Primary aldosteronism and thyroid disorders in atrial fibrillation: A Swedish nationwide case–control study

Background Atrial fibrillation is associated with hyperthyroidism. Patients with primary aldosteronism have an increased prevalence of atrial fibrillation. However, the prevalence of primary aldosteronism in the atrial fibrillation population is unknown. Aim This nationwide case–control study aimed to compare the prevalence of primary aldosteronism and thyroid disorders in patients with atrial fibrillation with that of age- and sex-matched controls. Methods We identified all atrial fibrillation cases in Sweden between 1987 and 2013 ( n = 713,569) by using the Swedish National Patient Register. A control cohort without atrial fibrillation was randomly selected from the Swedish Total Population Register with a case to control ratio of 1:2. This control cohort was matched for age, sex and place of birth ( n = 1,393,953). Results The prevalence of primary aldosteronism in December 2013 was 0.056% in the atrial fibrillation cohort and 0.024% in controls. At the same time, the prevalence of hypothyroidism was 5.9% in the atrial fibrillation cohort and 3.7% in controls. The prevalence of hyperthyroidism was 2.3% in the atrial fibrillation cohort and 0.8% in controls. Conclusion This study shows, for the first time, a doubled prevalence of primary aldosteronism in a large cohort of patients with atrial fibrillation compared with the general population. There is also an increased prevalence of hypo- and hyper-thyroidism in patients with atrial fibrillation compared with the general population.

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Risk of atrial fibrillation in people with type 1 diabetes compared with matched controls from the general population: a prospective case-control study

The Lancet Diabetes & Endocrinology ◽

10.1016/s2213-8587(17)30262-0 ◽

2017 ◽

Vol 5 (10) ◽

pp. 799-807 ◽

Cited By ~ 28

Author(s):

Sofia Dahlqvist ◽

Annika Rosengren ◽

Soffia Gudbjörnsdottir ◽

Aldina Pivodic ◽

Hans Wedel ◽

...

Keyword(s):

Atrial Fibrillation ◽

Type 1 Diabetes ◽

General Population ◽

Case Control Study ◽

Case Control ◽

Control Study ◽

Prospective Case Control Study

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Faculty Opinions recommendation of Non-steroidal anti-inflammatory drug use and risk of atrial fibrillation or flutter: population based case-control study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13274958.14631057 ◽

2011 ◽

Author(s):

Juan Tamargo

Keyword(s):

Atrial Fibrillation ◽

Drug Use ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Inflammatory Drug ◽

Anti Inflammatory ◽

Control Study

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Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study

Children ◽

10.3390/children8050419 ◽

2021 ◽

Vol 8 (5) ◽

pp. 419

Author(s):

Carmen Muntean ◽

Maria Săsăran

Keyword(s):

Vitamin D ◽

Urinary Tract ◽

Case Control Study ◽

Case Control ◽

Study Group ◽

Recurrent Utis ◽

Vitamin D Levels ◽

Tract Infections ◽

First Time ◽

Control Study

Vitamin D has emerged as a key factor in innate immunity. Its involvement in the pathogenesis of urinary tract infections (UTIs) has gained a lot of attention recently. The objective of this study is to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) levels and first-time or recurrent UTIs in children. A prospective, case-control study was conducted on 101 pediatric patients, who were divided into two groups: 59 patients with UTIs and 42 age-matched healthy controls. Serum 25(OH)D was determined in each child and expressed in ng/mL. Vitamin D presented significantly lower values in study group subjects than in healthy controls (p < 0.01). Moreover, a significantly higher prevalence of vitamin D insufficiency and deficiency was found in children with UTIs (p < 0.01). Patients with recurrent UTIs presented significantly lower levels of vitamin D than those with first-time UTIs (p = 0.04). Urinary tract abnormalities did not seem to exercise an additional effect upon vitamin D levels within the study group. In conclusion, first-time and recurrent UTIs are associated with lower vitamin D levels. Further studies are necessary to validate our findings, as well as future longitudinal research regarding efficacy of vitamin D supplementation in children with UTIs.

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Outbreak investigation of ceftriaxone-resistant Salmonella enterica serotype Typhi and its risk factors among the general population in Hyderabad, Pakistan: a matched case-control study

The Lancet Infectious Diseases ◽

10.1016/s1473-3099(18)30483-3 ◽

2018 ◽

Vol 18 (12) ◽

pp. 1368-1376 ◽

Cited By ~ 29

Author(s):

Farah Naz Qamar ◽

Mohammad Tahir Yousafzai ◽

Muhammad Khalid ◽

Abdul Momin Kazi ◽

Heeramani Lohana ◽

...

Keyword(s):

Risk Factors ◽

General Population ◽

Salmonella Enterica ◽

Case Control Study ◽

Case Control ◽

Outbreak Investigation ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

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Sporadic Hepatitis C Virus Infection: A Case-control Study of Transmission Routes in a Selected Hospital Sample of the General Population in Italy

Scandinavian Journal of Infectious Diseases ◽

10.1080/003655498750002231 ◽

1998 ◽

Vol 30 (1) ◽

pp. 11-15 ◽

Cited By ~ 24

Author(s):

Ubaldo Visco Comandini, Gianna Toss

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

General Population ◽

Virus Infection ◽

Case Control Study ◽

Case Control ◽

Hepatitis C Virus Infection ◽

Sporadic Hepatitis ◽

Hospital Sample ◽

Control Study

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Association between anxiety symptoms and atrial fibrillation in a community cohort of Chinese older adults: a case-control study

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-02278-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zhu-Xia Shen ◽

Yu-Min Sun ◽

Hui-Hui Gu ◽

Yan Zhang ◽

Zhi-Wen Shen ◽

...

Keyword(s):

Atrial Fibrillation ◽

Older Adults ◽

Heart Disease ◽

Odds Ratio ◽

Case Control Study ◽

Case Control ◽

Anxiety Symptoms ◽

Control Group ◽

Community Based ◽

Control Study

Abstract Background The association between anxiety and atrial fibrillation (AF) remains unclear. Moreover, this association has rarely been studied in Chinese individuals aged 60 years or older. This study investigated the association between anxiety and AF in a community-based case-control study of older adult residents in urban China. Methods The cases and controls were from a community-based study conducted in the Jingansi community in Shanghai, China, between January 2010 and December 2012. A total of 3622 residents aged 60 years or older without severe vision, hearing, or speaking impairments were eligible to participate in the physical examinations and questionnaire survey. AF was assessed based on a previous physician’s diagnosis, electrocardiogram, ambulatory electrocardiogram, or echocardiogram. Anxiety was evaluated using the Zung Self-Rating Anxiety Scale (ZSAS). Using the AF group as a reference, the control group consisted of randomly selected age- and sex-matched individuals in a 1:5 ratio (case:control = 1:5). The association between anxiety and AF in the AF group and the multifactor-matched control group was explored using logistic regression. Results In the AF and control groups, after adjusting for a history of coronary heart disease, valvular heart disease, hypertension, stroke, hyperlipidemia, and diabetes, as well as depression score, ZSAS scores (odds ratio 1.07; 95% confidence interval 1.02–1.12; p = 0.003), and anxiety symptoms (odds ratio 3.94; 95% confidence interval 1.06–14.70; p = 0.041) were associated with AF. Conclusions Anxiety symptoms were associated with AF in a Chinese older population. This suggests that older adults who have anxiety symptoms may need psychological intervention or treatment in daily life and care.

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Does Parkinson's Disease Increase the Risk of Atrial Fibrillation? Insights From Electrocardiogram and Risk Scores From a Case-Control Study

Frontiers in Neurology ◽

10.3389/fneur.2021.633900 ◽

2021 ◽

Vol 12 ◽

Author(s):

Mariana Alves ◽

Ana Mafalda Abrantes ◽

Gonçalo Portugal ◽

M. Manuela Cruz ◽

Sofia Reimão ◽

...

Keyword(s):

Atrial Fibrillation ◽

Case Control Study ◽

Case Control ◽

P Wave ◽

Risk Scores ◽

Wave Duration ◽

P Wave Duration ◽

Increased Risk ◽

The Mean ◽

Control Study

Background: Previous studies suggested that Parkinson's Disease (PD) patients could have an increased risk of atrial fibrillation. However, data supporting this association is not robust. We aimed to compare the potential risk of atrial fibrillation associated with PD in an age and gender matched case-control study, comparing the p-wave indexes from electrocardiograms and clinical risk scores among groups.Methods: A cross-sectional case-control study was performed. All subjects included in the analysis were clinically evaluated and subjected to a 12-lead electrocardiogram. Two blinded independent raters measured the p-wave duration. Subjects were classified as having normal P-wave duration (<120 ms), partial IAB (P-wave duration ≥ 120 ms, positive in inferior leads), and advanced IAB (p-wave duration ≥ 120 ms with biphasic morphology in inferior leads). Atrial fibrillation risk scores (CHARGE-AF, HATCH, and HAVOC) were calculated.Results: From 194 potential participants, three were excluded from the control group due to a previous diagnosis of atrial fibrillation. Comparing the PD patients (n = 97) with controls (n = 95), there were no statistically significant differences regarding the mean p-wave duration (121 ms vs. 122 ms, p = 0.64) and proportion of advanced interatrial block (OR = 1.4, 95%CI = 0.37–5.80, p = 0.58). All patients had a low or medium risk of developing atrial fibrillation based on the clinical scores. There were no differences between the PD patients and controls regarding the mean values of CHARGE-AF, HATCH, and HAVOC.Conclusions: Our results do not support the hypothesis that PD patients have an increased risk of atrial fibrillation based on the p-wave predictors and atrial fibrillation clinical scores.

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