Role of Omega-3 Polyunsaturated Fatty Acids in Treatment of Nasal Polyposis

Background Nasal polyposis is a common disease with steroids either systemic or topical being the key element in its medical treatment. With known side effects of systemic steroids, other anti-inflammatory agents should be evaluated, preferably the natural ones. Objective To evaluate the role of omega-3 polyunsaturated fatty acids in the treatment of nasal polyposis. Methods This is a single-blinded randomized-controlled trial including 164 patients with grade II nasal polyposis receiving a short course of systemic steroids until subsidence of polyposis. Patients were distributed equally after into 2 groups according to maintenance therapy with group I receiving omega-3 fatty acids in a dose of 3 g per day with local budesonide nasal spray and group II receiving only local budesonide nasal spray. Both groups were compared regarding incidence and grade of recurrence of polyposis and duration from onset of maintenance therapy to onset of recurrence. Results A nonsignificant effect for omega-3 was found on the incidence of recurrence of nasal polyposis ( P = .1) and the grade of recurrent polyposis ( P = .66). However, omega-3 intake had a highly significant effect on delaying the incidence of recurrence of polyposis ( P < .0001). Conclusion Omega-3 fatty acid has a beneficial effect on delaying the incidence of recurrence of nasal polyposis through its proven anti-inflammatory mechanism of action. This minimizes the need for systemic steroid administration with its known side effects. Omega-3 fatty acids supplementation should be considered while tailoring the maintenance regimen for medical treatment of chronic rhinosinusitis with nasal polyposis.

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The role of l-carnitine and omega-3 fatty acids in prevent meiotic damages to bovine oocytes matured in vitro with follicular fluid from womem with different stages of endometriosis

Fertility and Sterility ◽

10.1016/j.fertnstert.2018.07.1108 ◽

2018 ◽

Vol 110 (4) ◽

pp. e396-e397

Author(s):

V.S. Giorgi ◽

R.A. ferriani ◽

P. Navarro

Keyword(s):

Fatty Acids ◽

Follicular Fluid ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Bovine Oocytes

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Jumping on the Omega-3 Bandwagon: Distinguishing the Role of Long-Chain and Short-Chain Omega-3 Fatty Acids

Critical Reviews in Food Science and Nutrition ◽

10.1080/10408398.2010.509553 ◽

2012 ◽

Vol 52 (9) ◽

pp. 795-803 ◽

Cited By ~ 33

Author(s):

Giovanni M. Turchini ◽

Peter D. Nichols ◽

Colin Barrow ◽

Andrew J. Sinclair

Keyword(s):

Fatty Acids ◽

Short Chain ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Long Chain

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Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation

Diabetes/Metabolism Research and Reviews ◽

10.1002/dmrr.2414 ◽

2013 ◽

Vol 29 (6) ◽

pp. 431-445 ◽

Cited By ~ 28

Author(s):

Michael R. Flock ◽

Connie J. Rogers ◽

K. Sandeep Prabhu ◽

Penny M. Kris-Etherton

Keyword(s):

Fatty Acids ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Long Chain

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Fish consumption, contaminants and sudden unexpected death in epilepsy: many more benefits than risks

Brazilian Journal of Biology ◽

10.1590/s1519-69842010000300026 ◽

2010 ◽

Vol 70 (3) ◽

pp. 665-670 ◽

Cited By ~ 7

Author(s):

FA. Scorza ◽

RM. Cysneiros ◽

RM. Arida ◽

VC. Terra ◽

HR. Machado ◽

...

Keyword(s):

Fatty Acids ◽

Fish Consumption ◽

Sudden Unexpected Death ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Unexpected Death ◽

Positive Effects ◽

Increased Risk ◽

Fish And Shellfish

People with epilepsy have an increased risk of dying prematurely and the most common epilepsy-related category of death is sudden unexpected death in epilepsy (SUDEP). SUDEP is mainly a problem for patients with chronic uncontrolled epilepsy. The ultimate goal of research in SUDEP is to develop new methods to prevent it and actions other than medical and surgical therapies that could be very useful. Nutritional aspects, i.e., omega-3 fatty acids deficiency, could have an interesting role in this scenario. Some animal and clinical studies have suggested that omega-3 fatty acids could be useful in the prevention and treatment of epilepsy and hence SUDEP. It has been ascertained that the only foods that provide large amounts of omega-3 are seafood (fish and shellfish); however, some fish are contaminated with methylmercury, which may counteract the positive effects of omega-3 fatty acids. Our update review summarises the knowledge of the role of fish consumption on epilepsy research.

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The Role of Omega-3 Polyunsaturated Fatty Acids in Food Intake and Energy Homeostasis

Fatty Acids in Foods and their Health Implications,Third Edition - Food Science and Technology ◽

10.1201/9781420006902.ch35 ◽

2007 ◽

pp. 837-854

Author(s):

Harrison Weisinger ◽

Denovan Begg ◽

Andrew Sinclair ◽

Markandeya Jois ◽

Lauren Stahl ◽

...

Keyword(s):

Fatty Acids ◽

Food Intake ◽

Polyunsaturated Fatty Acids ◽

Energy Homeostasis ◽

Omega 3

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The Role of Micronutrients in Support of the Immune Response against Viral Infections

Nutrients ◽

10.3390/nu12103198 ◽

2020 ◽

Vol 12 (10) ◽

pp. 3198 ◽

Cited By ~ 1

Author(s):

Francesco Pecora ◽

Federica Persico ◽

Alberto Argentiero ◽

Cosimo Neglia ◽

Susanna Esposito

Keyword(s):

Fatty Acids ◽

Immune Response ◽

Immune System ◽

Viral Infections ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Optimal Function ◽

The Impact

Viral infections are a leading cause of morbidity and mortality worldwide, and the importance of public health practices including handwashing and vaccinations in reducing their spread is well established. Furthermore, it is well known that proper nutrition can help support optimal immune function, reducing the impact of infections. Several vitamins and trace elements play an important role in supporting the cells of the immune system, thus increasing the resistance to infections. Other nutrients, such as omega-3 fatty acids, help sustain optimal function of the immune system. The main aim of this manuscript is to discuss of the potential role of micronutrients supplementation in supporting immunity, particularly against respiratory virus infections. Literature analysis showed that in vitro and observational studies, and clinical trials, highlight the important role of vitamins A, C, and D, omega-3 fatty acids, and zinc in modulating the immune response. Supplementation with vitamins, omega 3 fatty acids and zinc appears to be a safe and low-cost way to support optimal function of the immune system, with the potential to reduce the risk and consequences of infection, including viral respiratory infections. Supplementation should be in addition to a healthy diet and fall within recommended upper safety limits set by scientific expert bodies. Therefore, implementing an optimal nutrition, with micronutrients and omega-3 fatty acids supplementation, might be a cost-effective, underestimated strategy to help reduce the burden of infectious diseases worldwide, including coronavirus disease 2019 (COVID-19).

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“Effect of the intervention with omega-3 fatty acids on nutritional and clinical aspects in patients with breast cancer receiving medical treatment”

10.1101/2021.02.08.21251389 ◽

2021 ◽

Author(s):

Palma-Gutierrez Edgardo ◽

Espinoza-Rado Erika ◽

Zafra-Tanaka Jessica Hanae

Keyword(s):

Breast Cancer ◽

Systematic Review ◽

Fatty Acids ◽

Medical Treatment ◽

Muscle Protein ◽

Data Extraction ◽

Risk Of Bias ◽

Clinical Aspects ◽

Omega 3 Fatty Acids ◽

Omega 3

ABSTRACTBackgroundIt is known that cancer can cause loss of body weight and muscle protein wasting, which leads to a state of malnutrition, which in turn worsens the prognosis and health of the cancer patient. It has been suggested that the promoting mechanism of this state is systemic inflammation, for which reason several clinical trials have used omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as adjuvants to antineoplastic treatment, mainly due to its anti-inflammatory effects. However, few systematic reviews and meta-analyzes have analyzed the effects of omega-3s in patients with breast cancer.ObjectiveThe aim of this study is to assess the effect of the supplementation with omega-3 fatty acids on nutritional and clinical outcomes in patients with breast cancer receiving medical treatment.MethodsA systematic review will be conducted, starting with a search in PubMed, CENTRAL and EMBASE using search terms related to omega-3 fatty acids and breast cancer. We will include only randomized controlled trials that assess the effects of omega-3 in patients with breast cancer receiving medical treatment.. Data will be extracted in a spread sheet. Study selection and data extraction will be conducted by two reviewers independently and the Cochrane Risk of Bias Tool for RCT will be used for assessment of risk of bias. Discrepancies will be reviewed with a third reviewer.ConclusionThis systematic review aims to provide an analysis on the outcomes of the usage of the intervention with omega-3 fatty acids on nutritional and clinical aspects in patients with breast cancer receiving medical treatment.

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The Role of Omega-3 Polyunsaturated Fatty Acids in the Treatment of Patients with Acute Respiratory Distress Syndrome: A Clinical Review

BioMed Research International ◽

10.1155/2015/653750 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 10

Author(s):

M. García de Acilu ◽

S. Leal ◽

B. Caralt ◽

O. Roca ◽

J. Sabater ◽

...

Keyword(s):

Fatty Acids ◽

Acute Respiratory Distress Syndrome ◽

Fatty Acid ◽

Polyunsaturated Fatty Acids ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Acute Onset ◽

Omega 3

Acute respiratory distress syndrome (ARDS) is defined as the acute onset of noncardiogenic edema and subsequent gas-exchange impairment due to a severe inflammatory process. Recent report on the prognostic value of eicosanoids in patients with ARDS suggests that modulating the inflammatory response through the use of polyunsaturated fatty acids may be a useful strategy for ARDS treatment. The use of enteral diets enriched with eicosapentaenoic acid (EPA) and gamma-linolenic acid (GLA) has reported promising results, showing an improvement in respiratory variables and haemodynamics. However, the interpretation of the studies is limited by their heterogeneity and methodology and the effect ofω-3 fatty acid-enriched lipid emulsion or enteral diets on patients with ARDS remains unclear. Therefore, the routine use ofω-3 fatty acid-enriched nutrition cannot be recommended and further large, homogeneous, and high-quality clinical trials need to be conducted to clarify the effectiveness ofω-3 polyunsaturated fatty acids.

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