scholarly journals Complement C3 and C-Reactive Protein Are Elevated in South Asians Independent of a Family History of Stroke

Stroke ◽  
2006 ◽  
Vol 37 (8) ◽  
pp. 2001-2006 ◽  
Author(s):  
Riyaz Somani ◽  
Peter J. Grant ◽  
Kirti Kain ◽  
Andrew J. Catto ◽  
Angela M. Carter
Keyword(s):  
Family History ◽  
South Asians ◽  
Complement C3 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
History Of

scholarly journals Association of Testosterone, Insulin-Like Growth Factor-I, and C-Reactive Protein with Metabolic Syndrome in Chinese Middle-Aged Men with a Family History of Type 2 Diabetes

2005 ◽  
Vol 90 (12) ◽  
pp. 6418-6423 ◽  
Author(s):  
Peter C. Y. Tong ◽  
Chung-Shun Ho ◽  
Vincent T. F. Yeung ◽  
Maggie C. Y. Ng ◽  
Wing-Yee So ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Family History ◽  
Total Testosterone ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein ◽  
Igf I ◽  
History Of ◽  
Hs Crp

Context: Age-related declines in testosterone and IGF-I are associated with deposition of visceral fat, a component of the metabolic syndrome (MES). Objective: Testosterone and IGF-I may interact with familial disposition to diabetes mellitus to increase the association with MES. Design: We conducted a cross-sectional cohort study. Setting: The study was conducted in a university teaching hospital. Subjects: Study subjects included 179 middle-aged men with a family history of diabetes (FH) (aged 39.1 ± 8.1 yr) and 128 men without FH (aged 43.8 ± 8.5 yr). Main Outcome Measures: Clinical characteristics, frequency of MES using the World Health Organization criteria with Asian definitions of obesity (body mass index ≥ 25 kg/m2), and serum levels of total testosterone, IGF-I, and high-sensitive C-reactive protein (hs-CRP) were measured. Results: Men with FH had higher frequency of MES than those without FH [39.1 vs. 23.4% (P = 0.004)]. On multivariate analysis, smoking (former and current smokers), low total testosterone, and IGF-I but elevated hs-CRP levels explained 35% of the MES variance in men with FH. The frequency of MES increased with declining tertiles of total testosterone and IGF-I but increasing tertiles of hs-CRP. After adjustment for age and smoking history, subjects with all three risk factors had a 13-fold increase in risk association with MES compared with those without hormonal and inflammatory risk factors. These risk associations were not found in men without FH in whom only smoking (ex and current) and low total testosterone level were independent predictors for MES, which explained 14% of the variance. Conclusions: Clustering of FH, hormonal abnormalities, and high hs-CRP is associated with MES in Chinese middle-aged men.

C-reactive protein and family history of myocardial infarction

1999 ◽  
Vol 144 ◽  
pp. 17
Author(s):  
M. Margaglione ◽  
G. Cappucci ◽  
D. Colaizzo ◽  
G. Vecchione ◽  
E. Grandone ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Family History ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
History Of

scholarly journals Correlation of Hemoglobin & C-Reactive Protein Levels with In-hospital Outcome of Patient with Acute Coronary Syndrome

2020 ◽  
Vol 17 (1) ◽  
pp. 3-8
Author(s):  
Md Mahboob Morshed ◽  
Md Joynul Islam ◽  
Fariha Haseen ◽  
Khandokar Shaheed Hussain ◽  
Muhammad Kamrul Amin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Acute Coronary Syndrome ◽  
Family History ◽  
C Reactive Protein ◽  
Hospital Outcome ◽  
Reactive Protein ◽  
Coronary Syndrome ◽  
History Of ◽  
Study Population

Background: Haemoglobina and CRP level may be related with the in-hospital outcome of acute coronary syndrome patients. Objective: The purpose of the present study was to correlate haemoglobin and CRP level with in-hospital outcome of patient with acute coronary syndrome. Methodology: This cross-sectional study was conducted in the Department of Cardiology at Mymensingh Medical College, Mymensingh, Bangladesh from December 2010 to November 2011 for a period of two (02) years. Patients of ACS who were presented within 12 hours of chest pain were included as study population. Study population were categorized in four groups according to the level of hemoglobin and C-reactive protein. Blood sample was collected for baseline laboratory investigations. Result: The mean age of the population was 52.18±8.88 years. Arrhythmia was more common in Group 1 which was 5(71.4%) cases and 6(46.2%) cases in VT and AF respectively. Arrhythmia was significantly correlated with age, sex, diabetes mellitus & CRP. Death was significantly correlated with age, diabetes mellitus, hypertension & CRP. Heart failure was significantly correlated with family history of IHD, CRP & Hemoglobin. Bleeding was only significantly correlated with CRP. No significant association was revealed between the types of arrhythmia and age, sex, smoking, diabetes, dyslipidaemia, family history of IHD and hypertension (P = 0.087). Only heart failure was strongly and significantly correlated with hemoglobin level (p=0.000). Bleeding (p=0.003), heart failure (p=0.022) and death (p=0.016) were significantly correlated with CRP level. Conclusion: In conclusion there is a correlation of haemoglobin and CRP level with in-hospital outcome of patient with acute coronary syndrome. Journal of Science Foundation 2019;17(1):3-8

scholarly journals Effects of Six-Week Endurance Training in Liver Enzymes, Lipid Profile, Interleukin-6 and High-Sensitivity C-Reactive Protein (hs-CRP) Responses in People with a Family History of Coronary Artery Disease

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Farzad Shiri ◽  
Amirabbas Monazzami ◽  
Mohammad Azizi
Keyword(s):  
Family History ◽  
Endurance Training ◽  
Liver Enzymes ◽  
Training Group ◽  
Moderate Intensity ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
History Of ◽  
Hs Crp

Background: Research on the effects of moderate-intensity endurance training on inflammatory indices and cardiovascular risk factors is limited. Objectives: The aim of this study was to determine the effects of six weeks of endurance training on liver enzymes, body composition, fat profile, interleukin-6, and C-reactive protein responses in people with a family history of coronary artery disease (CAD). Methods: Thirty men (30 - 45years) participated in this study who were divided into two groups, including the control group (n = 10) and training group (n = 20) systematically. The training group program consisted of running on a treadmill for 30 minutes with an intensity of 55 to 60% of maximum heart rate. These training programs were continued three times a week for six weeks. The control group did not perform any exercise program. ELISA technique was used to measure lipid profile, liver enzymes, interlukin-6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP), respectively. Results: The results showed that the variables of weight, liver enzymes, fat profile, IL-6, and hs-CRP were significantly different from the pre-test (P < 0.05). Also, in between-group comparison, the results showed that except for the variables of fat percentage and BMI in the other variables of the study, a significant difference was observed (P < 0.05). Conclusions: The results of this study suggest that moderate-intensity endurance training could be used as a useful way to reduce weight, levels of inflammatory markers, liver enzymes and cardiovascular risk factors in people with a family history of CAD.

scholarly journals C-Reactive Protein and Insulin Resistance in Subjects With Thalassemia Minor and a Family History of Diabetes

Diabetes Care ◽  
2002 ◽  
Vol 25 (8) ◽  
pp. 1480-1481 ◽  
Author(s):  
P. C.Y. Tong ◽  
M. C.Y. Ng ◽  
C. S. Ho ◽  
W. Y. So ◽  
J. K.Y. Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Family History ◽  
C Reactive Protein ◽  
Family History Of Diabetes ◽  
Reactive Protein ◽  
Thalassemia Minor ◽  
History Of

Genetic Polymorphism of 5,10-MTHFR Reductase Gene in Offspring of Patients with Myocardial Infarction

1999 ◽  
Vol 82 (07) ◽  
pp. 19-23 ◽  
Author(s):  
Donatella Colaizzo ◽  
Giuseppe Cappucci ◽  
Annamaria del Popolo ◽  
Gennaro Vecchione ◽  
Elvira Grandone ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Family History ◽  
Plasminogen Activator Inhibitor ◽  
Mthfr Gene ◽  
C Reactive Protein ◽  
Plasminogen Activator Inhibitor 1 ◽  
Protein Levels ◽  
Reactive Protein ◽  
History Of ◽  
Activator Inhibitor

SummaryA family history of myocardial infarction is a major determinant of ischemic disease. A C->T677 polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene has been identified as a cause of mild hyperhomocysteinemia, a risk factor for arterial thrombosis. We have investigated the relationship between the MTHFR TT genotype and a family history of myocardial infarction in a cohort of 982 apparently healthy individuals. Subjects whose first-degree relatives suffered from a myocardial infarction, showed raised median age (p <0.001), total cholesterol (p <0.001) and plasma fibrinogen (p = 0.023) and a higher than normal frequency of C-reactive protein levels >0.33 mg/dl (p = 0.012). Moreover, when compared to subjects without such family history, a higher number of homozygotes for the T allele of the MTHFR gene (p = 0.027), and of the 4G allele of the plasminogen activator inhibitor-1 gene (p = 0.002) was found in the subsetting of the offspring of patients with myocardial infarction. In a multiple logistic regression analysis, age (OR 1.02 [95%-CI: 1.00-1.05]), total cholesterol (OR 1.40 [95%-CI: 1.14-1.71]), C-reactive protein levels >0.33 mg/l (OR: 1.87 [95%-CI: 1.10-3.20]), plasminogen activator inhibitor-1 4G/4G (OR: 1.84 [95%-CI: 1.27-2.66]), and MTHFR TT genotype (OR 1.62 [95%-CI: 1.08-2.42]), were all associated with a family history of myocardial infarction. Thus, the MTHFR TT genotype independently accounts for the risk of a family history for myocardial infarction in the present setting.

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