Hemangiopericytoma: Incidence, Treatment, and Prognosis Analysis Based on SEER Database

Background. Hemangiopericytomas are rare tumors derived from pericytes surrounding the blood vessels. The clinicopathological characteristics and prognosis of hemangiopericytoma patients remain mostly unknown. In this retrospective cohort study, we assessed the clinicopathological characteristics of hemangiopericytoma patients, as well as the clinical usefulness of different treatment modalities. Material and Methods. We collected the clinicopathological data (between 1975 and 2016) of hemangiopericytoma and hemangioendothelioma patients from the Surveillance, Epidemiology, and End Results (SEER) database. Incidence, treatment, and patient prognosis were assessed. Results. Data from 1474 patients were analyzed in our study cohort (hemangiopericytoma: n = 1243 ; hemangioendothelioma: n = 231 ). The incidence of hemangiopericytoma in 2016 was 0.060 per 100,000 individuals. The overall survival (OS) and cancer-specific survival (CSS) did not differ between patients with hemangioendothelioma and those with hemangiopericytoma ( P = 0.721 , P = 0.544 ). The tumor grade had no effect on the OS of hemangiopericytoma patients. Multivariate analysis revealed the clinical usefulness of surgery in hemangiopericytoma patients ( HR = 0.15 , 95% confidence interval: 0.05-0.41, P < 0.001 ). In contrast, radiotherapy did not improve OS ( P = 0.497 ) or CSS ( P = 0.584 ), and chemotherapy worsened patient survival ( P < 0.001 ). Additionally, the combination of surgery and radiotherapy had a similar effect with surgery alone on hemangiopericytoma patient survival (OS: P = 0.900 ; CSS: P = 0.156 ). Surgery plus chemotherapy provided a worse clinical benefit than surgery alone ( P < 0.001 ). Conclusions. Our findings suggested that hemangiopericytoma had a similar prognosis with hemangioendothelioma. Surgery was the only effective treatment that provided survival benefits in hemangiopericytoma patients, while the clinical usefulness of adjuvant chemotherapy or radiotherapy was limited.

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Survival outcomes based on race in gastric carcinoma: A SEER database analysis.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.4_suppl.5 ◽

2011 ◽

Vol 29 (4_suppl) ◽

pp. 5-5

Author(s):

N. Didwaniya ◽

R. J. Edmonds ◽

P. T. Silberstein ◽

S. Subbiah

Keyword(s):

Gastric Cancer ◽

Gastric Carcinoma ◽

Survival Rates ◽

Tumor Grade ◽

The United States ◽

Lymph Node Involvement ◽

Tnm Staging ◽

Treatment Modalities ◽

Seer Database ◽

Cancer Specific Survival

5 Background: Gastric cancer is one of the leading causes of cancer related deaths worldwide with the incidence declining in the United States. However the prognosis remains poor with variable survivals being reported among different races. We analyzed the effect of race on patterns of disease presentation and survival rates using the Surveillance, Epidemiology, and End Results (SEER) database. Methods: A total of 9,851 patients were diagnosed with gastric cancer from year 2004 to 2007 were identified from SEER database. Age, race, TNM staging, grade, treatment modalities utilized and cancer specific survival was collected. Results: Out of 9,851 patients, 64.63% were white, 12.17% were black, and 13.04% were Asian-Pacific islanders. Median age was 73 years for whites, 70 years in blacks, and 71 years in Asians. Sex distribution amongst races was more or less similar with 58.83% of whites, 59.47% of blacks, and 54.24% of Asians being men. 23.62% of whites had T1 lesions, 28.10% had T2, 19.58% were T3 and 28.70% had T4 lesions. 26.76% of blacks presented with T1 lesions, 26.63% with T2, 16.08% with T3 and 30.53% with T4. 18.69% of Asians had T1 lesions, 26.84% with T2, 23.44% had T3 and 31.03% had T4 lesions. 37.80% of whites, 36.70% of blacks, and 44.44% of Asians had lymph node involvement. Tumor grade was similar among all races. Surgery was performed in 31.49% of whites, 33.13% of blacks, and 40.48% of Asians. 14.68% of whites, 14.10% of blacks, and 19.43 % of all Asians underwent radiation therapy. Median overall survival in localized disease was 44 months, 43 months and 98 months (p < 0.0001) while in regional disease it was 16 months, 15 months and 23 months in whites, blacks and Asians respectively (p < 0.0001). Median survival in distant disease was 4 months in both whites and blacks; it was 5 months in Asians (p < 0.0001). Conclusions: Cancer-specific survival in gastric carcinoma is significantly better in localized, regional and metastatic disease in Asians when compared to whites and blacks independent of T stage, grade, nodal involvement and treatment modalities utilized. The reason for this observation is unclear, exposure and genetic factors are potential causes and this needs to be investigated. No significant financial relationships to disclose.

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Behavior of breast cancer in young women: A Surveillance Epidemiology and End Results (SEER) database review.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.27_suppl.6 ◽

2012 ◽

Vol 30 (27_suppl) ◽

pp. 6-6

Author(s):

Anteneh A. Tesfaye ◽

Mohammad Mozayen ◽

Ioana Morariu ◽

David S. Eilender

Keyword(s):

Breast Cancer ◽

Lymph Nodes ◽

Young Women ◽

Tumor Size ◽

Hormone Receptor ◽

Age Groups ◽

Tumor Grade ◽

Seer Database ◽

Chi Square ◽

Cancer Specific Survival

6 Background: Advanced age is a major risk factor for breast cancer in women. Small sized studies have reported variable outcome of breast cancer in young women. Our study was done to evaluate tumor characteristic and cancer specific survival among young women. Methods: The 1973-2009 SEER database was reviewed for women with breast cancer diagnosed between 2004 and 2009. Patients were grouped by age into: A (≤35 years), B (36-50 years) and C (>50 years). Age, ethnicity, staging, lymph nodes status, micrometastasis in negative lymph nodes, tumor size, tumor grade, hormone receptor status were extracted. Data and survival were analyzed using chi square, Kaplan-Meier, Life table, and Cox proportional hazard model. The primary outcome was 5-year cancer-specific survival. Results: A total of 248,280 patients were included in the study, group A, B and C making 2.8%, 25.5% and 71.7% of study subjects respectively. The median tumor size was 2.4, 1.9, and 1.6 cm in groups A, B and C respectively (p=0.0001). Positive lymph nodes were seen in 52.5%, 43% and 34% in groups A, B and C respectively (p=0.0001). Regional disease was seen in 47.5%, 39.5% and 29.9% in groups A, B and C respectively (p=0.0001). Higher Grade histology was seen in 63.5%, 44.3% and 33.8% in groups A, B and C respectively (p=0.0001). ER-PR negative were found in 42.1%,26.4%, 22.6% of Groups A, B and C respectively (p=0.0001). Five year cancer specific survival was 82%, 89%, 86% in groups A, B and C respectively (p=0.0001). Independent prognostic factors are given in the table. Conclusions: Breast cancer is uncommon among young women (age <35). Compared to other age groups, breast cancer in young women presents with bigger tumor, higher nodal positivity, an advanced stage, higher tumor grade, higher hormone receptor negativity, and worse 5-year cancer-specific survival. [Table: see text]

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Construction and verification of prognostic nomogram for early-onset esophageal cancer

Bosnian Journal of Basic Medical Sciences ◽

10.17305/bjbms.2021.5533 ◽

2021 ◽

Author(s):

Xiaoxiao Liu ◽

Wei Guo ◽

Xiaobo Shi ◽

Yue Ke ◽

Yuxing Li ◽

...

Keyword(s):

Esophageal Cancer ◽

Early Onset ◽

Older Patients ◽

Clinicopathological Characteristics ◽

Calibration Plot ◽

Seer Database ◽

Training Set ◽

Related Factors ◽

Cancer Specific Survival ◽

Validation Set

This study aimed to build up nomogram models to evaluate overall survival (OS) and cancer-specific survival (CSS) in early-onset esophageal cancer (EOEC). Patients diagnosed with esophageal cancer (EC) from 2004 to 2015 were extracted from the Surveillance Epidemiology and End Results (SEER) database. Clinicopathological characteristics of younger versus older patients were compared, and survival analysis was performed in both groups. Independent related factors influencing the prognosis of EOEC were identified by univariate and multivariate Cox analysis, which were incorporated to construct a nomogram. The predictive capability of the nomogram was estimated by the concordance index (C-index), calibration plot, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA). A total of 534 younger and 17,243 older patients were available from the SEER database. Younger patients were randomly segmented into a training set (n=266) and a validation set (n=268). In terms of the training set, the C-index of the OS nomogram was 0.740 (95% CI: 0.707-0.773), and that of the CSS nomogram was 0.752 (95% CI: 0.719-0.785). In view of the validation set, the C-index of OS and CSS were 0.706 (95% CI: 0.671-0.741) and 0.723 (95%CI: 0.690-0.756), respectively. Calibration curves demonstrated the consistent degree of fit between actual and predicted values in nomogram models. From the perspective of DCA, the nomogram models were more beneficial than the tumor-node-metastasis (TNM) and the SEER stage for EOEC. In brief, the nomogram model can be considered as an individualized quantitative tool to predict the prognosis of EOEC patients to assist clinicians in making treatment decisions.

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PD-L1 expression in anogenital and oropharyngeal squamous cell carcinomas associated with different clinicopathological features, HPV status and prognosis: a meta-analysis

Bioscience Reports ◽

10.1042/bsr20203669 ◽

2021 ◽

Author(s):

Yuan Qin ◽

Jiaochen Luan ◽

Xiang Zhou ◽

Ying Li

Keyword(s):

Squamous Cell ◽

Meta Analysis ◽

Disease Free Survival ◽

Tumor Grade ◽

Clinicopathological Characteristics ◽

Squamous Cell Carcinomas ◽

Clinicopathological Features ◽

Advanced Age ◽

Cancer Specific Survival ◽

Hpv Status

Background: Little research has been done on clinicopathological characteristics and human papillomavirus (HPV) status of anogenital and oropharyngeal squamous cell carcinomas (SCC) with a strong expression of programmed death ligand 1 (PD-L1) in tumor cells. Therefore, we conducted this meta-analysis. Methods: We performed a comprehensive research in PubMed, Embase and Cochrane databases up to September 30th, 2020. The effect size was hazard ratio (HR) with 95% confidence interval (CI) for overall survival (OS), cancer specific survival (CSS), disease free survival (DFS). The pooled odds ratio (OR) with 95%CI were used to assess the association between PD-L1 expression and clinicopathological features along with HPV status. Results: A total of 2003 cases (944 anogenital and 1059 oropharynx SCC patients) were included. High PD-L1 expression in anogenital SCC cases were associated with advanced age (OR=1.63, 95%CI:1.04-2.58) and HPV negativity (OR=0.47,95%CI:0.31-0.71). Besides, PD-L1 positive anogenital SCC cases held a significant declined OS (HR=2.18, 95%CI:1.37-3.47) and CSS (HR=2.45, 95%CI:1.30-4.65). For oropharynx SCC, PD-L1 was more frequent in younger and HPV positive patients (OR=0.60, 95%CI:0.37-0.98; OR=3.01, 95%CI:1.78-5.09) and PD-L1 expression was relevant to better OS and DFS (HR=0.76, 95%CI:0.60-0.97; HR=0.50, 95%CI:0.33-0.75). Conclusions: The meta-analysis demonstrated that in anogenital SCC, PD-L1 positivity had to do with a worse outcome, which might attribute to advanced age, higher tumor grade, lymph node metastasis and HPV negativity, while in oropharynx cancer, PD-L1expression was related to better prognosis for the reason that PD-L1 was less frequent in the aged and negative HPV status.

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Predictive Model for Overall Survival and Cancer-Specific Survival in Patients with Esophageal Adenocarcinoma

Journal of Oncology ◽

10.1155/2021/4138575 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

He Huang ◽

Weiyue Fang ◽

Ying Lin ◽

Zhanzhong Zheng ◽

Zefan Wang ◽

...

Keyword(s):

Overall Survival ◽

Marital Status ◽

Esophageal Adenocarcinoma ◽

Treatment Strategies ◽

Area Under The Curve ◽

Tumor Grade ◽

Treatment Modalities ◽

Cancer Specific Survival ◽

Internal Validation ◽

Validation Set

Objective. Recent years, there has been a rapid increase in the incidence of esophageal adenocarcinoma (EAC), while the prognosis for patients diagnosed remains poor and has slightly improved. Methods. We extracted 6,466 cases with detailed demographical characteristics including age at diagnosis, sex, ethnicity, marital status, and clinical features, involving tumor grade and stage at diagnosis and treatment modalities (radiation therapy, chemotherapy, and surgery) from the Surveillance, Epidemiology, and End Results (SEER) (1975–2017) dataset. They were further randomly divided into the training and validating cohorts. Univariate and multivariate Cox analyses were conducted to determine significant variables for construction of nomogram. The predictive power of the model was then assessed by Harrell concordance index (C-index) and the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. Results. Multivariate analysis revealed that age, marital status, insurance, tumor grade, TNM stage, surgery, and chemotherapy all showed a significant association with overall survival (OS) and cancer-specific survival (CSS). These characteristics were employed to build a nomogram. Particularly, the discrimination of nomogram for OS and CSS prediction in the training set were excellent (C-index = 0.762, 95% CI: 0.754–0.770 and C-index = 0.774, 95% CI: 0.766–0.782). The AUC of the nomogram for predicting 2- and 5-year OS was 0.834 and 0.853 and CSS was 0.844 and 0.866. Similar results were observed in the internal validation set. Conclusion. We have successfully established a novel nomogram for predicting OS and CSS in EAC patients with good accuracy, which can help clinicians predict the survival of individual patient survival and provide optimal treatment strategies.

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Comprehensive Analysis of the Expression, Prognosis and Immune Infiltration of KPNA Family in Hepatocellular Carcinoma

10.21203/rs.3.rs-757231/v1 ◽

2021 ◽

Author(s):

Xiangyi Chen ◽

Dechen Yu ◽

Hai-Yu Zhou ◽

XiaoBo Zhang ◽

Yicun Hu ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Immune Cell ◽

Enrichment Analysis ◽

Tumor Grade ◽

Mapk Signaling ◽

Clinicopathological Characteristics ◽

Expression Level ◽

Immune Infiltration ◽

Kaplan Meier ◽

Patient Prognosis

Abstract Background: The primary function of the Karyophorin alpha family (KPNAs) is to assist the transport of proteins from the cytoplasm to the nucleus. Studies have found that KPNAs are involved in the occurrence and development of a variety of tumors. However, the expression level of KPNAs family members in HCC, its influence on prognosis, its relationship with immune infiltration, and its clinical significance are still unclear.Methods: We used UALCAN, GEPIA, HPA, TIMER, Kaplan-Meier Plotter, CBioPortal, String and Metascape databases to analyze the expression and mutation of KPNAs in Hepatocellular carcinoma (HCC), the expression level of KPNAs and the prognosis of patients, tumor immune cell infiltration, HCC clinicopathological characteristics Relationship. Finally, the biological functions of KPNAs related genes are analyzed. Results: The protein and mRNA of KPNAs were significantly up-regulated in HCC, and their expression levels were closely related to the prognosis of patients and the clinical characteristics of the tumor (tumor grade, stage, etc.). In addition, KPNAs in HCC are prone to mutations, which are not conducive to the prognosis of patients. Moreover, the expression of HCC is positively correlated with the infiltration of immune cells. Enrichment analysis found that KPNAs-related genes are mainly related to biological processes such as nuclear and cytoplasmic signaling, protein chromosome localization, and their pathways mainly include cell cycle and MAPK signaling pathways. Conclusion: KPNAs are significantly related to the occurrence, development and patient prognosis of HCC and may become the target of HCC immunotherapy in the future.

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Correlation of Trop-2 expression with clinicopathological characteristics, sTILs, AR expression and outcome in primary TNBC.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e12558 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e12558-e12558

Author(s):

Hava Izci ◽

Kevin Punie ◽

Lise Waumans ◽

Annouschka Laenen ◽

Hans Wildiers ◽

...

Keyword(s):

Breast Cancer ◽

Disease Free Survival ◽

Tumor Infiltrating Lymphocytes ◽

Tumor Grade ◽

Invasive Disease ◽

Clinicopathological Characteristics ◽

Calcium Signal ◽

Nodal Involvement ◽

Cancer Specific Survival ◽

Multiple Tumor

e12558 Background: Trophoblast cell-surface antigen-2 (Trop-2) is a transmembrane calcium signal transducer highly expressed in multiple tumor types including breast cancer. Trop-2 overexpression is associated with poor survival. Given the approval of sacituzumab govitecan in advanced triple-negative breast cancer (TNBC), Trop-2 emerges as an important target for antibody-drug conjugates. Limited data exist about correlations of Trop-2 expression with clinicopathological characteristics and outcome in early TNBC. Methods: We included 127 patients with early TNBC, treated with primary surgery at UZLeuven from 2005-2017. Trop-2 expression was determined with IHC (ab227689, Abcam) on whole slide tumor sections from resection specimens and assessed as continuous (H-score 0-300) and categorical (high 201-300, medium 100-200 and low < 100) variables. Stromal tumor infiltrating lymphocytes (sTIL; low, intermediate and high), mitotic score and androgen receptor (AR) expression (1% or 10%-cutoff) were scored. We assessed associations between Trop-2 expression and age, BMI, BRCA status, tumor grade and size, lymphovascular invasion (LVI), DCIS, nodal status, sTILs, AR, mitotic index and outcome (Invasive disease free survival and breast cancer specific survival). Results: The median age at diagnosis was 51y (range 26-80y) and the median follow-up 8.5y. Low, medium and high Trop-2 expression was seen in 50%, 37% and 13% of cases. AR was positive in 32% of cases (10%-cutoff). Higher Trop-2 expression was correlated with age (ρ = 0.192, p = 0.03) and inversely correlated with mitosis/mm² (ρ = -0.2, p = 0.02). Patients with high Trop-2-expression were older compared to patients with low Trop-2-expression (median 58 vs 47 years, p = 0.02). LVI was more frequent in Trop-2-high (65%) compared to TROP-2-medium (15%) or -low (16%) (p < 0.001). Median mitosis/mm² was higher in Trop-2-low (14) compared to Trop-2-medium (10) and -high (8) (p = 0.004). Patients in Trop-2-high subgroup had more nodal involvement (53%) compared to Trop-2-medium (23%) and -low (21%) (p = 0.03). There was no correlation between Trop-2 expression and sTILs, AR or outcome. Conclusions: In this patient cohort with TNBC treated with upfront surgery, higher Trop-2 expression was correlated with older age, with more LVI and nodal involvement, while mitosis/mm² were higher in tumors with low Trop-2 expression. Trop-2 expression was not correlated with sTILs, AR or outcome. Limited numbers of events warrant caution in interpretation.

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How to Choose the Best Procedure Type for Duodenal Neuroendocrine Tumors With a Maximum Diameter of 1 to 2 Cm a Propensity Score Matching Analysis Based on the SEER Database

10.21203/rs.3.rs-42716/v1 ◽

2020 ◽

Author(s):

Huanyu Tang ◽

jiebin xie ◽

Yueshan Pang ◽

Xia Hua ◽

xun Li

Keyword(s):

Propensity Score ◽

Propensity Score Matching ◽

Neuroendocrine Tumors ◽

Treatment Plan ◽

Clinicopathological Characteristics ◽

Maximum Diameter ◽

Seer Database ◽

Cancer Specific Survival ◽

Significant Difference ◽

Duodenal Neuroendocrine Tumors

Abstract Background: The treatment plan for duodenal neuroendocrine tumors (d-NETs) with a diameter between 1 and 2 cm is still controversy. Aim: To compare the effects of local endoscopic resection and radical resection on the prognosis of d-NETs with a maximum diameter of 1-2 cm. Methods: 286 eligible patients were identified from the SEER database. Propensity score matching (PSM) was done to match patients 1:1 on clinicopathological characteristics. Kaplan-Meier analysis was used to analyze the factors affecting the prognosis.Results: Before PSM, there was no significant difference in the cancer-specific survival (CSS) between the two groups (P = 0.595), but the tumor size, T stage, N stage, and M stage were significantly different between the two groups (all P < 0.05). After 1:1 PSM, the differences in clinicopathological characteristics between the two groups were significantly reduced (all P > 0.05). Survival analysis showed that only the tumor grade was correlated with the prognosis (P = 0); surgical method and other clinicopathological characteristics were not correlated with the prognosis (all P > 0.05). Conclusion: The surgical approach had no significant effect on the prognosis of d-NET patients with a maximum diameter of 1-2 cm and without lymph node metastasis.

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Development and Validation of Prognostic Nomogram for Patients With Small Intestinal Neuroendocrine Carcinoma

10.21203/rs.3.rs-77420/v1 ◽

2020 ◽

Author(s):

Guangrong Lu ◽

Limin Wu ◽

Jiajia Li ◽

Yushan Xia ◽

Xuchao Zhang ◽

...

Keyword(s):

Treatment Strategies ◽

Staging System ◽

Tumor Grade ◽

Tnm Staging ◽

Calibration Plot ◽

Seer Database ◽

Cancer Specific Survival ◽

Discrimination Power ◽

Tnm Staging System ◽

Small Intestinal

Abstract Small intestinal neuroendocrine carcinomas (SI NECs) are diagnosed very rarely, and the prognosis is extremely poor due to the metastatic disease of most patients at the time of diagnosis. This study aimed to establish nomogram models for prognostic evaluation of SI NEC in both overall survival (OS) and cancer-specific survival (CSS). Patients diagnosed with SI NEC between 2010 and 2015 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database and further randomly divided into the training and validating cohorts at a ratio of 7:3. Univariate and multivariate cox analysis was conducted to determine significant variables for construction of nomogram. The performance of the nomogram models were then assessed by concordance index (C-index), calibration plot and the area receiver operating characteristic (ROC) curve (AUC). A total of 1110 patients were retrospectively selected from the SEER database. Multivariate models revealed that age, tumor grade, American Joint Committee for Cancer (AJCC) stage, surgery and chemotherapy all showed a significant association with OS and CSS. The discrimination of nomogram for OS prediction was superior to that of the 7th AJCC Tumor-Node-Metastasis (TNM) staging system (C-index = 0.798, 95% CI, 0.762 - 0.833 vs 0.623, 95% CI, 0.580 - 0.666, P < 0.001). Similar results were also observed in CSS nomogram. Well-corresponded calibration plots were noticed using the nomograms. The comparisons of AUC values showed that the established nomograms exhibited better discrimination power than 7th TNM staging system for OS and CSS prediction. In conclusion, we have successfully established novel nomograms for predicting OS and CSS in patients with SI NEC, which can assist clinicians in making predictions about individual patient survival and provide improved treatment strategies.

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Value of Radiotherapy in Primary Gastric Cancer and Establishment of a Prognostic Nomogram Model

10.21203/rs.3.rs-133308/v1 ◽

2020 ◽

Author(s):

Tongchao Jiang ◽

Nan Li ◽

Haishuang Sun ◽

Tongcui Jiang

Keyword(s):

Gastric Cancer ◽

Prognostic Factors ◽

Lymph Node ◽

Cox Regression ◽

Tumor Grade ◽

Rank Test ◽

Seer Database ◽

Cancer Specific Survival ◽

Primary Tumor Site ◽

Entire Cohort

Abstract Background: This study aimed to compare the use of radiotherapy (RT) in gastric cancer (GC) patients from the SEER database and established a nomogram to assess cancer-specific survival (CSS).Methods: Patients from the SEER database between 2004 and 2013 were analyzed. Survival was analyzed by Kaplan-Meier curves and log-rank test. Prognostic factors in multivariate Cox analysis were screened to construct a nomogram. The performance the nomogram was validated via concordance index (C-index), calibration plots, and decision curve analyses (DCAs). Results: 9653 GC patients were analyzed totally. In the entire cohort, patients who received pre/postoperative RT had better survival than those who did not receive RT (P = 0.043 and < 0.001, respectively). Similar results were observed in lymph node-positive patients. However, no significant survival benefit was seen in lymph node-negative patients between postoperative RT group and no RT group (P = 0.057), but patients who received postoperative RT and those who did not receive RT experienced better survival than those who received preoperative RT (P < 0.001 and 0.001, respectively). Prognostic factors of GC analyzed by Cox regression model included age, race, tumor grade, tumor histology type, primary tumor site, T stage, lymph node metastasis ratio, RT status, and chemotherapy information independently (P < 0.001). The nomogram was established and showed excellent prediction performance, and its C-index of 0.725 were significantly higher than those of nomograms based AJCC system with C-index at 0.643. In addition, the calibration plots performed good consistency between the predicted and actual survival probabilities, and the DCAs indicated better clinical net benefits than the traditional AJCC system.Conclusions: RT can improve CSS in GC patients, especially those with positive lymph nodes. The construction and verification of a nomogram based on SEER database can effectively predict the survival outcomes of GC patients.

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