Abstract 16135: Higher Body Mass Index in Early Childhood is Associated With Adult Obesity in Patients With a Fontan Circulation

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Anjali P Chadayammuri ◽  
Tarek ALSAIED ◽  
Adam W Powell ◽  
Samuel G Wittekind ◽  
James Cnota ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Early Childhood ◽  
Body Mass ◽  
Diastolic Pressure ◽  
Fontan Procedure ◽  
Fontan Circulation ◽  
Adult Obesity ◽  
Obese Adults ◽  
Cardiac Testing

Introduction: Obesity is associated with comorbidities that may be detrimental to single-ventricle patients who have had a Fontan procedure. We assessed the prevalence of obesity in adults with a Fontan circulation and evaluated the hypothesis that higher body mass index (BMI) in early childhood is associated with obesity in adulthood. Methods: Retrospective cohort study of patients with a Fontan circulation aged 18-32 years, seen 2011-2019. Those with an atriopulmonary Fontan or chromosomal abnormality known to affect growth were excluded. Historical height and weight measurements, results of recent cardiac testing, and body mass index (BMI) over time were recorded. Obesity was defined as BMI ≥30 kg/m 2 . The associations between childhood anthropometrics, adult BMI, and most recent cardiac testing were assessed. Results: The cohort included 113 adults with a Fontan circulation (median age 22.7 [IQR 20.2-26.4] years; 44% female). There were no significant differences in age, age at Fontan, Fontan type, or ventricular morphology between obese (n=21, 19%; 52% female) and non-obese (n=92, 81%; 41% female) patients. Compared to non-obese adults, obese patients had higher BMI percentiles at age 2 years (80 th [33-95] vs 43 rd [13-82] percentile, p=0.02), at age 4 years (90 th [73-93] vs 57 th [22-81] percentile, p=0.002), and at the time of the Fontan procedure (85 th [51-98] vs 20 th [5-57] percentile, p=0.002). Being overweight at time of Fontan (BMI percentile >85%) strongly predicted later obesity (OR=18.3, 95% CI 3.7-90.3, p<0.001). Obese adults had lower peak VO 2 (19.1±5.2 vs 25.5±6.6 mL/kg/min, p<0.001,) a trend to a lower % predicted VO 2 (59±13 vs 65±14% predicted, p=0.06), higher systolic blood pressure (121±17 vs 112±12 mmHg, p=0.007) and higher ventricular end-diastolic pressure (11±4 vs 9±3 mmHg, p= 0.03). Adult BMI weakly correlated with ventricular end-diastolic pressure (r=0.24, p=0.048). Conclusions: Higher BMI in early childhood is associated with obesity in adults with a Fontan circulation. Adult obesity is associated with worse exercise capacity, higher blood pressure, and higher ventricular end-diastolic pressure. Weight interventions in children with a Fontan circulation may help prevent later obesity and its adverse consequences.

scholarly journals Association of accelerated body mass index gain with repeated measures of blood pressure in early childhood

2019 ◽  
Vol 43 (7) ◽  
pp. 1354-1362 ◽  
Author(s):  
Karen M. Eny ◽  
◽  
Jonathon L. Maguire ◽  
David W. H. Dai ◽  
Gerald Lebovic ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Early Childhood ◽  
Body Mass ◽  
Repeated Measures

scholarly journals Maternal hypertensive disorders in pregnancy and early childhood cardiometabolic risk factors: The Generation R Study

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261351
Author(s):  
Dionne V. Gootjes ◽  
Anke G. Posthumus ◽  
Vincent W. V. Jaddoe ◽  
Bas B. van Rijn ◽  
Eric A. P. Steegers
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Early Childhood ◽  
Body Mass ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Childhood Body Mass Index

The objective of this study was to determine the associations between hypertensive disorders of pregnancy and early childhood cardiometabolic risk factors in the offspring. Therefore, 7794 women from the Generation Rotterdam Study were included, an ongoing population-based prospective birth cohort. Women with a hypertensive disorder of pregnancy were classified as such when they were affected by pregnancy induced hypertension, pre-eclampsia or the haemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome during pregnancy. Early childhood cardiometabolic risk factors were defined as the body mass index at the age of 2, 6, 12, 36 months and 6 years. Additionally, it included systolic blood pressure, diastolic blood pressure, total fat mass, cholesterol, triglycerides, insulin and clustering of cardiometabolic risk factors at 6 years of age. Sex-specific differences in the associations between hypertensive disorders and early childhood cardiometabolic risk factors were investigated. Maternal hypertensive disorders of pregnancy were inversely associated with childhood body mass index at 12 months (confounder model: -0.15 SD, 95% CI -0.27; -0.03) and childhood triglyceride at 6 years of age (confounder model: -0.28 SD, 95% CI -0.45; -0.10). For the association with triglycerides, this was only present in girls. Maternal hypertensive disorders of pregnancy were not associated with childhood body mass index at 2, 6 and 36 months. No associations were observed between maternal hypertensive disorders of pregnancy and systolic blood pressure, diastolic blood pressure, body mass index, fat mass index and cholesterol levels at 6 years of age. Our findings do not support an independent and consistent association between maternal hypertensive disorders of pregnancy and early childhood cardiometabolic risk factors in their offspring. However, this does not rule out possible longer term effects of maternal hypertensive disorders of pregnancy on offspring cardiometabolic health.

scholarly journals Effects of Fresh Watermelon Consumption on the Acute Satiety Response and Cardiometabolic Risk Factors in Overweight and Obese Adults

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 595 ◽  
Author(s):  
Tiffany Lum ◽  
Megan Connolly ◽  
Amanda Marx ◽  
Joshua Beidler ◽  
Shirin Hooshmand ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Metabolic Diseases ◽  
Insulin Response ◽  
Postprandial Glucose ◽  
Overweight And Obesity ◽  
Daily Consumption ◽  
Obese Adults

Although some studies have demonstrated the beneficial effects of watermelon supplementation on metabolic diseases, no study has explored the potential mechanism by which watermelon consumption improves body weight management. The objective of this study was to evaluate the effects of fresh watermelon consumption on satiety, postprandial glucose and insulin response, and adiposity and body weight change after 4 weeks of intervention in overweight and obese adults. In a crossover design, 33 overweight or obese subjects consumed watermelon (2 cups) or isocaloric low-fat cookies daily for 4 weeks. Relative to cookies, watermelon elicited more (p < 0.05) robust satiety responses (lower hunger, prospective food consumption and desire to eat and greater fullness). Watermelon consumption significantly decreased body weight, body mass index (BMI), systolic blood pressure and waist-to-hip ratio (p ≤ 0.05). Cookie consumption significantly increased blood pressure and body fat (p < 0.05). Oxidative stress was lower at four week of watermelon intervention compared to cookie intervention (p = 0.034). Total antioxidant capacity increased with watermelon consumption (p = 0.003) in blood. This study shows that reductions in body weight, body mass index (BMI), and blood pressure can be achieved through daily consumption of watermelon, which also improves some factors associated with overweight and obesity (clinicaltrials.gov, NCT03380221).

Body mass index and age are associated with ventricular end-diastolic pressure in adults with a Fontan circulation

2021 ◽  
pp. 1-6
Author(s):  
Mary Howell ◽  
William E. Anderson ◽  
Jorge Alegria ◽  
Joseph Paolillo ◽  
Matthew C. Schwartz
Keyword(s):  
Body Mass Index ◽  
Multivariate Analysis ◽  
Pulmonary Artery ◽  
Body Mass ◽  
Diastolic Pressure ◽  
Univariate Analysis ◽  
Systolic Pressure ◽  
Fontan Circulation ◽  
Adult Patients ◽  
Ventricular Systolic Pressure

Abstract Introduction: Systemic ventricular end-diastolic pressure is an important haemodynamic variable in adult patients with Fontan circulation. Risk factors associated with elevated end-diastolic pressure have not been clearly identified in this population. Methods: All patients > 18 years with Fontan circulation who underwent cardiac catheterisation at our centre between 1/08 and 3/19 were included. Relevant patient variables were extracted. Univariate and multivariate general linear models were analysed to identify variables associated with end-diastolic pressure. Results: Forty-two patients were included. Median age was 24.0 years (20.9–29.0) with a body mass index of 23.7 kg/m2 (21.5–29.7). 10 (23.8%) patients had a systemic right ventricle. The median (Interquartile range) and mean pulmonary artery pressure were 11.0 mmHg (9.0–12.0) and 16.0 mmHg (13.0–18.0), respectively. On univariate analysis, end-diastolic pressure was positively associated with body mass index (p < 0.01), age > 25 years (p = 0.04), symptoms of heart failure (p < 0.01), systemic ventricular systolic pressure (p = 0.03), pulmonary artery mean pressure (p < 0.01), and taking diuretics (p < 0.01) or sildenafil (p < 0.01). End-diastolic pressure was negatively associated with aortic saturation (p < 0.01). On multivariate analysis, end-diastolic pressure was positively associated with age ≥ 25 years (p < 0.01), and body mass index (p = 0.04). Conclusions: In a cohort of adult patients with Fontan circulation undergoing catheterisation, end-diastolic pressure was positively associated with age ≥ 25 years and body mass index on multivariate analysis. Maintaining a healthy body mass index may offer haemodynamic benefit in adults with Fontan physiology.

scholarly journals HUBUNGAN INDEKS MASSA TUBUH DAN LINGKAR PINGGANG DENGAN TEKANAN DARAH PADA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI

e-CliniC ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Irene Moudy Sumayku ◽  
Karel Pandelaki ◽  
M. C. P. Wongkar
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Cross Section ◽  
Diastolic Pressure ◽  
P Value ◽  
Inclusion Criteria ◽  
P Values ◽  
Test Result

Abstract: Weight gain is very influential on the mechanism of the onset oh hypertension in people who are obese. However, this mechanism is not clearly understood but is suspected in people who are obese increased plasma volume and cardiac output will increase blood pressure. The purpose of this study was to determine the relation of body mass index, waist circumference and blood pressure of student in medical faculty of sam ratulangi university. Methods: This study is an analytical type with cross-section. Survey respondents as many as 127 students of the faculty of medicine UNSRAT that met the inclusion criteria. Respondents measured height, weight, waist circumference and blood pressure before the spearmen test. Result: There was a significant correlation between body mass index with systolic and diastolic blood pressure with p value of 0.001 and 0.004 (p<0.01). There was a significant correlation between waist circumference and systolic blood pressure and diastolic pressure with p values of 0.000 and 0.002 (p<0,01). And there also significant correlation between body mass index with waist circumference with a p value of 0.000 (p<0.01). Conclusion: The increase in body mass index and waist circumference may affect the blood pressure. Keywords: Body Mass Index,Waist Circumference, Blood Pressure.   Abstrak: Kenaikan berat badan (BB) sangat berpengaruh pada mekanisme timbulnya kejadian hipertensi pada orang yang obes akan tetapi mekanisme terjadinya hal tersebut belum dipahami secara jelas namun diduga pada orang yang obes terjadi peningkatan volume plasma dan curah jantung yang akan meningkatkan tekanan darah.Tujuan penelitian ini untuk mengetahui hubungan indeks massa tubuh dan lingkar pinggang dengan tekanan darah pada mahasiswa Fakultas Kedokteran UNSRAT. Metode: Jenis penelitian ini bersifat analitik dengan pendekatan cross-section.Responden penelitian sebanyak 127 mahasiswa Fakultas Kedokteran UNSRAT yang memenuhi kriteri inklusi. Responden di ukur tinggi badan,berat badan, lingkar pinggang dan tekanan darah. Selanjutnya dilakukan uji Spearmen. Hasil penelitian: Terdapat korelasi yang signifikan antara Indeks Massa Tubuh dengan tekanan darah sistolik dan diastolik dengan nilai p sebesar 0,001 dan 0,004 (p<0,01). Ada hubungan yang signifikan antara lingkar pinggang dengan tekanan darah sistolik dan tekanan darah diastolik dengan nilai p sebesar 0,000 dan 0,002 (p<0,01). Dan terdapat juga hubungan yang signifikan antara indeks massa tubuh dengan lingkar pinggang dengan nilai p sebesar 0,000 (p<0,01). Simpulan: Peningkatan Indeks Massa Tubuh dan lingkar pinggang dapat berpengaruh kepada tekanan darah.Kata kunci: IMT,Lingkar Pinggang, Tekanan darah.

scholarly journals Gambaran Tekanan Darah, Indeks Massa Tubuh, dan Aktivitas Fisik pada Mahasiswa Kedokteran Umum Angkatan Tahun 2014

2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Yoel P. Abaa ◽  
Hedison Polii ◽  
Pemsi M. Wowor
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Random Sampling ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Simple Random Sampling ◽  
Normal Body Mass Index ◽  
Cross Sectional

Abstract: This study was aimed to obtain the profile of blood pressure and factors that could influence blood pressure of Medical Faculty students of Sam Ratulangi University of Manado year 2014. This was a descriptive study with a cross sectional design. Study population consisted of 75 students year 2014. Respondents were 48 students obtained by using simple random sampling technique. The results showed that most respondents had normal systolic pressure (41 respondents; 85.4%), normal diastolic pressure (44 respondents; 91.6%), normal body mass index (27 respondents; 56.2%), and low physical activity (43 respondents; 89.6%). Conclusion: Most students had normal systolic blood pressure, normal diastolic blood pressure, normal BMI, and low physical activity.Keywords: blood pressure, body mass index, physical activity Abstrak: Penelitian ini bertujuan untuk mengetahui gambaran tekanan darah dan faktor-faktor yang dapat memengaruhi tekanan darah mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi Manado angkatan tahun 2014. Jenis penelitian ialah deskriptif dengan desain potong lintang. Populasi penelitian ialah seluruh mahasiswa angkatan 2014 Fakultas Kedokteran Universitas Sam Ratulangi yang berjumlah 75 orang. Terdapat 48 responden diperoleh dengan teknik simple random sampling. Hasil penelitian mendapatkan bahwa tekanan sistolik terbanyak ialah kategori normal (41 responden; 85,4%) dan tekanan diastolik terbanyak ialah kategori normal (44 responden; 91,6%). Indeks massa tubuh terbanyak ialah kategori normal (27 responden; 56,2%). Tingkat aktivitas fisik responden terbanyak yaitu aktifitas fisik ringan 43 orang (89,6%). Simpulan: Pada penelitian ini sebagian besar mahasiswa memiliki tekanan darah sistolik kategori normal, tekanan darah diastolik kategori normal, IMT normal, dan aktivitas fisik ringan.Kata kunci: tekanan darah, indeks massa tubuh, dan aktivitas fisik

Study on relations among increase in blood pressure values, dispersions of the myocardial indicator , body mass index and thickness of the skin-fat layer in 15-17 year old schoolchildren in Baku, Azerbaijan

2018 ◽  
Vol 7 (2) ◽  
pp. 69-73
Author(s):  
A. M. Mammadov ◽  
A. Kh. Aliyev ◽  
G. I. Panahova ◽  
A. M. Jafarova
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Heart Rate ◽  
Arterial Pressure ◽  
Body Mass ◽  
Diastolic Pressure ◽  
Beat Frequency ◽  
Heart Beat ◽  
The Body ◽  
Cardiometabolic Syndrome

In this study, relationship among arterial pressure (AP), systolic and diastolic pressure (SBP, DBP), heart beat frequency (HBF), dispersions of the myocardial indicator (MI), heart rate indicator (RI) and Body Mass Index (BMI) in schoolchildren of 15-17 years from Baku (Azerbaijan) were investigated. The results revealed that high values of above-mentioned indicators were gener-ally formed in groups with overweight and great distribution of the thickness of skin-fat layer (TSFL) on torso and top parts of the body. Aforementioned changes in these relationships indicate the formation of cardiometabolic syndrome in schoolchildren.

scholarly journals EFFECT OF LINEAR GROWTH RATE AND CHANGE IN BODY MASS INDEX IN CHILDHOOD AND ADOLESCENCE ON BLOOD PRESSURE IN AFRO-CARIBBEAN YOUTH: THE VULNERABLE WINDOWS COHORT STUDY

2021 ◽  
Author(s):  
Trevor S. Ferguson ◽  
Tamika Y. Royal-Thomas ◽  
Lisa Chin-Harty ◽  
Minerva M. Thame ◽  
Terrence E. Forrester ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Early Childhood ◽  
Cohort Study ◽  
Body Mass ◽  
Gestational Age ◽  
Growth Rates ◽  
Linear Growth ◽  
Early Infancy ◽  
Linear Growth Rate

ABSTRACTBackgroundFaster growth velocity during childhood may increase blood pressure (BP) in adults, but there are little data from African-origin populations. We evaluated the effect of postnatal linear growth (increase in height) and change in body mass index (BMI) from birth to adolescence on systolic and diastolic blood pressure (SBP and DBP) in Afro-Caribbean youth.MethodsWe used data from the Vulnerable Windows Birth Cohort Study in Jamaica. Children were followed from birth, with periodic anthropometric measurements. BP measurements started at age 1-year and every six months thereafter. Analyses used BP measurements (mmHg) from age 15-21 years. Linear growth and change in BMI measurements were calculated for: early infancy (0-6 months), late infancy (6 months - 2 years), early childhood (2-8 years), and later childhood (8-15 years). Conditional analyses were used to compute growth rates (as z-scores). Linear mixed models were used to estimate the effect of growth rates on BP.ResultsAnalyses included 365 individuals (162 males, 203 females) with mean age 16.7 years. In multivariable models, after adjustment for age, sex, birth length, gestational age and BMI at age 15 years, faster linear growth for early infancy (β=1.06, p=0.010) was significantly associated with higher SBP. For change in BMI, after adjustment for age, sex, gestational age, height and SES at birth, significant associations of higher SBP were seen for greater increase in BMI in late infancy (β=1.41, p=0.001), early childhood (β=1.22, p=0.001) and later childhood (β=0.74, p=0.035). Faster post-natal linear growth had no significant associations with DBP, but greater increase in BMI for each of the late infancy to late childhood periods was significantly associated with higher DBP. When both growth rates were modeled together, rate of change of BMI and faster linear growth in early infancy retained significance for SBP, but only change in BMI retained significance for DBP.ConclusionFaster linear growth and greater rate of increase in BMI were associated with higher SBP and DBP in Afro-Caribbean youth, but the BMI effect was stronger.

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