scholarly journals Gut Microbiota and Depressive Symptoms at the End of CRT for Rectal Cancer: A Cross-Sectional Pilot Study

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Velda J. Gonzalez-Mercado ◽  
Jean Lim ◽  
Leorey N. Saligan ◽  
Nicole Perez ◽  
Carmen Rodriguez ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Radiation Therapy ◽  
Depressive Symptoms ◽  
Depressive Symptom ◽  
Pilot Study ◽  
Gut Microbiota ◽  
Rating Scale ◽  
Cross Sectional ◽  
Symptom Scores ◽  
Functional Pathways

Background. The role of alterations in gut microbiota composition (termed dysbiosis) has been implicated in the pathobiology of depressive symptoms; however, evidence remains limited. This cross-sectional pilot study is aimed at exploring whether depressive symptom scores changed during neoadjuvant chemotherapy and radiation therapy to treat rectal cancer, and if gut microbial taxa abundances and predicted functional pathways correlate with depressive symptoms at the end of chemotherapy and radiation therapy. Methods. 40 newly diagnosed rectal cancer patients (ages 28-81; 23 males) were assessed for depressive symptoms using the Hamilton Rating Scale for Depression (HAM-D) and provided stool samples for 16S rRNA sequencing. Gut microbiome data were analyzed using QIIME2, and correlations and regression analyses were performed in R. Results. Participants had significantly higher depressive symptoms at the end as compared to before CRT. The relative abundances of Gemella, Bacillales Family XI, Actinomyces, Streptococcus, Lactococcus, Weissella, and Leuconostocaceae were positively correlated (Spearman’s rho = 0.42 to 0.32), while Coprobacter, Intestinibacter, Intestimonas, Lachnospiraceae, Phascolarctobacterium, Ruminiclostridium, Ruminococcaceae (UCG-005 and uncultured), Tyzzerella, and Parasutterella (Spearman’s rho = − 0.43   to − 0.31 ) were negatively correlated with HAM-D scores. Of the 14 predicted MetaCyc pathways that correlated with depressive symptom scores at the end of CRT, 11 (79%) were associated with biosynthetic pathways. Conclusions. Significant bacterial taxa and predicted functional pathways correlated with depressive symptoms at the end of chemotherapy and radiation therapy for rectal cancer which warrants further examination and replication of our findings.

Gut microbiota and fatigue in rectal cancer patients: a cross-sectional pilot study

2021 ◽  
Author(s):  
Velda J. González-Mercado ◽  
Jean Lim ◽  
Sara Marrero ◽  
Elsa Pedro ◽  
Leorey N. Saligan
Keyword(s):  
Rectal Cancer ◽  
Pilot Study ◽  
Gut Microbiota ◽  
Cancer Patients ◽  
Cross Sectional

scholarly journals Effect of Lacticaseibacillus paracasei Strain Shirota on Improvement in Depressive Symptoms, and Its Association with Abundance of Actinobacteria in Gut Microbiota

2021 ◽  
Vol 9 (5) ◽  
pp. 1026
Author(s):  
Machiko Otaka ◽  
Hiroko Kikuchi-Hayakawa ◽  
Jun Ogura ◽  
Hiroshi Ishikawa ◽  
Yukihito Yomogida ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Gut Microbiota ◽  
Intestinal Permeability ◽  
Rating Scale ◽  
Psychiatric Symptoms ◽  
Daily Intake ◽  
Probiotic Strain ◽  
Major Depressive ◽  
Colony Forming Units ◽  
And Biological Markers

We previously reported lower counts of lactobacilli and Bifidobacterium in the gut microbiota of patients with major depressive disorder (MDD), compared with healthy controls. This prompted us to investigate the possible efficacy of a probiotic strain, Lacticaseibacillus paracasei strain Shirota (LcS; basonym, Lactobacillus casei strain Shirota; daily intake of 8.0 × 1010 colony-forming units), in alleviating depressive symptoms. A single-arm trial was conducted on 18 eligible patients with MDD or bipolar disorder (BD) (14 females and 4 males; 15 MDD and 3 BD), assessing changes in psychiatric symptoms, the gut microbiota, and biological markers for intestinal permeability and inflammation, over a 12-week intervention period. Depression severity, evaluated by the Hamilton Depression Rating Scale, was significantly alleviated after LcS treatment. The intervention-associated reduction of depressive symptoms was associated with the gut microbiota, and more pronounced when Bifidobacterium and the Atopobium clusters of the Actinobacteria phylum were maintained at higher counts. No significant changes were observed in the intestinal permeability or inflammation markers. Although it was difficult to estimate the extent of the effect of LcS treatment alone, the results indicated that it was beneficial to alleviate depressive symptoms, partly through its association with abundance of Actinobacteria in the gut microbiota.

scholarly journals Trimethylamine N-Oxide, a Gut Microbiota-Derived Metabolite, Is Associated with Cardiovascular Risk in Psoriasis: A Cross-Sectional Pilot Study

2021 ◽  
Author(s):  
Mariusz Sikora ◽  
Norbert Kiss ◽  
Albert Stec ◽  
Joanna Giebultowicz ◽  
Emilia Samborowska ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Pilot Study ◽  
Gut Microbiota ◽  
Cross Sectional

scholarly journals Prevalence and Influencing Factors of Anxiety and Depression Symptoms Amongst Surgical Nurses During COVID-19 Pandemic: A Large-Scale Cross-Sectional Study

2020 ◽  
Author(s):  
Chun-Xia Ren ◽  
De-Cun Zhou ◽  
Yin-Guang Fan ◽  
Bao-Zhu Li ◽  
Wan-Fei Zhang ◽  
...  
Keyword(s):  
Social Support ◽  
Depressive Symptoms ◽  
Influencing Factors ◽  
Rating Scale ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Cross Sectional ◽  
Self Rating ◽  
Surgical Nurses

Abstract BackgroundThe outbreak of novel 2019 coronavirus disease (COVID-19) has imposed an enormous physical and psychological pressure on people across the world. This study focused on evaluating the prevalence and influencing factors of anxiety and depression symptoms in surgical nurses during the epidemic in China. MethodA cross-sectional, multicenter quantitative study was conducted in Anhui province (China) from March 3, 2020 to March 19, 2020, with a questionnaire package which consisted of general information questionnaire，Zung's self-rating anxiety scale (SAS), Zung's self-rating Depression Scale (SDS) and social support rating scale (SSRS). A total of 3600 surgical nurses participated in the survey by Wechat and QQ. Data were analysed using multiple linear regression models. ResultsA total of 3492 surgical nurses from 12tertiary hospitals and 12 secondary hospitals in one province of mainland China completed the survey. The prevalence rates of anxiety symptoms and depressive symptoms were 24.83% and 22.39%, respectively. The average level of anxiety and depression of surgical nurses were higher than that of the Chinese norm (P< 0.05).Levels of social support for surgical nurses were significantly negatively associated with the degree of anxiety (r = -0.630, P < 0.001) and depression (r = -0.578, P < 0.001). Fertility status (β = 1.469, P = 0.003), hospital (β = -0.611, P < 0.001), participation in care for COVID-19 patients (β = 2.229, P < 0.001), likelihood of being infected with COVID-19 (β = 1.146, P < 0.001), social support (β = -0.623, P < 0.001) were significantly influencing surgical nurses’ anxiety degree. Similarly, these characteristics were significantly associated with the odds of experiencing depression symptoms in surgical nurses. Divorce and widowed surgical nurses (β = -2.654, P < 0.001) were significantly more likely to experience depressive symptoms than single nurses. ConclusionIn this survey, we found that the surgical nurses had high anxiety and depression symptoms during the COVID-19 outbreak in China. The findings suggest that targeted psychological interventions to promote the mental health of surgical nurses with psychological problems need to be immediately implemented.

scholarly journals Depressive Symptoms, Pain, and Quality of Life among Patients with Nonalcohol-Related Chronic Pancreatitis

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Wendy E. Balliet ◽  
Shenelle Edwards-Hampton ◽  
Jeffery J. Borckardt ◽  
Katherine Morgan ◽  
David Adams ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Pancreatitis ◽  
Depressive Symptoms ◽  
Rating Scale ◽  
Depression Scale ◽  
Self Report ◽  
Cross Sectional ◽  
Depressive Symptomology ◽  
The Mean

Objective. The present study was conducted to determine if depressive symptoms were associated with variability in pain perception and quality of life among patients with nonalcohol-related chronic pancreatitis. Methods. The research design was cross-sectional, and self-report data was collected from 692 patients with nonalcohol-related, intractable pancreatitis. The mean age of the sample was 52.6 (); 41% of the sample were male. Participants completed the MOS SF12 Quality of Life Measure, the Center for Epidemiological Studies 10-item Depression Scale (CESD), and a numeric rating scale measure of “pain on average” from the Brief Pain Inventory. Results. Depressive symptoms were significantly related to participants’ reports of increased pain and decreased quality of life. The mean CESD score of the sample was 10.6 () and 52% of the sample scored above the clinical cutoff for the presence of significant depressive symptomology. Patients scoring above the clinical cutoff on the depression screening measure rated their pain as significantly higher than those below the cutoff () and had significantly lower physical quality of life () and lower mental quality of life (). Conclusion. Although causality cannot be determined based on cross-sectional, correlational data, findings suggest that among patients with nonalcoholic pancreatitis, the presence of depressive symptoms is common and may be a risk factor associated with increased pain and decreased quality of life. Thus, routine screening for depressive symptomology among patients with nonalcoholic pancreatitis may be warranted.

scholarly journals The influence of depressive symptoms and substance use on adherence to antiretroviral therapy. A cross-sectional prevalence study

2014 ◽  
Vol 133 (3) ◽  
pp. 179-186 ◽  
Author(s):  
Claudia Siqueira Tufano ◽  
Ricardo Abrantes do Amaral ◽  
Luciana Roberta Donola Cardoso ◽  
André Malbergier
Keyword(s):  
Substance Use ◽  
Depressive Symptoms ◽  
Rating Scale ◽  
Stable Condition ◽  
Treatment Interruption ◽  
Prevalence Study ◽  
Treatment Center ◽  
Cross Sectional ◽  
Cd4 Cell Count ◽  
The Past

CONTEXT AND OBJECTIVE:Adherence to antiretroviral treatment (ART) is not a stable condition, but is dynamic, like mental conditions. The aim of this study was to examine whether non-adherence to ART is related to demographic and immunological variables, substance use and presence of depressive symptoms.DESIGN AND SETTING:This was a cross-sectional prevalence study carried out at a public AIDS treatment center in the city of São Paulo, Brazil, between July 2006 and January 2007.METHODS:438 patients on regular ART schedules with recent laboratory tests answered a demographic questionnaire, questions about substance use, the Hamilton Depression Rating Scale (HDRS) and the Simplified Medication Adherence Questionnaire (SMAQ).RESULTS:The prevalence of non-adherence over the past three months (a pattern of treatment interruption) was 46.3%, and 27.2% also reported this in the past week (a pattern of missed doses). ART interruption was significantly related to older age, lower CD4+ cell count and homosexual/bisexual transmission. The pattern of missed doses was significantly related to younger age, higher HDRS scores and higher viral load of RNA HIV.CONCLUSION:ART interruption may reflect recall errors and changes to the Brazilian demographic characteristics of HIV infection. The missed doses may reflect lifestyle characteristics of younger individuals. Attendance for HIV-positive individuals, particularly younger patients, should involve interventions and counseling in relation to the presence of depressive symptoms.

scholarly journals Prevalence of Depression among Postmenopausal Women in National Guard Primary Healthcare Centers, Riyadh, Saudi Arabia

2019 ◽  
Vol 4 (2) ◽  
Keyword(s):  
Social Support ◽  
Saudi Arabia ◽  
Depressive Symptoms ◽  
Postmenopausal Women ◽  
Rating Scale ◽  
National Guard ◽  
Cross Sectional Study ◽  
Menopausal Symptoms ◽  
Cross Sectional ◽  
Medical City

Background: Reports of prevalence rates of depression in postmenopause show inconsistent results, with some studies demonstrating an increase in depressive symptoms whereas others show a decrease or no difference. Objectives: To estimate the prevalence and define some risk factors of depression in postmenopausal women aged 45-65 years in primary health care settings in Riyadh, Saudi Arabia. Subjects and Methods: This cross-sectional study was conducted throughout the period June-August, 2018 at King Abdul Aziz Medical City-National Guard (KAMC-NG) in Riyadh, Saudi Arabia, in three large primary care centers. It included a sample of postmenopausal women who completed at least 12 months of amenorrhea and aged between 45 and 65 years. The Arabic version of PHQ-9 was utilized to detect depression and Menopausal rating scale (MRS) was used to assess the severity of menopausal symptoms. Results: The study included 300 women. The prevalence of major depressive symptoms among them was 29%. More than half (60.7%) of the respondents had moderate social support, three quarters (75%) scored mild to severe symptoms on the menopausal rating scale while 25% were asymptomatic.Women who were: unmarried (84.2%), housewives (79.2%), illiterate (83.2%), menopaused since≥10 years (87.5%), having more than five children (81.4%), underwent oophorectomy (100%), with poor social support (93.9%) and never exercised (82.4%) were more likely to report mild to severe symptoms. Also, significantly higher percentages of participants who have hypertension (81.9%), diabetes (82.1%), Dyslipedemia (88.1%) and hypothyroidism (81.4 %) experienced mild to severe menopausal symptoms, p<0.05. The degree of severity on the PHQ has strong significant (P<0.001) correlation with marital status, employment status, educational level and income. Conclusion: Depression is a relatively common disorder among postmenopausal women in Riyadh. Some sociodemographic indicators were identified. Care should be paid to this important group and further larger studies are recommended.

Differentiation of ADHD and Depression Based on Cognitive Performance

2019 ◽  
pp. 108705471986578
Author(s):  
Madlen Paucke ◽  
Tina Stibbe ◽  
Jue Huang ◽  
Maria Strauss
Keyword(s):  
Depressive Symptoms ◽  
Mental Disorders ◽  
Neuropsychological Tests ◽  
Adult Adhd ◽  
Rating Scale ◽  
Reaction Times ◽  
Self Report ◽  
Diagnostic Process ◽  
Screening Methods ◽  
Cross Sectional

Objective: The aim of this study was to assess whether self-report scales and neuropsychological tests used for adult patients with ADHD can help to distinguish between ADHD-specific and depressive symptoms. Method: In a cross-sectional design, differences in self-report questionnaires and neuropsychological tests among clinical subgroups and healthy controls (HC) were evaluated. Patients in clinical groups were diagnosed with major depressive disorder (MDD) or ADHD with or without depressive symptoms according to Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) guidelines. Results: The Hyperactivity subscales of the Conners’ Adult ADHD Rating Scale (CAARS) differed between MDD and ADHD, whereas self-concept and inattention scales even distinguished comorbidity subgroups within the ADHD population. A reduced alertness and higher variations in reaction times measured by performance tests indicated problems in sustained attention in ADHD patients compared with HC. Conclusion: The diagnostic process of ADHD, and thereby the distinction from other symptom-overlapping, comorbid mental disorders, might be improved by utilizing ADHD-specific self-report questionnaires and neuropsychological tests, which are short, cost-effective, and standardized screening methods.

A pilot study of depression, stigma, and attitudes towards seeking professional psychological help among Arab adolescents

2016 ◽  
Vol 30 (4) ◽  
Author(s):  
Latefa A. Dardas ◽  
Susan Silva ◽  
Devon Noonan ◽  
Leigh Ann Simmons
Keyword(s):  
Public Schools ◽  
Depressive Symptoms ◽  
Pilot Study ◽  
Severe Depression ◽  
Self Report ◽  
Future Research ◽  
Mild Depression ◽  
Cross Sectional ◽  
Professional Help ◽  
Moderate Depression

Abstract The Arab region has the largest proportion of young people in the world and many of the factors that contribute to the onset of depression. Yet, very little is known about the current situation of depression and its associated stigma in this region. The purpose of this pilot study was to obtain preliminary data examining clinically significant depressive symptoms, depression stigma, and attitudes towards seeking professional help for depression among a sample of Arab adolescents from Jordan. Cross-sectional data were collected from 88 adolescents attending public schools in Jordan using self-report questionnaires that were available in, or translated into, Arabic. Among the 88 adolescents, 22% reported scores suggesting mild depression and 19% reported scores suggesting moderate depression, while 24% reported scores suggesting severe depression. The most frequently reported depressive symptoms were changes in sleep patterns (76%), changes in appetite (63%), agitation (62%), and crying (61%). The majority (73%) had moderate depression stigma, and 43% had negative attitudes towards seeking professional help. Yet, 67% believed they would find relief in psychotherapy if they ever had a serious emotional crisis. Findings suggest that the prevalence of depressive symptoms may be high among Jordanian adolescents. Further, many of these adolescents may experience depression-related stigma that affects their attitudes and willingness to seek professional help. To determine the true scope of these issues, including the prevalence of depression among Jordanian adolescents, future research should obtain data from a nationally representative sample.

scholarly journals Investigating the prevalence of and factors associated with depressive symptoms among urban and semi-urban school adolescents in Bangladesh: a pilot study

2019 ◽  
Author(s):  
Afifa Anjum ◽  
Sahadat Hossain ◽  
Tajuddin Sikder ◽  
Md Elias Uddin ◽  
Dewan Abdur Rahim
Keyword(s):  
Depressive Symptoms ◽  
Pilot Study ◽  
Psychological Health ◽  
Adolescent Depression ◽  
Urban Adolescents ◽  
Health Hazard ◽  
Sociodemographic Factors ◽  
Cross Sectional ◽  
Factors Associated ◽  
Use Of Social Media

Abstract Background Adolescent depression is an alarming issue for Bangladesh since a large number of Bangladeshi adolescents suffer from depression but cannot get proper treatment. This study aimed to investigate the prevalence of depression and factors associated with this psychological health hazard among urban and semi-urban adolescents of the Dhaka region in Bangladesh. Methods A cross-sectional pilot study was performed among 311 adolescents, grades 8–10, in Dhaka city and Savar Upazila, adjacent to the city, in 2018. Data were collected using a questionnaire consisting of items on sociodemographics, lifestyle information, screen-based sedentary behaviour (SBSB) and mental health. Results A total of 36.6% of the adolescents reported depressive symptoms, with a greater prevalence among females (42.9%) than males (25.7%). Sociodemographic factors including being female, residence and grade in school were significantly associated with depression. Logistic regression analysis showed that SBSBs, such as the use of social media (odds ratio [OR] 2.06 [95% confidence interval {CI} 1.27–3.35]), high screen time (>120 min/day; OR 2.35 [95% CI 1.30–4.25]) and sleep disturbance (OR 3.93 [95% CI 2.37–6.50]) were significantly linked with depressive symptoms. Conclusions Depressive symptoms are prevalent among urban and semi-urban adolescents of Dhaka, Bangladesh. Therefore, urgent initiatives should be taken to curb the spread of depression among Bangladeshi adolescents.

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