scholarly journals Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients

Viruses ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2223
Author(s):  
Elaine Coutinho Netto ◽  
Alfredo Carlos Silva ◽  
Célia Pedroso ◽  
Carlos Brites
Keyword(s):  
Vitamin D ◽  
Spastic Paraparesis ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Asymptomatic Carriers ◽  
Tnf Α ◽  
Ifn Γ ◽  
And Gender

Recent studies have shown the effects of vitamin D on host response to infectious diseases. Some studies detected a high prevalence of hypovitaminosis D in HIV-infected patients, but scarce information exists for HTLV-1 infection. We conducted a cross-sectional study to evaluate the frequency of hypovitaminosis D in HTLV-1 patients and its relationship with their immune response in HTLV-infected patients and in age- and gender-matched controls at a Brazilian rehabilitation hospital. We compared vitamin D, interleukin-6 (IL-6), tumoral necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) levels across groups. Logistic regression was utilized to assess the association between hypovitaminosis D and cytokine levels. We enrolled 161 HTLV-infected subjects (129 HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, 32 asymptomatic HTLV carriers) and equal number of HTLV-negative controls. We observed a significantly higher prevalence of hypovitaminosis D in patients with HAM/TSP than in HTLV asymptomatic carriers (p < 0.001), or controls (p < 0.001). HAM/TSP patients also had higher levels of IL-6 and IFN-γ than asymptomatic carriers. Patients with HAM/TSP and hypovitaminosis D had higher levels of TNF-α than asymptomatic HTLV carriers. These findings suggest hypovitaminosis D plays a role in HAM/TSP pathogenesis, and it needs to be evaluated in further studies.

scholarly journals Age and Spinal Disease Correlate to Albumin and Vitamin D Status

2021 ◽  
pp. 219256822098256
Author(s):  
Anderson Gomes Marin ◽  
Raphael de Rezende Pratali ◽  
Samuel Machado Marin ◽  
Carlos Fernando Pereira da Silva Herrero
Keyword(s):  
Vitamin D ◽  
Nutritional Status ◽  
Age Groups ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Surgical Approaches ◽  
Albumin Concentration ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Epidemiological Profile

Study Design: Cross-sectional study. Objectives: Thus, this study aimed to assess the epidemiological profile of a patient sample that underwent spinal surgery regarding their nutritional and vitamin D status. Methods: Serum albumin and vitamin D (25-hydroxyvitamin D) levels were measured in patients with different spinal surgical approaches and various pathologies at a single institution. 112 patients were retrospectively identified for inclusion and stratified by age into 4 age groups and by pathology. The nutritional status of the patients was classified in vitamin D inadequacy (< 30ng/mL), vitamin D deficiency (<20ng/mL), and hypoalbuminemia (<3.5g/dL). Data was analyzed comparing vitamin D, and albumin means considering gender, age group, and pathologies. Results: Twenty-eight (25.2%) patients had hypoalbuminemia. There was no difference between gender (p = 0.988); there was a significant decrease in albumin concentration increasing the age (p < 0.001). The prevalence of hypoalbuminemia was significantly higher in patients with trauma, tumor and infection than in those patients with degenerative and deformity diseases (p = 0.003). The prevalence of vitamin D inadequacy was 33.7%, and that of deficiency was 62.2%, while severe deficiency (< 10 ng/mL) in 16.3%. The vitamin D concentration was significantly different among the pathologies (P = 0.047), the lower concentration occurring in patients with tumor. Conclusion: Older patients, as well as patients with tumor and infectious pathologies, seem to have a higher prevalence of hypoalbuminemia, inferring malnutrition. There was a low epidemic level of vitamin D concentration, almost all patients presenting some degree of hypovitaminosis D, independent of age, gender and nutritional status.

scholarly journals High prevalence of peripheral neuropathy in multiple myeloma patients and the impact of vitamin D levels, a cross-sectional study

2021 ◽  
Author(s):  
B. E. Oortgiesen ◽  
J. A. Kroes ◽  
P. Scholtens ◽  
J. Hoogland ◽  
P. Dannenberg - de Keijzer ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Clinical Trial Registration ◽  
Cross Sectional ◽  
Validated Questionnaire ◽  
Vitamin D Levels ◽  
The Impact

Abstract Purpose Peripheral neuropathy (PN) is common in patients with multiple myeloma (MM). We hypothesized that the relationship between hypovitaminosis D and PN described in diabetes mellitus patients may also be present in MM patients. Methods To study this potential association, we assessed the incidence of hypovitaminosis D (vitamin D < 75 nmol/L [= 30 ng/mL]) in smouldering and active MM patients in two Dutch hospitals. Furthermore, a validated questionnaire was used to distinguish different PN grades. Results Of the 120 patients included between January 2017 and August 2018, 84% had an inadequate vitamin D level (median vitamin D level 49.5 nmol/L [IQR 34–65 nmol/L]; mean age: 68 years [SD ± 7.7]; males: 58%). PN was reported by 69% of patients (n = 83); however, of these 83 patients, PN was not documented in the medical records of 52%. An association was found between lower vitamin D levels and higher incidence of PN in the total population (P = 0.035), and in the active MM patients (P = 0.016). Conclusion This multi-centre cohort study showed that PN and hypovitaminosis D are common in MM patients, and addressing low vitamin D levels in the treatment of MM patients might be beneficial in reducing the risk of PN. More attention for PN is warranted, as PN is underreported by clinicians. Further research is needed to fully understand the implications of vitamin D in the development of PN in patients with MM. Clinical trial registration Netherland Trial Register NL5835, date of registration July 28, 2016

scholarly journals High Coping Self-Efficacy Associated With Lower Sweat Inflammatory Cytokines in Adults: A Pilot Study

2019 ◽  
Vol 22 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Melissa Hladek ◽  
Jessica Gill ◽  
Chen Lai ◽  
Kate Lorig ◽  
Sarah Szanton
Keyword(s):  
Chronic Disease ◽  
Pilot Study ◽  
Self Efficacy ◽  
Emotional Regulation ◽  
Longitudinal Research ◽  
Interleukin 10 ◽  
Cross Sectional Study ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Tnf Α

Introduction/Background: Chronic diseases, like diabetes and heart disease, are considered inflammatory conditions with elevated levels of the proinflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) and the anti-inflammatory cytokine interleukin-10 (IL-10). Disease progression is not consistent from person to person. Psychosocial factors are hypothesized to play a modifying role. Self-efficacy, the confidence in one’s ability to perform well in a specific life domain or at a specific task, is associated with better health outcomes. Coping self-efficacy is confidence in one’s ability to handle life’s problems through emotional regulation, problem-solving, and social support. Little is known about associations between coping self-efficacy and inflammation. Aim: The purpose of this pilot study was to examine associations between coping self-efficacy and IL-6, IL-10, and TNF-α levels. Method: This was a cross-sectional study conducted over two visits. Sociodemographic variables, chronic disease count, body mass index (BMI), and coping self-efficacy were collected. Inflammatory markers were collected via sweat using the sweat patch, a noninvasive collection device. Results: Higher TNF-α and IL-10 levels were significantly associated with low coping self-efficacy (β = −.03, p = .028; β = −.017, p = .007, respectively) after adjustment for age, sex, race, BMI, and chronic disease count. IL-6 trended toward significance after adjustment as well (β = −.22, p = .054). Conclusions: This pilot study showed that high coping self-efficacy was associated with lower IL-6, IL-10, and TNF-α levels, indicating a potential buffering effect of high coping self-efficacy. Further longitudinal research with larger sample sizes is needed.

scholarly journals Vitamin D Deficiency and Associated Risk Factors in Women from Riyadh, Saudi Arabia

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Nora A. AlFaris ◽  
Nora M. AlKehayez ◽  
Fatema I. AlMushawah ◽  
AbdulRhman N. AlNaeem ◽  
Nadia D. AlAmri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Saudi Arabia ◽  
Vitamin D Deficiency ◽  
Public Awareness ◽  
Public Health Problem ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Associated Risk Factors

AbstractVitamin D deficiency is an epidemic public health problem worldwide. It is common in the Middle East and is more severe in women. This cross-sectional study was conducted to assess vitamin D deficiency and associated risk factors in women living in Riyadh, Saudi Arabia. Serum 25-hydroxyvitamin D (25(OH)D) was measured in 166 women aged 30–65 years. Socio-demographic, lifestyle and health status characteristics, as well as intake of selected dietary supplements, were collected. Weight and height were measured. Vitamin D deficiency (25(OH)D < 20 ng/mL) was reported in 60.2% of participants. Mean of serum 25(OH)D was 20.7 ng/mL. Older age and taking the supplements of vitamin D, multi-vitamins or calcium were identified as factors that associated with a lower risk of hypovitaminosis D. A national strategy is needed to control a hypovitaminosis D crisis in Saudi Arabia. This could be accomplished by raising public awareness regarding vitamin D, regulating and enhancing vitamin D fortification and supplementation and screening vitamin D status among women at high risk.

scholarly journals Geographic and Seasonal Variation of Vitamin D: A Retrospective Study in Two Centers of Nepal

2020 ◽  
Vol 18 (1) ◽  
pp. 103-107
Author(s):  
Arun Sedhain ◽  
Gandhi R Bhattarai ◽  
Sanjaya Raya Yadav ◽  
Bhupendra Raj Pandey ◽  
Thakur Prasad Pant
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Winter Season ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Age Group ◽  
Cross Sectional ◽  
Study Results ◽  
The Status

Background: Vitamin D deficiency is a common problem in many countries throughout the world. This study aimed at understanding the status of vitamin D deficiency in relation to age, gender, geography and season among relatively bigger numbers of population residing in central and western regions of Nepal.Methods: This retrospective cross-sectional study was carried out by reviewing the records of vitamin D tests in two centers of Nepal- namely united reference laboratories at Pokhara and Chitwan Medical College at Chitwan. A total of 3320 individuals who were tested for clinical suspicion of vitamin D deficiency over a period of one year were included in the study. Results: Mean vitamin D level was 18.7 ng/mL. Majority of subjects tested for vitamin D were females (71.36 %) with female to male ratio of 2.49:1. Hypovitaminosis D (? 30 ng/mL) was found in 84.5% subjects and was moderate to severely deficit (<10 ng/mL) in 25.9% of subjects. Status of hypovitaminosis D was found to be less in ?50 years (79.9%) than the younger subjects (89.9% in ?18 years and 87.0% in 19-49 years age group). Vitamin D deficiency was found lower in hills districts (80.8% vs 89.7% in the plains), which was found to be more pronounced during winter through summer seasons as compared to fall season.Conclusions: Population residing in plain areas and summer, spring and winter season are found to have increased problem of Hypovitaminosis D. It is also found to be common among younger children and female of reproductive age group. We have also found out the increased problem of hypovitaminosis D among population residing in the plain areas than in the hills especially in the summer, spring and winter season.Keywords: Geographic variation; hypovitaminosis D; Nepal

scholarly journals Biomarkers of Inflammation and Redox Imbalance in Umbilical Cord in Pregnancies with and without Preeclampsia and Consequent Perinatal Outcomes

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Marilene Brandão Tenório Fragoso ◽  
Raphaela Costa Ferreira ◽  
Micaely Cristina dos Santos Tenório ◽  
Fabiana Andréa Moura ◽  
Orlando Roberto Pimentel de Araújo ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Umbilical Cord ◽  
Perinatal Outcomes ◽  
Cross Sectional Study ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Redox Imbalance ◽  
Adaptive Mechanisms ◽  
Tnf Α ◽  
Umbilical Cords

Objective. To compare redox imbalance and inflammation biomarkers in umbilical cords from pregnancies with and without preeclampsia (PE) and to analyse their relationships with perinatal outcomes. Methods. A controlled cross-sectional study was conducted in Maceió, Alagoas, Brazil, that involved pregnant women with PE and a group of women without the disease, through the application of a standardized questionnaire. After delivery, umbilical cord samples were collected to measure antioxidant defense, products from oxidative damage, and inflammation biomarkers such as myeloperoxidase (MPO), interleukin- (IL-) 6, IL-8, IL-10, and tumor necrosis factor-alpha (TNF-α). Statistical analyses were performed using Stata version 13.0 software and IBM Statistical Package for the Social Sciences (SPSS) 20.0, adopting a 95% confidence level ( α = 0.05 ), with the chi-square test, the Wilcoxon–Mann–Whitney test, and the multinomial and Poisson regression tests. Results. One hundred PE pregnant women and 50 women without the disease were studied. The umbilical cords from PE pregnancies showed higher levels of reduced glutathione (GSH) ( p ≤ 0.001 ), glutathione peroxidase (GPx) ( p = 0.016 ), and malondialdehyde (MDA) ( p = 0.028 ) and lower levels of IL-6 ( p = 0.030 ) and TNF-α ( p ≤ 0.001 ) than the other group, with some associations among these biomarkers with perinatal outcomes. Conclusion. The higher levels of GSH and GPx, in addition to the lower levels of IL-6 and TNF-α, found in the PE umbilical cord, may result from adaptive mechanisms to maintain the oxidative and inflammatory balance; however, despite these changes, the damage to the cell membranes was not minimized, as the MDA level was higher in women with PE than in women without the disease. This implies that a redox imbalance is present, confirming that other physiological and adaptive mechanisms are being activated to preserve foetal health. Therefore, the present work unveils an important role of the umbilical cord in controlling redox imbalance and inflammation in PE pregnancies. Our results reinforce the necessity for continuous research on GSH as a protective compound for the perinatal outcome, especially in PE women.

scholarly journals Vitamin D status and prevalence of hypovitaminosis D in different genders throughout life stages: A Brazilian cross-sectional study

Clinics ◽  
2021 ◽  
Vol 76 ◽  
Author(s):  
Lenora M. Camarate S.M. Leão ◽  
Bernardo Campos Rodrigues ◽  
Paulo Telles Pires Dias ◽  
Bárbara Gehrke ◽  
Thiago da Silva Pereira de Souza ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Life Stages ◽  
Vitamin D Status ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Prevalence of vitamin d deficiency and its correlation with anthropometric measurements in neonates in a tertiary care center: a cross sectional study

2021 ◽  
Vol 8 (2) ◽  
pp. 295
Author(s):  
Ashvini A. ◽  
Nalini A. ◽  
N. S. Raghupathy
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Care Center ◽  
Tertiary Care ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Anthropometric Measurements ◽  
Tertiary Care Center ◽  
Sectional Study ◽  
Cross Sectional

Background: Globally hypovitaminosis D is highly prevalent among all population unsparing pregnant mothers. Maternal hypovitaminosis has negative implications on growing fetus. In India, only limited data available on prevalence of neonatal vitamin D level. Hence this study was done to estimate the prevalence of cord blood vitamin D levels and its relation with anthropometric measurements in newborns.Methods: A cross sectional study was conducted in a tertiary care center on 30 newborns. Cord blood 25 OHD levels and anthropometric measurements were taken. Data were analyzed statistically.Results: Among 30 newborns, 10%, 43% and 46% of babies had vitamin D deficiency (<12 ng/ml), insufficiency and sufficiency respectively. 23% were low birth weight. 43% of low-birth-weight babies had statistically significant (p value<0.0001) hypovitaminosis D. No correlation found between vitamin D status and other anthropometric measurements.Conclusions: Prevalence of hypovitaminosis D has negative implications on birth weight which needs further studies.

scholarly journals Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile

2015 ◽  
Vol 0 (0) ◽  
Author(s):  
Roberto Romero ◽  
Piya Chaemsaithong ◽  
Nikolina Docheva ◽  
Steven J. Korzeniewski ◽  
Adi L. Tarca ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Plasma Concentrations ◽  
Maternal Plasma ◽  
Ionization Mass ◽  
Amniotic Cavity ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Plasma Cytokine ◽  
Tnf Α ◽  
Ifn Γ

AbstractFever is a major criterion for clinical chorioamnionitis; yet, many patients with intrapartum fever do not have demonstrable intra-amniotic infection. Some cytokines, such as interleukin (IL)-1, IL-6, interferon-gamma (IFN-γ), and tumor necrosis factor alpha (TNF-α), can induce a fever. The objective of this study was to determine whether maternal plasma concentrations of cytokines could be of value in the identification of patients with the diagnosis of clinical chorioamnionitis at term who have microbial-associated intra-amniotic inflammation.A retrospective cross-sectional study was conducted, including patients with clinical chorioamnionitis at term (n=41; cases) and women in spontaneous labor at term without clinical chorioamnionitis (n=77; controls). Women with clinical chorioamnionitis were classified into three groups according to the results of amniotic fluid culture, broad-range polymerase chain reaction coupled with electrospray ionization mass spectrometry (PCR/ESI-MS), and amniotic fluid IL-6 concentration: 1) no intra-amniotic inflammation; 2) intra-amniotic inflammation without detectable microorganisms; or 3) microbial-associated intra-amniotic inflammation. The maternal plasma concentrations of 29 cytokines were determined with sensitive and specific V-PLEX immunoassays. Nonparametric statistical methods were used for analysis, adjusting for a false discovery rate of 5%.1) The maternal plasma concentrations of pyrogenic cytokines (IL-1β, IL-2, IL-6, IFN-γ, and TNF-α) were significantly higher in patients with clinical chorioamnionitis at term than in those with spontaneous term labor without clinical chorioamnionitis; 2) the maternal plasma concentrations of cytokines were not significantly different among the three subgroups of patients with clinical chorioamnionitis (intra-amniotic inflammation with and without detectable bacteria and those without intra-amniotic inflammation); and 3) among women with the diagnosis of clinical chorioamnionitis, but without evidence of intra-amniotic inflammation, the maternal plasma concentrations of pyrogenic cytokines were significantly higher than in patients with spontaneous labor at term. These observations suggest that a fever can be mediated by increased circulating concentrations of these cytokines, despite the absence of a local intra-amniotic inflammatory response.1) The maternal plasma concentrations of pyrogenic cytokines (e.g. IL-1β, IL-2, IL-6, IFN-γ, and TNF-α) are higher in patients with intra-partum fever and the diagnosis of clinical chorioamnionitis at term than in those in spontaneous labor at term without a fever; and 2) maternal plasma cytokine concentrations have limited value in the identification of patients with bacteria in the amniotic cavity. Accurate assessment of the presence of intra-amniotic infection requires amniotic fluid analysis.

scholarly journals Hypovitaminosis D and Its Associated Factors in North Algerian Postmenopausal Women: Results of a Cross-Sectional Study

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
S. Oussedik-Lehtihet ◽  
C. Haouichat ◽  
N. Hammoumraoui ◽  
E. Ducros ◽  
C. Gouhier-Kodas ◽  
...  
Keyword(s):  
Vitamin D ◽  
Postmenopausal Women ◽  
Statistical Power ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Vitamin D Supplementation ◽  
Sample Population ◽  
Vitamin D Status ◽  
Sectional Study ◽  
Cross Sectional

Purpose. As the vitamin D status of Algerian postmenopausal women was poorly described, this cross-sectional study investigated the prevalence of low vitamin D status in a sample population. Secondarily, predictive factors of this hypovitaminosis D were explored.Methods. All the 336 selected women ≥ 45 years from Douera were interviewed to get anthropometric and lifestyle data, reproductive and medical history, medications, and calcium/vitamin D intakes. A blood sample was collected to measure 25-hydroxyvitamin D (25(OH)D) concentrations.Results. Approximately 86% of subjects had low vitamin D status (<20 ng/mL). Mean 25(OH)D level was 14.4 ± 5.3 ng/mL with a clear seasonal dynamic and a significant negative correlation with PTH levels (r  = −0.15,p=0.006). A multiple regression analysis using the 25(OH)D cutoff value of 17 ng/mL instead of the generally admitted level of 20 ng/mL was performed to increase statistical power. Other seasons than summer (OR 4.159 and 95% CI 2.456–7.043), obesity (≥30 kg/m2, OR 1.826, 95% CI 1.081–3.083), and veiling (OR 3.526, 95% CI 1.090–11.400) were significantly associated with 25(OH)D concentrations <17 ng/mL.Conclusions. In North Algeria, the abundant sunlight appears insufficient to fully offset hypovitaminosis D risk factors in postmenopausal women, especially obesity and veiling. It suggests the major need to increase vitamin D supplementation in this subpopulation.

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