scholarly journals Реологічні властивості слини та її мінералізуючий потенціал у пацієнтів із запально-деструктивними захворюваннями тканин пародонта на фоні уражень шлунково-кишкового тракту

Author(s):  
О. М Виноградова

РЕОЛОГІЧНІ ВЛАСТИВОСТІ СЛИНИ ТА ЇЇ МІНЕРАЛІЗУЮЧИЙ ПОТЕНЦІАЛ У ПАЦІЄНТІВ ІЗ ЗАПАЛЬНО-ДЕСТРУКТИВНИМИ ЗАХВОРЮВАННЯМИ ТКАНИН ПАРОДОНТА НА ФОНІ УРАЖЕНЬ ШЛУНКОВО-КИШКОВОГО ТРАКТУ - В роботі представлено результати вивчення реологічних властивостей ротової рідини: швидкості секреції, в’язкості, поверхневого натягу та її мінералізуючого потенціалу за вмістом кальцію та фосфору. Встановлено, що у хворих із запально-деструктивними захворюваннями пародонта на фоні уражень шлунково-кишкового тракту, Helicobacter-позитивних пацієнтів відзначається підвищення швидкості секреції та в’язкості слини на фоні зниження поверхневого натягу, зумовленого зменшенням концентрації кальцію та фосфору в ротовій рідині стосовно аналогічних значень у осіб із захворюваннями пародонта без соматичних захворювань та Helicobacter-негативних осіб з ураженням тканин пародонта на тлі патології травного тракту.<br />РЕОЛОГИЧЕСКИЕ СВОЙСТВА СЛЮНЫ И ЕЕ МИНЕРАЛИЗУЮЩИЙ ПОТЕНЦИАЛ У ПАЦИЕНТОВ С ВОСПАЛИТЕЛЬНО-ДЕСТРУКТИВНЫМИ ЗАБОЛЕВАНИЯМИ ТКАНЕЙ ПАРОДОНТА НА ФОНЕ ПОРАЖЕНИЙ ЖЕЛУДОЧНО-КИШЕЧНОГО ТРАКТА - В работе представлены результаты изучения реологических свойств ротовой жидкости: скорости секреции, вязкости, поверхностного натяжения и ее минерализирующего потенциала по содержанию кальция и фосфора. Установлено, что у больных с воспалительно-деструктивными заболеваниями пародонта на фоне поражений желудочно-кишечного тракта, Helicobacter-положительных пациентов отмечается повышение скорости секреции и вязкости слюны на фоне снижения поверхностного натяжения, обусловленного уменьшением концентрации кальция и фосфора в ротовой жидкости относительно аналогичных значений в особ с заболеваниями пародонта без соматических заболеваний и Helicobacter-отрицательных особ с поражением тканей пародонта на фоне патологии пищеварительного тракта.<br />RHEOLOGICAL PROPERTIES OF SALIVA AND ITS MINERALIZING POTENTIAL IN PATIENTS WITH INFLAMMATORY AND DESTRUCTIVE PARODONTIUM DISEASE ON THE BACKGROUND OF DEFEATS OF DIGESTIVE TRACT - This paper presents results of a study of the rheological properties of oral fluid, secretion rate, viscosity, surface tension and its mineralizing potential for calcium and phosphorus. Found that in patients with inflammatory and destructive parodontiuml diseases on the background of lesions of the gastrointestinal tract, Helicobacter-positive patients marked increase in secretion rate and viscosity of saliva on the background of lowering the surface tension caused by the decrease in the concentration of calcium and phosphorus in oral fluid in relation to similar values in persons with parodontium disease without systemic diseases and Helicobacter-negative individuals with lesions of parodontium pathology on the background of the digestive tract.<br />Ключові слова: пародонт, шлунково-кишковий тракт, ротова рідина.<br />Ключевые слова: пародонт, желудочно-кишечный тракт, ротовая жидкость.<br />Key words: parodontium, gastrointestinal tract, oral liquid.

2020 ◽  
Vol 5 (6) ◽  
pp. 262-267
Author(s):  
I. E. Shvets ◽  

The purpose of the study was to investigate the rheological properties of oral fluid and its mineralizing potential in persons with generalized periodontitis on the background of lesions of the gastrointestinal tract. Material and methods. The rheological properties of oral fluid and its mineralizing potential were studied in 100 patients (main group) and 50 patients (comparative group). The overall functional activity of the salivary glands was assessed by the rate of secretion of mixed saliva. Oral fluid was collected for 15 minutes by spitting into graduated test tubes. The rate of salivation (ml / min) was the total volume of saliva collected divided by the time of oral fluid collection. The viscosity of oral fluid was determined using an Oswald viscometer with a capillary length of 10.0 cm and a diameter of 0.4 mm. The surface tension of saliva was determined by the method of T. L. Redinova. In the oral fluid of patients examined the calcium content by the method of A. V. Karakamov and inorganic phosphate by the method of D. F. Boltz [10]. The research was performed in compliance with the basic provisions of the "Rules of ethical principles of scientific medical research with human participation", approved by the Declaration of Helsinki (1964-2013), ICH GCP (1996), EEC Directive № 609 (dated 24.11.1986), orders of the Ministry of Health of Ukraine № 690 dated 23.09.2009, № 944 dated 14.12.2009, № 616 dated 03.08.2012. Each patient signed an informed consent to participate in the study, and all measures were taken to ensure the anonymity of patients. To assess the probability of the obtained results of the study used a variational-statistical method of analysis using Microsoft Excel. Statistical calculation of the results of clinical and laboratory studies was carried out according to conventional methods. Results and discussion. In recent years, a number of researchers have tried to systematize the internal pathology associated with periodontal disease. In foreign literature, a number of priority somatic risk factors for generalized periodontitis, in particular gastrointestinal diseases, have been formulated. In patients with generalized periodontitis on the background of gastrointestinal pathology, an increase in oral viscosity was studied. Oral viscosity along with poor oral hygiene, and decreased local immunity may serve as an additional factor in increasing the formation of plaque, which contributes to the intensification of inflammatory and dystrophic periodontal diseases in this contingent of patients. Increasing the rate of salivation in patients of the main group can be considered as an adaptive-compensatory response of the salivary glands to changes in oral homeostasis. The decrease in the mineralizing potential of the oral fluid according to the surface tension, calcium, phosphorus content and their ratio indicates a decrease in the resistance of the oral fluid and demineralization of the enamel, which leads to deterioration of dental status in patients. It should be noted that in patients with generalized periodontitis on the background of gastrointestinal lesions, the imbalance of the analyzed indicators was more pronounced in almost healthy people with inflammatory-dystrophic diseases of periodontal tissues. In Helicobacter pylori-positive patients of both groups of the study, a decrease in the rheological properties of oral fluid was determined, which indicated more pronounced changes in oral fluid homeostasis compared with the data obtained in Helicobacter pylori-negative patients. Conclusion. The study showed that in Helicobacter pylori-positive patients of the main group the imbalance of physico-biochemical, rheological and remineralizing parameters of oral fluid were more pronounced than in Helicobacter pylori-negative patients of the main group and in Helicobacter pylori-positive patients of the comparison group


Author(s):  
V. I. Rozhko

The level of immunoglobulins and lysozyme in the oral fluid deviates from the norm at presence of the diseases of the gastrointestinal tract (GI), which is likely to be a trigger in the development of rampant caries in children. A detailed study of this aspect has made it possible to directly influence the inhibition of the pathological process.The aim of the study – to evaluate the effectiveness of the use of a complex of therapeutic and prophylactic measures aimed at increasing the resistance of the oral cavity in children with rampant caries on the background of diseases of the gastrointestinal tract in 12–14 days and 6 months after treatment; compare the data with these before treatment.Materials and Methods. The article presents the results of the study of the dynamics of immunological parameters in children with rampant caries on the background of diseases of the gastrointestinal tract. The increase of the indexes of immunoglobulins A, G, secretory immunoglobulin A, lysozyme in the oral liquid of the children of the main, comparative and control groups was determined by the method of radial immunodiffusion in Mancini agar and agar diffusion method containing 0.05 % biomass powder Micrococcus lysodeikticus.Results and Discussion. As a result of the proposed treatment and prophylactic complex, we managed to achieve a significant improvement in the immunological status of oral fluid in children with rampant caries on the background of GI tract diseases. Thus, after treatment (12–14 days), the content of IgA in the oral liquid of the children of the main group increased by 80.0 % higher in relation to the data before treatment. At the same time, in children of the main group, the decrease in the IgG concentration, which was lower than the data before treatment, was studied at 26.32 %. At 12–14 days after treatment in children with multiple caries, against the background of gastrointestinal lesions of the main group, an increase in sIgA and lysozyme was observed, which was 39.13 % and 23.85 % higher, respectively, for the data before treatment.Conclusions. The complex of therapeutic and prophylactic measures introduced and implemented in clinical practice causes a pronounced caries prophylactic effect and improves the state of hygiene, increases the acidity of the enamel and mineralizing properties of the oral liquid, normalizes microbiocenosis and immunological status, which in general optimizes the processes of remineralization.


2021 ◽  
pp. 102-106
Author(s):  
L.F. Kaskova ◽  
V.M. Batig ◽  
I.I. Drozda ◽  
O.V. Mytchenok

During the research it has been found that the hydrogen index and mineralizing potential of oral fluid in adolescents aged 15-18 who study in college is lower than in other study groups. The hydrogen index of college students increases slightly from 15 years to 17 years and reaches its maximum at 18 years. In schoolchildren and students of the university, an increase in the microcrystallization of oral fluid with age was observed, and in college students a decrease was noted. This indicates the need for preventative work with this cohort to identify risk factors that cause this situation. A study of the micro crystallization of oral fluid revealed a difference depending on the institution in which adolescents study. Comparison of school attenders at different ages did not reveal any significant difference, although the indicator at 15 years old was slightly lower than at 16, always corresponded to a satisfactory level of micro crystallization. In college students, the micro crystallization rate corresponded to a low level of 15 and 16 years old. Comparison of the results of the examined 17-18 years old, who study at the college and the university, it was found that the mineralizing potential of oral fluid is lower in college students at both 17 and 18 years old than at university students. The rate of adolescents studying at the university corresponded to a satisfactory level and those of college students - low at both 17 and 18 years. A pattern indicates the deterioration of oral homeostasis in adolescents enrolled in college at all ages compared to schoolchildren and university students.  In university students it was found probable increase in the values of the indicator. College students have a decrease in the mineralizing properties of oral fluid with age, but such properties are not significant. There were 540 teenagers who studied at school (107 people), college (317 people), university (116 people) in Chernivtsi. The age children were from 15 to 18 years. The study of the studied indicators was presented by the age and institution in which adolescents study. The hydrogen index (pH) was investigated using a strip of indicator paper (pH 0-12, manufactured by Lachema, Czech Republic). The indicator tape was immersed in oral fluid and the color of the paper was changed. The mineralizing potential of oral fluid was evaluated by its microcrystallization (PA Leus, 1977). Oral fluid collection was performed with a sterile pipette from the bottom of the oral cavity, at least 2 hours after a meal and rinsing with distilled water. Three drops of oral liquid were applied to ethyl alcohol and dried at room temperature. The drops, after drying, were examined using a microscope. The mineralizing potential of oral fluid was determined by the mean score, depending on the identified types of ISS. Evaluation of microcrystallization was performed by H.M. Saifulina, O.R. Pozdeev in average scores depending on the types of crystal formation: 0.1-1.0 - very low level; 1.1- 2.0 - low; 2,1- 3,0 - satisfactory; 3.1-4.0 - high; 4.1-5.0 - very high. The obtained results are processed by the method of variation statistics. Indicators at p£0.05 were considered available. Our research found that the hydrogen index and mineralizing potential of oral fluid in adolescents aged 15-18, who study in college is lower than in other study groups. The hydrogen index of college students increases slightly from 15 years to 17 years and reaches its maximum at 18 years. In schoolchildren and students of the university, an increase in the micro crystallization of oral fluid with age was observed, and decrease was established in college visitors. This indicates the need for preventative work with this cohort to identify risk factors that cause this situation.


Development ◽  
1984 ◽  
Vol 82 (1) ◽  
pp. 131-145
Author(s):  
B. B. Rawdon ◽  
Beverley Kramer ◽  
Ann Andrew

The aim of this experiment was to find out whether or not, at early stages of development, progenitors of the various types of gut endocrine cells are localized to one or more specific regions of the gastrointestinal tract. Transverse strips of blastoderm two to four somites in length were excised between the levels of somites 5 and 27 in chick embryos at 5- to 24-somite stages and were cultured as chorioallantoic grafts. The distribution of endocrine cells in the grafts revealed confined localization of progenitor cells only in the case of insulinimmunoreactive cells. Theprogenitors of cells with somatostatin-, pancreatic polypeptide-, glucagon-, secretin-, gastrin/CCK-, motilin-, neurotensin- and serotonin-like immunoreactivity were distributed along the length of the presumptive gut at the time of explantation; indeed, in many cases they were more widespread than are their differentiated progeny in normal gut of the same age. This finding indicates that conditions in grafts must differ from those that operate in the intact embryo. Also it may explain the occurrence of ectopic gut or pancreatic endocrine cells in tumours of the digestive tract.


2021 ◽  
pp. 60-64
Author(s):  
L.F. Kaskova ◽  
V.A. Honcharenko

The aim of our study was to find out the effect of our proposed treatment and prevention complex, which included oral administration of «Kvertulin» complex drug, «Imupret» drops, «Pikovit» multivitamin drug and «Exodent» local irrigation of the oral cavity with a solution of tooth elixir that influence on the rate of salivation and viscosity of oral fluid in children with chronic catarrhal gingivitis and diabetes mellitus.The treatment and prophylactic measures had positive effect on the homeostasis of the oral cavity, which assisted to reduce the viscosity of the oral fluid, increase the rate of salivation, as evidenced by observation of patients for 6 months. The treatment and prevention complex are recommended to use 2 times a year, as the studied indicators deteriorate over time.


Author(s):  
Snigdha Elaprolu ◽  
Gowri Sankar Marimuthu ◽  
Raghul Sekar ◽  
Sunil Kumar Saxena

<p class="abstract">Unusual foreign bodies in the digestive tract are common in psychiatric patients and children requiring screening of the entire gastrointestinal tract. We here report two cases of unusual ingested blunt foreign body in the upper digestive tract managed differently.</p>


2003 ◽  
Vol 2 (2) ◽  
pp. 99-103
Author(s):  
V. F. Kiritchuk ◽  
A. V. Lepilin ◽  
I. P. Apalkov ◽  
N. L. Yerokina

The aim is the study of EHF-therapy (extremely high frequency therapy) potential for the correction of microcirculatory injuries of patients with chronic generalized periodontitis in postsurgery period: in blood rheological properties and hemostasis system, change of oral fluid ability to coagulation. 42 patients have been examined and treated, including a complex periodontium examination: parodontal recess depth, stomatorrhagia at probing and gum capillary resistance. There have been determined a blood viscosity, erythrocyte aggregation, erythrocyte membrane deformability with rotation viscometer ABR-2; as well as activated partial thromboplastin time, prothrombin time, activity with coagulometer «Sola-Cey 2120» (Byelorussia) using reagents of «Tyekhnologiya-standart» company (Barnaul, Russia). An apparatus «Yavj-1» with wave-length of 5,6 mm with the exposure to biologically active face points (cv-26, cv-27, st-7, st-8) has been used for EHF-therapy. There has been demonstrated that patients with chronic generalized periodontitis had blood rheological and coagulation properties disturbed, that accompanied with the increase of blood viscosity, erythrocyte aggregation, tissue prothrombinase activity and the decrease of blood antithrombin and anticoagulant activity. Patients oral fluid components intensify the disturbances in blood rheological properties due to erythrocyte aggregation increase, and at the same time increase the blood coagulation potential. EHF-therapy recovers the blood rheological properties (its viscosity) more effectively, erythrocyte ability to aggregation and hemostasis system factors in comparison with the traditional treatment.


2003 ◽  
Vol 2 (4) ◽  
pp. 72-79
Author(s):  
V. F. Kiritchuk ◽  
V. Yu. Shirokov

The aim of investigation is to study blood rheological properties in patients with chronic generalised periodontitis combined with gastrointestinal tract disturbances. 205 patients have been examined including those with erosive ulcerous involvement of gastroduodenal area — 51, with stomach ulcer and duodenal ulcer — 62, with chronic colitis — 39, with nonspecific ulcer colitis — 53. Blood viscosity properties, indices of erythrocyte aggregation and deformability, rate of oxygen delivery to tissues have been evaluated by rotary viscometer АBR-2 (Russia). It has been revealed that blood rheological properties in patients with chronic generalised periodontitis combined with gastrointestinal tract disturbances had been disturbed, that was accompanied with the blood viscosity rise, erythrocyte aggregation increase and with the decrease of deformability and rate of oxygen delivery to tissues. The degree of violations in blood rheology indices was mostly expressed under chronic and plural erosions of gastroduodenal area, duodenal ulcer and severe course of chronic nonspecific ulcer colitis.


2013 ◽  
Vol 35 (1) ◽  
pp. 39 ◽  
Author(s):  
Hayley J. Stannard ◽  
Julie M. Old

This paper provides a macro- and microscopic description of the digestive tract of the kultarr (Antechinomys laniger), a small dasyurid marsupial. The digestive tract was simple, with no external differentiation between the small and large intestine, and lacked a caecum. Mean gross length of the kultarr digestive tract was 165.2 ± 32.1 mm. Microscopically, the tissues had cell types similar to those of other mammals. The new information will aid future post-mortem investigations of captive kultarrs and future studies of nutrition.


1980 ◽  
Vol 60 (2) ◽  
pp. 293-301 ◽  
Author(s):  
L. BUENO ◽  
J. FIORAMONTI ◽  
E. GEUX ◽  
Y. RAISSIGUIER

The electrical activity of the gastrointestinal tract and gallbladder was recorded in four sheep fed a Mg-deficient diet during 10 to 15 days. The mitigating effect of intravenous infusions of MgCl2 was tested at the end of the experimental period in animals presenting hypomagnesemia. Motility of the reticulo-rumen remained unchanged in Mg-deficient sheep except that there was no postprandial increased frequency of contractions. By contrast, the contractions of gallbladder, cecum and proximal colon were reduced in both amplitude and frequency. The amplitude but not the frequency of the antro-duodenal slow-waves was reduced. The amplitude of the regular spiking activity of the small intestine was reduced as well as the number of complexes produced per day. The activity of the spiral colon was correlated to the blood magnesium concentrations but Mg infusion was unable to restore immediately the motor profile of the rest of the gut to its intitial level. This was done within 2–3 days by changes in the diet in three of the four animals. It is concluded that the motility of the whole digestive tract, including the reticulo-rumen, is modified on a Mg-deficient diet and that hypomagnesemia, involved in the atony of the spiral colon, is only one of the factors responsible for the hypomotility.


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