Modification of angiogenic factors by regular and acute exercise during pregnancy

2010 ◽  
Vol 108 (5) ◽  
pp. 1217-1223 ◽  
Author(s):  
Tracey L. Weissgerber ◽  
Gregory A. L. Davies ◽  
James M. Roberts

This cross-sectional study examined mechanisms through which exercise might alter preeclampsia risk by estimating the effects of acute and chronic exercise on angiogenic markers in healthy pregnant women with different amounts of regular exercise participation. Serum-soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and soluble endoglin (sEng) were measured before and after 20 min of moderate-intensity cycle ergometry in normotensive, nonsmoking pregnant (16 active, 9 inactive, 34.1 ± 1.6 wk gestation) and nonpregnant (15 active, 12 inactive, midlate luteal phase) women. Inactive women did not regularly exercise at an intensity that was sufficient to cause sweating. Active women exercised for at least 3 h/wk. Inactive pregnant women had significantly lower PlGF concentrations [median (interquartile range): 268 (159, 290) vs. 278 (221, 647) pg/ml, P = 0.014] and higher sFlt-1 [5,180 (4,540, 5,834) vs. 4,217 (2,014, 5,481) pg/ml, P = 0.005] and sEng concentrations [9.1 (7.7, 16.7) vs. 7.8 (6.5, 10.1) ng/ml, P = 0.025] than active pregnant women. This effect of regular exercise participation was not observed in nonpregnant women. Acute exercise in pregnancy was not associated with antiangiogenic changes that might contribute to preeclampsia; rather, there was a small, but statistically significant, increase in PlGF following acute exercise in active pregnant women [278 (221, 647) vs. 335 (245, 628) pg/ml, P = 0.014]. sFlt-1 increased significantly following acute exercise in inactive nonpregnant women [90 (86, 100) vs. 106 (101, 116) pg/ml, P = 0.012], but not in active nonpregnant women. Regular exercise during pregnancy is associated with higher serum PlGF and lower sFlt-1 and sEng concentrations in late gestation, a difference that is unlikely to have predated the pregnancy.

Author(s):  
Daniela Ferreira D’Agostini Marin ◽  
Amanda Wernke ◽  
Daniela Dannehl ◽  
Dyulie Araujo ◽  
Gustavo Koch ◽  
...  

OBJECTIVE: The objective of this study was to evaluate C-section rates, before and after the implementation of the Project Appropriate Birth based on the Robson 10-group classification system. DESIGN: An observational, cross-sectional study. SETTING: Maternity hospital in South Brazil. POPULATION: All pregnant women attending, April 2016 through April 2017 (phase 1, pre-implementation of the Project Appropriate Birth) and June 2017 through June 2018 (phase 2, post-implementation of the Project Appropriate Birth). METHODS: Maternal and obstetric characteristics were evaluated, including Robson’s classification, based on the characteristics of pregnancy and childbirth. Chi-square test and crude and adjusted prevalence ratios were used to analyze study variables. The significance level was set at 5%. MAIN OUTCOME MEASURES: C-section rate for each group, their contribution to the overall c-section rate and the differences in these contributions before and after PPA implementation. RESULTS: C-section rates decreased from 62.4% to 55.6%, which represented a 10.9% reduction after the implementation of the Project Appropriate Birth. Pregnant women in Robson classification groups 1 through 4 had the greatest decrease in C-section rates, ranging from 49.1% to 38.6%, which represents a 21.5% reduction. The greatest contributors to the overall C-section rates were group 5 and group 2, accounting for more than 60% of the C-section deliveries. CONCLUSION: The Project Appropriate Birth had an important impact on the reduction of C-section rates, especially in Robson classification groups 1 through 4, which indicates that providing mothers with evidence-based interventions for labor and childbirth assistance will contribute to reduce C-section rates.


Author(s):  
Semra Akkoz Cevik ◽  
Emine Karacan ◽  
Aysegul Kılıçlı

Background: Superstition and traditional practices regarding pregnancy exist in various cultures around the world and are passed down from generation to generation. As a result of the literature review, it was observed that there weren't prospective and cross-sectional studies involving traditional practices and dietary preferences of pregnant women before and after determining the gender according to the gender of the baby they want. The purpose of this study was to determine dietary preferences, superstitions and traditional practices before and after determining the gender of the baby according to the desired gender of the baby among pregnant women.Methods: The research was a descriptive cross-sectional study and adopted the pretest-posttest research design. As the data collection tool, both investigators-designed questionnaire forms and the non-functional beliefs and practices scale (NFBPS) related to pregnancy to the same pregnant women were applied before and after the determination of baby gender in the first and second trimesters respectively.Results: The study found that 85% of the pregnant women thought that dietary preferences during pregnancy have an impact on the gender of the true baby. The results showed that superstitions and traditional practices were known and practiced by pregnant women at a young age, uneducated, living in the province and having a large family type (p<0.05).Conclusions: Health professionals, should pay attention to less educated, younger pregnant women to reinforce positive cultural health practices, discourage to them from using harmful ones superstition and traditional practice by providing non-critical scientific explanations. 


2019 ◽  
Vol 6 (2) ◽  
pp. 135-141 ◽  
Author(s):  
Ya-Nan Yin ◽  
Yan Huang ◽  
Xing-Hui Liu ◽  
Bi-Ru Luo

Abstract Objective To assess the patterns and intensities of physical activity among pregnant women in southwestern China, which help us create a fitness regimen based on the 2002 American College of Obstetricians and Gynecologists (ACOG) guidelines for exercise during pregnancy. Methods A cross-sectional study was performed to recruit pregnant women at a prenatal checking visit clinic with the self-administered Chinese version of Pregnancy Physical Activity Questionnaire (PPAQ). Results A total of 1179 Chinese pregnant women were enrolled, of whom 92.60% were classified as not meeting the ACOG guidelines. By intensity, 47.36% of the score was attributed to light-intensity activities (1.5 to <3.0 metabolic equivalent [MET]) in the first trimester; the other 2 trimesters were similar. By patterns, about 45.15% of the score was attributed to inactivity. More than 82.35% of enrolled pregnant women regarded slowly walking as the most common type of exercise during pregnancy. Conclusions This study represents a group of Chinese women who maintained an inactive lifestyle, including low-intensity activities and unitary type of exercises during their pregnancy. Health-care providers are advised to provide appropriate physical activity guidelines to pregnant women. Development of MET-hours/week recommendations is warranted to promote greater physical activity during pregnancy.


2009 ◽  
Vol 5 (3) ◽  
pp. 120
Author(s):  
Helfiyan Helfiyan ◽  
Hamam Hadi ◽  
Siti Helmyati

Background: Anemia among pregnant women may increase abortion, premature, low birth weight and even mortality before and after delivery. Factors causing anemia in Indonesia are lack of Fe, inadequate intake, demanding needs, and lack of nutrient facilitating Fe absorption. Besides, infection such as worm and malaria may cause anemia as well. Result of household health survey 2001 stated that prevalence of pregnant women with anemia was 40% in Indonesia. In Jambi Province, it was 39% in 2003 and 42.3% for Batang Hari Regency while infection of malaria was 50.0% in all age groups and many other districts that its environment were woods, humid, and wasted that may increase infection of hookworm.Objective: The study was proposed to know the correlation of hookworm, malaria with anemia among pregnant women by analyzing correlation of hookworm, malaria, and anemia and correlation of hookworm, malaria and Fe status among pregnant women.Method: This was cross sectional study. It held from September until December 2005 in Batang Hari Regency, Jambi Province. Subjects were 132 pregnant women. Examination of blood for Hb, malaria and ferritin were taken together while feces were later.Results: There were no significant correlation of Ascaris lumbricoides infection with anemia (p = 0.36; OR = 2.43), Trichiuris thrichiura infection with anemia (p = 0.30), 2 kinds of worm Ascaris lumbricoides + Trichiuris trichiura with anemia (p = 0.08; OR = 4.87), and infection of Ascaris lumbricoides + Necator americanus with anemia (p = 0.30). There was significant correlation of 3 kinds of worm Ascaris lumbricoides + Trichiuris trichiura + Necator americanus with anemia (p = 0.018; OR = 7.3). There were no significant correlation of Ascaris lumbricoides with ferritin (p = 0.17; OR = 3.23) and Trichiuris trichiura with ferritin (p = 0.25). There was significant correlation of 2 kinds of worm Ascaris lumbricoides + Trichiuris trichiura with ferritin (p = 0.04; OR = 6.4). There was no significant correlation of Ascaris lumbricoides + Necator americanus with ferritin p = 0.25. There were significant correlation of 3 kinds of worm (Ascaris lumbricoides + Trichiuris trichiura + Necator americanus) with ferritin p = 0.007; OR = 9.69 and ferritin with anemia p = 0.0001; OR = 17.45.Conclusion: There was no significant correlation of hookworms Ascaris lumbricoides, Trichiuris trichiura, Ascaris lumbricoides + Trichius trichiura, Ascaris lumbricoides + Necator americanus with anemia. There were significant correlation of infection of Ascaris lumbricoides + Trichiuris trichiura + Necator americanus with anemia and malaria with anemia. There was no correlation of hookworms Ascaris lumbricoides, Trichiuris trichiura, Ascaris lumbricoides + Neca- tor americanus with anemia. There were correlation of infection Ascaris lumbricoides + Trichiuris trichiura and Ascaris lumbricoides + Trichiuris trichiuris + Necator americanus with ferritin, malaria with ferritin, and ferritin with anemia.


2021 ◽  
Vol 20 (2) ◽  
pp. 75-92
Author(s):  
Ermioni Tsarna ◽  
Ioanna Mavrommati ◽  
Grigorios Bogdanis ◽  
Olga Triantafillidou ◽  
George Paltoglou ◽  
...  

Introduction: Physical activity and exercise during pregnancy is regarded safe and beneficial in absence of pregnancy complications. The aim of this cross-sectional study is to describe physical activity of pregnant women in Greece and explore if it changes during pregnancy compared to the period before pregnancy. Material and Methods: The study was conducted in a private maternity hospital. Women were asked to fill in an adapted questionnaire based on Pregnant Physical Activity Questionnaire; birth outcomes and anthropometric measurements of the neonate were collected by the research midwife. Results: In our study population of 193 pregnant women, approximately half reported no or minimal physical activity during pregnancy and were less active than current guidelines’ recommendations. Gynaecologist’s opinion regarding exercise during pregnancy was conceived as positive only by a minority of women. Overall, women were less active during pregnancy than before, although they spent more time slowly walking for fun or exercise. Lastly, significant decrease was observed in all occupational activities involving slow or quick walking and lifting weights. Conclusions: These results indicate that systematic counselling of pregnant women regarding physical activity and exercise during pregnancy will be needed to achieve optimal physical activity levels for the majority of women in Greece.


2007 ◽  
Vol 53 (9) ◽  
pp. 1623-1628 ◽  
Author(s):  
Alfredo Leaños-Miranda ◽  
Janeth Márquez-Acosta ◽  
Fernando Romero-Arauz ◽  
Guadalupe M Cárdenas-Mondragón ◽  
Roxana Rivera-Leaños ◽  
...  

Abstract Background: The protein:creatinine ratio in random, untimed urine samples correlates with 24-h protein excretion in pregnant women with and without hypertension. Nevertheless, whether this ratio is appropriate as a screening test for proteinuria is still unclear, in part because of the paucity of large studies. Methods: We measured protein:creatinine ratios in random urine samples and protein contents of 24-h urine samples in a cross-sectional study of 927 hospitalized pregnant women at ≥20-weeks of gestational age and in a 2nd cohort of 161 pregnant women. In the 2nd group, urine specimens were obtained before and after completion of the 24-h collections, avoiding 1st-morning void specimens. Results: Protein excretion was ≥300 mg/24 h in 282 patients (30.4%). The urine protein:creatinine ratio and the 24-h protein excretion were significantly correlated (r = 0.98, P &lt;0.001). The protein:creatinine ratio as an indicator of protein excretion ≥300 mg/24 h was ≥0.3. The sensitivity and specificity were 98.2% and 98.8%, respectively. Positive and negative predictive values were 97.2% and 99.2%, respectively, and positive and negative likelihood ratios were 79.2 and 0.02, respectively. The diagnostic accuracy of the urinary protein:creatinine ratio was corroborated in the 2nd cohort of patients, which also showed no statistically significant difference in protein:creatinine ratio between samples obtained &gt;24 h apart. Conclusions: Random urinary protein:creatinine ratio is a reliable indicator of significant proteinuria (&gt;300 mg/day) in nonambulatory pregnant women, irrespective of sampling time during the daytime. The protein:creatinine ratio may be reasonably used as an alternative to the 24-h urine collection method.


Author(s):  
Vicente Antonello ◽  
Marjane Cunegatto ◽  
Elisa Rosin ◽  
Júlia Castilhos ◽  
Fabrícia Beduschi ◽  
...  

Objective To analyze the prescription of antimicrobial agents for pregnant women admitted into the obstetrics service who presented with acute pyelonephritis. Methods Three cross-sectional studies were performed comparing the prescription of antimicrobials for pyelonephritis in pregnant women in the time periods evaluated (2010–2011: 99 patients evaluated; 2013: 116 patients evaluated; 2015: 107 patients evaluated), at the Hospital Fêmina, Porto Alegre, in the state of Rio Grande do Sul, Brazil. The analysis was performed before and after the promotion of an institutional protocol for the treatment of pyelonephritis during pregnancy, and on a third occasion after the introduction of a smartphone-based mobile educational tool. Results The evaluation of the prescribing physicians and the adequacy of the prescriptions between the different periods studied revealed a significant increase in appropriate conduct for the choice of antimicrobial (2010: 83.8%; 2013: 95.7%; and 2015: 100%), route of administration (2010: 97%; 2013: 100%; and 2015: 100%), and interval (2010: 91.9%; 2013: 95.7%; and 2015: 100%), following the introduction of the protocol, and again after the implementation of the software application with orientations on the antimicrobial treatment. Conclusion The use of specific mobile applications should be encouraged to attain a better quality and accuracy in prescriptions and to include strategies that not only reduce the risk of negative outcomes, but also improve the quality of care and treatment for maintaining the health both of the mother and of the baby.


Medicina ◽  
2020 ◽  
Vol 56 (6) ◽  
pp. 274
Author(s):  
Rudite Lagzdina ◽  
Maija Rumaka ◽  
Gita Gersone ◽  
Peteris Tretjakovs

Background and Objectives: Skeletal muscles are considered to be the main source of circulating irisin, both at rest and during physical activity. The aim of this study was to investigate the connection between irisin, body composition, and energy metabolism in humans. Materials and Methods: Serum irisin concentrations before and after acute aerobic exercise on a treadmill in 84 healthy adults were measured and their association with body composition and energy expenditure (EE) (obtained from indirect calorimetry) was determined. Results: The total pre-exercise irisin concentrations in males and females were similar, but higher in females when expressed per body mass kg (p < 0.001). There was an association between pre-exercise irisin per body mass kg, visceral fat rating (rho = −0.52, p = 0.001), and lean tissue % (rho = 0.41, p < 0.05) in males and lean body mass index (LBMI) (rho = −0.59, p < 0.001) in females. The pre-exercise irisin concentration correlated with the resting metabolic rate (RMR) in both sexes (rho = 0.44 in males, rho = 0.36 in females; p < 0.05), but with walking, running, and the EE difference from RMR in running (Δ running EE) in males only (rho = 0.32 to 0.37, p < 0.05). There was no significant change in irisin concentration after exercise in 58% of participants, while it decreased in 23%, and increased in 19%. In male subjects with no change in irisin concentration after exercise, running (p < 0.05) and Δ running EE per body mass kg (p < 0.05) were higher than in those with decreased irisin concentration. Conclusions: These findings indicate that the association of irisin concentration with body composition and EE parameters has sex-dependent differences, and acute exercise can lead to various changes in post-exercise irisin levels.


2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Reni Nofita ◽  
Dorsinta Siallagan ◽  
Yuliyanti Yuliyanti

 Anemia in pregnancy is potentially harmful to the mother and child. Based Riskesdas 2013 the prevalence of anemia among pregnant women in Indonesia amounted to 37.1%, this indicates the incidence of pregnancy anemia in Indonesia is still quite high, this study aims to Know the knowledge before and after getting a health education about the link between diet and the incidence of high risk in pregnancy puskesmass District, Ciputat timur.Metode this research is descriptive analysis with cross sectional study design. Location of the research conducted at the health center subdistrict, Ciputat east, Rengas, Pisangan, Pondok Ranji. Samples in this study were 84 maternal sample is taken by accidental sampling technique. The research instrument used was a questionnaire and book ANC. Data analysis using Chi Square Results of the study of 84 pregnant women, obtained 20.9% experienced anemia There is a significant correlation between regularity of the diet and the incidence of anemia, with p value 0.002. There is a significant relationship between the processing of foodstuffs with anemia, with p value 0,007. There is a significant relationship between the type of food in consumption with anemia, with p value 0.002.Keyword: Diet, Anemia, Pregnancy


Author(s):  
Maria Hashmi ◽  
Qurat-Ul- Ain ◽  
Noor-Us-Saba Shaikh ◽  
Jeetendar Valecha

Background: Exercise during pregnancy is very beneficial for maternal health and fetus also. Proper knowledge in pregnant mothers is very important to promote practicing of it. Objective: To assess the knowledge and attitude of pregnant women regarding antenatal exercises. Methods: This is a cross-sectional study done in Isra institute of rehabilitation and sciences, Karachi & JPMC, Karachi. Total of 266 pregnant women during their 2nd and 3rd trimester and willing to participate in study were included from different gynecological departments of Hyderabad. Complete history was assessed regarding patient’s age, gestational age, educational status and any previous known pathology. Data were collected through face to face interviews and a validated and modified questionnaire with informed consent. For recording all the data, a designed questioner proforma was used. SPSS version 20 was utilized for data analysis, which was then summarized by descriptive statistics using frequency tables, charts and percentages. Results: Total 266 pregnant women were interviewed; the mean age was 27.86±4.79 years, with a minimum and maximum age of 18 and 44 years respectively. Majority (54.97%) of the women did not have knowledge regarding antenatal exercise. However, 79.0% of women showed positive attitude towards antenatal care. Conclusions: Majority of pregnant women had inadequate knowledge regarding antenatal exercises, while most of whom with a positive attitude.


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