scholarly journals Biomarkers of Inflammation and Redox Imbalance in Umbilical Cord in Pregnancies with and without Preeclampsia and Consequent Perinatal Outcomes

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Marilene Brandão Tenório Fragoso ◽  
Raphaela Costa Ferreira ◽  
Micaely Cristina dos Santos Tenório ◽  
Fabiana Andréa Moura ◽  
Orlando Roberto Pimentel de Araújo ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Umbilical Cord ◽  
Perinatal Outcomes ◽  
Cross Sectional Study ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Redox Imbalance ◽  
Adaptive Mechanisms ◽  
Tnf Α ◽  
Umbilical Cords

Objective. To compare redox imbalance and inflammation biomarkers in umbilical cords from pregnancies with and without preeclampsia (PE) and to analyse their relationships with perinatal outcomes. Methods. A controlled cross-sectional study was conducted in Maceió, Alagoas, Brazil, that involved pregnant women with PE and a group of women without the disease, through the application of a standardized questionnaire. After delivery, umbilical cord samples were collected to measure antioxidant defense, products from oxidative damage, and inflammation biomarkers such as myeloperoxidase (MPO), interleukin- (IL-) 6, IL-8, IL-10, and tumor necrosis factor-alpha (TNF-α). Statistical analyses were performed using Stata version 13.0 software and IBM Statistical Package for the Social Sciences (SPSS) 20.0, adopting a 95% confidence level ( α = 0.05 ), with the chi-square test, the Wilcoxon–Mann–Whitney test, and the multinomial and Poisson regression tests. Results. One hundred PE pregnant women and 50 women without the disease were studied. The umbilical cords from PE pregnancies showed higher levels of reduced glutathione (GSH) ( p ≤ 0.001 ), glutathione peroxidase (GPx) ( p = 0.016 ), and malondialdehyde (MDA) ( p = 0.028 ) and lower levels of IL-6 ( p = 0.030 ) and TNF-α ( p ≤ 0.001 ) than the other group, with some associations among these biomarkers with perinatal outcomes. Conclusion. The higher levels of GSH and GPx, in addition to the lower levels of IL-6 and TNF-α, found in the PE umbilical cord, may result from adaptive mechanisms to maintain the oxidative and inflammatory balance; however, despite these changes, the damage to the cell membranes was not minimized, as the MDA level was higher in women with PE than in women without the disease. This implies that a redox imbalance is present, confirming that other physiological and adaptive mechanisms are being activated to preserve foetal health. Therefore, the present work unveils an important role of the umbilical cord in controlling redox imbalance and inflammation in PE pregnancies. Our results reinforce the necessity for continuous research on GSH as a protective compound for the perinatal outcome, especially in PE women.

scholarly journals High Coping Self-Efficacy Associated With Lower Sweat Inflammatory Cytokines in Adults: A Pilot Study

2019 ◽  
Vol 22 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Melissa Hladek ◽  
Jessica Gill ◽  
Chen Lai ◽  
Kate Lorig ◽  
Sarah Szanton
Keyword(s):  
Chronic Disease ◽  
Pilot Study ◽  
Self Efficacy ◽  
Emotional Regulation ◽  
Longitudinal Research ◽  
Interleukin 10 ◽  
Cross Sectional Study ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Tnf Α

Introduction/Background: Chronic diseases, like diabetes and heart disease, are considered inflammatory conditions with elevated levels of the proinflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) and the anti-inflammatory cytokine interleukin-10 (IL-10). Disease progression is not consistent from person to person. Psychosocial factors are hypothesized to play a modifying role. Self-efficacy, the confidence in one’s ability to perform well in a specific life domain or at a specific task, is associated with better health outcomes. Coping self-efficacy is confidence in one’s ability to handle life’s problems through emotional regulation, problem-solving, and social support. Little is known about associations between coping self-efficacy and inflammation. Aim: The purpose of this pilot study was to examine associations between coping self-efficacy and IL-6, IL-10, and TNF-α levels. Method: This was a cross-sectional study conducted over two visits. Sociodemographic variables, chronic disease count, body mass index (BMI), and coping self-efficacy were collected. Inflammatory markers were collected via sweat using the sweat patch, a noninvasive collection device. Results: Higher TNF-α and IL-10 levels were significantly associated with low coping self-efficacy (β = −.03, p = .028; β = −.017, p = .007, respectively) after adjustment for age, sex, race, BMI, and chronic disease count. IL-6 trended toward significance after adjustment as well (β = −.22, p = .054). Conclusions: This pilot study showed that high coping self-efficacy was associated with lower IL-6, IL-10, and TNF-α levels, indicating a potential buffering effect of high coping self-efficacy. Further longitudinal research with larger sample sizes is needed.

scholarly journals Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients

Viruses ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2223
Author(s):  
Elaine Coutinho Netto ◽  
Alfredo Carlos Silva ◽  
Célia Pedroso ◽  
Carlos Brites
Keyword(s):  
Vitamin D ◽  
Spastic Paraparesis ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Asymptomatic Carriers ◽  
Tnf Α ◽  
Ifn Γ ◽  
And Gender

Recent studies have shown the effects of vitamin D on host response to infectious diseases. Some studies detected a high prevalence of hypovitaminosis D in HIV-infected patients, but scarce information exists for HTLV-1 infection. We conducted a cross-sectional study to evaluate the frequency of hypovitaminosis D in HTLV-1 patients and its relationship with their immune response in HTLV-infected patients and in age- and gender-matched controls at a Brazilian rehabilitation hospital. We compared vitamin D, interleukin-6 (IL-6), tumoral necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) levels across groups. Logistic regression was utilized to assess the association between hypovitaminosis D and cytokine levels. We enrolled 161 HTLV-infected subjects (129 HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, 32 asymptomatic HTLV carriers) and equal number of HTLV-negative controls. We observed a significantly higher prevalence of hypovitaminosis D in patients with HAM/TSP than in HTLV asymptomatic carriers (p < 0.001), or controls (p < 0.001). HAM/TSP patients also had higher levels of IL-6 and IFN-γ than asymptomatic carriers. Patients with HAM/TSP and hypovitaminosis D had higher levels of TNF-α than asymptomatic HTLV carriers. These findings suggest hypovitaminosis D plays a role in HAM/TSP pathogenesis, and it needs to be evaluated in further studies.

scholarly journals Body Mass Index Changes during Pregnancy and Perinatal Outcomes - A Cross-Sectional Study

2017 ◽  
Vol 40 (01) ◽  
pp. 011-019 ◽  
Author(s):  
Sirlei Morais ◽  
Simony Nascimento ◽  
Ana Godoy-Miranda ◽  
Karina Kasawara ◽  
Fernanda Surita
Keyword(s):  
Body Mass Index ◽  
Cesarean Section ◽  
Pregnant Women ◽  
Gestational Age ◽  
Perinatal Outcomes ◽  
Cross Sectional Study ◽  
Large For Gestational Age ◽  
Sectional Study ◽  
Cross Sectional ◽  
Prenatal Visit

Objective To evaluate the relation between changes the body mass index (BMI) percentile, reflected in the Atalah curve, and perinatal outcomes. Methods A cross-sectional study with 1,279 women was performed. Data regarding gestational weight, sociodemographic characteristics and perinatal outcomes were collected through medical charts, prenatal card and interviews in the postpartum period. Women could be classified according to the Atalah curve in the following categories: low weight, adequate weight, overweight, and obese. The BMI was calculated at the first and at the last prenatal care visits, and these values were compared. Results An increase in the BMI category according to the Atalah classification occurred in 19.9% of pregnant women, and an increase of 3.4, 5.8 and 6.4 points of BMI were found for women respectively classified in the adequate weight, overweight and obese categories at the first prenatal visit. Women with high school education presented a lower chance of increasing their BMI (odds ratio [OR] 0:47 [0.24- 0.95]). Women who evolved with an increase in the the Atalah classification were associated with cesarean section (OR 1.97–2.28), fetal macrosomia (OR 4.13–12.54) and large for gestational age newborn (OR 2.88–9.83). Conclusion Pregnant women who gained enough weight to move up in their BMI classification according to the Atalah curve had a higher chance of cesarean section and macrosomia. Women classified as obese, according to the Atalah curve, at the first prenatal visit had a high chance of cesarean section and delivering a large for gestational age newborn.

scholarly journals HUBUNGAN INFEKSI CACING DENGAN TNF α DAN KADAR HEMOGLOBIN PADA IBU HAMIL

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Arif P. Yanto ◽  
Damajanty H. C. Pangemanan ◽  
Joice N. A. Engka
Keyword(s):  
Immune Response ◽  
Iron Deficiency ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
World Health ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Tnf Α ◽  
Health Organization

Abstract: Currently more than 2 billion people infected with worms. High prevalence is found primarily in industrialized countries (developing countries). In Indonesia worms is a public health problem after malnutrition. Worms often associated with deficiency anemia espencially iron deficiency. World Health Organization (WHO) reported that the prevelence of pregnant women who experienced approximately 35-75% iron deficiency and increased along with increasing gestational age. Burden of disease and morbidity from worm disease is transmitted through the ground is influenced by the highly complex immune response, TNF immune response against bacteria, fungal invasion, viruses and parasites. The research is analytic survey doing by cross sectional study. After that data collected were processed using SPSS. All of the population are pregnant women in 6 working areas of North Bolaang Mongondow district health center and the population sampel section is taken by purposive sampling. By using the chi square test at the 95 % confidence level of this study showed there is a correlation worm infection with TNF α in pregnant women and there is no corelation worm infection with hemoglobin levels in pregnant women. No correlation between worm infections and hemoglobin levels and there is correlation between worm infection with TNF α in pregnant women in North Bolaang Mongondow regency.Keywords: worm infection, TNF α, and Hb.Abstrak: Saat ini lebih dari 2 miliar penduduk dunia terinfeksi cacing. Prevalensi yang tinggi ditemukan terutama di negara-negara non industri (negara yang sedang berkembang). Di Indonesia cacingan merupakan masalah kesehatan masyarakat setelah malnutrisi. Penyakit cacingan sering dihubungkan dengan kejadian anemia, terutama defisiensi besi. Badan kesehatan dunia World Health Organization (WHO) melaporkan bahwa prevalensi ibu-ibu hamil yang mengalami defisiensi besi sekitar 35-75% serta semakin meningkat seiring bertambahnya usia kehamilan. Beban penyakit dan angka kesakitan dari penyakit cacing yang ditularkan lewat tanah ini dipengaruhi oleh respon imun yang sangat kompleks. TNF α sebagai respon kekebalan terhadap bakteri, invasi jamur, virus dan parasit. Penelitian dilakuakan bersifat survei analitik dengan rancangan cross sectional study. Selanjtunya data yang terkumpul diolah dengan menggunakan bantuan komputer program SPSS. Populasi adalah semua ibu hamil yang ada di wilayah kerja 6 puskesmas kabupaten Bolaang Mongondow Utara dan sampel di ambil dengan cara purposive sampling. Dengan menggunakan uji Chi Square pada tingkat kepercayaan 95% Penelitian ini menunjukan ada hubungan infeksi cacing dengan TNF α pada ibu hamil dan tidak ada hubungan infeksi cacing dengan kadar hemoglobin pada ibu hamil. Tidak ada hubungan antara infeksi cacing dengan kadar hemoglobin dan ada hubungan infeksi cacing dengan TNF α pada ibu hamil di Kabupaten Bolaang Mongondow Utara.Kata kunci: infeksi cacing, TNF α, dan kadar Hb.

scholarly journals Rho(D) Immune Globulin (anti-D) Concentration-Time Curve After Antenatal Immunoprophylaxis in RhD-Negative Pregnant Women

2021 ◽  
Author(s):  
Ana Cláudia Rabelo e Silva ◽  
Flávia Leite Souza Santos ◽  
Silvana Maria Quintana ◽  
Ricardo Carvalho Cavalli ◽  
Alessandra Cristina Marcolin ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Perinatal Outcomes ◽  
Cross Sectional Study ◽  
Blood Type ◽  
Time Curve ◽  
Cross Sectional ◽  
Abo Incompatibility ◽  
Concentration Time ◽  
Indirect Antiglobulin Test ◽  
Antiglobulin Test

Abstract Objectives: To assess anti-D concentration through maternal indirect antiglobulin test (IAT) titers and scores after RhD-negative pregnant women receive antenatal anti-D until delivery. Methods: Cross-sectional study. Twenty-seven RhD-negative pregnant women were evaluated after receiving a prenatal anti-D dose around 28th week of pregnancy. Serial blood samples were collected at 3, 7, 21, 42, 63 and 84 days after anti-D administration. We performed IAT by conventional tube test (CTT) and gel microcolumn assay (GMA) to assess anti-D scores and titers. Statistical analyzes were performed using IBM SPSS Statistics software. Results: Anti-D had maximum scores values ​around 7 days after its administration, and scores were higher in GMA than CTT for all patients. Anti-D was detected at delivery in 59% of the participants by IAT performed in GMA. Overweight and obese pregnant women may present lower concentrations of anti-D. No correlation was found between maximum scores when comparing them with these variables: newborn RhD blood type; maternal-fetal ABO incompatibility and the number of pregnancies. Conclusions: Administering 300 μg of anti-D in 28th week of pregnancy should be compared in studies analyzing perinatal outcomes, since anti-D was not detectable in 41% of patients, suggesting a significant period without prophylaxis.

scholarly journals Association of Insulin Resistance with Serum Interleukin-6 and TNF-α Levels during Normal Pregnancy

2011 ◽  
Vol 6 ◽  
pp. BMI.S6150 ◽  
Author(s):  
Abdolreza Sotoodeh Jahromi ◽  
Parvin Zareian ◽  
Abdolhossein Madani
Keyword(s):  
Insulin Resistance ◽  
Pregnant Women ◽  
Gestational Age ◽  
Normal Pregnancy ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Tnf Α ◽  
Factor Α

Overview The purpose of this study was to evaluate the role of Tumor Necrosis Factor-α (TNF-α) in insulin resistance (IR) during normal pregnancy. Approach This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively, and in 21 healthy non pregnant women. Serum TNF-α concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Results There were significant differences between serum TNF-α and IL-6 levels in pregnant women as compared with maternal healthy controls. There was significant correlation between gestational age and Body Mass Index (BMI) (r = 0.28, P = 0.01). There was no significant correlation between gestational age and insulin resistance (IR). We also did not find correlations between IR and TNF-α and IR and IL-6 in pregnant women. Conclusion In conclusion, our findings suggest that TNF-α and IL-6 are not greatly contributed to pregnancy induced insulin resistance in normal pregnancy.

scholarly journals Abnormal Vaginal Flora in Low-Risk Pregnant Women Cared for by a Public Health Service: prevalence and Association with Symptoms and Findings from Gynecological Exams

2010 ◽  
Vol 18 (5) ◽  
pp. 919-927 ◽  
Author(s):  
Danielle Cristina Alves Feitosa Gondo ◽  
Marli Teresinha Cassamassimo Duarte ◽  
Márcia Guimarães da Silva ◽  
Cristina Maria Garcia de Lima Parada
Keyword(s):  
Pregnant Women ◽  
Trichomonas Vaginalis ◽  
Care Service ◽  
Perinatal Outcomes ◽  
Cross Sectional Study ◽  
Vaginal Flora ◽  
Low Risk ◽  
Vaginal Candidiasis ◽  
Cross Sectional ◽  
Quantitative Descriptive

This study identifies the prevalence of vaginal flora alterations in low-risk pregnant women and their association with reported symptoms and gynecological exams. This quantitative, descriptive, cross-sectional study was conducted in public primary care service units in Botucatu, SP, Brazil from 2006 to 2008 with 289 pregnant women from a stratified sample obtained by sampling by care unit. Tests of vaginal content were performed using Gram’s method and testing for Trichomonas vaginalis using Diamond’s medium. The prevalence of altered vaginal flora was 49.5%, of which bacterial vaginosis (20.7%), vaginal candidiasis (11.8%) and intermediate flora (11.1%) were the most frequent, not considering associations. Results revealed a high prevalence of vaginal flora alterations with little relation to symptoms, but in agreement with findings from the gynecological exams. Considering undesirable maternal and perinatal outcomes and feasible laboratory practices, the establishment of a routine for diagnosing vaginal flora alterations in low-risk pregnant women is suggested.

Frequency of True and False Umbilical Cord Knots and their Relation Maternal Age and Parity

2021 ◽  
Vol 15 (7) ◽  
pp. 1513-1515
Author(s):  
Sabahat Gul ◽  
Sumaira Hassan ◽  
Urooj Fatima
Keyword(s):  
Umbilical Cord ◽  
Maternal Age ◽  
Medical Science ◽  
Advanced Maternal Age ◽  
Cross Sectional Study ◽  
Significant Relation ◽  
Chi Square ◽  
Cross Sectional ◽  
High Parity ◽  
Umbilical Cords

Background: Umbilical Cord Knots both true and false are common abnormalities whichobstruct the blood flow and oxygen supply to the fetus and are frequently associated with advanced age and high parity of the mother. Aim: To find the frequency of true and falseumbilical cord knots in 100 samples of placentae (with attached umbilical cords ) and their relation to maternal age and parity. Study design: Descriptive cross sectional study. Place of study: Anatomy Department of (BMSI) Basic Medical Science Institute, JPMC Karachi. Methodology: 100 normal vaginally delivered full term placentae with attached umbilical cords were studied with direct Visual examination of the cords. The study included frequency, type and location of the knots and their relation with maternal age and parity. Data collected was analyzed by SPSS version 23 and presented in the form of tables and figures, cross tabulations of umbilical cord knots with age of mother and parity was done. Chi square test was used as test of significance asvariablesunder study are qualitative in nature. Results: This study showed that frequency of umbilical cord knots in 100 samples of placentae was 14% out of which 10(72%) were false knot and 4(28%) were true knot. Bothtrue and false knots were more frequent in male babies. There was statistically significant relation of knots with advanced maternal age (>30) and high parity (>5). Conclusion: Frequency of true umbilical cord knots is 4%. Most of knots are found in male babies and there is statistically significant relation of umbilical cord knots with advanced maternal age and high parity. Keywords: Umbilical cord, true knots, false knots, fetus.

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