scholarly journals Evaluating Drug Risk Using GAN and SMOTE Based on CFDA’s Spontaneous Reporting Data

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Jianxiang Wei ◽  
Guanzhong Feng ◽  
Zhiqiang Lu ◽  
Pu Han ◽  
Yunxia Zhu ◽  
...  
Keyword(s):  
Spontaneous Reporting ◽  
Feature Space ◽  
Sample Space ◽  
Classification Model ◽  
Data Set ◽  
Over The Counter ◽  
Feature Enhancement ◽  
Drug Risk ◽  
Proposed Model ◽  
Post Marketing

Adverse drug reactions (ADRs) pose health threats to humans. Therefore, the risk re-evaluation of post-marketing drugs has become an important part of the pharmacovigilance work of various countries. In China, drugs are mainly divided into three categories, from high-risk to low-risk drugs, namely, prescription drugs (Rx), over-the-counter drugs A (OTC-A), and over-the-counter drugs B (OTC-B). Until now, there has been a lack of automated evaluation methods for the three status switch of drugs. Based on China Food and Drug Administration’s (CFDA) spontaneous reporting database (CSRD), we proposed a classification model to predict risk level of drugs by using feature enhancement based on Generative Adversarial Networks (GAN) and Synthetic Minority Over-Sampling Technique (SMOTE). A total of 985,960 spontaneous reports from 2011 to 2018 were selected from CSRD in Jiangsu Province as experimental data. After data preprocessing, a class-imbalance data set was obtained, which contained 887 Rx (accounting for 84.72%), 113 OTC-A (10.79%), and 47 OTC-B (4.49%). Taking drugs as the samples, ADRs as the features, and signal detection results obtained by proportional reporting ratio (PRR) method as the feature values, we constructed the original data matrix, where the last column represents the category label of each drug. Our proposed model expands the ADR data from both the sample space and the feature space. In terms of feature space, we use feature selection (FS) to screen ADR symptoms with higher importance scores. Then, we use GAN to generate artificial data, which are added to the feature space to achieve feature enhancement. In terms of sample space, we use SMOTE technology to expand the minority samples to balance three categories of drugs and minimize the classification deviation caused by the gap in the sample size. Finally, we use random forest (RF) algorithm to classify the feature-enhanced and balanced data set. The experimental results show that the accuracy of the proposed classification model reaches 98%. Our proposed model can well evaluate drug risk levels and provide automated methods for status switch of post-marketing drugs.

A Sentiment Classification Model Using Group Characteristics of Writing Style Features

2017 ◽  
Vol 31 (12) ◽  
pp. 1756016 ◽  
Author(s):  
Huan Zhao ◽  
Xixiang Zhang ◽  
Keqin Li
Keyword(s):  
Classification Accuracy ◽  
Sentiment Classification ◽  
Classification Model ◽  
Writing Style ◽  
Data Set ◽  
Proposed Model ◽  
Polarity Classification ◽  
And Gender ◽  
Authorship Identification ◽  
Group Characteristics

Sentiment analysis is becoming increasingly important mainly because of the growth of web comments. Sentiment polarity classification is a popular process in this field. Writing style features, such as lexical and word-based features, are often used in the authorship identification and gender classification of online messages. However, writing style features were only used in feature selection for sentiment classification. This research presents an exploratory study of the group characteristics of writing style features on the Internet Movie Database (IMDb) movie sentiment data set. Furthermore, this study utilizes the specific group characteristics of writing style in improving the performance of sentiment classification. We determine the optimum clustering number of user reviews based on writing style features distribution. According to the classification model trained on a training subset with specific writing style clustering tags, we determine that the model trained on the data set of a specific writing style group has an optimal effect on the classification accuracy, which is better than the model trained on the entire data set in a particular positive or negative polarity. Through the polarity characteristics of specific writing style groups, we propose a general model in improving the performance of the existing classification approach. Results of the experiments on sentiment classification using the IMDb data set demonstrate that the proposed model improves the performance in terms of classification accuracy.

scholarly journals Intelligent phishing detection scheme using deep learning algorithms

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Moruf Akin Adebowale ◽  
Khin T. Lwin ◽  
M. A. Hossain
Keyword(s):  
Deep Learning ◽  
Large Data ◽  
Classification Model ◽  
High Tech ◽  
Data Set ◽  
Detection Scheme ◽  
Content Type ◽  
Phishing Attacks ◽  
Proposed Model ◽  
Phishing Detection

PurposePhishing attacks have evolved in recent years due to high-tech-enabled economic growth worldwide. The rise in all types of fraud loss in 2019 has been attributed to the increase in deception scams and impersonation, as well as to sophisticated online attacks such as phishing. The global impact of phishing attacks will continue to intensify, and thus, a more efficient phishing detection method is required to protect online user activities. To address this need, this study focussed on the design and development of a deep learning-based phishing detection solution that leveraged the universal resource locator and website content such as images, text and frames.Design/methodology/approachDeep learning techniques are efficient for natural language and image classification. In this study, the convolutional neural network (CNN) and the long short-term memory (LSTM) algorithm were used to build a hybrid classification model named the intelligent phishing detection system (IPDS). To build the proposed model, the CNN and LSTM classifier were trained by using 1m universal resource locators and over 10,000 images. Then, the sensitivity of the proposed model was determined by considering various factors such as the type of feature, number of misclassifications and split issues.FindingsAn extensive experimental analysis was conducted to evaluate and compare the effectiveness of the IPDS in detecting phishing web pages and phishing attacks when applied to large data sets. The results showed that the model achieved an accuracy rate of 93.28% and an average detection time of 25 s.Originality/valueThe hybrid approach using deep learning algorithm of both the CNN and LSTM methods was used in this research work. On the one hand, the combination of both CNN and LSTM was used to resolve the problem of a large data set and higher classifier prediction performance. Hence, combining the two methods leads to a better result with less training time for LSTM and CNN architecture, while using the image, frame and text features as a hybrid for our model detection. The hybrid features and IPDS classifier for phishing detection were the novelty of this study to the best of the authors' knowledge.

scholarly journals An Efficient Model for TV broadcast Audio Classification through InceptionV3 and ResNet50

2020 ◽  
Vol 9 (5) ◽  
pp. 2234-2238
Keyword(s):  
Classification Model ◽  
Audio Classification ◽  
Development Environment ◽  
Data Set ◽  
Novel Approach ◽  
Proposed Model ◽  
Audio Data ◽  
Data Surveillance ◽  
Voice Data

In the recent advancements of applications, one of the challenging task in many gadgets are incorporated, which is based on audio classification and recognition. A set of emotion detection after post-surgical issues, classification of various voice sequence, classification of random voice data, surveillance and speaker detection audio data act as a crucial input. Most of the audio data is inherent with the environmental noise or instrumental noise. Extracting the unique features from the audio data is very important to determine the speaker effectively. Such kind of a novel idea is evaluated here. The research focus is based on classification of TV broadcast audios in which the type of audio is being class separated through a novel approach. The design evaluates, the five different categories of audio data such as advertisement, news, songs, cartoon and sports from the data collected using the TV tuner card. The proposed design associated with python as a Development environment. The audio samples are converted to images using Spectrogram and then transfer learning is applied on the pretrained models ResNet50 and Inceptionv3 to extract the deep features and to classify the audio data. Inception V3 is compared here with the ResNet50 to get greater accuracy in classification. The pre-trained models are models that was trained on the ImageNet data set for a certain task and are used here to quick train the audio classification model on training set with high accuracy. The proposed model produces accuracy of 94% for Inceptionv3 which gives greater accuracy when compared with the ResNet50 which gives 93%. accuracy.

scholarly journals MMPC-RF: A Deep Multimodal Feature-Level Fusion Architecture for Hybrid Spam E-mail Detection

2021 ◽  
Vol 11 (24) ◽  
pp. 11968
Author(s):  
Ghizlane Hnini ◽  
Jamal Riffi ◽  
Mohamed Adnane Mahraz ◽  
Ali Yahyaouy ◽  
Hamid Tairi
Keyword(s):  
Electronic Mail ◽  
Feature Space ◽  
Classification Model ◽  
Final Decision ◽  
Proposed Model ◽  
Feature Level Fusion ◽  
Strong Representation ◽  
Intelligent Approach ◽  
E Mail ◽  
Level Fusion

Hybrid spam is an undesirable e-mail (electronic mail) that contains both image and text parts. It is more harmful and complex as compared to image-based and text-based spam e-mail. Thus, an efficient and intelligent approach is required to distinguish between spam and ham. To our knowledge, a small number of studies have been aimed at detecting hybrid spam e-mails. Most of these multimodal architectures adopted the decision-level fusion method, whereby the classification scores of each modality were concatenated and fed to another classification model to make a final decision. Unfortunately, this method not only demands many learning steps, but it also loses correlation in mixed feature space. In this paper, we propose a deep multimodal feature-level fusion architecture that concatenates two embedding vectors to have a strong representation of e-mails and increase the performance of the classification. The paragraph vector distributed bag of words (PV-DBOW) and the convolutional neural network (CNN) were used as feature extraction techniques for text and image parts, respectively, of the same e-mail. The extracted feature vectors were concatenated and fed to the random forest (RF) model to classify a hybrid e-mail as either spam or ham. The experiments were conducted on three hybrid datasets made using three publicly available corpora: Enron, Dredze, and TREC 2007. According to the obtained results, the proposed model provides a higher accuracy of 99.16% compared to recent state-of-the-art methods.

scholarly journals A New Text Classification Model Based on Contrastive Word Embedding for Detecting Cybersecurity Intelligence in Twitter

Electronics ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 1527 ◽  
Author(s):  
Han-Sub Shin ◽  
Hyuk-Yoon Kwon ◽  
Seung-Jin Ryu
Keyword(s):  
Deep Learning ◽  
Text Classification ◽  
Area Under The Curve ◽  
Word Embedding ◽  
Classification Model ◽  
Data Set ◽  
Feature Vectors ◽  
Model Based ◽  
Proposed Model ◽  
The Difference

Detecting cybersecurity intelligence (CSI) on social media such as Twitter is crucial because it allows security experts to respond cyber threats in advance. In this paper, we devise a new text classification model based on deep learning to classify CSI-positive and -negative tweets from a collection of tweets. For this, we propose a novel word embedding model, called contrastive word embedding, that enables to maximize the difference between base embedding models. First, we define CSI-positive and -negative corpora, which are used for constructing embedding models. Here, to supplement the imbalance of tweet data sets, we additionally employ the background knowledge for each tweet corpus: (1) CVE data set for CSI-positive corpus and (2) Wikitext data set for CSI-negative corpus. Second, we adopt the deep learning models such as CNN or LSTM to extract adequate feature vectors from the embedding models and integrate the feature vectors into one classifier. To validate the effectiveness of the proposed model, we compare our method with two baseline classification models: (1) a model based on a single embedding model constructed with CSI-positive corpus only and (2) another model with CSI-negative corpus only. As a result, we indicate that the proposed model shows high accuracy, i.e., 0.934 of F1-score and 0.935 of area under the curve (AUC), which improves the baseline models by 1.76∼6.74% of F1-score and by 1.64∼6.98% of AUC.

EXPONENTIATED HALF-LOGISTIC LOMAX DISTRIBUTION WITH PROPERTIES AND APPLICATION

2019 ◽  
Vol XVI (2) ◽  
pp. 1-11
Author(s):  
Farrukh Jamal ◽  
Hesham Mohammed Reyad ◽  
Soha Othman Ahmed ◽  
Muhammad Akbar Ali Shah ◽  
Emrah Altun
Keyword(s):  
Real Data ◽  
Continuous Model ◽  
Model Parameters ◽  
Data Set ◽  
Lomax Distribution ◽  
Mathematical Properties ◽  
Proposed Model ◽  
Probability Weighted Moment ◽  
Record Statistics ◽  
Maximum Likelihood Criterion

A new three-parameter continuous model called the exponentiated half-logistic Lomax distribution is introduced in this paper. Basic mathematical properties for the proposed model were investigated which include raw and incomplete moments, skewness, kurtosis, generating functions, Rényi entropy, Lorenz, Bonferroni and Zenga curves, probability weighted moment, stress strength model, order statistics, and record statistics. The model parameters were estimated by using the maximum likelihood criterion and the behaviours of these estimates were examined by conducting a simulation study. The applicability of the new model is illustrated by applying it on a real data set.

Drug Target Group Prediction with Multiple Drug Networks

2020 ◽  
Vol 23 (4) ◽  
pp. 274-284 ◽  
Author(s):  
Jingang Che ◽  
Lei Chen ◽  
Zi-Han Guo ◽  
Shuaiqun Wang ◽  
Aorigele
Keyword(s):  
Drug Target ◽  
Low Cost ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Support Vector ◽  
Multiple Drug ◽  
Property A ◽  
Multiple Networks ◽  
Proposed Model ◽  
The One

Background: Identification of drug-target interaction is essential in drug discovery. It is beneficial to predict unexpected therapeutic or adverse side effects of drugs. To date, several computational methods have been proposed to predict drug-target interactions because they are prompt and low-cost compared with traditional wet experiments. Methods: In this study, we investigated this problem in a different way. According to KEGG, drugs were classified into several groups based on their target proteins. A multi-label classification model was presented to assign drugs into correct target groups. To make full use of the known drug properties, five networks were constructed, each of which represented drug associations in one property. A powerful network embedding method, Mashup, was adopted to extract drug features from above-mentioned networks, based on which several machine learning algorithms, including RAndom k-labELsets (RAKEL) algorithm, Label Powerset (LP) algorithm and Support Vector Machine (SVM), were used to build the classification model. Results and Conclusion: Tenfold cross-validation yielded the accuracy of 0.839, exact match of 0.816 and hamming loss of 0.037, indicating good performance of the model. The contribution of each network was also analyzed. Furthermore, the network model with multiple networks was found to be superior to the one with a single network and classic model, indicating the superiority of the proposed model.

Human Activity Recognition using Fourier Transform Inspired Deep Learning Combination Model

2019 ◽  
Vol 9 (1) ◽  
pp. 16-31
Author(s):  
Kyungkoo Jun
Keyword(s):  
Fourier Transform ◽  
Deep Learning ◽  
Short Term Memory ◽  
Window Size ◽  
Sensor Data ◽  
Data Sets ◽  
Data Set ◽  
Proposed Model ◽  
Testing Data ◽  
Labeling Scheme

Background & Objective: This paper proposes a Fourier transform inspired method to classify human activities from time series sensor data. Methods: Our method begins by decomposing 1D input signal into 2D patterns, which is motivated by the Fourier conversion. The decomposition is helped by Long Short-Term Memory (LSTM) which captures the temporal dependency from the signal and then produces encoded sequences. The sequences, once arranged into the 2D array, can represent the fingerprints of the signals. The benefit of such transformation is that we can exploit the recent advances of the deep learning models for the image classification such as Convolutional Neural Network (CNN). Results: The proposed model, as a result, is the combination of LSTM and CNN. We evaluate the model over two data sets. For the first data set, which is more standardized than the other, our model outperforms previous works or at least equal. In the case of the second data set, we devise the schemes to generate training and testing data by changing the parameters of the window size, the sliding size, and the labeling scheme. Conclusion: The evaluation results show that the accuracy is over 95% for some cases. We also analyze the effect of the parameters on the performance.

AN EFFICIENT MACHINE LEARNING MODEL FOR PREDICTION OF ACUTE MYOCARDIAL INFARCTION

2020 ◽  
Vol 13 ◽  
Author(s):  
Dhilsath Fathima.M ◽  
S. Justin Samuel ◽  
R. Hari Haran
Keyword(s):  
Machine Learning ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Logistic Regression ◽  
Decision Tree ◽  
Learning Model ◽  
Training Dataset ◽  
Data Set ◽  
Machine Learning Model ◽  
Proposed Model

Aim: This proposed work is used to develop an improved and robust machine learning model for predicting Myocardial Infarction (MI) could have substantial clinical impact. Objectives: This paper explains how to build machine learning based computer-aided analysis system for an early and accurate prediction of Myocardial Infarction (MI) which utilizes framingham heart study dataset for validation and evaluation. This proposed computer-aided analysis model will support medical professionals to predict myocardial infarction proficiently. Methods: The proposed model utilize the mean imputation to remove the missing values from the data set, then applied principal component analysis to extract the optimal features from the data set to enhance the performance of the classifiers. After PCA, the reduced features are partitioned into training dataset and testing dataset where 70% of the training dataset are given as an input to the four well-liked classifiers as support vector machine, k-nearest neighbor, logistic regression and decision tree to train the classifiers and 30% of test dataset is used to evaluate an output of machine learning model using performance metrics as confusion matrix, classifier accuracy, precision, sensitivity, F1-score, AUC-ROC curve. Results: Output of the classifiers are evaluated using performance measures and we observed that logistic regression provides high accuracy than K-NN, SVM, decision tree classifiers and PCA performs sound as a good feature extraction method to enhance the performance of proposed model. From these analyses, we conclude that logistic regression having good mean accuracy level and standard deviation accuracy compared with the other three algorithms. AUC-ROC curve of the proposed classifiers is analyzed from the output figure.4, figure.5 that logistic regression exhibits good AUC-ROC score, i.e. around 70% compared to k-NN and decision tree algorithm. Conclusion: From the result analysis, we infer that this proposed machine learning model will act as an optimal decision making system to predict the acute myocardial infarction at an early stage than an existing machine learning based prediction models and it is capable to predict the presence of an acute myocardial Infarction with human using the heart disease risk factors, in order to decide when to start lifestyle modification and medical treatment to prevent the heart disease.

scholarly journals Comparison of Spectroscopic Techniques Combined with Chemometrics for Cocaine Powder Analysis

2020 ◽  
Vol 44 (8) ◽  
pp. 851-860
Author(s):  
Joy Eliaerts ◽  
Natalie Meert ◽  
Pierre Dardenne ◽  
Vincent Baeten ◽  
Juan-Antonio Fernandez Pierna ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Near Infrared ◽  
Evaluation Criteria ◽  
Classification Model ◽  
Support Vector ◽  
Spectroscopic Techniques ◽  
Data Set ◽  
Promising Tool ◽  
Powder Analysis ◽  
Mir Spectra

Abstract Spectroscopic techniques combined with chemometrics are a promising tool for analysis of seized drug powders. In this study, the performance of three spectroscopic techniques [Mid-InfraRed (MIR), Raman and Near-InfraRed (NIR)] was compared. In total, 364 seized powders were analyzed and consisted of 276 cocaine powders (with concentrations ranging from 4 to 99 w%) and 88 powders without cocaine. A classification model (using Support Vector Machines [SVM] discriminant analysis) and a quantification model (using SVM regression) were constructed with each spectral dataset in order to discriminate cocaine powders from other powders and quantify cocaine in powders classified as cocaine positive. The performances of the models were compared with gas chromatography coupled with mass spectrometry (GC–MS) and gas chromatography with flame-ionization detection (GC–FID). Different evaluation criteria were used: number of false negatives (FNs), number of false positives (FPs), accuracy, root mean square error of cross-validation (RMSECV) and determination coefficients (R2). Ten colored powders were excluded from the classification data set due to fluorescence background observed in Raman spectra. For the classification, the best accuracy (99.7%) was obtained with MIR spectra. With Raman and NIR spectra, the accuracy was 99.5% and 98.9%, respectively. For the quantification, the best results were obtained with NIR spectra. The cocaine content was determined with a RMSECV of 3.79% and a R2 of 0.97. The performance of MIR and Raman to predict cocaine concentrations was lower than NIR, with RMSECV of 6.76% and 6.79%, respectively and both with a R2 of 0.90. The three spectroscopic techniques can be applied for both classification and quantification of cocaine, but some differences in performance were detected. The best classification was obtained with MIR spectra. For quantification, however, the RMSECV of MIR and Raman was twice as high in comparison with NIR. Spectroscopic techniques combined with chemometrics can reduce the workload for confirmation analysis (e.g., chromatography based) and therefore save time and resources.

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