A Meta-Analysis of Driver Eye-Scanning Behavior While Navigating

1995 ◽  
Vol 39 (17) ◽  
pp. 1127-1131 ◽  
Author(s):  
Thomas A. Dingus
Keyword(s):  
Visual Attention ◽  
Meta Analysis ◽  
Low Frequency ◽  
Visual Display ◽  
Graphic Representation ◽  
Baseline Condition ◽  
Left And Right ◽  
Scanning Behavior ◽  
Frequency Occurrence ◽  
Navigation Condition

A meta-comparison of link analyses was performed using two eye scanning studies. One study was an analysis of the Etak navigator performed by Antin, Dingus, Hulse and Wierwille, (1990). Antin and his associates compared the Etak system to a paper map control condition and a memorized route baseline condition. The second study was an evaluation of the TravTek system performed by Dingus, McGehee, Hulse, Jahns, Natarajan, Mollenhauer and Fleischman (1995). The TravTek Camera Car Evaluation tested six different navigation conditions (a TravTek visual display of a full, heading-up route map with voice guidance, the same TravTek route map without voice guidance, a TravTek visual display showing a graphic representation of static turn-by-turn information, the same turn-by-turn screens without voice guidance, a textual paper direction list with large legible font, and a conventional paper map). The eye glance data shown in the comparison of these two studies revealed several interesting findings. In all conditions, scanning of instruments, mirrors and signs/ landmarks was a low frequency occurrence and largely constant. Increases in visual attention by a navigation condition draws attention from forward, left and right roadway scanning resources. Thus, navigating draws upon potentially valuable accident avoidance resources in some circumstances. The eye scanning results also shared the relative benefits of the addition of a highlighted route to a moving map display, the simplification of a visual display from a full map to a turn-by-turn graphic, and the addition of a voice supplement to a navigation aid.

scholarly journals A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Evangelina López de Maturana ◽  
◽  
Juan Antonio Rodríguez ◽  
Lola Alonso ◽  
Oscar Lao ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Functional Analysis ◽  
Genetic Susceptibility ◽  
In Silico ◽  
Complex Disease ◽  
Meta Analysis ◽  
Low Frequency ◽  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Phenotypic Variance

Abstract Background Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic variance. Methods We complemented a new conventional PC GWAS (1D) with genome spatial autocorrelation analysis (2D) permitting to prioritize low frequency variants not detected by GWAS. These were further expanded via Hi-C map (3D) interactions to gain additional insight into the inherited basis of PC. In silico functional analysis of public genomic information allowed prioritization of potentially relevant candidate variants. Results We identified several new variants located in genes for which there is experimental evidence of their implication in the biology and function of pancreatic acinar cells. Among them is a novel independent variant in NR5A2 (rs3790840) with a meta-analysis p value = 5.91E−06 in 1D approach and a Local Moran’s Index (LMI) = 7.76 in 2D approach. We also identified a multi-hit region in CASC8—a lncRNA associated with pancreatic carcinogenesis—with a lowest p value = 6.91E−05. Importantly, two new PC loci were identified both by 2D and 3D approaches: SIAH3 (LMI = 18.24), CTRB2/BCAR1 (LMI = 6.03), in addition to a chromatin interacting region in XBP1—a major regulator of the ER stress and unfolded protein responses in acinar cells—identified by 3D; all of them with a strong in silico functional support. Conclusions This multi-step strategy, combined with an in-depth in silico functional analysis, offers a comprehensive approach to advance the study of PC genetic susceptibility and could be applied to other diseases.

scholarly journals Association between Metabolic Syndrome Components and Cardiac Autonomic Modulation among Children and Adolescents: A Systematic Review and Meta-Analysis

Biology ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 699
Author(s):  
Rashmi Supriya ◽  
Fei-Fei Li ◽  
Yi-De Yang ◽  
Wei Liang ◽  
Julien S. Baker
Keyword(s):  
Risk Factors ◽  
Young People ◽  
Correlation Coefficient ◽  
High Frequency ◽  
Meta Analysis ◽  
Low Frequency ◽  
Autonomic Modulation ◽  
Cross Sectional ◽  
Cross Sectional Studies ◽  
Positive Correlations

Background: the clustering of metabolic syndrome (MetS) risk factors is becoming more prevalent in children, leading to the development of type 2 diabetes (T2D) and cardiovascular diseases in early adulthood. The impact of MetS risk factors on cardiac autonomic modulation (CAM) or vice versa has been noted to track from childhood to pre-adolescence and adolescence. Understating associations in this age group may help to improve the clinical outcomes of the MetS, even when MetS symptoms are not visible. Potential damage from each individual MetS component and the ability to predict early cardiac damage or upcoming cardiovascular events is very important. Therefore, the present systematic review and meta-analysis investigated the associations between CAM and MetS risk factors individually to verify which of the MetS risk components were significantly correlated with heart rate variability (HRV) indices before or at the onset of the MetS among young people. The purpose of this review was to outline the importance of potentially screening HRV indices in young people even with only one MetS risk factor, as a pre-indicator for early cardiovascular risk stratification. Methods: cross-sectional studies that examined the relationship of MetS risk factors with HRV indices were searched using four databases including PubMed, the Cochrane clinical trials library, Medline and the Web of Science. Correlation coefficients with 95% confidence intervals (95% CI), and random effects meta-analyses of the association between MetS risk factors with HRV indices were performed. Results: out of 14 cross-sectional studies and one case-control study, 8 studies (10 data sets) provided association data for the meta-analysis. Our results indicated significant positive correlations for systolic blood pressure (SBP) (correlation coefficient 0.13 (95%CI: 0.06; 0.19), I2 = 47.26%) and diastolic blood pressure (DBP) (correlation coefficient 0.09 (95%CI: −0.01; 0.18), I2 = 0%) with a Low Frequency/High Frequency ratio (LF/HF). Significant negative correlations for waist circumference (WC) (correlation coefficient −0.12 (95%CI: −0.19; −0.04), I2 = 51.50%), Triglycerides (TGs) (correlation coefficient −0.09 (95%CI: −0.15; −0.02), I2 = 0%) and ≥2 MetS risk factors (correlation coefficient −0.10 (95%CI: −0.16; −0.03), I2 = 0%); with high frequency (HF) were revealed. Significant positive correlations for high density lipoprotein (HDL) (correlation coefficient 0.08 (95%CI: 0.05; 0.11), I2 = 0%) and significant negative correlations of ≥2 MetS risk (correlation coefficient −0.04 (95%CI: −0.12; 0.03), I2 = 0.0%) with low frequency (LF) were revealed. Significant negative correlations for TGs (correlation coefficient −0.09 (95%CI: −0.23; 0.05), I2 = 2.01%) with a mean square root of the sum of differences between mean time between two successive intervals (rMSSD) and significant positive correlation of HDL (correlation coefficient 0.09 (95%CI: −0.01; 0.19), I2 = 0.33%) with standard deviation of the time between two successive intervals (SDNN) were also revealed. An Egger’s test indicated that there was no obvious publication bias for any of the above relationships except for TGs and rMSSD. The significance level stipulated for the meta-analysis was p < 0.05. Conclusions: lipid profiles (HDL and TGs), WC and BP were associated with CAM in young people up to the age of 19 years. The use of HRV indices to predict future MetS risk, and relationships with individual risk factors including HDL, BP, WC and TGs, were established. Future studies related to young people (up to the age of 19 years) are recommended to explore the associations reported here further.

scholarly journals Effect of Acupuncture on Heart Rate Variability: A Systematic Review

2014 ◽  
Vol 2014 ◽  
pp. 1-19 ◽  
Author(s):  
Joanne W. Y. Chung ◽  
Vincent C. M. Yan ◽  
Hongwei Zhang
Keyword(s):  
Systematic Review ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
High Frequency ◽  
Healthy Subjects ◽  
Keyword Search ◽  
Data Extraction ◽  
Meta Analysis ◽  
Low Frequency ◽  
Control Group

Aim.To summarize all relevant trials and critically evaluate the effect of acupuncture on heart rate variability (HRV).Method.This was a systematic review with meta-analysis. Keyword search was conducted in 7 databases for randomized controlled trials (RCTs). Data extraction and risk of bias were done.Results.Fourteen included studies showed a decreasing effect of acupuncture on low frequency (LF) and low frequency to high frequency ratio (LF/HF ratio) of HRV for nonhealthy subjects and on normalized low frequency (LF norm) for healthy subjects. The overall effect was in favour of the sham/control group for high frequency (HF) in nonhealthy subjects and for normalized high frequency (HF norm) in healthy subjects. Significant decreasing effect on HF and LF/HF ratio of HRV when acupuncture was performed on ST36 among healthy subjects and PC6 among both healthy and nonhealthy subjects, respectively.Discussion.This study partially supports the possible effect of acupuncture in modulating the LF of HRV in both healthy and nonhealthy subjects, while previous review reported that acupuncture did not have any convincing effect on HRV in healthy subjects. More published work is needed in this area to determine if HRV can be an indicator of the therapeutic effect of acupuncture.

scholarly journals Improving power for robust trans-ethnic meta-analysis of rare and low-frequency variants with a partitioning approach

2014 ◽  
Vol 23 (2) ◽  
pp. 238-244 ◽  
Author(s):  
Sergii Zakharov ◽  
Xu Wang ◽  
Jianjun Liu ◽  
Yik-Ying Teo
Keyword(s):  
Meta Analysis ◽  
Low Frequency

scholarly journals Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4260
Author(s):  
Liana Najjar ◽  
Joshua Sutherland ◽  
Ang Zhou ◽  
Elina Hyppönen
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Meta Analysis ◽  
Low Frequency ◽  
Nucleotide Polymorphisms ◽  
Hydroxyvitamin D ◽  
Quantitative Synthesis ◽  
25 Hydroxyvitamin D

Several observational studies have examined vitamin D pathway polymorphisms and their association with type 1 diabetes (T1D) susceptibility, with inconclusive results. We aimed to perform a systematic review and meta-analysis assessing associations between selected variants affecting 25-hydroxyvitamin D [25(OH)D] and T1D risk. We conducted a systematic search of Medline, Embase, Web of Science and OpenGWAS updated in April 2021. The following keywords “vitamin D” and/or “single nucleotide polymorphisms (SNPs)” and “T1D” were selected to identify relevant articles. Seven SNPs (or their proxies) in six genes were analysed: CYP2R1 rs10741657, CYP2R1 (low frequency) rs117913124, DHCR7/NADSYN1 rs12785878, GC rs3755967, CYP24A1 rs17216707, AMDHD1 rs10745742 and SEC23A rs8018720. Seven case-control and three cohort studies were eligible for quantitative synthesis (n = 10). Meta-analysis results suggested no association with T1D (range of pooled ORs for all SNPs: 0.97–1.02; p > 0.01). Heterogeneity was found in DHCR7/NADSYN1 rs12785878 (I2: 64.8%, p = 0.02). Sensitivity analysis showed exclusion of any single study did not alter the overall pooled effect. No association with T1D was observed among a Caucasian subgroup. In conclusion, the evidence from the meta-analysis indicates a null association between selected variants affecting serum 25(OH)D concentrations and T1D.

scholarly journals The use of ‘PICO for synthesis’ and methods for synthesis without meta-analysis: protocol for a survey of current practice in systematic reviews of health interventions

F1000Research ◽  
2021 ◽  
Vol 9 ◽  
pp. 678
Author(s):  
Miranda S. Cumpston ◽  
Joanne E. McKenzie ◽  
James Thomas ◽  
Sue E. Brennan
Keyword(s):  
Health Systems ◽  
Systematic Reviews ◽  
Current Practice ◽  
Meta Analysis ◽  
Visual Display ◽  
Health Interventions ◽  
Synthesis Process ◽  
Future Research ◽  
Synthesis Methods ◽  
Definition Of

Introduction: Systematic reviews involve synthesis of research to inform decision making by clinicians, consumers, policy makers and researchers. While guidance for synthesis often focuses on meta-analysis, synthesis begins with specifying the ’PICO for each synthesis’ (i.e. the criteria for deciding which populations, interventions, comparators and outcomes are eligible for each analysis). Synthesis may also involve the use of statistical methods other than meta-analysis (e.g. vote counting based on the direction of effect, presenting the range of effects, combining P values) augmented by visual display, tables and text-based summaries. This study examines these two aspects of synthesis. Objectives: To identify and describe current practice in systematic reviews of health interventions in relation to: (i) approaches to grouping and definition of PICO characteristics for synthesis; and (ii) methods of summary and synthesis when meta-analysis is not used. Methods: We will randomly sample 100 systematic reviews of the quantitative effects of public health and health systems interventions published in 2018 and indexed in the Health Evidence and Health Systems Evidence databases. Two authors will independently screen citations for eligibility. Two authors will confirm eligibility based on full text, then extract data for 20% of reviews on the specification and use of PICO for synthesis, and the presentation and synthesis methods used (e.g. statistical synthesis methods, tabulation, visual displays, structured summary). The remaining reviews will be confirmed as eligible and data extracted by a single author. We will use descriptive statistics to summarise the specification of methods and their use in practice. We will compare how clearly the PICO for synthesis is specified in reviews that primarily use meta-analysis and those that do not. Conclusion: This study will provide an understanding of current practice in two important aspects of the synthesis process, enabling future research to test the feasibility and impact of different approaches.

Effect of Compatibility of S-R Mapping on Reactions toward the Stimulus Source

1979 ◽  
Vol 23 (1) ◽  
pp. 420-421
Author(s):  
J. Richard Simon ◽  
Paul E. Sly ◽  
Sivakumar Vilapakkam
Keyword(s):  
Reaction Time ◽  
Choice Reaction Time ◽  
Simon Effect ◽  
Visual Display ◽  
Control Action ◽  
Interesting Aspect ◽  
Left And Right ◽  
Stimulus Source

The purpose of this research was to gain a better understanding of some of the factors which affect the speed of translating information from a visual display into an appropriate control action. The research focused on the concept of “logical recoding” proposed originally by Hedge and Marsh (1975) to explain the results of their study concerning the effect of an irrelevant directional cue (location of a stimulus) on choice reaction time to a relevant symbolic cue (color of the stimulus). Their subjects pressed a green or red key located on the left and right in response to the onset of a green or red stimulus presented in either a left or right window. When subjects were instructed to press the key which was the same color as the stimulus, they reacted faster when the location of the stimulus and response corresponded than when they did not. Hedge and Marsh used the label “Simon effect” to refer to this finding (Simon, 1969; Simon, 1970). The interesting aspect of the Hedge and Marsh findings was that when subjects were instructed to press the alternate colored key, reactions were faster when the location of the stimulus and response key did not correspond than when they corresponded. In other words, reversing the compatibility of S-R mapping produced a reversal of the Simon effect. Hedge and Marsh explained this reversal in terms of logical recoding; i.e., they proposed that with incompatible S-R mapping instructions, subjects recoded the irrelevant location cue as well as the relevant symbolic cue, thus causing them to respond faster on the side opposite the location of the stimulus.

scholarly journals Exome-chip association analysis of intracranial aneurysms

Neurology ◽  
2019 ◽  
Vol 94 (5) ◽  
pp. e481-e488 ◽  
Author(s):  
Femke N.G. van 't Hof ◽  
Dongbing Lai ◽  
Jessica van Setten ◽  
Michiel L. Bots ◽  
Ilonca Vaartjes ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Intracranial Aneurysms ◽  
Matrix Protein ◽  
Meta Analysis ◽  
Low Frequency ◽  
Minor Allele ◽  
Extracellular Matrix Protein ◽  
Fisher Exact Test ◽  
Replication Cohort ◽  
Variant Analysis

ObjectiveTo investigate to what extent low-frequency genetic variants (with minor allele frequencies <5%) affect the risk of intracranial aneurysms (IAs).MethodsOne thousand fifty-six patients with IA and 2,097 population-based controls from the Netherlands were genotyped with the Illumina HumanExome BeadChip. After quality control (QC) of samples and single nucleotide variants (SNVs), we conducted a single variant analysis using the Fisher exact test. We also performed the variable threshold (VT) test and the sequence kernel association test (SKAT) at different minor allele count (MAC) thresholds of >5 and >0 to test the hypothesis that multiple variants within the same gene are associated with IA risk. Significant results were tested in a replication cohort of 425 patients with IA and 311 controls, and results of the 2 cohorts were combined in a meta-analysis.ResultsAfter QC, 995 patients with IA and 2,080 controls remained for further analysis. The single variant analysis comprising 46,534 SNVs did not identify significant loci at the genome-wide level. The gene-based tests showed a statistically significant association for fibulin 2 (FBLN2) (best p = 1 × 10−6 for the VT test, MAC >5). Associations were not statistically significant in the independent but smaller replication cohort (p > 0.57) but became slightly stronger in a meta-analysis of the 2 cohorts (best p = 4.8 × 10−7 for the SKAT, MAC ≥1).ConclusionGene-based tests indicated an association for FBLN2, a gene encoding an extracellular matrix protein implicated in vascular wall remodeling, but independent validation in larger cohorts is warranted. We did not identify any significant associations for single low-frequency genetic variants.

Hemispheric Laterality for Spatial Analysis in Children with Reading Problems

1986 ◽  
Vol 63 (2) ◽  
pp. 537-538 ◽  
Author(s):  
Sarah Grogan
Keyword(s):  
Spatial Perception ◽  
Visual Display ◽  
Spatial Processing ◽  
Poor Readers ◽  
Reading Problems ◽  
Left Hand ◽  
The Poor ◽  
Average Intelligence ◽  
Left And Right ◽  
Average Readers

Lateralisation for tactile-spatial perception was studied in 21 10- to 15-yr.-old boys of average intelligence who were underachieving in reading and 21 matched controls. Controls showed a significant advantage at recognising shapes on a visual display when they had been actively felt with the left hand. There was no difference between left- and right-hand scores in the poor readers. This supports Witelson's (1977) finding that poor readers are less lateralised for spatial-processing than are average readers.

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