Quercetin ameliorates atrazine-induced changes in the testicular function of rats

2014 ◽  
Vol 32 (7) ◽  
pp. 1278-1285 ◽  
Author(s):  
Sunny O Abarikwu ◽  
Ebenezer O Farombi
Keyword(s):  
Protective Effect ◽  
Sperm Motility ◽  
Lethal Dose ◽  
Testicular Function ◽  
Lactate Dehydrogenase Activity ◽  
Abnormal Sperm ◽  
Sperm Counts ◽  
Male Wistar Rats ◽  
Induced Changes ◽  
Sexually Mature

The protective effect of quercetin (QT) on atrazine (ATZ)-induced testicular damage in rats was investigated. Sexually mature male Wistar rats (weighing 220–250 g) divided into four groups with six animals in each group were given ATZ (120 mg kg−1; 1/16 of the median lethal dose for an oral dose) and/or QT (10 mg kg−1) daily via gavage for 16 days. By the end of day 16, rats given ATZ alone had significantly lower sperm counts, daily spermatozoa production, and sperm motility and significantly higher abnormal sperm numbers than the untreated control rats. The rats given ATZ alone also had significantly decreased 3β-hydroxtsteroid dehydrogenase (HSD) and 17β-HSD activities than the control rats. Lactate dehydrogenase activity and malondialdehyde levels were significantly increased, whereas superoxide dismutase activity decreased but glutathione levels remain unaffected after ATZ exposure. These changes were reversed toward control values in the QT + ATZ-treated animals, though the sperm motility was 28% below the control levels but was still higher than in the ATZ-treated rats. The results indicate that QT might improve testicular function of rats exposed to ATZ, but its protective effect on sperm motility might be partial.

An investigation into the effects of ketoconazole on testicular function in Wistar rats

1986 ◽  
Vol 111 (2) ◽  
pp. 246-251 ◽  
Author(s):  
A. I. Vawda ◽  
A. G. Davies
Keyword(s):  
Germ Cells ◽  
Wistar Rats ◽  
Term Treatment ◽  
Plasma Testosterone ◽  
Testicular Function ◽  
Sperm Number ◽  
Abnormal Sperm ◽  
Long Term Treatment ◽  
Sexually Mature

Abstract. Ketoconazole was administered orally to sexually mature Wistar rats and testicular function assessed. A single oral dose of 24 mg ketoconazole/kg body weight lowered plasma testosterone and DHT levels by 83 and 50%, respectively within 2 h, without altering gonadotrophin levels. Treatment for up to 7 days decreased epididvmal sperm number and motility and increased the proportion of abnormal sperm. The sperm appeared to be most affected 3 days after a single dose of ketoconazole and recovery had taken place by the seventh day. Daily treatment for up to 90 days also decreased sperm number and motility and increased the proportion of abnormal sperm, but did not affect testicular germ cells. No significant change was noted in the weights of the testis, epididymis, seminal vesicle and prostate; nor was there a change in testicular DNA, RNA and protein contents. Although fertility appeared to be impaired by long-term treatment, some of the treated rats mated successfully.

Protective effect of esterified glucomannan on aflatoxin-induced changes in testicular function, sperm quality, and seminal plasma biochemistry in rams

2014 ◽  
Vol 81 (3) ◽  
pp. 373-380 ◽  
Author(s):  
Mehmet Bozkurt Ataman ◽  
Hasan Hüseyin Dönmez ◽  
Nurcan Dönmez ◽  
Emrah Sur ◽  
Mustafa Numan Bucak ◽  
...  
Keyword(s):  
Protective Effect ◽  
Seminal Plasma ◽  
Sperm Quality ◽  
Testicular Function ◽  
Plasma Biochemistry ◽  
Induced Changes

scholarly journals The Protective Effect of Vitamin E Against Genotoxicity of Lead Acetate Intraperitoneal Administration in Male Rat

2013 ◽  
Vol 5 (4) ◽  
pp. 412-419 ◽  
Author(s):  
Nadia AITHAMADOUCHE ◽  
Nesrine SADI ◽  
Omar KHAROUBI ◽  
Miloud SLIMANI ◽  
Abdelkader AOUES
Keyword(s):  
Vitamin E ◽  
Lead Acetate ◽  
Sperm Morphology ◽  
Intraperitoneal Administration ◽  
Male Rat ◽  
Protective Effects ◽  
Sperm Counts ◽  
Male Wistar Rats ◽  
E 600 ◽  
Sexually Mature

Lead is industrial pollutant that may have toxic effects on the male. The aim of this study was to further investigate the protective effects of vitamin E on lead acetate (Pb) induced reproductive toxicities and genotoxicity effects in male rat. Sexually mature male Wistar rats (weighing 120-160 g) were given Pb (20 mg/Kg) and vitamin E (600 mg/kg/rat) orally for 20 days. The sperm counts, sperm motility, sperm morphology, chromosomal aberrations, FSH, LH and testosterone levels, and histopathological changes in the testes of these rats, were investigated at the end of 20 days. Result revealed a statistically significant (p

scholarly journals Testicular function following oral exposure to Tramadol and Cannabis sativa ethanol extracts in male Wistar rats

2020 ◽  
Vol 8 (2) ◽  
pp. 63-72
Author(s):  
A.O. Ige ◽  
D.T. Oluwole ◽  
M.O. Olaoye ◽  
E.O. Adewoye
Keyword(s):  
Sperm Motility ◽  
Cannabis Sativa ◽  
Serum Testosterone ◽  
Oral Exposure ◽  
Testicular Function ◽  
Global Challenge ◽  
Testicular Dysfunction ◽  
Male Wistar Rats ◽  
Ethanol Extracts ◽  
Testicular Histology

Objective: Substance abuse is a global challenge. This study investigated the effects of two commonly abused substances, tramadol and/or  Cannabis sativa ethanol extracts (ECS), on testicular function in Wistar male rats.Methods: Twenty-animals were equally divided into 4groups that received 0.9%NaCl (0.2ml), tramadol (40mg/kg), ECS (2mg/kg) and tramadol + ECS for 30days, respectively (daily p.o). Following anesthesia, blood samples were obtained and serum testosterone was determined. Testes and  epididymis were harvested and weighed. Sperm motility, viability and counts were evaluated in the epididymis while superoxide dismutase (SOD), catalase, lactate dehydrogenase (LDH) levels and histology (Haematoxylin & Eosin) were evaluated in the testis.Results: Sperm motility, viability, counts, testosterone level and testicular CAT was reduced in all experimental groups compared to control. Relative epididymal weights increased in tramadol only and ECS only compared to control. Testicular SOD was decreased only in the tramadol only and co-treatment (tramadol + ECS), respectively. LDH was increased in the tramadol only treatment group. Testicular histology in tramadol and co-treatment groups showed structural aberrations that are consistent with impaired spermatogenesis, antioxidant depletion and oxidative stress.Conclusion: Abuse of tramadol and/or Cannabis sativa ethanol extracts may predispose to testicular dysfunction resulting from decline in testicular antioxidants, testicular steroidogenesis and spermatogenesis. Keywords: Tramadol, Cannabis sativa, spermatogenic function, oxidative stress, testicular architecture

scholarly journals Effect of a Traditional Herbal Prescription, Kyung-Ok-Ko, on Male Mouse Spermatogenic Ability after Heat-Induced Damage

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Deok-Sang Hwang ◽  
Hyo Geun Kim ◽  
Sodam Park ◽  
Nam Doo Hong ◽  
Jong Hoon Ryu ◽  
...  
Keyword(s):  
Body Weight ◽  
Heat Stress ◽  
Protective Effect ◽  
Sperm Motility ◽  
Modern Concept ◽  
Seminiferous Tubules ◽  
Antioxidant Enzyme Activities ◽  
Testicular Function ◽  
Male Mice ◽  
Testicular Weight

Kyung-Ok-Ko (KOK), a well-known traditional Korean medicinal formula, has long been used to invigorate the essentialqi. This use of KOK may be associated with reproductive ability as a more modern concept. The protective effect of KOK was evaluated against deterioration of testicular function induced by heat exposure in male mice. Male fertility was disrupted by scrotal heat stress at 43°C for 5 weeks. KOK (0.25, 0.50, and 2.00 g/kg/day) was administered orally at 3 h after the stress. To evaluate the protective effect of KOK, body weight, testicular weight, sperm count, sperm motility, and histopathological changes in the testes were evaluated. KOK-treated mice significantly recovered their general health, as evidenced by body weight. KOK-treated mice also showed significantly higher testes weights, sperm counts, and sperm motility than did the heat stress group. KOK-treated mice significantly recovered the morphological appearance of the seminiferous tubules and seminiferous epithelium. Furthermore, KOK-treated mice significantly increased antioxidant enzyme activities and reduced the protein expressions of apoptosis in the testes. KOK significantly protects against heat-induced damage to testicular function in male mice by inhibiting oxidative stress and apoptosis, indicating that KOK may be an effective agent for treatment of heat-induced male infertility.

scholarly journals Space Radiation-Induced Alterations in the Hippocampal Ubiquitin-Proteome System

2021 ◽  
Vol 22 (14) ◽  
pp. 7713
Author(s):  
Alyssa Tidmore ◽  
Sucharita M. Dutta ◽  
Arriyam S. Fesshaye ◽  
William K. Russell ◽  
Vania D. Duncan ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Performance ◽  
Space Radiation ◽  
Label Free ◽  
Proteomic Profiling ◽  
Neurocognitive Deficits ◽  
Male Wistar Rats ◽  
Radiation Induced ◽  
Induced Changes

Exposure of rodents to <20 cGy Space Radiation (SR) impairs performance in several hippocampus-dependent cognitive tasks, including spatial memory. However, there is considerable inter-individual susceptibility to develop SR-induced spatial memory impairment. In this study, a robust label-free mass spectrometry (MS)-based unbiased proteomic profiling approach was used to characterize the composition of the hippocampal proteome in adult male Wistar rats exposed to 15 cGy of 1 GeV/n 48Ti and their sham counterparts. Unique protein signatures were identified in the hippocampal proteome of: (1) sham rats, (2) Ti-exposed rats, (3) Ti-exposed rats that had sham-like spatial memory performance, and (4) Ti-exposed rats that impaired spatial memory performance. Approximately 14% (159) of the proteins detected in hippocampal proteome of sham rats were not detected in the Ti-exposed rats. We explored the possibility that the loss of the Sham-only proteins may arise as a result of SR-induced changes in protein homeostasis. SR-exposure was associated with a switch towards increased pro-ubiquitination proteins from that seen in Sham. These data suggest that the role of the ubiquitin-proteome system as a determinant of SR-induced neurocognitive deficits needs to be more thoroughly investigated.

Effects of Myrtus communis leaf extracts on CdCl2-induced metabolic disturbance in male wistar rats

2020 ◽  
Vol 9 (5) ◽  
pp. 185-192
Author(s):  
Hafsa Dellaoui ◽  
Abdelkrim Berroukche ◽  
Bakhta Bouzouira ◽  
Narimen Taibi ◽  
Mohamed Zouidi ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Methanol Extract ◽  
Cadmium Accumulation ◽  
Male Rats ◽  
Myrtus Communis ◽  
Leaf Extracts ◽  
Male Wistar Rats ◽  
Sugar Levels ◽  
Induced Changes ◽  
Preventive Effects

Cadmium (Cd) is widespread in the environment. Cd toxicity targets liver and renal tissues and generates oxidative stress. Medicinal plants produce antioxidants scavenging reactive oxygen species (ROS) and chelate heavy metals. This study aimed to investigate the preventive effects of Myrtus communis leaves hydro-methanol extract (HME) and aqueous extract (AE) on Cdinduced toxicity. The experiments were carried out, during 30 days, on male rats; GR1 (controls), GR2 treated with CdCl2 (18 mg/kg), GR3 co-treated with HME (1 g/kg) and Cd (18 mg/kg), GR4 co-treated with AE (1 g/kg) and Cd (18 mg/kg), GR5 with HME and GR6 with AE. Cd induced changes in biochemical parameters (transaminases, urea, creatinine and blood sugar)related to hepato renal function, increased tissue mortification and decreased animals’ body weight. While the treatment animals, with M. communis leaves (HME) or (AE), regulated blood sugar levels. Hepatic steatosis and loss of glomeruli were particularly induced either by Cd or a co-treatment with Cd and plant extracts. M. communis extracts (HME and EA) can regulate blood sugar levels and prevent cadmium accumulation.

Hereditary haemochromatosis gene (HFE) H63D mutation shows an association with abnormal sperm motility

2008 ◽  
Vol 36 (7) ◽  
pp. 1709-1714 ◽  
Author(s):  
Aysen Gunel-Ozcan ◽  
M. Murad Basar ◽  
Ucler Kısa ◽  
Handan C. Ankaralı
Keyword(s):  
Sperm Motility ◽  
Hereditary Haemochromatosis ◽  
H63d Mutation ◽  
Abnormal Sperm

scholarly journals The use of Portland cement in the repair of mandibular fractures in rats

2011 ◽  
Vol 26 (6) ◽  
pp. 426-432
Author(s):  
Reginaldo Inojosa Carneiro Campello ◽  
Belmiro Cavalcanti do Egito Vasconcelos ◽  
Gerhilde Callou Sampaio ◽  
Antonio Rolim ◽  
Gabriela Granja Porto
Keyword(s):  
Portland Cement ◽  
Bone Healing ◽  
Soft Tissues ◽  
Lethal Dose ◽  
Mandibular Fracture ◽  
Point Of View ◽  
Control Group ◽  
Mandibular Fractures ◽  
Male Wistar Rats ◽  
Experimental Group

PURPOSE: To evaluate the bone healing of mandibular fractures following the use of Portland cement. METHODS: Thirty-two male Wistar rats were divided into control and experimental groups. In the control group the rats were submitted to a mandibular fracture, which was reduced, and the soft tissues were sutured. In the experimental group the rats had the mandibular fracture reduced and maintained with the Portland cement. The animals were euthanized 7 and 21 days after surgery by injecting a lethal dose of anesthetic. The following variables were studied: weight of the animals, radiographic images, histopathological features and time of surgery. RESULTS: A weight loss was observed in the specimens of both groups at the different times of evaluation, a greater difference in weight before and after surgery being found in the experimental group, which was statistically significant (p <0.05, p = 0.041). From the histological point of view, with a margin of error (5.0%) the only two significant differences (p <0.05) recorded in the variables were "Material deployed" and "Bone resorption" during the evaluations at 7 and 21 days, respectively. CONCLUSION: The Portland cement served to promote bone healing.

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