scholarly journals Growth Factors in Oral Tissue Engineering: New Perspectives and Current Therapeutic Options

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Luca Fiorillo ◽  
Gabriele Cervino ◽  
Pablo Galindo-Moreno ◽  
Alan Scott Herford ◽  
Gianrico Spagnuolo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
English Language ◽  
Scientific Evidence ◽  
Contemporary Literature ◽  
Molecular Features ◽  
Oral Tissue ◽  
Scaffold Materials ◽  
Morphogenetic Factors ◽  
Initial Research

The present investigation is aimed at systematically analyzing the recent literature about the innovative scaffold involved in the reconstructive surgeries by applying growth factors and tissue engineering. An extensive review of the contemporary literature was conducted according to the PRISMA guidelines by accessing the PubMed, Embase, and Scopus Elsevier databases. Authors performed the English language manuscript research published from 2003 to 2020. A total of 13 relevant studies were included in the present review. The present systematic review included only papers with significant results about correlation between scaffold, molecular features of growth factor, and reconstructive surgeries in oral maxillofacial district. The initial research with filters recorded about 1023 published papers. Beyond reading and considering of suitability, only 42 and then 36 full-text papers were recorded for the revision. All the researches recorded the possibility of using growth factors on rebuilding atrophic jaws. Different growth factors like morphogenetic factors, cytokines, and inflammatory ones and their application over different scaffold materials were recorded. Further investigations should be required in order to state scientific evidence about a clear advantage of applying tissue engineering for therapeutic purpose.

scholarly journals SCAFOLDS IN PERIODONTAL SURGERY. Review

2019 ◽  
Vol 15 (1-2) ◽  
pp. 87-92
Author(s):  
O.V. Chumachenko ◽  
D.V. Topchii ◽  
U.S. Gromovy ◽  
S.V. Plyatsko
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Bone Morphogenetic Proteins ◽  
Alveolar Bone ◽  
Periodontal Diseases ◽  
Cell Structure ◽  
Maxillofacial Surgery ◽  
Bone Defects ◽  
Clinical Approach ◽  
Scaffold Materials

Relevance. Substitution of bone defects in destructive periodontitis is one of the most difficult tasks of maxillofacial surgery. Today, tissue engineering, which makes up the classical triad: biomaterials + cells + growth factors, is the most effective and technologically promising for restoring the parameters and structure of the alveolar bone. Objective. The goal is to summarize  of literature data on the possibilities of using modified scaffold materials, bone morphogenetic proteins, growth factors in tissue engineering in the replacement of jaw bone defects. Materials and methods.Scientific literature search was carry out using scientometric bases such as Scopus, PubMed, Web of Science, RSCI during 18 years (2001-2018). The literature sources on the possibility of using osteoinductive and osteoconductive materials in dentistry is analyzed. Also the data on the possibility and prospects of using individual osteoregenerative drugs for periodontal diseases and for the elimination of jaw defects was analyzed. The characteristics of the composition, properties, manufacturing methods and mechanism of action of osteoplastic materials was analyzed. Results. Advantages of osteoreparative technologies using scaffolds are their sufficient hydrophilicity, the possibility of complete biocompatibility, biodegradation of the material without any toxic effects on the patient’s body, the possibility of penetration into the cell structure and different molecular sizes (including those stimulating angiogenesis), maintaining the required volume, the possibility of programming the composition and properties at the manufacturing stage and the like. Tissue-engineering constructs have shown their high mechanical and biological properties for osteogenic differentiation and cell replacement. In addition, it is possible to expand operational protocols depending on the specific anatomical and physiological conditions in each patient. Conclusion. The use of modified scaffold materials, bone morphogenetic proteins, growth factors in tissue engineering allows us to restore the structure and volume when replacing defects in the bone tissue of the jaw. Tissue engineering (matrices, growth factors, cells) is becoming an attractive clinical approach for bone regeneration.

Role of Growth Factors and Endothelial Cells in Therapeutic Angiogenesis and Tissue Engineering

2006 ◽  
Vol 1 (3) ◽  
pp. 333-343 ◽  
Author(s):  
Masashi Nomi ◽  
Hideaki Miyake ◽  
Yoshifumi Sugita ◽  
Masato Fujisawa ◽  
Shay Soker
Keyword(s):  
Tissue Engineering ◽  
Endothelial Cells ◽  
Growth Factors ◽  
Therapeutic Angiogenesis

scholarly journals Hard Dental Tissues Regeneration—Approaches and Challenges

Materials ◽  
2021 ◽  
Vol 14 (10) ◽  
pp. 2558
Author(s):  
Mihaela Olaru ◽  
Liliana Sachelarie ◽  
Gabriela Calin
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Stem Cell ◽  
Growth Factors ◽  
Present Review ◽  
Modern Concept ◽  
Dental Tissues ◽  
Tissue Engineering Approach ◽  
Hard Dental Tissues ◽  
Review Reports

With the development of the modern concept of tissue engineering approach and the discovery of the potential of stem cells in dentistry, the regeneration of hard dental tissues has become a reality and a priority of modern dentistry. The present review reports the recent advances on stem-cell based regeneration strategies for hard dental tissues and analyze the feasibility of stem cells and of growth factors in scaffolds-based or scaffold-free approaches in inducing the regeneration of either the whole tooth or only of its component structures.

657 BLADDER AUGMENTATION BY TISSUE ENGINEERING USING MULTIPLE SCAFFOLDS IN ONE BLADDER AND GROWTH FACTORS IN A PORCINE MODEL

2011 ◽  
Vol 10 (2) ◽  
pp. 212
Author(s):  
L.A.J. Roelofs ◽  
B.B.M. Kortmann ◽  
Gier R.P.E. De ◽  
F. Farag ◽  
T.M. Tiemessen ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Porcine Model ◽  
Bladder Augmentation

scholarly journals Scaffolds for Growth Factor Delivery as Applied to Bone Tissue Engineering

2012 ◽  
Vol 2012 ◽  
pp. 1-25 ◽  
Author(s):  
Keith A. Blackwood ◽  
Nathalie Bock ◽  
Tim R. Dargaville ◽  
Maria Ann Woodruff
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Donor Site ◽  
Structural Features ◽  
Donor Site Morbidity ◽  
Tissue Type ◽  
Specific Cell ◽  
Growth Factor Delivery

There remains a substantial shortfall in the treatment of severe skeletal injuries. The current gold standard of autologous bone grafting from the same patient has many undesirable side effects associated such as donor site morbidity. Tissue engineering seeks to offer a solution to this problem. The primary requirements for tissue-engineered scaffolds have already been well established, and many materials, such as polyesters, present themselves as potential candidates for bone defects; they have comparable structural features, but they often lack the required osteoconductivity to promote adequate bone regeneration. By combining these materials with biological growth factors, which promote the infiltration of cells into the scaffold as well as the differentiation into the specific cell and tissue type, it is possible to increase the formation of new bone. However due to the cost and potential complications associated with growth factors, controlling the rate of release is an important design consideration when developing new bone tissue engineering strategies. This paper will cover recent research in the area of encapsulation and release of growth factors within a variety of different polymeric scaffolds.

Tissue Engineering of the Intervertebral Disc With Cultured Nucleus Pulposus Cells Using Atelocollagen Scaffold and Growth Factors

Spine ◽  
2012 ◽  
Vol 37 (6) ◽  
pp. 452-458 ◽  
Author(s):  
Kwang-Il Lee ◽  
Seong-Hwan Moon ◽  
Hyang Kim ◽  
Un-Hye Kwon ◽  
Ho-Joong Kim ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Nucleus Pulposus Cells

scholarly journals Immunobiology and Application of Aloe vera-Based Scaffolds in Tissue Engineering

2021 ◽  
Vol 22 (4) ◽  
pp. 1708
Author(s):  
Saeedeh Darzi ◽  
Kallyanashis Paul ◽  
Shanilka Leitan ◽  
Jerome A. Werkmeister ◽  
Shayanti Mukherjee
Keyword(s):  
Tissue Engineering ◽  
Foreign Body ◽  
Scientific Evidence ◽  
Aloe Vera ◽  
Material Design ◽  
Foreign Body Response ◽  
The Body ◽  
Design Strategies ◽  
Immunomodulatory Effects ◽  
Body Response

Aloe vera (AV), a succulent plant belonging to the Liliaceae family, has been widely used for biomedical and pharmaceutical application. Its popularity stems from several of its bioactive components that have anti-oxidant, anti-microbial, anti-inflammatory and even immunomodulatory effects. Given such unique multi-modal biological impact, AV has been considered as a biomaterial for regenerative medicine and tissue engineering applications, where tissue repair and neo-angiogenesis are vital. This review outlines the growing scientific evidence that demonstrates the advantage of AV as tissue engineering scaffolds. We particularly highlight the recent advances in the application of AV-based scaffolds. From a tissue engineering perspective, it is pivotal that the implanted scaffolds strike an appropriate foreign body response to be well-accepted in the body without complications. Herein, we highlight the key cellular processes that regulate the foreign body response to implanted scaffolds and underline the immunomodulatory effects incurred by AV on the innate and adaptive system. Given that AV has several beneficial components, we discuss the importance of delving deeper into uncovering its action mechanism and thereby improving material design strategies for better tissue engineering constructs for biomedical applications.

TRENDS AND CHALLENGES OF CARTILAGE TISSUE ENGINEERING

2009 ◽  
Vol 21 (03) ◽  
pp. 149-155 ◽  
Author(s):  
Hsu-Wei Fang
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Growth Factors ◽  
Bone Cells ◽  
Cartilage Tissue Engineering ◽  
Bioactive Molecules ◽  
In Vivo Studies ◽  
Cartilage Tissue

Cartilage injuries may be caused by trauma, biomechanical imbalance, or degenerative changes of joint. Unfortunately, cartilage has limited capability to spontaneous repair once damaged and may lead to progressive damage and degeneration. Cartilage tissue-engineering techniques have emerged as the potential clinical strategies. An ideal tissue-engineering approach to cartilage repair should offer good integration into both the host cartilage and the subchondral bone. Cells, scaffolds, and growth factors make up the tissue engineering triad. One of the major challenges for cartilage tissue engineering is cell source and cell numbers. Due to the limitations of proliferation for mature chondrocytes, current studies have alternated to use stem cells as a potential source. In the recent years, a lot of novel biomaterials has been continuously developed and investigated in various in vitro and in vivo studies for cartilage tissue engineering. Moreover, stimulatory factors such as bioactive molecules have been explored to induce or enhance cartilage formation. Growth factors and other additives could be added into culture media in vitro, transferred into cells, or incorporated into scaffolds for in vivo delivery to promote cellular differentiation and tissue regeneration.Based on the current development of cartilage tissue engineering, there exist challenges to overcome. How to manipulate the interactions between cells, scaffold, and signals to achieve the moderation of implanted composite differentiate into moderate stem cells to differentiate into hyaline cartilage to perform the optimum physiological and biomechanical functions without negative side effects remains the target to pursue.

scholarly journals Development of Learning Media Based on VideoScribe to Improve Writing Skill for Descriptive Text of English Language Study

2018 ◽  
Vol 3 (2) ◽  
pp. 187 ◽  
Author(s):  
Novita Aryuntini ◽  
Indri Astuti ◽  
Yohanes Gatot Sutapa Yuliana
Keyword(s):  
Data Collection ◽  
English Language ◽  
Development Model ◽  
Performance Tests ◽  
Development Research ◽  
Instructional Media ◽  
Development Stages ◽  
Before And After ◽  
And Performance ◽  
Initial Research

This study generally aims to develop VideoScribe-based learning media to improve the ability in writing descriptive text in English subjects. The development model used in this study is a combination of Borg and Gall development research steps, and the design of 4D-Thiagarajan  learning model includes initial research and information gathering, planning stages, design stages, development stages, revision, and final product stages. The techniques of data collection in this study were carried out through indirect communications and test. Data collection tools used was questionnaires, observation’s sheet, and performance tests. The results showed that the design of instructional media development in this study consisted of (1) The design of the development of learning media was conducted using the modified models Borg and Gall and 4D Thiagarajan. (2) The application of VideoScribe-based learning media through activity as follows a) preparation, b) introduction, d) Evaluation, e) closing. (3) After applying VideoScribe-based learning media to improve students’ ability on writing Descriptive Text in English subjects and conducted pretest and posttest, it can be concluded that there is an increase in students' ability in writing Descriptive Text before and after the use of learning media.

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