The Impact of Health Claims on Consumer Search and Product Evaluation Outcomes: Results from FDA Experimental Data

Sambucus nigra L. (S. nigra) is a shrub widespread in Europe and western Asia, traditionally used in medicine, that has become popular in recent years as a potential source of a wide range of interesting bioactive compounds. The aim of the present work was to develop a topical S. nigra extract formulation based on ethosomes and thus to support its health claims with scientific evidence. S. nigra extract was prepared by an ultrasound-assisted method and then included in ethosomes. The ethosomes were analyzed in terms of their size, stability over time, morphology, entrapment capacity (EC), extract release profile, stability over time and several biological activities. The prepared ethosomes were indicated to be well defined, presenting sizes around 600 nm. The extract entrapment capacity in ethosomes was 73.9 ± 24.8%, with an interesting slow extract release profile over 24 h. The extract-loaded ethosomes presented collagenase inhibition activity and a very good skin compatibility after human application. This study demonstrates the potential use of S. nigra extract incorporated in ethosomes as a potential cosmeceutical ingredient and on further studies should be performed to better understand the impact of S. nigra compounds on skin care over the time.

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Governance of differential stakeholder interests in supply chains and networks

Journal on Chain and Network Science ◽

10.3920/jcns2013.1001 ◽

2013 ◽

Vol 13 (2) ◽

pp. 99-105 ◽

Cited By ~ 1

Author(s):

E.F.M. Wubben ◽

H.J. Bremmers ◽

P.T.M. Ingenbleek ◽

A.E.J. Wals

Keyword(s):

Social Sciences ◽

Business Models ◽

Production Systems ◽

Stakeholder Management ◽

Data Gathering ◽

Health Claims ◽

Stakeholder Dialogue ◽

Stakeholder Interests ◽

Multi Stakeholder ◽

The Impact

Competing frames and interests regarding food provision and resource allocation, adding to the increased global interdependencies, necessitate agri-food companies and institutions to engage themselves in very diverse multi-stakeholder settings. To develop new forms of interaction, and governance, researchers with very different backgrounds in social sciences try to align, or at least share, research trajectories. This first paper in a special issue on governance of differential stakeholder interests discusses, first, different usages of stakeholder categories, second, the related intersubjectivity in sciences, third, an rough sketch of the use of stakeholder management in different social sciences. Social science researchers study a wide variety of topics, such as individual stakeholder impact on new business models, stakeholder group responses to health claims, firm characteristics explaining multi-stakeholder dialogue, and the impact of multi-stakeholder dialogue on promoting production systems, and on environmental innovations. Interestingly, researchers use very different methods for data gathering and data analysis.

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SOME CHARACTERISTICS OF THE COMPOUND MULTIPLICITY IN HIGH-ENERGY NUCLEUS–NUCLEUS INTERACTIONS

International Journal of Modern Physics E ◽

10.1142/s0218301311019532 ◽

2011 ◽

Vol 20 (08) ◽

pp. 1735-1754 ◽

Cited By ~ 8

Author(s):

M. MOHERY ◽

M. ARAFA

Keyword(s):

Experimental Data ◽

Impact Parameter ◽

Mass Number ◽

Multiplicity Distribution ◽

High Energy ◽

Projectile Nucleus ◽

Target Mass ◽

Compound Multiplicity ◽

Multiplicity Distributions ◽

The Impact

The present paper deals with the interactions of 22 Ne and 28 Si nuclei at (4.1–4.5)A GeV /c with emulsion. Some characteristics of the compound multiplicity nc given by the sum of the number of shower particles ns and grey particles ng have been investigated. The present experimental data are compared with the corresponding ones calculated according to modified cascade evaporation model (MCEM). The results reveal that the compound multiplicity distributions for these two reactions are consistent with the corresponding ones of MCEM data. It can also be seen that the peak of these distributions shifts towards a higher value of nc with increasing projectile mass. It may further be seen that the compound multiplicity distributions becomes broader with increasing target size and its width increases with the size of the projectile nucleus. In addition, it has been found that the MCEM can describe the compound multiplicity characteristics of the different projectile, target and the correlation between different emitted particles. The values of average compound multiplicity increase with increasing mass of the projectile. Furthermore, it is observed that while the value of 〈nc〉 depends on the mass number of the projectile Ap and the target mass number At, the value of the ratio 〈nc〉/D(nc) seems to be independent of Ap and At. The impact parameter is found to affect the shape of the compound multiplicity distribution. Finally, the dependence of the average compound multiplicity on the numbers of grey and black particles, and the sum of them, is obvious. The values of the slope have been found to be independent of the projectile nucleus.

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What Is the Impact of Prior Authorization on the Incidence of Pediatric Tonsillectomy?

Otolaryngology ◽

10.1177/0194599820969631 ◽

2020 ◽

pp. 019459982096963

Author(s):

Vanessa F. Torrecillas ◽

Kaden Neuberger ◽

Alexander Ramirez ◽

Paul Krakovitz ◽

Jeremy D. Meier

Keyword(s):

Elective Surgery ◽

Lag Time ◽

Cross Sectional Study ◽

Health Claims ◽

Third Party ◽

Prior Authorization ◽

Cross Sectional ◽

Before And After ◽

The Mean ◽

The Impact

Objective Third-party payers advocate for prior authorization (PA) to reduce overutilization of health care resources. The impact of PA in elective surgery is understudied, especially in cases where evidence-based clinical practice guidelines define operative candidacy. The objective of this study is to investigate the impact of PA on the incidence of pediatric tonsillectomy. Study Design Cross-sectional study. Setting Health claims database from a third-party payer. Methods Any pediatric patient who had evaluation for tonsillectomy from 2016 to 2019 was eligible for inclusion. A time series analysis was used to evaluate the change in incidence of tonsillectomy before and after PA. Lag time from consultation to surgery before and after PA was compared with segmented regression. Results A total of 10,047 tonsillectomy claims met inclusion and exclusion criteria. Female patients made up 51% of claims, and the mean age was 7.9 years. Just 1.5% of claims were denied after PA implementation. There was no change in the incidence of tonsillectomy for all plan types ( P = .1). Increased lag time from consultation to surgery was noted immediately after PA implementation by 2.38 days (95% CI, 0.23-4.54; P = .030); otherwise, there was no significant change over time ( P = .98). Conclusion A modest number of tonsillectomy claims were denied approval after implementation of PA. The value of PA for pediatric tonsillectomy is questionable, as it did not result in decreased incidence of tonsillectomy in this cohort.

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The penetration and ricochet of ogive-nosed rigid projectiles obliquely impacting metallic targets

International Journal of Protective Structures ◽

10.1177/20414196211037702 ◽

2021 ◽

pp. 204141962110377

Author(s):

Yaniv Vayig ◽

Zvi Rosenberg

Keyword(s):

Experimental Data ◽

Numerical Simulations ◽

Dynamic Pressure ◽

Oblique Impacts ◽

Simulation Results ◽

The Impact ◽

Penetration Depths ◽

Resistance To Penetration ◽

Good Agreement

A large number of 3D numerical simulations were performed in order to follow the trajectory changes of rigid CRH3 ogive-nosed projectiles, impacting semi-infinite metallic targets at various obliquities. These trajectory changes are shown to be related to the threshold ricochet angles of the projectile/target pairs. These threshold angles are the impact obliquities where the projectiles end up moving in a path parallel to the target’s face. They were found to depend on a non-dimensional entity which is equal to the ratio between the target’s resistance to penetration and the dynamic pressure exerted by the projectile upon impact. Good agreement was obtained by comparing simulation results for these trajectory changes with experimental data from several published works. In addition, numerically-based relations were derived for the penetration depths of these ogive-nosed projectiles at oblique impacts, which are shown to agree with the simulation results.

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Ozone Production With Plasma Discharge: Comparisons Between Activated Air and Activated Fuel/Air Mixture

10.1115/gt2021-60167 ◽

2021 ◽

Author(s):

Ghazanfar Mehdi ◽

Maria Grazia De Giorgi ◽

Donato Fontanarosa ◽

Sara Bonuso ◽

Antonio Ficarella

Keyword(s):

Experimental Data ◽

Plasma Chemistry ◽

Kinetic Scheme ◽

Plasma Discharge ◽

Chemical Kinetic ◽

Ozone Production ◽

Air Plasma ◽

Flammability Limits ◽

Combustion Enhancement ◽

The Impact

Abstract This study focused on the comparative analysis about the production of ozone and active radicals in presence of nanopulsed plasma discharge on air and on fuel/air mixture to investigate its effect on combustion enhancement. This analysis is based on numerical modeling of air and methane/air plasma discharge with different repetition rates (100 Hz, 1000 Hz and 10000 Hz). To this purpose, a two-step approach has been proposed based on two different chemistry solvers: a 0-D plasma chemistry solver (ZDPlasKin toolbox) and a combustion chemistry solver (CHEMKIN software suite). Consequently, a comprehensive chemical kinetic scheme was generated including both plasma excitation reactions and gas phase reactions. Validation of air and methane/air mechanisms was performed with experimental data. Kinetic models of both air and methane/air provides good fitting with experimental data of O atom generation and decay process. ZDPlasKin results were introduced in CHEMKIN in order to analyze combustion enhancement. It was found that the concentrations of O3 and O atom in air are higher than the methane/air activation. However, during the air activation peak concentration of ozone was significantly increased with repetition rates and maximum was observed at 10000 Hz. Furthermore, ignition timings and flammability limits were also improved with air and methane/air activation but the impact of methane/air activation was comparatively higher.

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Abstract P457: Systems Analysis To Understand The Impact Of The CDK Module On Cardiomyocyte Proliferation

Circulation Research ◽

10.1161/res.129.suppl_1.p457 ◽

2021 ◽

Vol 129 (Suppl_1) ◽

Author(s):

Bryana N Harris ◽

Laura Woo ◽

Jeffrey J Saucerman

Keyword(s):

Experimental Data ◽

Cell Cycle ◽

Transcription Factor ◽

Dna Synthesis ◽

Current Knowledge ◽

Cycle Phase ◽

Cyclin D ◽

Cardiomyocyte Proliferation ◽

The Core ◽

The Impact

Rationale: Heart failure is caused by the inability of adult mammalian hearts to overcome the loss of cardiomyocytes (CMs). This is due partly to the limited proliferative capacity of CMs, which exit the cell cycle and do not undergo cell division. Current knowledge in cardiac regeneration lacks an understanding of the molecular regulatory networks that determine whether CMs will progress through the cell cycle to proliferate. Our goal is to use computational modeling to understand the expression and activation levels of the core cell cycle network, specifically cyclins and cyclin-cyclin-dependent kinase (CDK) complexes. Methods: A model of core cell cycle dynamics was curated using previously published studies of CM proliferation regulators. This model incorporates those regulators known to stimulate G1/S and G2/M transitions through the core CDKs. The activity of each of the 22 network nodes (22 reactions) was predicted using a logic-based differential equation approach. The CDK model was then coupled with a minimal ODE model of cell cycle phase distributions and validated based on descriptions and experimental data from the literature. To prioritize key nodes for experimental validation, we performed a sensitivity analysis by stimulating individual knockdown for every node in the network, measuring the fractional activity of all nodes. Results: Our model confirmed that the knockdown of p21 and Rb protein and the overexpression of E2F transcription factor and cyclinD-cdk4 showed an increase in cells going through DNA synthesis and entering mitosis. A combined knockdown of p21 and p27 showed an increase of cells entering mitosis. Cyclin D-cdk4 and p21 overexpression showed a decrease and increase of Rb expression, respectively. Of the 14 model predictions, 12 agreed with experimental data in the literature. A comprehensive knockdown of the model nodes suggests that E2F (a key transcription factor driving DNA synthesis) is positively regulated by cyclin D while negatively regulated by GSK3B, SMAD3, and pRB. Conclusion: This model enables us to predict how cardiomyocytes respond to stimuli in the CDK network and identify potential therapeutic regulators that induce cardiomyocyte proliferation.

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Experimental and Simulation of a Cam and Translated Roller Follower Over a Range of Speeds

Volume 4A: Dynamics, Vibration, and Control ◽

10.1115/imece2016-65506 ◽

2016 ◽

Author(s):

Louay S. Yousuf ◽

Dan B. Marghitu

Keyword(s):

Experimental Data ◽

Lyapunov Exponent ◽

High Resolution ◽

Lyapunov Exponents ◽

Planar Motion ◽

Largest Lyapunov Exponents ◽

Set Up ◽

The Impact ◽

Impact With Friction

In this study a cam and follower mechanism is analyzed. There is a clearance between the follower and the guide. The mechanism is analyzed using SolidWorks simulations taking into account the impact and the friction between the roller follower and the guide. Four different follower guide’s clearances have been used in the simulations like 0.5, 1, 1.5, and 2 mm. An experimental set up is developed to capture the general planar motion of the cam and follower. The measures of the cam and the follower positions are obtained through high-resolution optical encoders (markers). The effect of follower guide’s clearance is investigated for different cam rotational speeds such as 100, 200, 300, 400, 500, 600, 700 and 800 R.P.M. Impact with friction is considered in our study to calculate the Lyapunov exponent. The largest Lyapunov exponents for the simulated and experimental data are analyzed and selected.

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