scholarly journals The Role of Hyperthermia in the Multidisciplinary Treatment of Malignant Tumors

2019 ◽  
Vol 18 ◽  
pp. 153473541987634 ◽  
Author(s):  
Yi Cheng ◽  
Shanshan Weng ◽  
Linzhen Yu ◽  
Ning Zhu ◽  
Mengyuan Yang ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Current Literature ◽  
Clinical Studies ◽  
Malignant Tumors ◽  
Multidisciplinary Treatment ◽  
Underlying Mechanism ◽  
Research Area ◽  
Future Prospects ◽  
Cancer Treatments

Hyperthermia is often used in combination with chemotherapy and radiotherapy for cancer treatment. Recently, immunotherapy has become a popular research area, breaking exciting new ground with concurrent immunotherapy and hyperthermia. Much evidence has demonstrated the effectiveness of multidisciplinary synergistic therapy, and the underlying mechanism has been gradually explored. In this review, we focus on the mechanism of various cancer treatments in the current literature and recent advances in hyperthermia. Additionally, we review clinical studies of hyperthermia combined with other therapies in the previous 10 years and propose future prospects for hyperthermia in multidisciplinary synergistic therapy.

scholarly journals Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy

2018 ◽  
Vol 19 (12) ◽  
pp. 3950 ◽  
Author(s):  
Marilina García-Aranda ◽  
Elisabet Pérez-Ruiz ◽  
Maximino Redondo
Keyword(s):  
Cancer Treatment ◽  
World Health ◽  
Apoptosis Resistance ◽  
Hallmarks Of Cancer ◽  
Cancer Treatments ◽  
Over Expression ◽  
Promising Strategy ◽  
Anti Cancer ◽  
Health Organization

Abstract: According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to overcome resistance to chemo- and immunotherapy.

scholarly journals Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2617
Author(s):  
Vitor Rodrigues da Costa ◽  
Rodrigo Pinheiro Araldi ◽  
Hugo Vigerelli ◽  
Fernanda D’Ámelio ◽  
Thais Biude Mendes ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Treatment ◽  
Cancer Biology ◽  
Clinical Applications ◽  
Future Prospects ◽  
Hallmarks Of Cancer ◽  
Cancer Heterogeneity ◽  
Important Health ◽  
Clinical Potential

Cancer is one of the most important health problems and the second leading cause of death worldwide. Despite the advances in oncology, cancer heterogeneity remains challenging to therapeutics. This is because the exosome-mediated crosstalk between cancer and non-cancer cells within the tumor microenvironment (TME) contributes to the acquisition of all hallmarks of cancer and leads to the formation of cancer stem cells (CSCs), which exhibit resistance to a range of anticancer drugs. Thus, this review aims to summarize the role of TME-derived exosomes in cancer biology and explore the clinical potential of mesenchymal stem-cell-derived exosomes as a cancer treatment, discussing future prospects of cell-free therapy for cancer treatment and challenges to be overcome.

scholarly journals The Role of Anesthetic Selection in Perioperative Bleeding

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Koichi Yuki ◽  
James A. DiNardo ◽  
Sophia Koutsogiannaki
Keyword(s):  
Clinical Studies ◽  
Underlying Mechanism ◽  
Critical Component ◽  
Anesthetic Drugs ◽  
Perioperative Bleeding ◽  
The Future ◽  
Future Direction

Perioperative bleeding is one of the major comorbidities associated with surgery. While anesthesia is a critical component to perform surgery, a number of clinical studies supported the contribution of anesthetic drugs to perioperative bleeding. Here, we reviewed the literature on this topic including the underlying mechanism and discussed the future direction on coagulation research in anesthesia.

scholarly journals The growing role of precision and personalized medicine for cancer treatment

TECHNOLOGY ◽  
2018 ◽  
Vol 06 (03n04) ◽  
pp. 79-100 ◽  
Author(s):  
Paulina Krzyszczyk ◽  
Alison Acevedo ◽  
Erika J. Davidoff ◽  
Lauren M. Timmins ◽  
Ileana Marrero-Berrios ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Cancer Treatment ◽  
Cancer Care ◽  
Patient Population ◽  
Effective Drug ◽  
Regulatory Agencies ◽  
Cancer Treatments ◽  
Disease Heterogeneity ◽  
And Personalized Medicine

Cancer is a devastating disease that takes the lives of hundreds of thousands of people every year. Due to disease heterogeneity, standard treatments, such as chemotherapy or radiation, are effective in only a subset of the patient population. Tumors can have different underlying genetic causes and may express different proteins in one patient versus another. This inherent variability of cancer lends itself to the growing field of precision and personalized medicine (PPM). There are many ongoing efforts to acquire PPM data in order to characterize molecular differences between tumors. Some PPM products are already available to link these differences to an effective drug. It is clear that PPM cancer treatments can result in immense patient benefits, and companies and regulatory agencies have begun to recognize this. However, broader changes to the healthcare and insurance systems must be addressed if PPM is to become part of standard cancer care.

scholarly journals The role of herpes and human papillomavirus infection in prostate and bladder carcinogenesis

2022 ◽  
Vol 20 (4) ◽  
pp. 153-161
Author(s):  
L. M. Mikhaleva ◽  
A. A. Kamalov ◽  
G. G. Maryin ◽  
V. K. Karpov ◽  
E. P. Akopyan ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Malignant Tumors ◽  
Hpv Infection ◽  
Research Area ◽  
Scientific Data ◽  
Sexually Transmitted ◽  
Depth Study ◽  
Hpv Types ◽  
Oncogenic Hpv

Human papillomavirus (HPV) is a small epithelial, non-enveloped, double-stranded DNA virus that belongs to the Papillomaviridae family. HPV infection is one of the most common sexually transmitted infections, and certain types of HPV are known to be carcinogenic to humans. According to the scientific literature, there is reliable information about the role of highly oncogenic HPV types in the development of cervical, anal, vulvar, vaginal, penile, and oropharyngeal cancer.Currently, a relevant and promising research area is the study of the role of HPV infection in prostate cancer (PC) and bladder cancer (BC), but scientific data on the potential pathogenetic relationship between these phenomena remain contradictory. An in-depth study of the question how herpes and human papillomavirus affect the origin of malignant tumors of the prostate and bladder, as well as the course of these diseases, and the prognosis of their development can become a source of information for development of new approaches to their diagnosis, prevention, and monitoring of morbidity. This literature review analyzes the results of modern studies on the role of oncogenic HPV types in the carcinogenesis of PC and BC. 

Initial coin offerings: an emergent research area

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Ana Brochado ◽  
Michael Louis Troilo
Keyword(s):  
Current Literature ◽  
Design Methodology ◽  
Semantic Analysis ◽  
Research Area ◽  
Future Research ◽  
Content Type ◽  
Scopus Database ◽  
Future Work ◽  
Initial Coin Offerings

Purpose The purpose of this paper is to identify the main insights current literature offers regarding initial coin offerings (ICOs) and the avenues for future research. Design/methodology/approach The approach consists of a systematic literature review of 130 papers from the SCOPUS database published in English between January 2018 and December 2020, with supplemental semantic analysis of the abstracts to obtain key themes and concepts. Findings Regulation and the determinants of ICO success are the main themes for current research and represent fruitful areas of continued scholarship. The research agenda in ICOs is just beginning and several topics and questions merit future inquiry: the behaviour of issuers and investors, the importance of human capital, the role of intermediaries and infomediaries and the use of signalling. Originality/value To the knowledge, this is one of the first systematic studies of current literature in ICOs. It provides a roadmap for future work on a phenomenon that will only grow in significance.

Role of Nanoparticles in Cancer Therapy

2022 ◽  
pp. 363-388
Author(s):  
Zeeshan Ahmad Bhutta ◽  
Ayesha Kanwal ◽  
Ambreen Ashar ◽  
Moazam Ali ◽  
Ashar Mahfooz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Genetic Material ◽  
Modern Medicine ◽  
Cancer Treatments ◽  
Delivery Methods ◽  
Anticancer Drug Delivery ◽  
Scientific Fields

The rapid growth of nanotechnology towards the development of nanomedicines has improved cancer treatment. Nanomedicine provides the opportunity to implement complex and targeted multifunctional strategies. Today, nanoparticles (NPs) have many uses in a number of scientific fields. In recent years, it has been repeatedly reported that NPs hold a significant place in the regulation of modern medicine by implementing a varying number of clinical approaches like drug carrying substances, genetic material delivery to tumors, as well as in radiography as a contrast media agent. Various nanomaterials based on organic, inorganic, lipid or glycan compounds, and synthetic polymers have been used to develop and improve new cancer treatments. In this chapter, the authors discussed the role of NPs in cancer treatment among various anticancer drug delivery methods.

scholarly journals Performance measurement approach for innovation capability in SMEs

2016 ◽  
Vol 65 (2) ◽  
pp. 162-176 ◽  
Author(s):  
Minna Saunila
Keyword(s):  
Performance Measurement ◽  
Current Literature ◽  
Business Performance ◽  
Research Area ◽  
Future Research ◽  
Innovation Capability ◽  
Content Type ◽  
Body Of Knowledge ◽  
Key Issues

Purpose – The purpose of this paper is to present a framework for improving innovation capability through performance measurement in small- and medium-sized enterprises (SMEs). The development of an organisation’s innovation capability is considered increasingly important in the current literature. Developing such capability is essential, as innovation plays a key role in the survival and growth of organisations. A review of current literature highlights the need for a framework on the development of innovation capability, especially in SMEs. Design/methodology/approach – A literature review was used to form an understanding of previous work in the research area. Previous literature was used to define the key concepts and further to build the conceptual framework. Findings – As a result of the study, a framework for improving innovation capability through performance measurement in SMEs is presented. Key issues that must be addressed are highlighted and discussed. Practical/implications – The paper contains suggestions for improving innovation capability through performance measurement. Using the results of this study, practitioners can enhance their innovation capability by measurement and by taking better account of different situations regarding the development of innovation capability. The framework clarifies the issue of how innovation capability and its determinants can be managed through measurement, and therefore it assists especially SMEs in their attempts to cope with the increasing need for innovation as an asset of their business performance. Originality/value – There are very few examples in the current literature of frameworks for the issue, especially for SMEs. The role of performance measurement in developing innovation capability is also ignored in the current literature. The paper is relevant for academics, as it clarifies the existing body of knowledge and provides a platform for future research.

scholarly journals Role of miR-221/222 in Tumor Development and the Underlying Mechanism

2019 ◽  
Vol 2019 ◽  
pp. 1-15
Author(s):  
Qian Song ◽  
Quanlin An ◽  
Bing Niu ◽  
Xiaoling Lu ◽  
Ning Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Posttranscriptional Regulation ◽  
Blood Circulation ◽  
Cancer Colorectal ◽  
Malignant Tumors ◽  
Tumor Development ◽  
Underlying Mechanism ◽  
Gene Expressions ◽  
Eukaryotic Organisms

MicroRNA-221/222 (miRNA-221/222, miR-221/222) is a noncoding microRNA which is widely distributed in eukaryotic organisms and deeply involved in the posttranscriptional regulation of gene expressions. According to recent studies, abnormal expressions of miR-221/222 are closely related to the occurrence and development of various kinds of malignant tumors. The role of miR-221/222 in tumor development and their potential molecular mechanism in various cancers, including liver cancer, colorectal cancer, cervical cancer, ovarian cancer, and endometrial carcinoma, are summarized and reviewed in this paper. Moreover, the potential translational biomarker role of abnormal miR-221/222 level in tumor or blood circulation for tumor diagnosis is also discussed.

scholarly journals Tackling Resistance to Cancer Immunotherapy: What Do We Know?

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4096
Author(s):  
Soehartati A. Gondhowiardjo ◽  
Handoko ◽  
Vito Filbert Jayalie ◽  
Riyan Apriantoni ◽  
Andreas Ronald Barata ◽  
...  
Keyword(s):  
Immune System ◽  
Cancer Treatment ◽  
Cancer Immunotherapy ◽  
Small Subset ◽  
Mechanisms Of Resistance ◽  
Conventional Surgery ◽  
Cancer Treatments ◽  
Conventional Cancer Treatment ◽  
Combinatorial Treatment

Cancer treatment has evolved tremendously in the last few decades. Immunotherapy has been considered to be the forth pillar in cancer treatment in addition to conventional surgery, radiotherapy, and chemotherapy. Though immunotherapy has resulted in impressive response, it is generally limited to a small subset of patients. Understanding the mechanisms of resistance toward cancer immunotherapy may shed new light to counter that resistance. In this review, we highlighted and summarized two major hurdles (recognition and attack) of cancer elimination by the immune system. The mechanisms of failure of some available immunotherapy strategies were also described. Moreover, the significance role of immune compartment for various established cancer treatments were also elucidated in this review. Then, the mechanisms of combinatorial treatment of various conventional cancer treatment with immunotherapy were discussed. Finally, a strategy to improve immune cancer killing by characterizing cancer immune landscape, then devising treatment based on that cancer immune landscape was put forward.

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