scholarly journals Hemoglobin Hirose: α2β237(C3) Tryptophan Yielding Serine

Blood ◽  
1971 ◽  
Vol 38 (6) ◽  
pp. 730-738 ◽  
Author(s):  
KOTARO YAMAOKA
Keyword(s):  
Family Members ◽  
Chemical Characterization ◽  
The Third ◽  
The Family ◽  
Western Japan ◽  
Slow Moving ◽  
Clinically Significant ◽  
Β Chain ◽  
Screening Survey

Abstract During an electrophoretic screening survey for hemoglobinopathies in western Japan, a slow-moving variant of hemoglobin A, to be designated hemoglobin Hirose, was found in a family of Japanese origin. Chemical characterization of hemoglobin Hirose revealed that tryptophan at the 37th position of the β-chain was replaced by serine, the third residue of C-helix of the β-chain involving contacts between αl and β2 subunits. Even though the oxygen equilibrium of this hemoglobin was abnormal, none of the family members showed any clinically significant symptoms.

scholarly journals Maciej Ziemierski, Testamenty krakowskiej rodziny Królików z XVII w.

2020 ◽  
Vol 26 ◽  
pp. 11-41
Author(s):  
Maciej Ziemierski
Keyword(s):  
18Th Century ◽  
Family Members ◽  
17Th Century ◽  
16Th Century ◽  
Fourth Generation ◽  
Third Generation ◽  
The Third ◽  
The Family ◽  
The Town ◽  
Distinguished Member

17th century testaments of the Królik family from Krakow The article is dedicated to the Królik family from Krakow, who lived in the town from the late 16th century until the first years of the 18th century. The family members initially worked as tailors, later reinforcing the group of Krakow merchants in the third generation (Maciej Królik). Wojciech Królik – from the fourth generation – was a miner in Olkusz. The text omits the most distinguished member of the family, Wojciech’s oldest brother, the Krakow councillor Mikołaj Królik, whose figure has been covered in a separate work. The work shows the complicated religious relations in the family of non-Catholics, initially highly engaged in the life of the Krakow Congregation, but whose members gradually converted from Evangelism to Catholicism. As a result, Wojciech Królik and his siblings became Catholics. This work is complemented by four testaments of family members, with the first, Jakub Królik’s, being written in 1626 and the last one, Wojciech Królik’s, written in 1691.

In silico, Physico-chemical characterization and analysis of Sandalwood proteins

2018 ◽  
Vol 3 (02) ◽  
pp. 150-157
Author(s):  
Asad Amir ◽  
Neelesh Kapoor ◽  
Hirdesh Kumar ◽  
Mohd. Tariq ◽  
Mohd. Asif Siddiqui
Keyword(s):  
Secondary Structure ◽  
In Silico ◽  
Chemical Characterization ◽  
In Silico Analysis ◽  
Chemical Parameters ◽  
Physico Chemical ◽  
In Silico Studies ◽  
The Family ◽  
Silico Analysis

Sandalwood is a commercially and culturally important plant species belonging to the family Santalaceae and the genus Santalum. In Indian sandalwood is renowned for its oil, which is highly rated for its sweet, fragrant, persistent aroma and the fixative property which is highly demanded by the perfume industry. For better production and varieties, requires to understanding the functions of proteins, their analysis and characterization of proteins sequences and their structures, their localizations in cell and their interaction with other functional partner. Due to limited number of in silico studies on sandalwood, in the present study we have performed in silico analysis by characterization of sandalwood proteins. Total 23 proteins were obtained and characterization using UniProtKB, identifying their physico-chemical parameters using ProtParam tool and prediction of their secondary structure elements using GOR of all 23 proteins.

scholarly journals General Characteristics, Phytochemistry and Pharmacognosy of Lippia sidoides

2015 ◽  
Vol 10 (11) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Luiz Gustavo de L. Guimarães ◽  
Maria Laura M. da Silva ◽  
Paula Campos J. Reis ◽  
Maria Tereza R. Costa ◽  
Lívia L. Alves
Keyword(s):  
Essential Oil ◽  
Traditional Medicine ◽  
Biological Activities ◽  
Chemical Characterization ◽  
Northeastern Brazil ◽  
Lippia Sidoides ◽  
Aerial Parts ◽  
The Family ◽  
Cultivation Methods

Lippia sidoides Cham. is a plant that belongs to the family Verbenaceae and is commonly known as “alecrim-pimenta”. It was first found in northeastern Brazil, where it is extensively used in traditional medicine. Many studies have been made with the essential oil of L. sidoides, which has a high content of the isomeric compounds thymol and carvacrol. L. sidoides extracts, and particularly the essential oil extracted from its aerial parts, have shown many biological activities such as antifungal, antibacterial, and insecticidal. Given the great biological potentialities of L. sidoides and the amount of recent studies about this plant, the present study aimed to make a survey of its general attributes, cultivation methods, chemical characterization of its extracts and essential oil, as well as its different biological activities.

scholarly journals HRG Tokushima: Molecular and Cellular Characterization of Histidine-Rich Glycoprotein (HRG) Deficiency

Blood ◽  
1998 ◽  
Vol 91 (1) ◽  
pp. 128-133 ◽  
Author(s):  
Toshio Shigekiyo ◽  
Hidemasa Yoshida ◽  
Kazuya Matsumoto ◽  
Hiroyuki Azuma ◽  
Sadao Wakabayashi ◽  
...  
Keyword(s):  
Family Members ◽  
Japanese Woman ◽  
Nucleotide Position ◽  
Single Nucleotide ◽  
Her Family ◽  
Intracellular Degradation ◽  
Congenital Deficiency ◽  
The Family ◽  
Normal Japanese

AbstractPreviously, we found the first congenital deficiency of histidine-rich glycoprotein (HRG) in a Japanese woman with thrombosis. To elucidate the genetic basis of this deficiency, we first performed Southern blot analysis and found no gross deletion or insertion in the proband's HRG gene. We then examined the nucleotide sequences of all seven exons of the proband's HRG gene. A single nucleotide substitution, G to A at nucleotide position 429, which mutates Gly85 to Glu in the first cystatin-like domain, was found in exon 3 in 13 of 22 amplified clones. This mutation generates a unique Taq I site. Exon 3 was amplified from the proband, her family members, and 50 unrelated normal Japanese individuals, and Taq I fragmentation was examined. Fragmentation of exon 3 was observed in one allele of the genes from the proband and the family members who also have decreased plasma levels of HRG. Fifty unrelated normal Japanese individuals had a normal HRG gene, indicating that the G to A mutation is not a common polymorphism. To elucidate the identified mutation as a cause for the secretion defect of HRG in the proband's plasma, we constructed and transiently expressed the recombinant Tokushima-type HRG mutant (Gly85 to Glu) in baby hamster kidney (BHK) cells, and examined an intracellular event of the mutant protein. The results showed that only about 20% of the Tokushima-type HRG was secreted into the culture medium, and intracellular degradation of the mutant was observed. Thus, the present study strongly suggests that the HRG deficiency is caused by intracellular degradation of the Gly85 to Glu mutant of HRG in the proband.

scholarly journals Multi-Factor Diagnostic and Recommendation System for Boron in Neutral and Acidic Soils

Agronomy ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 410 ◽  
Author(s):  
Richardly Lenz Clove Dupré ◽  
Lotfi Khiari ◽  
Jacques Gallichand ◽  
Claude Alla Joseph
Keyword(s):  
Recommendation System ◽  
Learning Algorithm ◽  
Chemical Characterization ◽  
Automatic Machine ◽  
Hot Water ◽  
Hot Water Extraction ◽  
The Third ◽  
Crop Type ◽  
Yield Responses

Despite its inconveniences, the most recognized method to extract boron from soils is that of hot water extraction (BHW), which is used for diagnostics and recommendations. However, the Mehlich-3 (M3) method is widely used to extract and diagnose several elements at once (P, K, Ca, Mg, Al, B, Cu, Zn, Fe, and Mn) and is well adapted to routine analyses. The objective of our study was to develop a soil diagnostic and recommendation system for boron as a function of measured BM3 (and other interacting elements), crop type, and spreading methods. This system is based on three databases from either the international literature or the chemical characterization of acidic-to-neutral soils typical from Québec (Canada). The first database came from the characterization of 365 samples typical of Québec soils; it has been used to predict, by the AutoML (Automatic Machine Learnig) supervised learning algorithm, BM3 as a function of a set of parameters from the following: BHW, pHW, organic carbon (OC), CaM3, KM3, and MgM3. Depending on the parameters used, the R2 between the measured and observed BM3 varied from 0.36 to 0.99. This database allowed us to define two classifications for soil boron diagnostics and fertility evaluation. The Cate–Nelson analysis for these two models allowed us to define three boron fertility classes: Low, medium and high; that is 0.00–0.23, 0.23–0.58, and 0.58–3.70 mg B kg−1, respectively, for BHW, and 0.00–0.65, 0.65–1.03, and 1.03–12.70 mg B kg−1, respectively, for BM3. The third database was extracted from 130 yield responses to increasing levels of boron; it was used to define a recommendation model for boron, based on AutoML, as a function of BM3, pHW, the crop boron requirement (medium, high), and the type of spreading (broadcast, sidedress, foliar spraying). This model resulted in an R2 of 0.63.

scholarly journals Priprioca (Cyperus articulatus var. nodosus, Cyperaceae) Hydrolate as Larvicidal against Aedes aegypti

2020 ◽  
pp. 91-98
Author(s):  
Inês Ribeiro Machado ◽  
Keila Rêgo Mendes ◽  
Adriano Rodrigues De Paula ◽  
Michelly Rios Arévalo ◽  
Amanda Sousa Silva ◽  
...  
Keyword(s):  
Essential Oil ◽  
Aedes Aegypti ◽  
Plant Extracts ◽  
Chemical Characterization ◽  
Bioactive Substances ◽  
Commercial Products ◽  
Larvicidal Effect ◽  
The Third ◽  
Hydrolysis Of

Dengue cases have grown significantly in Brazil in recent years. Studies with plant extracts show the insecticidal potential of bioactive substances that become candidates for future commercial products. This work evaluated the larvicidal effect of essential oil, without hydrolysis of Cyperus articulatus var. nodosus against the third and fourth wide stage of Aedes aegypti, which reduces larvae survival by as much as the 3th and 4th instar of Ae. aegypti. A chemical characterization of the hydrogen skeletons was performed by the GC-MS, revealing verbenone (%), trans-sabinol (%) and mirtenol (%) as major compounds. 


scholarly journals Η Βυζαντινή Οικογένεια των Αγιοθεοδωριτών (ΙΙI)

2017 ◽  
Vol 27 ◽  
pp. 53 ◽  
Author(s):  
Ελισάβετ ΜΑΔΑΡΙΑΓΑ
Keyword(s):  
Family Members ◽  
Chronological Order ◽  
14Th Century ◽  
The Third ◽  
12Th Century ◽  
The Family

This paper is the third and last part of our prosopographical study on the Hagiotheodorites family members. Here, all known Hagiotheodorites are listed and studied in chronological order from the 12th century, during which most of the family members are active, up to the 14th century.

scholarly journals HRG Tokushima: Molecular and Cellular Characterization of Histidine-Rich Glycoprotein (HRG) Deficiency

Blood ◽  
1998 ◽  
Vol 91 (1) ◽  
pp. 128-133
Author(s):  
Toshio Shigekiyo ◽  
Hidemasa Yoshida ◽  
Kazuya Matsumoto ◽  
Hiroyuki Azuma ◽  
Sadao Wakabayashi ◽  
...  
Keyword(s):  
Family Members ◽  
Japanese Woman ◽  
Nucleotide Position ◽  
Single Nucleotide ◽  
Her Family ◽  
Intracellular Degradation ◽  
Congenital Deficiency ◽  
The Family ◽  
Normal Japanese

Previously, we found the first congenital deficiency of histidine-rich glycoprotein (HRG) in a Japanese woman with thrombosis. To elucidate the genetic basis of this deficiency, we first performed Southern blot analysis and found no gross deletion or insertion in the proband's HRG gene. We then examined the nucleotide sequences of all seven exons of the proband's HRG gene. A single nucleotide substitution, G to A at nucleotide position 429, which mutates Gly85 to Glu in the first cystatin-like domain, was found in exon 3 in 13 of 22 amplified clones. This mutation generates a unique Taq I site. Exon 3 was amplified from the proband, her family members, and 50 unrelated normal Japanese individuals, and Taq I fragmentation was examined. Fragmentation of exon 3 was observed in one allele of the genes from the proband and the family members who also have decreased plasma levels of HRG. Fifty unrelated normal Japanese individuals had a normal HRG gene, indicating that the G to A mutation is not a common polymorphism. To elucidate the identified mutation as a cause for the secretion defect of HRG in the proband's plasma, we constructed and transiently expressed the recombinant Tokushima-type HRG mutant (Gly85 to Glu) in baby hamster kidney (BHK) cells, and examined an intracellular event of the mutant protein. The results showed that only about 20% of the Tokushima-type HRG was secreted into the culture medium, and intracellular degradation of the mutant was observed. Thus, the present study strongly suggests that the HRG deficiency is caused by intracellular degradation of the Gly85 to Glu mutant of HRG in the proband.

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