scholarly journals The Diagnostic Value of β-Human Chorionic Gonadotropin, Progesterone, and Ischemia-Modified Albumin and Their Combined Use in the Prediction of First Trimester Abortions

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Mehmet A. Osmanağaoğlu ◽  
S. Caner Karahan ◽  
Turhan Aran ◽  
Süleyman Güven ◽  
Elif Turgut ◽  
...  
Keyword(s):  
Multivariate Logistic Regression Analysis ◽  
Serum Levels ◽  
First Trimester ◽  
Diagnostic Value ◽  
Multivariate Logistic Regression ◽  
Missed Abortion ◽  
Ischemia Modified Albumin ◽  
Group I ◽  
Combined Use ◽  
Group Ii

Objective. To investigate serum levels of free β-HCG, progesterone, and ischemia-modified albumin (IMA) and their combined use in the prediction of first trimester abortions. Methods. A total of 156 pregnant women between 5 and 13 weeks of gestational age were included in this study. At admission, serum levels of free β-HCG, progesterone, and IMA were noted and all cases were divided into two groups; Group I (n=77) resulted in abortion including missed abortion, incomplete/complete abortion, and inevitable abortion whereas Group II (n=79) included normal pregnancies. Results. Compared to Group II, the significantly decreased value of free β-HCG progesterone and significantly increased value of IMA were found in Group I (P<0.01, P<0.01, P<0.01, resp.). When combining all three parameters, sensitivity 75%, specificity 99%, PPV 98%, and NPV 76% were obtained. The multivariate logistic regression analysis revealed the free β-HCG, progesterone, and IMA independent factors in the prediction of abortions. Conclusions. The combined use of free β-HCG, progesterone, and IMA levels can be useful in the prediction of first trimester spontaneous abortions.

scholarly journals The Role of Platelet Indices in Prediction of Pre-eclampsia

2021 ◽  
pp. 69-77
Author(s):  
Walaa Abdelghafar Elbasuony ◽  
Hossam Abd el-mohsein Hodeib ◽  
Adel Elshahat Eljejawy ◽  
Karam Abd el-fattah Shaheen
Keyword(s):  
Obstetric Care ◽  
First Trimester ◽  
Diagnostic Value ◽  
University Hospital ◽  
Distribution Width ◽  
Platelet Indices ◽  
Group I ◽  
Gestational Week ◽  
First Trimester Of Pregnancy ◽  
Group Ii

Objective: The aim of this work is to investigate the diagnostic value of platelet count (PC), mean platelet volume (MPV), the PC to MPV ratio and platelet distribution width (PDW) for prediction of pre-eclampsia (PE). Subjects and Methods: This prospective cohort study included 100 pregnant women, in the first trimester of pregnancy attending to University Hospital, Obstetric Outpatient Clinic, for routine obstetric care from January 2019 to December 2019. Routine obstetric follow-up consists of monthly visits until 32nd gestational week, bimonthly visits between 32nd and 36th gestational week, and weekly thereafter. Patients were classified into two groups: group I: 9 pre-eclamptic patients and group II: non pre-eclamptic 91 patients. CBC indices were measured at each planned visit Results: PC, PC/MPV were significantly decreased, MPV and PDW were significantly increased in group I than group II at the 2nd part of pregnancy. To predict pre-eclampsia, PC at cut-off ≤214, sensitivity was 77.78, specificity was 76.92. MPV at cut-off >9.7, sensitivity was 77.78, specificity was 100.00, PC-MPV at cut-off ≤26.89, sensitivity was 88.89, specificity was 78.02. PDW at cut-off >10.4, sensitivity was 88.89, specificity was 54.95. Conclusion: The increase in the MPV and PDW and the decrease in PC and PC/MPV were observed in preeclampsia. Thus, the platelet indices which are easily available, as well as economical, can also be used in the prediction and early diagnosis of preeclampsia.

scholarly journals Predictive Factors of Efficacy Maintenance after Testosterone Treatment Cessation

2019 ◽  
Vol 8 (2) ◽  
pp. 151 ◽  
Author(s):  
Min Park ◽  
Jeong Yeo ◽  
Sun Park ◽  
Woong Na ◽  
Du Moon
Keyword(s):  
Predictive Factors ◽  
Multivariate Logistic Regression Analysis ◽  
Conclusive Evidence ◽  
Total Testosterone ◽  
Multivariate Logistic Regression ◽  
Testosterone Treatment ◽  
Group I ◽  
Baseline Characteristics ◽  
Group Ii ◽  
Long Acting

There is no conclusive evidence as to whether patients with testosterone deficiency (TD) who benefit from testosterone treatment (TRT) must continue the treatment for the rest of their lives. In some patients, the effect of TRT does not maintained after stopping TRT and, some patients show no significant TD symptoms, with normal testosterone levels after TRT cessation. Therefore, we investigated the predictive factors of response maintenance after TRT cessation. A total of 151 men with TD who responded to TRT were followed up for six months after TRT discontinuation. Ninety-two patients (Group I) failed to show response maintenance; 59 patients (Group II) had a maintained response. The groups did not differ in baseline characteristics or the type of TRT (oral, gel, short/long-acting injectables). However, TRT duration was significantly longer (10.7 vs. 5.2 months), and peak total testosterone (TT) level was significantly higher (713.7 vs. 546.1 ng/dL), in Group II than in Group I. More patients regularly exercised in Group II than in Group I (45.8% vs. 9.8%, p < 0.001). A multivariate logistic regression analysis revealed that exercise (B = 2.325, odds ratio = 10.231, p < 0.001) and TRT duration (B = 0.153, Exp(B) = 1.166, p < 0.001) were independent predictive factors of response maintenance. In men with TD who respond to TRT, longer treatment periods can improve the response durability after TRT cessation, regardless of the type of TRT. Additionally, regular exercise can increase the probability of maintaining the response after TRT cessation.

scholarly journals EFFICACY OF VAGINAL MISOPROSTOL IN FIRST AND SECOND TRIMESTER MISSED ABORTIONS

2020 ◽  
pp. 1-4
Author(s):  
Hema T ◽  
Annapoorani R ◽  
Karthiyayini M
Keyword(s):  
Failure Rate ◽  
First Trimester ◽  
P Value ◽  
Second Trimester ◽  
Missed Abortion ◽  
Interval Change ◽  
Group I ◽  
The Mean ◽  
Group Ii ◽  
Vaginal Misoprostol

Objectives : Missed abortion is a common problem in obstetrics and gynecology. This study aims to study the efficacy of vaginal misoprostol in termination of first and second trimester missed abortions. Materials and Methods: Fifty women with missed abortions were included in the study, out of which 30 patients were in first trimester comprised of group I, other 20 patients in second trimester were designated as group II. After getting informed consent, 200 mcg misoprostol was kept in posterior fornix, every 4 hours 200 mcg was repeated until the patient expelled. Parameters analyzed were induction abortion interval, change in PCV, success rate. Results : In the present study out of the 70% (21/30) cases belonging to group I – the mean induction abortion interval was between 12-16 hrs. In group II category in (19/20) 95% of women , the mean induction abortion interval was less than 8 hrs. One patient failed to expel even after maximum of 4 dose and hence underwent surgical termination giving a failure rate of 5%, ‘P’ value is also significant. Conclusion : Vaginal Prostoglandin E analogue (misoprostol) is a very safe and effective method to be used in missed abortion. It was more effective and successful in II trimester compared to I trimester. The failure rate was very minimum and complications were almost nil with very few side effects

Androgen secretion in women with threatened miscarriage

2020 ◽  
Vol 19 (5) ◽  
pp. 22-28
Author(s):  
М.М. Amiraslanova ◽  
◽  
I.V. Kuznetsova ◽  
E.P. Gitel ◽  
◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
First Trimester ◽  
Total Testosterone ◽  
Third Trimester ◽  
Group Iii ◽  
The Third ◽  
Threatened Miscarriage ◽  
Group I ◽  
Androgen Secretion ◽  
Group Ii

Objective. To assess androgen secretion and its possible effect on pregnancy in women with threatened miscarriage in the first trimester. Patients and methods. This prospective observational study included 120 pregnant women divided into four groups. Group I comprised 32 patients with threatened miscarriage and hyperandrogenism who received corticosteroids; Group II was composed of 28 patients with threatened miscarriage and hyperandrogenism who did not receive corticosteroids; Group III included 30 patients with threatened miscarriage and no hyperandrogenism; and Group IV comprised 30 women with normal pregnancy. Serum levels of dehydroepiandrosterone sulfate (DHEA-S), 17-hydroxyprogesterone (17-OHP), and total testosterone were measured on the following weeks of gestation: 5–8, 9–12, 13–18, 19–24, and 25–32. We also evaluated clinical outcomes of pregnancy. Results. We observed no significant differences in 17-ОНР and DHEA-S secretion between women from Group III and controls. Patients from Group II demonstrated higher hormone levels than controls; however, their dynamics of 17-ОНР and testosterone secretion was similar to that in women without hyperandrogenism, so their DHEA-S levels decreased and reached control values by the third trimester. Corticosteroids reduced 17-ONR secretion in the second and third trimesters and DHEA-S secretion in the third trimester. Women receiving corticosteroids demonstrated the poorest clinical pregnancy outcomes. Conclusion. Hyperandrogenism should be considered as one of the risk factors for poor pregnancy outcomes. Administration of corticosteroids to reduce androgen levels impairs normal dynamics of their secretion, does not improve pregnancy outcomes, and is potentially harmful; therefore, these drugs should not be used for such purposes. Key words: pregnancy, hyperandrogenism, corticosteroid therapy, pregnancy outcomes, pregnancy loss, androgen secretion, threatened miscarriage

scholarly journals Increased Serum Levels of Asymmetric Dimethylarginine and Symmetric Dimethylarginine and Decreased Levels of Arginine in Sudanese Patients with Essential Hypertension

2020 ◽  
Vol 45 (5) ◽  
pp. 727-736
Author(s):  
Sahar Gamil ◽  
Jeanette Erdmann ◽  
Edzard Schwedhelm ◽  
Khalid Hussein Bakheit ◽  
Ihab B.B. Abdalrahman ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Essential Hypertension ◽  
Amino Acid ◽  
Asymmetric Dimethylarginine ◽  
Multivariate Logistic Regression Analysis ◽  
Serum Levels ◽  
Control Group ◽  
Multivariate Logistic Regression ◽  
Symmetric Dimethylarginine

Introduction: Essential hypertension (EH) is a disease caused by various environmental and genetic factors. Nitric oxide (NO) is important for the functional integrity of the endothelium. It is produced in endothelial cells by endothelial NO synthase (eNOS) that mediates the conversion of the amino acid arginine into NO and citrulline. Asymmetric dimethylarginine (ADMA) acts as an inhibitor of eNOS. In contrast, symmetric dimethylarginine (SDMA) has no direct effect on eNOS but plays an important role competing with arginine for transport across the amino acid transporter. ADMA and SDMA have been found to play a central role in the development of cardiovascular diseases. Serum ADMA levels may serve as a future diagnostic marker and a target of therapy in hypertensive patients in the Sudanese population. This study aimed to investigate the relation between serum arginine, ADMA, and SDMA levels with EH in the Sudanese population. Methods: Patients (n = 260) with established hypertension and controls (n = 144) with normal blood pressure were included in this case-control study. Serum blood samples were analyzed for arginine, ADMA, and SDMA, using high-performance liquid chromatography-tandem mass spectrometry. Other laboratory data were measured using routine methods. Mann-Whitney’s U test and χ2 tests were used for continuous and categorical data, respectively. A multivariate logistic regression analysis was conducted to investigate the independent effect of multiple variables on the development of hypertension. Results: Serum arginine levels were significantly lower in the patient group than in the control group (p < 0.001). ADMA and SDMA levels were significantly higher in the patient group than the control group (p < 0.001, p = 0.001, respectively). Multivariate logistic regression analysis showed that only older age, being a male, and arginine levels are independent factors controlling the development of hypertension (p < 0.001, p < 0.001, and p = 0.046, respectively). ADMA and SDMA levels were not independent factors for the development of hypertension. Conclusions: This study demonstrated increased serum levels of ADMA and SDMA and decreased arginine levels in Sudanese patients with EH. Lowering serum ADMA levels or increasing the arginine levels might be a novel therapeutic target in these individuals.

scholarly journals Value of Entheseal Ultrasonography and Serum Cartilage Oligomeric Matrix Protein in the Preclinical Diagnosis of Psoriatic Arthritis

2010 ◽  
Vol 3 ◽  
pp. CMAMD.S4461 ◽  
Author(s):  
Hanan Mohamed Farouk ◽  
Afaf Abdel Alim Mostafa ◽  
Sahar S. Youssef ◽  
Moataz Mohammed Samy Elbeblawy ◽  
Naglaa Youssef Assaf ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Serum Levels ◽  
Lower Limbs ◽  
Control Group ◽  
Group I ◽  
Significant Difference ◽  
Preclinical Diagnosis ◽  
Group Ii

Objective To evaluate the utility of entheseal ultrasonography and serum COMP in the preclinical diagnosis of psoriatic arthritis. Methods 60 psoriatic patients were divided into: 30 patients with psoriasis (group I) and 30 patients with psoriatic arthritis as control (group II). They underwent independent clinical and ultrasonographic examination of both lower limbs at the calcaneal insertions of Achilles tendons. Psoriatic arthritis disease activity and severity was assessed by modified DAS28 and Steinbrockers scores. Serum levels of COMP were measured for all patients by ELISA. Results On clinical examination, no entheseal abnormalities were detected in group I while they were present in 23.3% of group II with statistically significant difference between them ( P < 0.001). Ultrasonographic entheseal abnormalities were detected in 33.3% of group I and in 46.7% of group II with no significant difference between them ( P > 0.05). Serum COMP were significantly elevated in group I and II with no statistically significant difference between them (mean ± SD 5.9 ± 3 and 6.8 ± 12 respectively, P > 0.05). Entheseal ultrasound was more specific (67%) while serum COMP was more sensitive (87%) in the preclinical diagnosis of psoriatic arthritis. Serum COMP levels were significantly correlated with CRP in both groups and with DAS28 and Steinbrockers scores in group II ( P < 0.01). Conclusion Entheseal ultrasonography and serum COMP levels may be used complementary to each other for preclinical diagnosis of psoriatic arthritis. Serum COMP seems to be promising prognostic marker for psoriatic arthritis patients.

Urinary Chorionic Gonadotrophin Determination

1966 ◽  
Vol 12 (9) ◽  
pp. 577-585 ◽  
Author(s):  
Derek Watson
Keyword(s):  
Normal Values ◽  
First Trimester ◽  
Diagnostic Value ◽  
Chorionic Gonadotrophin ◽  
Routine Method ◽  
Normal Range ◽  
Missed Abortion ◽  
Abnormal Pregnancy ◽  
Endogenous Production ◽  
First Trimester Of Pregnancy

Abstract Successful laboratory tests for early pregnancy utilize the endogenous production and excretion of chorionic gonadotrophin (CG). There is wide variation in sensitivity and specificity of various biological and commercially available immunochemical methods for determining urinary CG levels. Normal values for immunochemically reactive CG during the first trimester of pregnancy are given. Serial determinations of CG have diagnostic value in assessing various abnormal pregnancy states. An abnormally increased urinary output of CG is observed in some neoplasms—e.g., chorionepithelioma, and a rapidly rising CG level is strongly suggestive of molar pregnancy. Urinary CG levels falling below the normal range mayindicate an ectopic pregnancy or an inevitable, incomplete, or "missed" abortion. The immunochemical CG determination also offers a sensitive, simple, and convenient routine method for following patients who have been treated for hydatidiformmole or chorionepithelioma.

Prevalence of antibodies to prothrombin in solid phase (aPT) and to phosphatidylserine-prothrombin complex (aPS/PT) in patients with and without lupus anticoagulant

2013 ◽  
Vol 109 (02) ◽  
pp. 207-213 ◽  
Author(s):  
Savino Sciascia ◽  
Veronica Murru ◽  
Cesar Garcia-Fernandez ◽  
Giovanni Sanna ◽  
Munther Khamashta ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Lupus Anticoagulant ◽  
Pregnancy Loss ◽  
Solid Phase ◽  
Multivariate Logistic Regression Analysis ◽  
Diagnostic Value ◽  
Multivariate Logistic Regression ◽  
Independent Risk Factors ◽  
True Relationship

SummaryAntibodies to prothrombin in solid phase (aPT) and those to phosphatidiyserine- prothrombin complex (aPS/PT) have been suggested to strongly correlate with the presence of lupus anticoagulant (LA). As their clinical diagnostic value and true relationship with the LA remains elusive, we designed this study to evaluate the prevalence and significance of aPT and aPS/PT in a large cohort of patients with and without LA. Samples from 257 patients were included. aPT and aPS/PT were tested by ELISA. LA was tested as per the current criteria from the ISTH Subcommittee on LA-Phospholipid-dependent antibodies. aPS/PT and aPT were found in 51% and 32% of LA-positive (LA+ve) patients and in 22% and 28% of LA-negative (LA-ve) patients, respectively. Thrombosis, particularly venous thrombosis was associated with IgG aPT in the LA+ve group (p=0.0006) and in the LA-ve group (p=0.017). Antibodies to phosphatidylserine-prothrombin, either IgG and IgM were associated with thrombosis in general (p=0.0003) in particularly with venous thrombosis in the LA+ve group (p<0.0001 for IgG and p=0.025 for IgM; respectively) and the LA-ve group (p=0.028, 0.02 and 0.001, respectively). Further multivariate logistic regression analysis showed that LA and of IgG and/or IgM aPS/PT were independent risk factors for thrombosis and pregnancy loss. In conclusion, aPS/PT, but not aPT, are more frequently found in patients with LA. Their association with thrombosis seems to be independent of the presence of LA.

scholarly journals Ischemia Modified Albumin Can Predict Necrosis at Incarcerated Hernias

2013 ◽  
Vol 35 ◽  
pp. 807-810 ◽  
Author(s):  
Hüseyin Kadioğlu ◽  
Dilek Ömür ◽  
Süleyman Bozkurt ◽  
Ekrem Ferlengez ◽  
Naim Memmı ◽  
...  
Keyword(s):  
Sham Group ◽  
Ischemia Modified Albumin ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Predictive Effect

Purpose. To evaluate the predictive effect of IMA in incarcerated hernias.Methods. Three groups () of rats were operated. Group I aimed to mimic incarceration, group II aimed the strangulation, and group III was the sham group. IMA and LDH measurements were made.Results. IMA levels were significantly higher in strangulation mimicking group and IMA levels were normal at postoperative 6th hour in incarceration mimicking group. LDH levels were significantly higher in both incarceration and strangulation mimicking groups.Conclusion. IMA seems to be an effective marker in incarcerated hernias to predict necrosis. But we need further studies to generalise this hypothesis.

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