C-Reactive Protein (CRP) and Health Resort Reaction

Incident tissue-damaging factors trigger a systemic response manifested by inflammatory reaction. Acute-phase proteins are a diagnostic and prognostic marker in various systemic homeostasis disorders. In the course of health resort therapy, a so-called health resort reaction is observed presenting with, e.g., exacerbation of organ-related disorders, elevated body temperature, increased erythrocyte sedimentation rate, and leukocyte counts. The objective of the study was to demonstrate a change in the concentration of C-reactive protein (CRP) as a result of health resort radon therapy as well as to determine the relationship between this change and the phenomenon known as health resort reaction. The study was conducted in Swieradow-Zdroj resort. The study population consisted of patients undergoing radon-active water bath treatment. Standard tests were used to determine CRP levels before the treatment as well as 5 and 18 days into the treatment. The study group consisted of n = 34 patients with osteoarthritis and spondyloarthritis. The control group consisted of 17 employees of the health resort who were also burdened with osteoarthritis or spondyloarthritis yet did not undergo radon therapy and had absolutely no contact with radon materials. The study revealed no statistically significant increase in the concentration of CRP. This trial is registered with NCT03274128. The study was carried out as part of the statutory task SUB.E060.19.001.

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Serum Endothelial Cell–Specific Molecule 1 (Endocan) Levels in Patients With Acute Myocardial Infarction and Its Clinical Significance

Angiology ◽

10.1177/0003319716651349 ◽

2016 ◽

Vol 68 (4) ◽

pp. 354-359 ◽

Cited By ~ 15

Author(s):

Chong-Rong Qiu ◽

Qiang Fu ◽

Jian Sui ◽

Qian Zhang ◽

Peng Wei ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Endothelial Cell ◽

Endothelial Dysfunction ◽

High Sensitivity ◽

Control Group ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

The Relationship

Endothelial dysfunction is involved in the process of acute myocardial infarction (AMI), that is, the endothelial cell–specific molecule 1 (ESM-1; endocan) is a novel endothelial dysfunction marker. However, the relationship between patients with AMI and serum ESM-1 levels is not very clear. Patients with AMI (n = 216) and a control group (n = 60) without AMI were included in the study. High-sensitivity C-reactive protein (hsCRP) was measured, and the severity of AMI was assessed by a modified Gensini stenosis scoring system. Serum ESM-1 levels were significantly higher in the AMI group ( P < .05). High-sensitivity C-reactive protein levels were also significantly higher in the AMI group ( P < .05). In patients with AMI, serum ESM-1 levels were not significantly correlated with hsCRP levels. There was no significant correlation between serum ESM-1 level and Gensini score. Our findings suggest that serum ESM-1 levels may be a novel biomarker of endothelial dysfunction in patients with AMI.

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Plasma Concentrations of C-Reactive Protein and Fibrinogen in Ischaemic Stroke

Journal of International Medical Research ◽

10.1177/147323000203000607 ◽

2002 ◽

Vol 30 (6) ◽

pp. 591-596 ◽

Cited By ~ 12

Author(s):

İ İyigün ◽

Y Bakirci

Keyword(s):

Ischaemic Stroke ◽

Cerebral Artery ◽

Plasma Concentrations ◽

Control Group ◽

C Reactive Protein ◽

Arterial Lesion ◽

Reactive Protein ◽

The Difference ◽

Unconscious Patients ◽

The Relationship

This study investigated how fibrinogen and C-reactive protein (CRP) levels change in response to neural damage occurring after ischaemia, and the relationship between the distribution of the arterial lesion, the disease prognosis and the levels of these substances. Fibrinogen and CRP levels were measured in blood samples obtained from 83 patients admitted to hospital within 72 h of a first ischaemic stroke. The patients were evaluated clinically with the Glasgow Outcome Scale (GOS), and results were compared with 43 age-matched controls. The fibrinogen and CRP levels in unconscious patients with hemiparesis or hemiplegia were higher than those in conscious hemiplegic patients. Also, the difference in GOS values between the unconscious patients with hemiparesis or hemiplegia and conscious patients with hemiparesis or hemiplegia was statistically significant. Patients with large infarcts in the median cerebral artery and anterior cerebral artery had higher fibrinogen and CRP concentrations than the control group. In conclusion, fibrinogen and CRP may be important measures for determining the prognosis and outcome in patients following ischaemic stroke.

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Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation

Mediators of Inflammation ◽

10.1155/2012/606207 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 10

Author(s):

Ertuğrul Kurtoğlu ◽

Hasan Korkmaz ◽

Erdal Aktürk ◽

Mücahid Yılmaz ◽

Yakup Altaş ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Systemic Inflammation ◽

High Sensitivity ◽

Control Group ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp ◽

Artery Disease ◽

The Relationship

Objectives. There are limited clinical data revealing the relationship between mitral annular calcification (MAC) and systemic inflammation. The goal of the present study was to compare high-sensitivity C-reactive protein (hs-CRP) levels in patients with and without MAC and investigate the relationship between MAC and hs-CRP.Methods. One hundred patients with MAC who underwent transthoracic echocardiography (TTE) and 100 age-matched controls without MAC who underwent TTE were included in our study. Hs-CRP levels were compared between groups.Results. Prevalence of female gender, hypertension, and coronary artery disease were significantly higher in the MAC group than in the control group (64% versus 45%,P=0.007, 42% versus 28%,P=0.03and 37% versus 18%,P=0.003, resp.). On multivariate analysis, age, gender, and coronary artery disease were the only independent predictors of MAC. The levels of hs-CRP were higher in the MAC group than in the control group (2.02±0.35versus1.43±0.47 mg/dl,P<0.001). This increase in hs-CRP levels in the MAC group persisted in patients without hypertension, coronary artery disease, and in male patients when compared to the control group.Conclusions. Our study demonstrated that hs-CRP, which is a sensitive marker of systemic inflammation, increased in patients with MAC.

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Comparative Characteristics Of Ferrokinetic Parameters And Their Relationship With Inflammation In Patients With CHF In Advanced And Senile Age

The American Journal of Medical Sciences and Pharmaceutical Research ◽

10.37547/tajmspr/volume03issue04-19 ◽

2021 ◽

Vol 03 (04) ◽

pp. 142-149

Author(s):

Akhmedova N.Sh. ◽

Keyword(s):

Heart Failure ◽

Iron Deficiency ◽

Acute Phase ◽

Acute Phase Proteins ◽

Deficiency Anemia ◽

Control Group ◽

C Reactive Protein ◽

Anemia Of Chronic Disease ◽

Functional Iron Deficiency ◽

Reactive Protein

To perform a comparative analysis of anemia of chronic disease (ACD) and iron-deficiency anemia (IDA) in late middle-aged and elderly patients with chronic heart failure (CHF) by ferrokinetic parameters, inflammation indexes, and their associations. Materials and methods. 65 patients with ischemic heart disease were evaluated, including 35 patients with CHF and ACD, 10 patients with CHF and IDA, and 20 patients without CHF, ACD, and IDA (control group, CG). Results. Patients with CHF and IDA had true iron deficiency whereas 54% of patients with CHF and ACD had functional iron deficiency, and 46% of patients had no iron deficiency. Levels of acute phase proteins, ferritin and hepcidin, C-reactive protein (CRP), and interleukin-6 (IL-6) were highly significantly different in patients with CHF and ACD and patients with CHF and IDA; positive and significant correlations were found for levels of IL-6 and ferritin, IL-6 and CRP, and CRP and hepcidin. In patients with CHF and IDA, levels of acute phase proteins, ferritin and hepcidin, CRP, and IL-6 were low and correlations of IL-6 with ferritin, IL-6 with CRP, and CRP with hepcidin were non-significant. Concentrations of erythropoietin were significantly higher in patients with CHF and ACD and patients with CHF and IDA compared to the control group; however, significant differences between them were absent.

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Association Between Permanent Non-Valvular Atrial Fibrillation with Microalbuminuria and C-Reactive Protein

Galen Medical Journal ◽

10.31661/gmj.v10i0.2106 ◽

2021 ◽

Vol 10 ◽

pp. 2106

Author(s):

Rahimeh Eskandarian ◽

Maryam Niknahad ◽

Raheb Ghorbani ◽

Mahboubeh Darban

Keyword(s):

Atrial Fibrillation ◽

Protein C ◽

Demographic Data ◽

Control Group ◽

C Reactive Protein ◽

Primary And Secondary Prevention ◽

Reactive Protein ◽

Urine Creatinine ◽

The Relationship ◽

Control Study

Background: An understanding of atrial fibrillation (AF) mechanisms, as the most common cardiac arrhythmia, is essential for primary and secondary prevention. Some studies indicated an association between microalbuminuria and C-reactive protein (CRP) protein, with the incidence and prevalence of AF. This study aimed to investigate the relationship between permanent non-valvular AF with microalbuminuria and reactive protein C. Materials and Methods: In this case-control study, 40 permanent non-valvular AF patients and 40 non-AF patients (control group) were studied. Demographic data and measurements of albumin, urine creatinine, CRP, and microalbuminuria were recorded and compared between the two groups. Results: In patients with permanent non-valvular atrial fibrillation, CRP level (P<0.001) and microalbuminuria (P=0.012) were significantly higher than the control group. Also, in patients with permanent non-valvular AF, the CRP positive (P = 0.014) and microalbuminuria (P = 0.003) were significantly higher than controls. The results showed that elevated chance of permanent non-valvular AF with abnormal CRP was 4.25 (odds ratio [OR]= 4.25, 95% confidence interval [CI]: 1.18-1.28; P= 0.026), and with microalbuminuria was 6.54 (OR= 6.54, 95% CI: 1.65-25.89; P=0.007). Conclusion: An elevated CRP level and microalbuminuria were significantly associated with permanent non-valvular atrial fibrillation. A longitudinal study is necessary.[GMJ.2021;10:e2106] DOI:10.31661/gmj.v10i0.2106

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The Relationship between Serum Procalcitonin and Dialysis Adequacy in Peritoneal Dialysis Patients

Iranian Journal of Public Health ◽

10.18502/ijph.v50i3.5591 ◽

2021 ◽

Author(s):

Benyong WANG ◽

Chan GAO ◽

Qi CHEN ◽

Ming WANG ◽

Xiao FEI ◽

...

Keyword(s):

Peritoneal Dialysis ◽

High Sensitivity ◽

Serum Levels ◽

Control Group ◽

C Reactive Protein ◽

Dialysis Patients ◽

Roc Curve Analysis ◽

Dialysis Adequacy ◽

Reactive Protein ◽

The Relationship

Background: To detect the serum procalcitonin (PCT) levels of peritoneal dialysis (PD) patients. Methods: We analyzed the relationship between the PCT Level and dialysis adequacy. We studied 120 peritoneal dialysis patients without signs of infection in Affiliated Hangzhou First People's Hospital and 120 controls from Jan 2014 to Apr 2016. PCT and high sensitivity C-reactive protein (hs-CRP) were detected. 120 PD patients were divided into two groups according to the dialysis adequacy. A correlation analysis was processed between the PCT level and the total solute clearance (Kt/V). The value of PCT for identifying the dialysis adequacy in PD patients was assessed by ROC curve analysis. Results: PCT level in serum of PD group (0.29±0.24 ng/ml) was higher than that of the control group (0.02±0.01 ng/ml) (P<0.01). Compared with the inadequate dialysis group (0.5±0.37 ng/ml), the PCT Level of the adequate dialysis group (0.23±0.15 ng/ml) was lower (P<0.01). There were negative correlations between PCT and Kt/v(r=- 0.451), Prealbumin (PA) (r=-0.258), Glomerular Filtration Rate (eGFR; r=-0.280), while there was positive correlation between PCT and Hypersensitive c-reactive protein (r=0.458) (P<0.01). At a serum PCT cut-off value of 0.283 ng/ml, the sensitivity and specificity for identifying the dialysis adequacy in PD patients were 0.913 and 0.805 respectively. The serum levels of PCT in peritoneal dialysis patients were significantly higher than the levels in healthy controls. Conclusion: The serum level of PCT can be used as an indirect maker to evaluate the adequacy of dialysis.

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Two new inflammatory markers related to the CURB-65 score for disease severity in patients with community-acquired pneumonia: The hypersensitive C-reactive protein to albumin ratio and fibrinogen to albumin ratio

Open Life Sciences ◽

10.1515/biol-2021-0011 ◽

2021 ◽

Vol 16 (1) ◽

pp. 84-91

Author(s):

Bing Luo ◽

Minjie Sun ◽

Xingxing Huo ◽

Yun Wang

Keyword(s):

Inflammatory Markers ◽

Characteristic Curve ◽

Community Acquired Pneumonia ◽

Low Risk ◽

Control Group ◽

C Reactive Protein ◽

Albumin Ratio ◽

Lymphocyte Ratio ◽

Reactive Protein ◽

The Relationship

Abstract Background The objective of this study was to investigate the relationship among hypersensitive C-reactive protein to albumin ratio (CAR), fibrinogen to albumin ratio (FAR), and the CURB-65 score for community-acquired pneumonia (CAP) severity. Methods Clinical data and laboratory indicators of 82 patients with CAP and 40 healthy subjects were retrospectively analysed. The relationship among CAR, FAR, and the severity of CAP was then analysed. Results CAR and FAR in patients with low-risk CAP were significantly higher than those in the normal control group (P < 0.05). CAR and FAR in patients with medium–high-risk CAP were further increased compared with those in patients with low-risk CAP (P < 0.05). CAR and FAR were positively correlated with hypersensitive C-reactive protein, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and CURB-65 scores (P < 0.05). In the receiver operating characteristic curve for predicting severe CAP, the area under the curve of combining four biomarkers (CAR + FAR + NLR + PLR) was the largest. CAR was also an independent risk factor for severe CAP (OR = 8.789, 95% CI: 1.543–50.064, P = 0.014). Conclusions CAR and FAR may be used as the inflammatory markers for CAP severity evaluation.

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Serum P-Cresyl Sulfate Is a Predictor of Central Arterial Stiffness in Patients on Maintenance Hemodialysis

Toxins ◽

10.3390/toxins12010010 ◽

2019 ◽

Vol 12 (1) ◽

pp. 10 ◽

Cited By ~ 4

Author(s):

Yu-Hsien Lai ◽

Chih-Hsien Wang ◽

Chiu-Huang Kuo ◽

Yu-Li Lin ◽

Jen-Pi Tsai ◽

...

Keyword(s):

Arterial Stiffness ◽

Area Under The Curve ◽

Maintenance Hemodialysis ◽

Control Group ◽

Liquid Chromatography Mass Spectrometry ◽

C Reactive Protein ◽

Optimal Cutoff ◽

Reactive Protein ◽

And Control ◽

The Relationship

Arterial stiffness (AS) has an important impact on the outcomes of patients on hemodialysis (HD), and p-cresyl sulfate (PC) can mediate the process of vascular damage. We aimed to investigate the relationship between carotid–femoral pulse wave velocity (cfPWV) and the level of PCs in HD patients. Serum PCs were quantified using liquid chromatography mass spectrometry. Patients who were on standard HD for more than 3 months were enrolled and categorized according to the cfPWV into the high AS (>10 m/s) and control (≤10 m/s) groups. Forty-nine (41.5%) patients belonged to the high AS group and had a higher incidence of diabetes mellitus (DM) and increased systolic blood pressure, serum C-reactive protein, and PC levels but had lower creatinine, compared with those in the control group. In HD patients, the risk for developing high AS increased in the presence of DM (OR 4.147, 95% confidence interval (CI) 1.497–11.491) and high PCs (OR 1.067, 95% CI 1.002–1.136). Having DM (r = 0.446) and high PC level (r = 0.174) were positively associated with cfPWV. The most optimal cutoff value of PC for predicting AS was 18.99 mg/L (area under the curve 0.661, 95% CI 0.568–0.746). We concluded that DM and PCs were promising predictors of high AS in patients on maintenance HD.

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Comparison of serum procalcitonin, haptoglobin and C-reactive protein levels in goats with Corynebacterium pseudotuberculosis

Indian Journal of Animal Research ◽

10.18805/ijar.b-932 ◽

2018 ◽

Author(s):

G. Akgul ◽

M.B. Akgul ◽

D. Ozen ◽

S. Kahya Demýrbýlek

Keyword(s):

Acute Phase ◽

Acute Phase Proteins ◽

Dairy Farm ◽

Diagnostic Information ◽

Control Group ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Serum Haptoglobin ◽

Significant Difference

This study was conducted to investigate the response of acute phase proteins, mainly Haptoglobin, C-reactive protein, Procalcitonin and the negative acute phase response, especially albumin in goats suffering from C. pseudotuberculosis. A total of 19 Turkish hair goats between the ages of 1.5 and 2 years in a special dairy farm was selected for the study, consisting of 9 healthy animals and 10 with C. pseudotuberculosis. There was a statistically significant difference in serum haptoglobin, C-reactive protein, procalcitonin and albumin levels in goats with C. pseudotuberculosis, compared to the control group (p less than 0.05). The results showed that Haptoglobin, C-reactive protein and Procalcitonin produce a higher, and Alb a lower, response in goats with C. pseudotuberculosis compared to the control. The presented study suggests that C. pseudotuberculosis can influence the level of acute phase proteins in goats. These results indicate that monitoring a number of acute phase proteins can increase the diagnostic information available for this disease.

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Coagulase-NegativeStaphylococcus, Catheter-Related, Bloodstream Infections and their Association with Acute Phase Markers of Inflammation in the Intensive Care Unit: An Observational Study

Canadian Journal of Infectious Diseases and Medical Microbiology ◽

10.1155/2012/198383 ◽

2012 ◽

Vol 23 (4) ◽

pp. 204-208 ◽

Cited By ~ 5

Author(s):

Oleksa Rewa ◽

John Muscedere ◽

Steve Reynolds ◽

Xuran Jiang ◽

Daren K Heyland

Keyword(s):

Intensive Care ◽

Acute Phase ◽

Bloodstream Infections ◽

Blood Cultures ◽

Control Group ◽

C Reactive Protein ◽

Surgical Intensive Care ◽

Reactive Protein ◽

Markers Of Inflammation ◽

The Relationship

OBJECTIVE: To examine the relationship between the isolation of coagulase-negativeStaphylococcusin blood cultures and acute phase markers of inflammation.METHODS: The present study was a prospective observational analysis conducted at three medical/surgical intensive care units (ICUs) involving adult patients with an expected ICU stay of more than 24 h duration.RESULTS: Of the 598 patients enrolled, 573 developed suspected bloodstream infection and 434 (72.6%) had blood cultures sent 24 h after ICU admission; 142 were excluded due to positive cultures from other sites. Of the remaining 292 patients, 31 (10.7%) grew coagulase-negativeStaphylococcus, 59 (20.2%) grew known pathogenic organisms and 202 (69.2%) did not grow any organisms in their blood cultures. Twenty-five patients without suspicion of infection served as the control group. Interleukin (IL)-6, procalcitonin (PCT) and C-reactive protein (CRP) levels were highest among the known pathogen group (IL-6 271.8 U/L, PCT 4.6 U/L and CRP 164 mg/L), were similar between the coagulase-negativeStaphylococcusand negative culture groups (IL-6 67.0 U/L versus 61.4 U/L [P=1.00]; PCT 1.0 U/L versus 0.9 U/L [P=0.80]; and CRP 110 mg/L versus 103 mg/L [P=0.75]), and were lowest in the control group (IL-6 31.0 U/L, PCT 0.2 U/L and CRP 41.0 mg/L). In the coagulase-negativeStaphylococcusgroup, patients who died by day 28 had increased inflammatory bio-marker levels compared with survivors, although the differences were not statistically significant.CONCLUSIONS: Coagulase-negativeStaphylococcusisolated from blood cultures were associated with lower levels of inflammation compared with bloodstream infections due to known pathogens and were comparable with levels in patients with negative cultures.

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