Association of Daytime Napping and Diagnosed Diabetes in Middle-Aged Premenopausal, Middle-Aged Postmenopausal, and Older Postmenopausal Chinese Women

Purpose: To examine associations of daytime napping and diagnosed diabetes in middle-aged premenopausal, middle-aged postmenopausal, and older postmenopausal Chinese women. Design: Quantitative, cross-sectional. Setting: 2015 cross-sectional data from China Health and Retirement Longitudinal Study. Participants were recruited from 150 counties/districts and 450 villages/resident committees. Participants: Six thousand nine hundred and forty women aged 45 years and older (mean age = 61 years) stratified by age and menopausal status. Measures: The outcome was self-reported diagnosed diabetes. The exposure was self-reported daytime napping (0, >0-≤60, or >60 min/d). Participants were stratified to middle-aged premenopausal, middle-aged postmenopausal, and older postmenopausal women according to their age (≤60 or >60 years) and menopausal status. Analysis: One-way analysis of variance and χ2 tests were conducted to explore differences on characteristics of middle-aged premenopausal, middle-aged postmenopausal, and older postmenopausal women. Multiple logistic regressions were used to estimate adjusted odds ratios (ORs) for diagnosed diabetes according to daytime napping in the total sample, middle-aged premenopausal, middle-aged postmenopausal, and older postmenopausal Chinese women. Results: Participants’ mean self-reported daytime napping duration was 34 minutes. Women who napped more than 60 minutes were more likely to report diagnosed diabetes (OR = 1.39, 95% confidence interval (CI), 1.09-1.76) comparing to those who did not nap, after adjusting for potential confounders. No statistical significance of interaction term between daytime napping and age/menopausal status was detected ( P = .602 and P = .558) among total women. The stratified analysis revealed the significant association among middle-aged postmenopausal women napping more than 60 minutes (OR = 1.81, 95% CI, 1.18-2.77). The association, however, was found to be insignificant in middle-aged premenopausal women and older postmenopausal women. Conclusions: Long daytime nap (>60 min/d) was associated with diagnosed diabetes in middle-aged postmenopausal women in China.

Download Full-text

Association among age, gender, menopausal status and small dense low-density lipoprotein cholesterol: a cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2020-041613 ◽

2021 ◽

Vol 11 (2) ◽

pp. e041613

Author(s):

Toshihide Izumida ◽

Yosikazu Nakamura ◽

Yukihiro Sato ◽

Shizukiyo Ishikawa

Keyword(s):

Postmenopausal Women ◽

Low Density Lipoprotein ◽

Menopausal Status ◽

Density Lipoprotein ◽

Premenopausal Women ◽

Cross Sectional Study ◽

Lipoprotein Cholesterol ◽

Low Density ◽

Low Density Lipoprotein Cholesterol ◽

Cross Sectional

ObjectivesSmall dense low-density lipoprotein cholesterol (sdLDL-C) might be a better cardiovascular disease (CVD) indicator than low-density lipoprotein cholesterol (LDL-C); however, details regarding its epidemiology remain elusive. The present study aimed at evaluating the association between the demographic factors, such as age, gender and menopausal status, and sdLDL-C levels and sdLDL-C/LDL-C ratio in the Japanese population.DesignThis was a cross-sectional study.Setting13 rural districts in Japan, 2010–2017.ParticipantsThis study included 5208 participants (2397 men and 2811 women), who underwent the health mass screening that was conducted in accordance with the medical care system for the elderly and obtained informed consent for this study.ResultsIn total, 517 premenopausal women (mean age ±SD, 45.1±4.2 years), 2294 postmenopausal women (66.5±8.8 years) and 2397 men (64.1±11.2 years) were analysed. In men, the sdLDL-C levels and sdLDL-C/LDL-C ratio increased during younger adulthood, peaked (36.4 mg/dL, 0.35) at 50–54 years, and then decreased. In women, relatively regular increasing trends of sdLDL-C level and sdLDL-C/LDL-C ratio until approximately 65 years (32.7 mg/dL, 0.28), followed by a downward or pleated trend. Given the beta value of age, body mass index, fasting glucose and smoking and drinking status by multiple linear regression analysis, standardised sdLDL-C levels and sdLDL-C/LDL-C ratio in 50-year-old men, premenopausal women and postmenopausal women were 26.6, 22.7 and 27.4 mg/dL and 0.24, 0.15 and 0.23, respectively. The differences between premenopausal and postmenopausal women were significant (p<0.001).ConclusionsSdLDL-C and sdLDL-C/LDL-C ratios showed different distributions by age, gender and menopausal status. A subgroup-specific approach would be necessary to implement sdLDL-C for CVD prevention strategies, fully considering age-related trends, gender differences and menopausal status.

Download Full-text

Urinary Equol is Associated with Bioavailable Testosterone but not Total Testosterone in Women

10.20944/preprints201906.0163.v1 ◽

2019 ◽

Author(s):

Hong-li Dong ◽

Feng Xiong ◽

Qing-wei Zhong ◽

Yi-hong Li ◽

Meng Liu ◽

...

Keyword(s):

Postmenopausal Women ◽

Menopausal Status ◽

Premenopausal Women ◽

Positive Association ◽

Sex Hormone ◽

Sex Hormone Binding Globulin ◽

Total Testosterone ◽

Significant Positive Association ◽

Cross Sectional ◽

Bioavailable Testosterone

Little is known about the association between equol and bioavailable testosterone (BT) in adults. We examined the associations of urinary equol concentrations with serum total, bioavailable and free testosterone (FT), dehydroepiandrosterone sulfide (DHEAS), free androgen index (FAI) and sex hormone-binding globulin (SHBG) concentrations. This cross-sectional study included 1904 women aged 59.7 years. Urinary equol and serum sex hormone concentrations were measured. Overall, urinary equol tended to be inversely associated with bioactive forms of androgenic indices (BT, FT or FAI) but not with total testosterone (TT) or DHEAS. Urinary equol was also positively associated with SHBG. In multi-covariate-adjusted analyses stratified by menopausal status, graded and inverse associations between urinary equol and bioactive forms of androgenic indices (BT, FT and FAI) were observed in postmenopausal women (all p-trends <0.05), but not in premenopausal women. A significant positive association between urinary equol and SHBG was observed only in postmenopausal women. No significant associations were observed between urinary equol and TT or DHEAS in either group. A path analysis indicated that these associations of equol with androgens in postmenopausal women might be mediated by SHBG. Our findings indicated urinary equol exhibited graded and inverse associations with BT or FT but not TT in women.

Download Full-text

Assessment of FMO3 SNPs in Relation to TMAO in Generally Healthy United States Adults

Current Developments in Nutrition ◽

10.1093/cdn/nzab050_007 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 940-940

Author(s):

Kristen James ◽

Erik Gertz ◽

Catherine Kirschke ◽

Liping Huang ◽

Charles Stephensen ◽

...

Keyword(s):

Postmenopausal Women ◽

Cystatin C ◽

A Priori ◽

Menopausal Status ◽

Premenopausal Women ◽

Cross Sectional Study ◽

Full Cohort ◽

Cross Sectional ◽

Relationship Of ◽

The Relationship

Abstract Objectives The hepatic enzyme flavin monooxygenase 3 (FMO3) oxidizes many metabolites including trimethylamine to the atherogenic molecule trimethylamine n-oxide (TMAO). Variants in the open reading frame of the FMO3 gene alter the enzyme's activity; therefore, we genotyped two a priori missense FMO3 SNPs in a cohort of unmedicated healthy adults. We hypothesized that the SNPs might affect the activity of the encoded enzyme leading to reductions in circulating TMAO. FMO3 expression is upregulated by estrogen, thus we also assessed the relationship of the SNPs and TMAO in pre- and postmenopausal women. Methods DNA was extracted from whole blood from 349 subjects (182 women) who were enrolled in a cross-sectional study at the USDA/ARS WHNRC. SNPs rs2266782 (G > A, p.Glu158Lys) and rs2266780 (A > G, p.Glu308Gly) were genotyped using TaqMan SNP genotyping kits and PCR. TMAO was purified from fasted plasma and quantified using high resolution LC-MS. Regression models were built to assess the relationship of the SNPs to TMAO in the full cohort and by self-reported menopausal status in women. Models assessing the full cohort were adjusted for plasma cystatin C and a sex*age interaction, whereas the menopausal analysis was adjusted for cystatin C. Results The cohort's minor allele frequencies were 36.5% and 17.5% for SNPs rs2266782 and rs2266780, respectively, which were consistent with the genome aggregation exome reports. For both SNPs, median TMAO concentrations increased in individuals carrying the risk alleles, however the differences by genotypes were not significant. In women, the AA genotype at rs2266780 was associated with reduced TMAO levels in pre-, but not postmenopausal women (P = 0.01). This effect was not identified in females with AG or GG genotypes, regardless of their menopausal state. Conclusions Effects of the evaluated FMO3 SNPs on TMAO levels were not identified in the full cohort. However, the SNP rs2266780 was associated with reduced TMAO in premenopausal women with the AA genotype but not women with the AG or GG genotypes, nor those who were postmenopausal. This finding reinforces previous observations that risks for cardiovascular diseases increase after menopause in women. Funding Sources The Beef Checkoff, R01HL128572; USDA-ARS 2032–53,000–001–00-D, 2032–51,530–022–00-D, and 2032–51,000-004–00D; NCATS NIH UL1 TR001860.

Download Full-text

Emirati women’s attitudes towards menopause: Implications for health care policy

Post Reproductive Health ◽

10.1177/2053369119848888 ◽

2019 ◽

Vol 25 (2) ◽

pp. 71-79 ◽

Cited By ~ 1

Author(s):

Linda Smail ◽

Ghufran A Jassim ◽

Qasim M Al-Shboul ◽

Afaaf Saeed Hattawi

Keyword(s):

Health Care ◽

Postmenopausal Women ◽

Menopausal Status ◽

Premenopausal Women ◽

Sampling Technique ◽

Cross Sectional ◽

Negative Attitudes ◽

Oral Contraceptive Pills ◽

Reproductive Characteristics ◽

Positive Attitudes

Objectives To investigate the attitudes of Emirati women aged 30–64 years towards menopause and determine the relationships between these attitudes and their sociodemographic and reproductive characteristics. Study design A community-based cross-sectional study was conducted with 497 Emirati women attending five primary health care centres in Dubai using a multistage stratified and clustered random sampling technique. Emirati women were interviewed face-to-face via a structured questionnaire with two parts: sociodemographic and reproductive characteristics and the attitudes towards menopause scale. Results The mean ± S.D. of age was 42.06 years ± 8.716 (median 40 years). Mean age at menopause for the study sample (N = 436) was 49.94 years ± 4.593 (median 50 years). Of the respondents, 36.6% had completed high school, and 41.4% had graduated from university. Approximately, 70.8% of the women were premenopausal, 13.1% were perimenopausal and 16.1% were postmenopausal. Sixty-four percent of the respondents had never used oral contraceptive pills, while 32.9% were past users; 44.6% were employed outside the home. Mean average attitudes score ± S.D. was 2.42 ± 0.26 (minimum score of 1 indicates very negative attitudes, maximum score of 4 indicates very positive attitudes). Statistically significant differences in mean average attitudes score were noted for employment and menopausal status, and mean average attitudes score was positively correlated with age. Premenopausal women held more positive attitudes towards menopause than peri- and postmenopausal women. Conclusions Emirati women displayed neutral to positive attitudes towards menopause and premenopausal women exhibited more negative attitudes towards menopause than postmenopausal women.

Download Full-text

Menopausal Status Dependence of Early Mortality Reduction Due to Diagnosis of Smaller Breast Cancers (T1 v T2-T3): Relevance to Screening

Journal of Clinical Oncology ◽

10.1200/jco.2004.12.139 ◽

2004 ◽

Vol 22 (1) ◽

pp. 102-107 ◽

Cited By ~ 36

Author(s):

Romano Demicheli ◽

Gianni Bonadonna ◽

William J.M. Hrushesky ◽

Michael W. Retsky ◽

Pinuccia Valagussa

Keyword(s):

Postmenopausal Women ◽

Statistical Significance ◽

Menopausal Status ◽

Premenopausal Women ◽

Primary Treatment ◽

Surgical Removal ◽

Breast Cancers ◽

Mortality Reduction ◽

Younger Women ◽

The Difference

Purpose To provide data relevant to the paradoxical mortality excess for women age 40 to 49 years observed during the first 6 to 8 years in the invited group in all mammography screening studies. Patients and Methods In 1,173 patients undergoing mastectomy alone as primary treatment, allocated to subsets according to menopausal status and tumor size, hazard rates for death were calculated. The ratios between the hazard rate for T2-T3 patients and the corresponding value for T1 patients were assessed over time. Results For postmenopausal patients, the ratio appeared to be time-dependent, dropping from the maximum value of approximately 5 at the first year after surgery to a near constant value of approximately 2 after 5 to 6 years. Premenopausal patients, on the contrary, showed a nearly constant ratio of approximately 3. Therefore, although in each T-category the 10-year survival of premenopausal and postmenopausal patients was similar, its time distribution was menopause-dependent. In particular, the difference between cumulative survival of premenopausal and postmenopausal T2-T3 patients attained statistical significance after 3 years. Conclusion The mortality reduction due to the diagnosis of smaller tumors is significantly higher for postmenopausal women than for premenopausal women during early postsurgery time. According to the hypothesis that primary tumor surgical removal, occurring sooner in the invited group than in the control arm of screening trials, results in some acceleration of metastasis development, a greater number of unfavorable events (recurrence and death) should occur in the invited group. We suggest that for younger women, the early balance between benefit from tumor downsizing and harm from surgery-induced metastasis acceleration results in harm. This disadvantage does not occur in postmenopausal women.

Download Full-text

The Association Between 25-hyroxyvitmin D Concentration and Macronutrients Consumption with Obesity-related Variables in Korean Women (P18-062-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz039.p18-062-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Miae Doo ◽

Chunyang Wang ◽

Yoojin Jeon ◽

Hyejin Chun

Keyword(s):

Vitamin D ◽

Chronic Disease ◽

Postmenopausal Women ◽

Interaction Effect ◽

Dietary Protein ◽

Menopausal Status ◽

Premenopausal Women ◽

Science Research ◽

Korean Women ◽

Cross Sectional

Abstract Objectives Deficiency of vitamin D is increasing in worldwide and has been reported to be associated with chronic disease such as obesity, cardiovascular disease, and hypertension. The risk of vitamin D deficiency and chronic disease is related with higher prevalence after menopause. Methods Using a cross-sectional study of 8726 Korean women, this study was investigated combined interaction effect of vitamin D concentration and dietary macronutrients consumption on obesity-related variables in relation to menopausal status. Results The percentage of vitamin D insufficient (vitamin D < 50 nmol/L) in premenopausal and postmenopausal women was 84.5% and 67.7%, respectively. The subjects with vitamin D insufficient group had higher obesity-related variables such as BMI (P = 0.019), FG (P = 0.019), TG (P < 0.001), and HDL-C (P = 0.006) than those in the vitamin D sufficient group (vitamin D ≥ 50 nmol/L). The interaction effect of menopausal status and vitamin D concentration on obesity-related variables significantly differ. The subjects with vitamin D insufficient group among postmenopausal women had higher BMI (P < 0.001), waist circumference (P = 0.011), fasting glucose (P = 0.035) and triglycerides (P = 0.001) compared to those with sufficient group. Also, among only postmenopausal women, the subjects who were vitamin D insufficient, the risk of obesity was significantly increased by 1.1297 (95% CI = 1.078–1.560) using the vitamin D sufficient as reference. However, the obesity-related variables and risk of obesity according to vitamin D concentration did not differ among premenopausal women. Moreover, among the subjects with a low dietary protein consumption, the subjects in vitamin D deficient had an increasing trend in the risk of obesity by 1.308 times (95% CI = 1.039–1.647) than those with sufficient group. However, those findings did not differ among premenopausal women. Conclusions Thus, the risk of obesity due to vitamin D deficient in postmenopausal women may be modified by the consumption of dietary protein. Funding Sources This study was supported by the research funds of Kunsan National University and the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded.

Download Full-text

Exogenous female sex steroid hormones and risk of asthma and asthma-like symptoms: a cross sectional study of the general population

Thorax ◽

10.1136/thx.56.8.613 ◽

2001 ◽

Vol 56 (8) ◽

pp. 613-616

Author(s):

P Lange ◽

J Parner ◽

E Prescott ◽

C Suppli Ulrik ◽

J Vestbo

Keyword(s):

General Population ◽

Postmenopausal Women ◽

Hormone Replacement ◽

Premenopausal Women ◽

Cross Sectional Study ◽

Asthma Medication ◽

Hormonal Contraceptives ◽

Cross Sectional ◽

Heart Study ◽

Prescription Practice

BACKGROUNDRecent evidence suggests a role for hormonal factors in the aetiology of asthma.METHODSData from a large study of women selected from the general population were used to relate treatment with oral hormonal contraceptives (OCP) and postmenopausal hormone replacement therapy (HRT) to the following asthma indicators: self-reported asthma, wheezing, cough at exertion, and use of medication for asthma. The study sample comprised 1536 premenopausal and 3016 postmenopausal women who participated in the third round of the Copenhagen City Heart Study in 1991–4. A total of 377 women were taking OCP (24.5% of premenopausal women) and 458 were on HRT (15.2% of postmenopausal women).RESULTSIn premenopausal women 4.8% reported having asthma. The prevalence of self-reported asthma, wheeze, use of asthma medication, and cough at exertion was not significantly related to use of OCP. In postmenopausal women the prevalence of self-reported asthma was 6.2%. A weak but consistent association was observed between HRT and self-reported asthma (OR 1.42 (95% CI 0.95 to 2.12)), wheeze (OR 1.29 (95% CI 1.02 to 1.64)), cough at exertion (OR 1.34 (95% CI 1.01 to 1.77)), and use of asthma medication (OR 1.45 (95% CI 0.97 to 2.18)).CONCLUSIONSIn this study of the general population no relationship was found between the use of OCP and asthma. Although an association was observed between HRT and asthma and asthma-like symptoms, this was relatively weak and it is concluded that there is no necessity to change present prescription practice.

Download Full-text

Stature is inversely associated with self-reported diabetes in middle-aged Mexican women

Revista Panamericana de Salud Pública ◽

10.26633/rpsp.2017.32 ◽

2017 ◽

Vol 41 ◽

pp. 1

Author(s):

Ruy Lopez-Ridaura ◽

Karl P Puchner ◽

Eduardo Ortiz-Panozo ◽

Isabel Vieitez ◽

Martín Lajous

Keyword(s):

Menopausal Status ◽

Urban Environments ◽

Urban Setting ◽

Mexican Women ◽

Inverse Association ◽

Middle Aged ◽

Cross Sectional ◽

Multivariable Regression Model ◽

Multivariable Regression ◽

Sectional Analysis

Objective. To investigate whether stature is associated with two highly prevalent cardiom- etabolic disorders—diabetes mellitus (DM) and high blood pressure (HBP) —in middle-aged Mexican women. Methods. We conducted a cross-sectional analysis of a sample of 93 481 middle-aged Mexican female teachers, all participating in the Mexican Teachers Cohort (MTC, or ESMaestras) study. We used a multivariable regression model to investigate the association of stature quintiles with the self-reported outcomes of DM and HBP. Results. After adjusting for birth cohort, ethnicity, family history, birthweight, occupation of household’s head during participant’s childhood, menopausal status, and geographical region of birthplace, stature was inversely associated with DM, with the odds for DM being 9% higher in the lowest stature quintile when compared to the highest stature quintile. Stratification for location of residence resulted in confirmation of the above-mentioned findings only in partici- pants living in urban environments. Conclusions. We found an inverse association of stature with DM but not with HBP. Our data suggest that urban setting might be an important effect modifier of this association, which merits further investigation since it might provide valuable insights into the epidemiological transition occurring in developing countries.

Download Full-text

Appraisal of awareness on medical emergencies and its management among dentists in Bhubaneswar, India

Roczniki Państwowego Zakładu Higieny ◽

10.32394/rpzh.2021.0160 ◽

2021 ◽

pp. 193-201

Author(s):

Ramesh Nagarajappa ◽

Ipsita Mahapatra ◽

Dharmashree Satyarup ◽

Sharmistha Mohanty

Keyword(s):

Statistical Significance ◽

Emergency Situation ◽

Total Sample ◽

Chi Square ◽

Cross Sectional ◽

Dental Office ◽

Dental Practitioners ◽

Medical Emergencies ◽

And Gender ◽

Dental Professional

Background. Medical emergencies can be distressing for any dental professional, whether in a dental practice, hospital or other sites. Objectives. To assess the knowledge and awareness of dental practitioners towards medical emergencies and its management in Bhubaneswar. Material and Methods. In this cross-sectional investigation, a self-administered questionnaire which included demographic details and 19 questions regarding knowledge about medical emergencies, was disseminated to a random sample of 183 dentists working in their private dental clinic set up in Bhubaneswar. Chi-square test was used for statistical analysis. Results. Total sample size was 183, out of which 79 (43.17%) were males and 104 (56.83%) were females. The mean age was found out to be 30.7 ± 5.38 years. Practically 96% of the practitioners were not certain enough to deal with the emergency conditions at dental office. Around 67% had not attended any workshop on emergency training. It was amazing to observe that larger part (90%) of the experts didn't possess first aid kit at their dental office. In instances of handling emergency situation at the dental chair no statistical significance (p>0.05) with respect to age and gender was found. Conclusion. This investigation showed that hypothetically dental professionals had better knowledge on medical emergencies yet at the same time they were not equipped efficiently to manage the same at their workplace.

Download Full-text

Abstract P048: A Model Of Chronic Insufficient Sleep Increases Markers Of Insulin Resistance In Postmenopausal But Not Premenopausal Women

Circulation ◽

10.1161/circ.143.suppl_1.p048 ◽

2021 ◽

Vol 143 (Suppl_1) ◽

Author(s):

Faris M Zuraikat ◽

Samantha Scaccia ◽

Ayanna Campbell ◽

Bin Cheng ◽

Marie-Pierre St-Onge

Keyword(s):

Insulin Resistance ◽

Insulin Sensitivity ◽

Adverse Effects ◽

Postmenopausal Women ◽

Menopausal Status ◽

Premenopausal Women ◽

Full Sample ◽

Insulin Levels ◽

Short Sleep ◽

Sleep Condition

Introduction: Insufficient sleep is widely prevalent among US adults and is a risk factor for type 2 diabetes (T2D). Experimental studies show adverse effects of acute, severe short sleep on insulin sensitivity, but it is unclear whether these reflect risks associated with milder short sleep routinely observed in the general population. To date, no study has evaluated the impact of prolonged mild sleep curtailment on markers of insulin resistance in women or whether these effects differ by menopausal status, known to impact insulin sensitivity. Hypothesis: Glucose and insulin levels, as well as a measure of insulin resistance (HOMA-IR), will increase during 6 wk of sleep restriction (SR) relative to adequate sleep (AS). Adverse effects of prolonged short sleep will be exacerbated in postmenopausal women. Methods: Thirty-four women (age: 38±14 y; BMI: 25.6±3.6 kg/m2; n=10 postmenopausal) with adequate habitual total sleep time (TST) (453±33 min) took part in a randomized crossover study with two 6-wk phases: AS and SR. In AS, participants were asked to maintain stable nightly bed and wake times determined from 2 wk of screening with wrist actigraphy and sleep logs. In SR, bedtime was delayed to reduce TST by approximately 1.5 h/night. Sleep was measured continuously using actigraphy and verified weekly for compliance. At wk 0, 3, 4, and 6 fasting blood samples were collected. Outcomes included glucose and insulin levels as well as HOMA-IR scores, calculated from those values. Linear-mixed models tested interactions of sleep condition with week on outcome measures in the full sample and by menopausal status. Results: Sleep condition impacted the change in TST from baseline (P<0.0001), which was reduced in SR and unchanged in AS (-79±6 vs -4±6min). In the full sample, there was no sleep condition by week interactions for glucose (P=0.67), insulin (P=0.14), or HOMA-IR (P=0.16). Similar results were observed in premenopausal women (all P>0.50). However, in postmenopausal women, there was a significant effect of sleep condition on change in insulin (P=0.046) and HOMA-IR (P=0.039) over the 6 wk. In SR, insulin (slope: 0.26±0.28 μU/mL) and HOMA-IR (slope: 0.07±0.08) increased, while AS resulted in reductions in these outcomes (insulin slope: -0.56±0.29 μU/mL; HOMA-IR slope: -0.16±0.08). Conclusions: We provide the first evidence that chronic short sleep, even if mild, adversely affects insulin sensitivity in postmenopausal women. In contrast, maintenance of AS may improve glycemic regulation. Interestingly, prolonged short sleep did not impact markers of insulin resistance in premenopausal women; further investigation into these life-stage related differences, including underlying mechanisms, is warranted. Results suggest that, in postmenopausal women, a group at heightened risk of poor sleep and T2D, achieving adequate sleep may be an effective strategy to improve cardiometabolic health.

Download Full-text