scholarly journals A New Chromene Isolated from Ageratum conyzoides

2011 ◽  
Vol 6 (9) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Abiodun Humphrey Adebayo ◽  
Chang-Jiu Ji ◽  
Yu-Mei Zhang ◽  
Wen-Jun He ◽  
Guang-Zhi Zeng ◽  
...  
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Inhibitory Activity ◽  
Cancer Cell Line ◽  
Ethanol Extract ◽  
2D Nmr ◽  
Ageratum Conyzoides ◽  
2D Nmr Spectroscopy ◽  
Whole Plant ◽  
First Time

From the ethanol extract of the whole plant of Ageratum conyzoides L. (Compositae), one new chromene, 2,2-dimethylchromene 7-methoxy-6- O-β-D-glucopyranoside, was isolated, together with thirteen known compounds, seven of which were being reported for the first time. The compounds were all characterized by MS, IR, 1D- and 2D-NMR spectroscopy. 7,3′,5′-Tri- O-methyltricetin (7), precocene II (9), 3,5,7,4′-tetrahydroxyflavone (13) and 5,6,7,3′,4′,5′-hexamethoxyflavone (14) exhibited inhibitory activity on the P-388 cancer cell line with IC50 values of 12.8, 24.8, 3.5 and 7.8 μM respectively, while compound 9 exhibited inhibitory activity on the HT-29 cancer cell line with an IC50 value of 61μM; the others showed no significant cytotoxic activity on the cell lines tested.

Phenylpropanoid and Iridoid Glucosides from the Whole Plant of Hemiphragma heterophyllum and Their alpha-Glucosidase Inhibitory Activities

Planta Medica ◽  
2020 ◽  
Vol 86 (03) ◽  
pp. 205-211
Author(s):  
Yan-Hong Li ◽  
Jia-Meng Dai ◽  
Cui Yang ◽  
Meng-Yuan Jiang ◽  
Yong Xiong ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Ethanol Extract ◽  
2D Nmr ◽  
Positive Control ◽  
Iridoid Glucoside ◽  
2D Nmr Spectroscopy ◽  
Whole Plant ◽  
Ic50 Value ◽  
Iridoid Glucosides ◽  
Alpha Glucosidase

AbstractThree phenylpropanoid glucosides (1 – 3) and one iridoid glucoside (11), together with eleven known glucosides, were isolated from the ethanol extract of the whole plant of Hemiphragma heterophyllum. Their structures were elucidated by means of 1D and 2D NMR spectroscopy, HRMS, and chemical methods. All compounds except 11 and 13 – 15 showed varying degrees of α-glucosidase inhibitory activity. Compounds 5, 9, and 12 were marginally active in the bioassay, while compounds 1 – 4, 6 – 8, and 10 exhibited appreciable inhibitory activity with an IC50 value of 33.6 ~ 83.1 µM, which was much lower than that of the positive control acarbose (IC50 = 310.8 µM).

The Inhibition of Ethanol Extract of Phaleria macrocarpa Stem Bark on COX-2 Expression of HCT116 Colorectal Cancer Cell Line

2019 ◽  
Vol 12 (6) ◽  
pp. 2902
Author(s):  
Ratu Shafira Hanifah ◽  
Nadia Aida Novitarani ◽  
Fadhilah Harmen ◽  
Aryo Tedjo ◽  
Norma Nur Azizah ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Ethanol Extract ◽  
Stem Bark ◽  
Colorectal Cancer Cell ◽  
Colorectal Cancer Cell Line ◽  
Phaleria Macrocarpa ◽  
Cox 2

scholarly journals Anticancer Activities of Chemical Constituents from Leaves and Twigs of Mitrephora winitii

2021 ◽  
Vol 21 (3) ◽  
pp. 699
Author(s):  
Sukee Sukdee ◽  
Puttinan Meepowpan ◽  
Narong Nantasaen ◽  
Siriporn Jungsuttiwong ◽  
Sarinya Hadsadee ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Chemical Constituents ◽  
Cancer Cell Line ◽  
2D Nmr ◽  
Anticancer Activities ◽  
Chromatographic Separations ◽  
Chemical Structures ◽  
Anti Cancer ◽  
First Time ◽  
Mcf 7

The genus Mitrephora has been investigated and its anti-inflammatory, anti-bacterial and anti-parasitical activities were examined along with its potential as an anti-cancer cell line and inhibitor for platelet aggregation. In this work, air-dried leaves and twigs of M. winitii were grounded and extracted with n-hexane, ethyl acetate and methanol, respectively. Chromatographic separations of these extracts led to the isolation of three known compounds and one new compound (compound 2). The chemical structures of these were identified using spectroscopic investigation of 1D- and 2D-NMR and the resulting data confirmed these as stigmasterol (1), (3,4-dimethoxyphenyl)(5-(3,4-dimethoxyphenyl)-4-(hydroxymethyl)tetrahydrofuran-3-yl)methanol (2), diayangambin (3), and methyl-L-inositol (4). The chemical constituents were reported the first time in M. winitii. Compound 2 showed anti-cancer cell lines with ED50 13.07 µg/mL against KB cells and then was tested for cytotoxicity against MCF-7 cells with ED50 11.77 µg/mL.

scholarly journals N-Containing Metabolites from the Marine Sponge Agelas clathrodes

2013 ◽  
Vol 8 (12) ◽  
pp. 1934578X1300801
Author(s):  
Fan Yang ◽  
Rui-Hua Ji ◽  
Jiang Li ◽  
Jian-Hong Gan ◽  
Hou-Wen Lin
Keyword(s):  
South China Sea ◽  
Cell Line ◽  
Cancer Cell ◽  
South China ◽  
Marine Sponge ◽  
Cancer Cell Line ◽  
Spectrometric Analysis ◽  
Chemical Structures ◽  
Naturally Occurring ◽  
First Time

A new bisuracil analogue, 3,3-bis(uracil-1-yl)-propan-1-aminium (1), together with four known N-containing metabolites (2–5), were isolated from the South China Sea sponge Agelas clathrodes. Their chemical structures were established on the basis of spectroscopic and spectrometric analysis and comparison with known compounds. Compound 1 is an unusual naturally occurring bisuracil analogue, and compound 2 was isolated from a natural source for the first time. Compounds 2 and 4 exhibit moderate cytotoxicity against cancer cell line SGC7901.

scholarly journals Flavonoid Constituents of Carduncellus Mareoticus (Del.) Hanelt and their Biological Activities

2008 ◽  
Vol 3 (5) ◽  
pp. 1934578X0800300
Author(s):  
Marwan M. Shabana ◽  
Moshera M. El-Sherei ◽  
Mohamed Y. Moussa ◽  
Amany A. Sleem ◽  
Hosam M. Abdallah
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Biological Activities ◽  
Cancer Cell Line ◽  
Ethanolic Extract ◽  
Ethyl Acetate Fraction ◽  
Moderate Activity ◽  
First Time

The total ethanolic extract (TEE) of Carduncellus mareoticus (Del.) Hanelt showed antioxidant and antihyperlipidemic activities, which were attributed to the ethyl acetate fraction (EAF). Also TEE showed potent cytotoxic activity against a cervix cancer cell line (IC50 = 5 μg/mL) and moderate activity against a breast cancer cell line. Chemical investigation of EAF led to the isolation of a new flavonoid, 8-hydroxy-5-methoxyluteolin 7- O-β-D-glucopyranoside (11), along with ten known metabolites (1–10). Three of these compounds, isorhamnetin 3- O-β-D-glucopyranoside (7), luteolin 3′- O-β-D-glucopyranoside (8), and eriodictyol 7- O-β-D-glucopyranoside (9) are reported for the first time from the genus Carduncellus, and two compounds, chrysoeriol 7- O-β-D-glucopyranoside (6), and luteolin 7- O-β-D-glucopyranoside (10), for the first time from C. mareoticus. The rest of the isolated compounds, chrysoeriol (1), luteolin (2), quercetin (3), kaempferol 3- O-α-L-arabinopyranoside (4), and kaempferol 3- O-β-D-glucopyranoside (5) have been previously reported from the genus.

scholarly journals IN VITRO CYTOTOXIC ACTIVITY OF SECOISOLARICIRESINOL DIGLUCOSIDE ON HT-29, PA-1 CELL LINES, AND α-AMYLASE INHIBITORY ACTIVITY

2019 ◽  
pp. 168-173
Author(s):  
GUNABHUSHANA DADDALA ◽  
SWAROOPARANI A
Keyword(s):  
Cytotoxic Activity ◽  
Cell Line ◽  
Cancer Cell ◽  
Inhibitory Activity ◽  
Ovarian Cancer Cell Line ◽  
Cancer Cell Line ◽  
Secoisolariciresinol Diglucoside ◽  
Human Colon Cancer ◽  
Ht 29

Objective: The present study was conducted to evaluate the in vitro cytotoxic activity and α- amylase inhibitory activity of secoisolariciresinol diglucoside (SDG). Methods: The cytotoxic activity was conducted on HT-29 (human colon cancer cell line) and PA-1 (human ovarian cancer cell line) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and the α- amylase inhibitory activity using acarbose as a standard. Both the tests were evaluated at different concentrations, 3.125–100 μg/ml and 50–2000 μg correspondingly and the concentration required for a 50% inhibition of viability (IC50) was determined graphically. The effect of the samples on the proliferation of HT-29 and PA-1 was expressed as the percentage cell viability. Results: SDG exhibited a considerable dose- and time-dependent inhibition on both HT-29 and PA-1 and also observed a concentration-dependent α-amylase inhibitory activity that leads in reduction of starch hydrolysis and hence eventually to lowered glucose levels. Conclusion: The present in vitro study concluded that SDG can be a potent anticancer and moderate hyperglycemic component.

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