada pasien diwilayah kerja Puskesmas Sukamerindu Kota Bengkulu. Kata Kunci : hipertensi,  tekanan darah, rebusan rosella ABSTRACT Effect of rosella stew on blood pressure (hypertension) reduction in patients in the Pukesmas area Sukamerindu Bengkulu. Hypertension is an increase in systolic blood pressure of more than 140 mmHg and diastolic of more than 90 mmHg. This study discusses the benefits of rosella stew used for reducing blood pressure by most people. This research is a quantitative research with pre-exemplary design. The population in this study were hypertensive patients seeking treatment at the Sukamerindu Public Health Center in Bengkulu City in January-December 2018 as many as 52 adults affected by hypertension. Sampling technique with total sampling with inclusion and exclusion criteria so that the samples taken were 30 people who met the criteria in the provision of rosella stew and 22 people who did not meet the criteria for rosella stew for decreasing hypertension. Data collection in this study uses secondary data by looked at documentation records at Puskesmas Sukamerindu Bengkulu.The results of this study showed: Wilcoxon Sign Rank Test statistical test Results of systolic blood pressure before and after treatment obtained a value of Z = -4.293 with p = value = 0.000 0.05 means significant, then Ho is rejected and Ha is accepted. So there is Effect of rosella stew to Decreasing of blood pressure (hypertension) in patients at area of Pukesmas Sukamerindu Bengkulu. The results of diastolic blood pressure before and after the treatment showed that the value of Z = -3.075 with p = value = 0.002 0.05 means significant, then Ho was rejected and Ha was accepted. So there is Effect of rosella stew to Decreasing of blood pressure (hypertension) in patients at area of Pukesmas Sukamerindu Bengkulu. Keywords: blood pressure, hypertension, rosella stew

scholarly journals Does Green Economy Video Really Work? The Effectiveness of Using Video Content Marketing in Forming MSMEs Perception and Behavior to Implement Green Economy

2019 ◽  
Vol 16 (1) ◽  
pp. 34
Author(s):  
Rizka Zulfikar ◽  
Prihatini Ade Mayvita
Keyword(s):  
Green Economy ◽  
Rank Test ◽  
Video Content ◽  
Wilcoxon Sign Rank Test ◽  
Analysis Technique ◽  
Before And After ◽  
Wilcoxon Sign Rank ◽  
Sign Rank Test ◽  
And Behavior ◽  
Content Marketing

This study aims to assess the effectiveness of the use of video content marketing in performing SMEs perceptions and behavior in implementing the concept of a green economy. The expected results of this research will make the using of video marketing content can be used as a material consideration for use in socialization and guidance to SMEs about the concept of green economy. This study was conducted in South Kalimantan province with the population, and the sample was SMEs in South Kalimantan province as much as 164 respondents. Researcher use purposive sampling as research method with one group pretest-posttest as research design. The data was collected using interviews and questionnaires. Data analysis technique are descriptive statistics and Wilcoxon Sign Rank Test. This study found that there is an average difference of perception and behavior of respondents about green economy before and after treatment with the video content marketing.

scholarly journals ANALISIS PERBEDAAAN AVERAGE ABNORMAL RETURN DAN TRADING VOLUME ACTIVITY SEBELUM DAN SESUDAH PERISTIWA DIVIDEN TUNAI PADA PERUSAHAAN YANG TERDAFTAR DI JAKARTA ISLAMIC INDEX (JII) PERIODE 2014 – 2017

2020 ◽  
Vol 6 (12) ◽  
pp. 2512
Author(s):  
Azyyati Yusrina ◽  
Puji Sucia Sukmaningrum
Keyword(s):  
Abnormal Return ◽  
Trading Volume ◽  
Rank Test ◽  
Volume Activity ◽  
Wilcoxon Sign Rank Test ◽  
Average Abnormal Return ◽  
Before And After ◽  
Wilcoxon Sign Rank ◽  
Sign Rank Test ◽  
Observation Period

This study aims to find out and explain the market reaction caused by the corporate action announcement in the form of dividend cash made by issuers registered in the Jakarta Islamic Index for the period of 2014 to 2017. The object of research is issuers who carry out activities on the announcement of Cash Devidend in the period of observation that are registered in the Jakarta Islamist Index which has been determined based on certain criteria (purposive sampling). There are 17 issuers with a total of 91 being the research sample. The observation period consists of 60 days estimated period, 10 days before the cume date and 10 days after the cume date. The focus of the research is to see the reaction shown by changes in Average Abnormal Return and Trading Volume Activity by using paired sample t-test for trading volume activity variables and Wilcoxon sign-rank test for abnormal return variables. Processing data using Stata ver statistical tools 14 by setting a significant level of 5%. The results showed that there were significant differences in Average Abnormal Return before and after the announcement and there were no differences in the Trading Volume Activity before and after the announcement.Keywords: event study, cash deviden, Average Abnormal Return, Trading Volume Activity

scholarly journals The effect of education on knowledge and attitudes in using halal cosmetic products

2021 ◽  
Vol 4 (2) ◽  
pp. 83
Author(s):  
Siti Lailaturrohmah ◽  
Alviyana Lutviyani
Keyword(s):  
Sampling Technique ◽  
Rank Test ◽  
P Value ◽  
Cosmetic Products ◽  
Knowledge And Attitudes ◽  
Analysis Technique ◽  
Cosmetic Ingredients ◽  
Before And After ◽  
Wilcoxon Sign Rank ◽  
High Level

Consumers' awareness of halal cosmetics is still low. The high level of dependence on a product and the lack of consumer knowledge of cosmetic ingredients makes it difficult for consumers to switch to cosmetic products that are halal certified. Minimal education that is easily accessible regarding the halalness of a cosmetic product among the community is a problem that results in the lack of awareness of halal. This study aims to obtain information about the effect of halal education on knowledge and attitudes in the use of cosmetics. The method used in this study is an experimental design with a sample size of 30 respondents who are active users of cosmetics both labeled halal and not labeled halal. The sampling technique used was accidental sampling. Data on the knowledge and halal attitudes of respondents before and after education were obtained from filling out questionnaires which were carried out online. The data analysis technique used was the Wilcoxon Sign Rank Test using SPSS 16. The results of the respondents' research indicated that there were significant differences in their knowledge and attitudes towards the use of cosmetics before and after halal education with p value ≤ 0.05.

Pirenzepine prevents diethyl pyrocarbonate inhibition of central CO2 sensitivity

1988 ◽  
Vol 65 (5) ◽  
pp. 1962-1966 ◽  
Author(s):  
E. E. Nattie ◽  
J. W. Mills ◽  
L. C. Ou
Keyword(s):  
Ventral Surface ◽  
Blocking Agent ◽  
Inhibitory Effect ◽  
Ventrolateral Medulla ◽  
Inhibitory Effects ◽  
Co2 Sensitivity ◽  
Diethyl Pyrocarbonate ◽  
Maximum Value ◽  
Chemosensitive Areas ◽  
Co2 Chemosensitivity

Application by pledget of the M1-antimuscarinic receptor agent pirenzepine (40 mM) to the rostral chemosensitive areas of the ventrolateral medulla in anesthetized, paralyzed, vagotomized, glomectomized, and servoventilated cats inhibited the slope of the integrated phrenic response to CO2 by 32.5% (P less than 0.03) and the maximum value by 21.1% (P less than 0.01). Similar application of the imidazole-histidine blocking agent diethyl pyrocarbonate (DEPC) decreased the slope by 40.3% (P less than 0.01) and the maximum value by 29.3% (P less than 0.05). Both responses confirm previous results. DEPC treatment decreased the effectiveness of subsequent pirenzepine application such that although slope and maximum were further decreased, the values were not significantly different from those after DEPC. Pirenzepine treatment prevented any subsequent DEPC inhibitory effect. The results raise the possibility that the inhibitory effects of DEPC on CO2 chemosensitivity are via muscarinic receptors and that muscarinic receptor involvement in CO2 chemosensitivity requires the presence of imidazole-histidine. Analysis by scintillation counting of successive 100-micron sections of medulla after rostral area application of [3H]pirenzepine indicated that the pirenzepine and DEPC effects are most probably within 2.0 mm of the ventral surface as measured from the midline, well away from the dorsal and ventral respiratory group neurons.

scholarly journals Analisis Kinerja Keuangan Sektor Perbankan Sebelum dan Sesudah Adanya Perusahaan Teknologi Finansial

2021 ◽  
Vol 1 (2) ◽  
pp. 91-102
Author(s):  
Raysa Azahra Ade Putri ◽  
◽  
Dewi Cahyani Pangestuti ◽  
Agus Kusmana ◽  
◽  
...  
Keyword(s):  
Financial Management ◽  
Stock Exchange ◽  
Financial Statements ◽  
Rank Test ◽  
Management Innovation ◽  
Before And After ◽  
Wilcoxon Sign Rank ◽  
Sign Rank Test ◽  
Research Period ◽  
Financial Technology

Abstract Purpose: The intention of the research was to examine if there were any discrepancies in banks ’ financial performance before and after the introduction of financial tech firms. Research Methodology: The study's subject was registered banking on the Indonesia Stock Exchange (IDX), with 38 banks chosen as a sample over a two-year period before the introduction of financial tech firms (2013-2014) and two years after the existence of financial tech firms (2016-2017). With a 5% significance rate, the tests utilized in this paper were Paired Sample T-test (normal data) and Wilcoxon Sign Rank Test (abnormal data) with SPSS 25 software assistance. Results: The outcomes of this research, after the arrival of financial technology enterprises, there is a discrepancy in profitability, liquidity, and capital. Limitations: This research's limitations are that certain banks did not leak consecutive financial statements during the research period, and earlier studies had no specific explanation on the same topic. Contribution: The insights can be used by academics as a reference, by the Bank as a foundation for financial management innovation, and by investors as a source of knowledge and consideration when making investment decisions.

scholarly journals The Effect of Elderly Cognitive Care on the Cognitive Function and Physical Activity of Elderly

2018 ◽  
Vol 1 (2) ◽  
pp. 37-48
Author(s):  
Hyan Oktodia Basuki ◽  
Joni Haryanto ◽  
Tiyas Kusumaningrum
Keyword(s):  
Physical Activity ◽  
Cognitive Function ◽  
Quantitative Research ◽  
Intervention Group ◽  
The Elderly ◽  
Rank Test ◽  
P Value ◽  
Before And After ◽  
Quasi Experimental ◽  
Wilcoxon Sign Rank

Background. The process of aging causes various health problems namely the physiological changes of the elderly. The increase in number of elderly is directly proportional to the problems of elderly, including the decreased cognitive function and physical activity. This phenomenon is most commonly found in people over the age of 60 years, but also can attack the age of 40 years.  Methods. type of research using quantitative research with quasi experimental pre-posttest design. The Sampling method uses non-probability sampling with purposive sampling. The sample of this research is 62 elderly, divided into treatment and control groups in Puskesmas Jetak Tuban. The questionnaire in this research uses MMSE for cognitive function and Index katz for physical activity. The research was conducted from March to April 2018. Results. the statistical test results uses wilcoxon sign rank test obtained significant values of cognitive function intervention group and physical activity variables, before and after given the intervention, the Elderly Cognitive Care has a calculated value Z= -4.32 and Z = -3.94 with significant value α = 0.00. This result means if value of p value ≤0.05, then the hypothesis is accepted, this means that there is influence of Elderly Cognitive Care to cognitive function and physical activity of elderly in Puskesmas Jetak Tuban. Conclusion. There is an enhancement in cognitive function and physical activity in the elderly, after being given Elderly Cognitive Care. This intervention can be used as management for the elderly against the reduction in cognitive function and physical activity.

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