scholarly journals Feline Myeloproliferative Disease. Changing Manifestations in the Peripheral Blood

1978 ◽  
Vol 15 (4) ◽  
pp. 437-448 ◽  
Author(s):  
J. W. Harvey ◽  
R. P. Shields ◽  
J. M. Gaskin
Keyword(s):  
Peripheral Blood ◽  
Severe Anemia ◽  
Erythroid Cells ◽  
Myeloproliferative Disease ◽  
Blood Picture ◽  
Stages Of Development ◽  
Initial Examination ◽  
Progressive Development ◽  
Clinical Recovery ◽  
Erythroid Precursors

A 4 1/2-year-old cat had myeloproliferative disease characterized by severe anemia. Peripheral blood had a profusion of relatively normal-appearing nucleated erythroid cells in all stages of development and a few primitive cells with nucleoli. The term “erythremic myelosis” best described the appearance of the peripheral blood. Two weeks later, the peripheral blood picture was that of regenerative anemia. During the next 2 months the cat made an apparent clinical recovery without treatment, but relapsed 3 months after the initial examination. One-fourth of the cells in circulation at the time of relapse contained nucleoli and appeared identical to those described in reticuloendotheliosis in cats. This transition suggested the progressive development of a greater degree of immaturity of erythroid precursors with time. The use of the term “reticuloendotheliosis” in conjunction with feline myeloproliferative disease was considered and determined inappropriate.

scholarly journals The immunoregulatory function of peripheral blood CD71+ erythroid cells in systemic-onset juvenile idiopathic arthritis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hikaru Kanemasa ◽  
Masataka Ishimura ◽  
Katsuhide Eguchi ◽  
Tamami Tanaka ◽  
Etsuro Nanishi ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Inflammatory Diseases ◽  
Active Phase ◽  
Serum Levels ◽  
Cell Interaction ◽  
Erythroid Cells ◽  
Peripheral Blood Mononuclear ◽  
Systemic Onset

AbstractCD71+ erythroid cells (CECs) are recognized to have an immunoregulatory function via direct cell–cell interaction and soluble mediators. Circulating CECs appear in newborns or patients with hemolytic and cardiopulmonary disorders. To assess the biological role of CECs in systemic inflammation, we studied the gene expression and function in systemic-onset juvenile idiopathic arthritis (SoJIA). Peripheral blood mononuclear cells of SoJIA patients expressed upregulated erythropoiesis-related genes. It represented the largest expansion of CECs during active phase SoJIA among other inflammatory diseases. Despite the opposing roles of erythropoietin and hepcidin in erythropoiesis, both serum levels were in concert with the amounts of SoJIA-driven CECs. Circulating CECs counts in inflammatory diseases were positively correlated with the levels of C-reactive protein, IL-6, IL-18, or soluble TNF receptors. Co-culture with active SoJIA-driven CECs suppressed secretions of IL-1β, IL-6, and IL-8 from healthy donor monocytes. The top upregulated gene in SoJIA-driven CECs was ARG2 compared with CECs from cord blood controls, although cytokine production from monocytes was suppressed by co-culture, even with an arginase inhibitor. CECs are driven to the periphery during the acute phase of SoJIA at higher levels than other inflammatory diseases. Circulating CECs may control excessive inflammation via the immunoregulatory pathways, partly involving arginase-2.

scholarly journals On the question of the blood picture in latent malaria

1921 ◽  
Vol 17 (3) ◽  
pp. 339-351
Author(s):  
R. Zach
Keyword(s):  
Clinical Picture ◽  
Peripheral Blood ◽  
Blood Picture ◽  
The Face

In malarial areas, along with obvious manifestations of malarial diseases, there is, as is known, a significant number of cases of latent malaria, that is, such forms of the latter, when there is no definite clinical picture on the face, nor plasmodia in the peripheral blood.

Growth and Differentiation of Transplanted W/Wv Marrow

Blood ◽  
1967 ◽  
Vol 30 (5) ◽  
pp. 601-616 ◽  
Author(s):  
JERRY P. LEWIS ◽  
LOIS F. O’GRADY ◽  
SELDON E. BERNSTEIN ◽  
ELIZABETH S. RUSSELL ◽  
FRANK E. TROBAUGH
Keyword(s):  
Macrocytic Anemia ◽  
Severe Anemia ◽  
Early Stages ◽  
Erythroid Precursors ◽  
Erythroid Maturation ◽  
Reduced Rate ◽  
Immature Cells ◽  
Erythroid Development ◽  
Mutant Genes ◽  
Late Stages

Abstract This paper reports new data on the effect of the action of the mutant genes W and Wv on murine hemopoiesis. Our studies demonstrate that the presence of these mutant genes produces: (1) a macrocytic anemia with neither granulocytopenia nor thrombocytopenia; (2) a severe defect in the early stages of hemopoietic repopulation manifested by (a) an apparent block in the differentiation of immature cells into erythroid precursors, and (b) a greatly reduced rate of proliferation of differentiated hemopoietic elements. These data demonstrate the existence of genetic influence on repopulation and differentiation of transplanted marrow and suggest that severe anemia may result not only from defects in the late stages of erythroid development but also from abnormalities in the early stages of erythroid maturation and hemopoietic repopulation.

scholarly journals Dynamics of GATA transcription factor expression during erythroid differentiation

Blood ◽  
1993 ◽  
Vol 82 (4) ◽  
pp. 1071-1079 ◽  
Author(s):  
M Leonard ◽  
M Brice ◽  
JD Engel ◽  
T Papayannopoulou
Keyword(s):  
Transcription Factor ◽  
Cell Lines ◽  
Peripheral Blood ◽  
Erythroid Differentiation ◽  
Regulatory Control ◽  
Leukemic Cells ◽  
Erythroid Cells ◽  
Gata Factor ◽  
Erythroid Progenitors ◽  
Factor Expression

Abstract Although the formation of terminally differentiated erythroid cells has been shown to require the presence of a functional GATA-1 gene in vivo, the role of this transcription factor and other members of the GATA family at earlier stages of erythroid differentiation is unclear. In this report, the expression of GATA-1, GATA-2, and GATA-3 has been examined in enriched peripheral blood progenitors before and after culture in a well-characterized liquid culture system. In addition primary leukemic cells as well as several erythroleukemic and nonerythroid cell lines were analyzed for GATA factor expression. The results show that the profile of GATA factor expression in erythroid cells is distinct from that of myeloid or lymphoid lineages. Erythroleukemic cell lines express little or no GATA-3, but high levels of GATA-1 and GATA-2. When they are induced to display the terminal erythroid phenotype, little change in the level of GATA-1 is detected but a significant decline in the levels of GATA-2 is observed commensurate with the degree of maturation achieved by the cells. Enrichment of erythroid progenitors from peripheral blood leads to selection of cells that express both GATA-1 and GATA-2. As the enriched populations are cultured in suspension in the presence of multiple cytokines, the levels of both GATA-1 and GATA-2 initially increase. However, in cultures containing only erythropoietin, which show exclusive erythroid differentiation, the levels of GATA-1 continue to increase, whereas GATA-2 expression declines as erythroid maturation progresses. In contrast, cultures lacking Epo (ie, with interleukin-3 and kit ligand) display limited progression towards both the myeloid and erythroid pathways, and high levels of expression of both GATA-1 and GATA-2 are maintained. Despite the initial upregulation of GATA-1 expression in the latter cultures, terminal erythroid differentiation does not occur in the absence of erythropoietin. These results indicate that GATA-1 upregulation is associated with both the initiation and the maintenance of the erythroid program, but that these two processes appear to be under separate regulatory control. Thus, the dynamic changes in the levels of different GATA factors that occur during primary erythroid differentiation suggest that the levels of these factors may influence the progression to specific hematopoietic pathways.

scholarly journals Anemia in antenatal patients and its outcome: an experience in tertiary care centre

2018 ◽  
Vol 7 (8) ◽  
pp. 3263
Author(s):  
Shabnam Ara ◽  
Cimona Lyn Saldanha ◽  
Insha Khan
Keyword(s):  
Vaginal Delivery ◽  
Serum Ferritin ◽  
Peripheral Blood ◽  
Post Partum ◽  
Tertiary Care ◽  
Deficiency Anemia ◽  
Normal Vaginal Delivery ◽  
Blood Picture ◽  
Co Morbidity ◽  
Term Delivery

Background: Anemia is the most common hematological abnormality detected during the pregnancy and forms a major problem in affecting the females especially in the developing countries.Methods: All pregnant females with clinical evidence of anemia without any other co-morbidity attending the antenatal clinic were included in the study. Patients were studied in terms of the age, parity, inter-pregnancy spacing, type of pregnancy, post-partum outcome along with the biochemical tests like peripheral blood picture, hemoglobin estimation, and serum ferritin levels.Results: Total no. of patients was 500, age ≤20 years were 60 and ≥35 years were 107, mild anemia (10-10.9 gm%) 160, moderate anemia (7-10 gm%) 250, severe anemia (<7 gm%) 90. Normal vaginal delivery with medio-lateral episiotomy was done in 385 patients, normal vaginal delivery without medio-lateral episiotomy in 35 while lower-segment caesarean section in 80 patients. Pre-term delivery was done in 95 patients, post-term delivery in 20. 90 babies delivered were low-birth weight (<2500 gm), antepartum hemorrhage was seen in 10 patients while 20 patients had Post-partum hemorrhage.Conclusions: The present study concludes that anemia is still rampant in the society especially in pregnant women. The main cause of anemia-in-pregnancy is still the iron deficiency anemia. The peripheral blood picture, hemoglobin estimation, and serum ferritin levels form the basic pillars in the evaluation of the etiology and type of anemia. The multiple government sponsored facilities are to be made available to each pregnant female and that requires community, government as well as healthcare professional’s participation.

scholarly journals Idiopathic myelofibrosis mimicking hemolytic anemia

2012 ◽  
Vol 2 (4) ◽  
pp. 324-327
Author(s):  
R Baral ◽  
G Aryal ◽  
KC Shiva Raj
Keyword(s):  
Bone Marrow ◽  
Clinical Course ◽  
Myeloproliferative Disorder ◽  
Severe Anemia ◽  
Idiopathic Myelofibrosis ◽  
Blood Picture ◽  
Bone Marrow Fibrosis ◽  
Hematopoietic Stem ◽  
Chronic Myeloproliferative Disorder ◽  
Marrow Fibrosis

Idiopathic Myelofibrosis is an infrequent chronic myeloproliferative disorder characterized by varying degrees of bone marrow fibrosis and extra medullary hematopoiesis, with the fibrosis being a reactive phenomenon to a neoplastic proliferation of a pluripotent hematopoietic stem cell. Idiopathic Myelofibrosis is heterogeneous in presentation and clinical course, with anemia being one of the most important problems. We present a case of a 59 year old male who presented with severe anemia, the peripheral blood picture mimicking hemolysis with numerous schistocytes and teardrop cells.Journal of Pathology of Nepal (2012) Vol. 2, 323-327DOI: http://dx.doi.org/10.3126/jpn.v2i4.6888

The development and pathogenesis of Leucocytozoon simondi in Canada and domestic geese in Algonquin Park, Ontario

1976 ◽  
Vol 54 (5) ◽  
pp. 634-643 ◽  
Author(s):  
Sherwin S. Desser ◽  
Andrée K. Ryckman
Keyword(s):  
Red Blood Cells ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Primary Infection ◽  
Clinical Signs ◽  
Peripheral Circulation ◽  
Branta Canadensis ◽  
Canada Geese ◽  
Severe Anemia ◽  
Branta Canadensis Interior

The development of Leucocytozoon simondi was studied in naturally and experimentally infected Branta canadensis maxima, Branta canadensis interior, and Anser domesticus. The number of mature round gametocytes in the peripheral blood of the Canada geese increased between days 9 and 15 post exposure (PE) and decreased rapidly thereafter. Mean peak parasitemias recorded on day 13 PE were (per 1000 red blood cells (RBC)): 8 gametocytes in B.c. maxima, 16 gametocytes in B.c. interior, and 17 gametocytes in A. domesticus. About 3 weeks PE, gametocytes disappeared from the peripheral circulation and were not observed again during the autumn, winter, and spring in birds kept in the laboratory.Haematocrit determinations in the Canada geese revealed a low fluctuating anemia during the primary infection which subsided by day 21 PE. A more severe anemia was recorded in A. domesticus with a mean low packed RBC value of about 18% on day 11 PE. Immature and mature hepatic schizonts were observed in the Canada and domestic geese between days 3 and 8 PE. Neither megaloschizonts nor elongate gametocytes were seen. Clinical signs, pathology, and mortality commonly associated with L. simondi infection in ducks were not observed. Hypotheses are advanced to explain reports of severe pathogenesis associated with L. simondi infections in Canada geese in other localities.

scholarly journals Severe anemia and adverse pregnancy outcome in a tertiary care hospital in North India

2018 ◽  
Vol 7 (2) ◽  
pp. 483
Author(s):  
Premlata Yadav
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Peripheral Blood ◽  
Tertiary Care ◽  
Significant Risk ◽  
North India ◽  
Deficiency Anemia ◽  
Care Hospital ◽  
Severe Anemia ◽  
In Pregnancy

Background: Anaemia is commonest medical disorder in pregnancy with 88% prevalence in India mainly due to ignorance, poverty and gender bias. 40-60% of maternal deaths in developing countries. According to the recent standard laid down by WHO anemia is present when the hemoglobin (Hb) concentration in the peripheral blood is less than 11 gm/dl. The most common cause of anemia in pregnancy is iron deficiency. Anemia is diagnosed by estimating the hemoglobin concentration and examining a peripheral blood smear for the characteristic red blood cell changes. The aim of the study was to determine the association between severe anemia, maternal and perinatal complications.Methods: Case control study was done in department of Obstetrics and Gynecology, Rajendra Institute of Medical Sciences Ranchi, India from February 2016 to July 2016. 100 pregnant women, admitted for delivery and having severe anemia were studied and compared with 100 non-anaemic women of similar demographic features. Maternal and perinatal complications were observed. Pearson, chi-square and Fischer exact tests were used to calculate significance of results.Results: Of the severely anaemic mothers, 36% babies were low birth weight (p=0.042) and 20% were small for gestational age (p = 0.026), as compared to 18% and 10% of controls, respectively.Conclusions: Severe maternal anemia carries significant risk of hemorrhage and infection in the mother. It is also associated with preterm birth, low birth weight.

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