scholarly journals Smoking status and second-hand smoke biomarkers in COPD, asthma and healthy controls

2020 ◽  
Vol 6 (2) ◽  
pp. 00192-2019 ◽  
Author(s):  
Matteo Bradicich ◽  
Macé M. Schuurmans
Keyword(s):  
Sensitivity And Specificity ◽  
Smoking Status ◽  
Final Analysis ◽  
Integrated Approach ◽  
Second Hand Smoke ◽  
Healthy Controls ◽  
Tobacco Exposure ◽  
Urinary Cotinine ◽  
Pubmed Database ◽  
Shs Exposure

IntroductionTobacco smoke worsens COPD and asthma. For healthy individuals, quantifying active and second-hand smoke (SHS) exposure clarifies the epidemiology of tobacco consumption and the efficacy of nonsmoking measures. Identifying tobacco exposure biomarkers and cut-offs might allow the creation of sensitive and specific tests.AimWe describe the state-of-the-art serum, urinary cotinine and exhaled carbon monoxide (CO) cut-offs for assessing smoking status and SHS exposure in adult patients with COPD or asthma, and healthy controls.MethodologyAfter a keyword research in the PubMed database, we included papers reporting on the cut-offs of the investigated biomarkers in one of the populations of interest. Papers published before 2000, not in English, or reporting only data on nonadult subjects or on pregnant women were excluded from the analysis. 14 papers were included in the final analysis. We summarised diagnostic cut-offs for smoking status or SHS exposure in COPD, asthmatic and healthy control cohorts, reporting sensitivity and specificity when available.ConclusionSerum and urinary cotinine and exhaled CO are easy-to-standardise, affordable and objective tests for assessing smoking status and SHS exposure. Evidence on cut-offs with good sensitivity and specificity values is available mainly for healthy controls. For COPD and asthmatic patients, most of the currently available evidence focuses on exhaled CO, while studies on the use of cotinine with definite sensitivity and specificity values are still missing. Solid evidence on SHS exposure is available only for healthy controls. An integrated approach with a combination of these markers still needs evaluation.

scholarly journals Second-Hand Smoking among Intermediate and Secondary School Students in Madinah, Saudi Arabia

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Abdulmohsen H. Al-Zalabani ◽  
Soliman M. Amer ◽  
Khaled A. Kasim ◽  
Reem I. Alqabshawi ◽  
Ayat R. Abdallah
Keyword(s):  
Saudi Arabia ◽  
Secondary School ◽  
Secondary School Students ◽  
Smoking Status ◽  
Public Health Problem ◽  
Parental Smoking ◽  
Second Hand Smoke ◽  
School Students ◽  
Related Factors ◽  
Shs Exposure

Background and objectives. Second-hand smoke (SHS) is an important public health problem worldwide. The study aimed to estimate the prevalence of SHS exposure and its associated risk factors among intermediate and secondary school students.Methods. A cross-sectional study was conducted in 2013 among 3400 students from 34 intermediate and secondary schools in Madinah City, Saudi Arabia. Data about sociodemographic and smoking-related factors and SHS exposure were collected using a self-administered questionnaire.Results. Of the 3210 students analyzed, the prevalence of SHS exposure was 32.7% 49.3%, and 25% inside, outside, and both inside and outside the home, respectively. The highest risk of SHS exposure was associated with the adolescent’s smoking status, parental smoking, close friends smoking, and family structure. The risk was markedly increased in association with parental smoking for exposure inside the home (OR = 6.49; 95% CI = 5.44–7.73) and with close friends smoking for exposure outside the home (OR = 4.16; 95% CI = 3.54–4.77). The risk of SHS, however, was lower among adolescents having knowledge about smoking and highly educated parents.Conclusion. The study revealed a considerably high prevalence of SHS both inside and outside the home among adolescents. Knowledge and beliefs about SHS exposure are the main preventable approach.

Prevalence of second-hand tobacco smoke in relation to smoke-free legislation in the European Union

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Schiavone ◽  
C Anderson ◽  
U Mons ◽  
V Winkler
Keyword(s):  
Public Health ◽  
European Union ◽  
Tobacco Control ◽  
Smoking Status ◽  
Public Health Problem ◽  
Second Hand Smoke ◽  
The European Union ◽  
Control Policies ◽  
Tobacco Control Policies ◽  
Shs Exposure

Abstract Background Second-hand smoke (SHS) is still an important public health problem. With joining the Framework Convention on Tobacco Control (FCTC), all parties acknowledged the health risks of SHS and agreed to implement policies to protect their populations from SHS in public places. The aim of this study was to explore the SHS exposure in restaurants and bars as well as its associations with smoke-free legislation in the European Union. Methods Data of Eurobarometer surveys 2014 and 2017 were used to estimate prevalence of SHS exposure. We also extracted data on individual confounders such as smoking status, gender, sex, age and information on social economic status. Additionally, we collected data on country specific data on smoking regulations in restaurants and bars from the Tobacco Control Scale to analyse associations with SHS exposure using multilevel logistic regression. Smoking regulations were categorized into the following three categories: partial ban, comprehensive ban with minor exceptions, and complete ban. Results Preliminary results on the prevalence of SHS in restaurants showed a decrease from 11.8% (95% confidence intervals (CI) 11.2-12.5) in 2014 to 8.8% (95% CI 8.3-9.3) in 2017. The crude multilevel model controlling only for smoking prevalence resulted in an odds ratio of 0.39 (95% CI 0.19-0.77) for comprehensive ban with minor exceptions and 0.28 (95% CI 0.16-0.50) for complete ban versus partial ban. Odds ratios remained at significant levels when controlling for all available confounders. Conclusions Between 2014 and 2017, SHS exposure in restaurants decreased significantly. Furthermore, strong associations with smoking regulations were observed suggesting a high compliance. Many tobacco control policies have been introduced during the last years but several countries need to strengthen their smoke-free tobacco control policies to further reduce SHS exposure preventing death, disease and disability. Key messages SHS exposure remains a significant public health challenge. The implementation of effective measures could be strengthened through a convergence of tobacco control strategies and policies among European Union member states.

scholarly journals Validation of Self-Reported Smoker and Second Hand Smoke Exposure by Urinary Cotinine within The Malaysian Cohort Project

2019 ◽  
Vol 5 (1) ◽  
pp. 15
Author(s):  
Noraidatulakma Abdullah
Keyword(s):  
High Performance ◽  
Smoking Status ◽  
Smoke Exposure ◽  
Misclassification Rate ◽  
Second Hand Smoke ◽  
Urinary Cotinine ◽  
Urine Cotinine ◽  
Second Hand Smoke Exposure ◽  
Former Smokers

Background: Validation of self-reported questionnaire is very crucial in ensuring the quality and reliability of data collection. Objective: The aim of this study were i) to validate the questionnaire on tobacco smoke intake and second hand smoke exposure among The Malaysian Cohort (TMC) subjects through the determination of urinary cotinine levels, ii) to determine the optimal cut-off point of urine cotinine that discriminates smokers from non-smokers and iii) to estimate misclassification rate between self-reported smoking and urinary cotinine level.Methods: Urine samples from a total of 775 The Malaysian Cohort subjects (104 smokers, 102 former smokers and 569 non-smokers) were obtained and urinary cotinine levels were determined by high-performance liquid chromatography (HPLC). Differences between groups were compared using Kruskal Wallis and Mann-Whitney tests. The Receiver Operating Characteristic (ROC) curved was performed to define the optimal urinary cotinine cut-off point.Results: Urinary cotinine concentration significantly (p<0.001) correlated with smoking status (r=0.46), the average number of cigarettes smoked per day (r=0.53), duration of smoking (r=0.33) and number of cigarettes packed per year (r=0.47). Smokers and second hand smokers have significantly higher median cotinine levels (978.40 and 21.31 respectively) compared to non-smokers (15.52) and non-exposed (13.60) subjects. Cotinine level at cut-off value of 1.51 ng/mg creatinine is able to distinguish smokers and non-smokers with a sensitivity of 84.62% and specificity of 81.97%.Conclusion: The Malaysian Cohort self-reported smoking questionnaire is a reliable tool in assessing the use of tobacco and second hand smoke exposure among the subjects.

scholarly journals Effect of secondhand smoke exposure on lung function among non-smoking population

2019 ◽  
Vol 6 (4) ◽  
pp. 1116
Author(s):  
Aravind C. ◽  
Ragul B. ◽  
Monisha .
Keyword(s):  
Lung Function ◽  
Secondhand Smoke ◽  
Smoking Status ◽  
Cross Sectional Study ◽  
Exposed Group ◽  
Analysis Of Covariance ◽  
Cross Sectional ◽  
Urinary Cotinine ◽  
Significant Difference ◽  
Shs Exposure

Background: Secondhand Smoke (SHS) exposure is known to be associated with various cardiovascular and respiratory problems but its effect on pulmonary function remains unexplored. This study was done to evaluate the effect of Secondhand Smoke (SHS) exposure on lung function among non-smoking population.Methods: This cross-sectional study was conducted in Bahour, Pondicherry from 2017-2018.  350 participants, age 40 year and older, with no respiratory symptoms or prior lung diseases were included in this study. Both self-reported history and measurement of urinary cotinine level were used to evaluate the smoking status. Spirometry data, including FVC and FEV1 were used to assess lung function. Diverse variables between groups were compared using T- test and Chi-square test. Analysis of covariance (ANCOVA) adjusted for age, height, alcohol consumption, and level of exercise was used to see any statistical differences in lung function parameters between non-SHS exposed and SHS-exposed groups.Results: Among 350 non-smokers, 120 were SHS-exposed. The urinary cotinine levels clearly distinguished SHS exposure, and the mean urinary cotinine levels were 7±0.3 and 11±0.4 in non-SHS exposed group vs SHS-exposed group, respectively. However, both groups had no significant difference in lung function and was found normal.Conclusions: SHS exposure urinary cotinine is a valuable marker.

scholarly journals Association between cotinine-verified smoking status and moderately increased albuminuria in the middle-aged and older population in Korea: A nationwide population-based study

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246017
Author(s):  
Yeonjoo Choi ◽  
Joo-Hyun Park ◽  
Do-Hoon Kim ◽  
Hyun Jin Kim ◽  
Euijung Suh ◽  
...  
Keyword(s):  
Large Scale ◽  
Smoking Status ◽  
Positive Association ◽  
Population Based ◽  
P Value ◽  
Tobacco Exposure ◽  
Middle Aged ◽  
Significant Positive Association ◽  
Urinary Cotinine ◽  
Urine Albumin

Objectives Although several self-reported questionnaire-based studies have found an association between smoking and moderately increased albuminuria, this result remains controversial. We investigated whether moderately increased albuminuria was associated with smoking status, verified by urinary cotinine (an objective biomarker of tobacco exposure), using population-based, nationally representative data. Methods This study included 2059 participants aged ≥ 50 years from the 2014 Korean National Health and Nutrition Examination Survey. Individuals with a urinary cotinine level ≥ 50 ng/mL were identified as cotinine-verified smokers. Moderately increased albuminuria was defined as a urine albumin-to-creatinine ratio ranging between ≥ 30 mg/g and < 300 mg/g. Multivariable logistic regression was used to evaluate the association between cotinine-verified smoking status and moderately increased albuminuria. Results Among the study participants, 16.9% were cotinine-verified smokers, 84.8% of whom were men. After adjustment for multiple covariates, cotinine-verified smokers showed a significant positive association with moderately increased albuminuria (adjusted odds ratio: 4.37, 95% confidence interval: 1.63–11.71) compared with cotinine-verified non-smokers. The association between urinary cotinine and moderately increased albuminuria did not differ with age, sex, obesity, or comorbidities (P-value for interaction > 0.05 in all cases). Conclusion This large-scale observational study showed that cotinine-verified smoking is associated with moderately increased albuminuria in the Korean middle-aged and older general population, suggesting that smoking must be strictly controlled to reduce the risk of moderately increased albuminuria.

scholarly journals The Prevalence of Secondhand Smoke and Its Associated Factors among Adults Residing in the Low Income Residence, Kuala Terengganu, Malaysia

2021 ◽  
Vol 5 (1) ◽  
pp. 19-24
Author(s):  
Intan Suhana Munira Mat Azmi ◽  
Nik Nor Ronaidi Nik Mahdi ◽  
Aniza Abd Aziz ◽  
Yuzana Mohd Yusop ◽  
Myat Moe Thwe Aung ◽  
...  
Keyword(s):  
Low Income ◽  
Smoking Status ◽  
Occupational Status ◽  
Cross Sectional Study ◽  
Second Hand Smoke ◽  
Chi Square ◽  
Cross Sectional ◽  
Shs Exposure ◽  
Laws And Policies ◽  
Socio Demographic Factors

Worldwide, 40% of children, 33% and 35% of male and female non-smokers respectively, were regularly exposed to second-hand smoke indoors. The practice to avoid second hand smoke at home are mostly individual-driven although in public places SHS can be executed by laws and policies such as gazetted smoke-free zones. A cross sectional study was conducted at Flat Bukit Kecil, Kuala Terengganu involving 211 respondents. Self-administered questionnaire was used and data were analysed. Descriptive statistics and Pearson chi square were employed. Findings revealed significant associations between socio demographic factors; gender (p=0.002), ethnicity (p=0.006), and occupational status (p=0.014) with SHS exposure. SHS exposure was also found to be significantly associated with respondents’ vaping (p=0.035) and smoking status (p<0.001), and respondents with existing tobacco related morbidity (p=0.040). In conclusion, the prevalence of SHS among adult residents in Flat Bukit Kecil, Kuala Terengganu (57.8%) was higher in comparison with other local studies. Restaurants were found to be the most common place of SHS exposure followed by workplace and home. In general, the residents demonstrated poor attitude and practice towards SHS whilst knowledge was good on SHS. Malay smoker residents, aged above 40 years old, employed, allowed guests smoking inside the house and had a family history of tobacco related diseases were more likely to be exposed to SHS than its counterpart.   Keywords: adults, KAP, low income residence, SHS  

Factors Associated With the Differences Between Self-Report Smoking and Urinary Cotinine Criteria

2021 ◽  
pp. 101053952098624
Author(s):  
Gyeong-Min Lee ◽  
Jang-Ho Yoon ◽  
Woo-Ri Lee ◽  
Li-Hyun Kim ◽  
Ki-Bong Yoo
Keyword(s):  
Secondhand Smoke ◽  
Smoking Status ◽  
Self Report ◽  
Regression Analyses ◽  
Urinary Cotinine ◽  
Factors Associated ◽  
Independent Variables ◽  
Shs Exposure ◽  
The Difference ◽  
Nonsmoker Group

During self-reporting, respondents underreport their smoking status for various reasons. We aimed to evaluate the difference between smoking status self-reporting and urinary cotinine tests in Korea respondents. Logistic regression analyses were performed to identify factors associated with the differences between self-reporting and urinary cotinine criteria. The dependent variable was the underreporting of smoking status; independent variables were sociodemographic, health status, and secondhand smoke (SHS) exposure. Total underreporting was 3.6% when Cot ≥164 and 4.0% when Cot-variable (classified) criteria underreported. Positive associations were found between smoking and age, education, drinking, and SHS. Underreporting in the nonsmoker group (odds ratio [OR] = 2.336; confidence interval [CI] = 1.717-3.179) was significantly associated with SHS, but this difference was nonsignificant in the ex-smoker group (OR = 1.184; CI = 0.879-1.638). Underreporting was 3.6% to 4.0%, and C-statistics was about 0.7, indicating that outcomes could be classified. SHS in nonsmokers was positively associated with underreporting; however, only the nonsmoker group had positive associations, demonstrating unintentional underreporting due to SHS.

scholarly journals Recent Developments in the Determination of Biomarkers of Tobacco Smoke Exposure in Biological Specimens: A Review

2021 ◽  
Vol 18 (4) ◽  
pp. 1768
Author(s):  
Hernâni Marques ◽  
Pedro Cruz-Vicente ◽  
Tiago Rosado ◽  
Mário Barroso ◽  
Luís A. Passarinha ◽  
...  
Keyword(s):  
Tobacco Smoke ◽  
Solid Phase ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
World Health ◽  
Second Hand Smoke ◽  
Tobacco Exposure ◽  
Wide Range ◽  
Recent Developments

Environmental tobacco smoke exposure (ETS) and smoking have been described as the most prevalent factors in the development of certain diseases worldwide. According to the World Health Organization, more than 8 million people die every year due to exposure to tobacco, around 7 million due to direct ETS and the remaining due to exposure to second-hand smoke. Both active and second-hand exposure can be measured and controlled using specific biomarkers of tobacco and its derivatives, allowing the development of more efficient public health policies. Exposure to these compounds can be measured using different methods (involving for instance liquid- or gas-chromatographic procedures) in a wide range of biological specimens to estimate the type and degree of tobacco exposure. In recent years, a lot of research has been carried out using different extraction methods and different analytical equipment; this way, liquid–liquid extraction, solid-phase extraction or even miniaturized procedures have been used, followed by chromatographic analysis coupled mainly to mass spectrometric detection. Through this type of methodologies, second-hand smokers can be distinguished from active smokers, and this is also valid for e-cigarettes and vapers, among others, using their specific biomarkers. This review will focus on recent developments in the determination of tobacco smoke biomarkers, including nicotine and other tobacco alkaloids, specific nitrosamines, polycyclic aromatic hydrocarbons, etc. The methods for their detection will be discussed in detail, as well as the potential use of threshold values to distinguish between types of exposure.

scholarly journals Inadequate Gestational Weight Gain and Exposure to Second-Hand Smoke during Pregnancy Increase the Risk of Low Birth Weight: A Cross-Sectional Study among Full-Term Infants

2021 ◽  
Vol 18 (3) ◽  
pp. 1068
Author(s):  
Muliana Edi ◽  
Yit Chin ◽  
Fui Woon ◽  
Geeta Appannah ◽  
Poh Lim ◽  
...  
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Pregnant Women ◽  
Medical Records ◽  
Cross Sectional Study ◽  
Second Hand Smoke ◽  
Sectional Study ◽  
Cross Sectional ◽  
Shs Exposure ◽  
At Home

Despite the advancement of the healthcare system, low birth weight (LBW) remains as one of the leading causes of under-five mortality. This cross-sectional study aimed to determine the prevalence of LBW and its associated factors among 483 third trimester pregnant women recruited from six selected public health clinics in the Federal Territory of Kuala Lumpur and the state of Selangor, Malaysia. Pregnant women were interviewed for information on socio-demographic characteristics, smoking behaviour, and second-hand smoke (SHS) exposure at home and in the workplace. Information on the obstetrical history and prenatal care visits history were retrieved from the maternal medical records, while infant’s birth outcomes were retrieved from infant medical records. The prevalence of LBW (<2.5 kg) in infants was 10.4%, with a mean birth weight of 3.0 [standard deviation (SD) 0.4] kg. Results from the multivariable logistic regression model showed that inadequate weight gained during pregnancy [odds ratio (OR) = 2.41, 95% confidence interval (CI) = 1.18–4.90] and exposure to SHS at home (OR = 1.92, 95% CI = 1.03–3.55) were significantly associated with LBW. In conclusion, pregnant women should monitor their rate of weight gain throughout pregnancy and avoid SHS exposure at home to reduce the risk of delivering LBW infants.

scholarly journals Self-reported and cotinine-verified smoking and increased risk of incident hearing loss

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Woncheol Lee ◽  
Yoosoo Chang ◽  
Hocheol Shin ◽  
Seungho Ryu
Keyword(s):  
Smoking Status ◽  
Objective Measure ◽  
Self Report ◽  
Urinary Cotinine ◽  
Increased Risk ◽  
Former Smokers ◽  
Never Smokers ◽  
Time Varying Covariates ◽  
New Onset

AbstractWe examined the associations of smoking status and urinary cotinine levels, an objective measure of smoking, with the development of new-onset HL. This cohort study was performed in 293,991 Korean adults free of HL who underwent a comprehensive screening examination and were followed for up to 8.8 years. HL was defined as a pure-tone average of thresholds at 0.5, 1.0, and 2.0 kHz ≥ 25 dB in both ears. During a median follow-up of 4.9 years, 2286 participants developed new-onset bilateral HL. Self-reported smoking status was associated with an increased risk of new-onset bilateral HL. Multivariable-adjusted HRs (95% CIs) for incident HL comparing former smokers and current smokers to never-smokers were 1.14 (1.004–1.30) and 1.40 (1.21–1.61), respectively. Number of cigarettes, pack-years, and urinary cotinine levels were consistently associated with incident HL. These associations were similarly observed when introducing changes in smoking status, urinary cotinine, and other confounders during follow-up as time-varying covariates. In this large cohort of young and middle-aged men and women, smoking status based on both self-report and urinary cotinine level were independently associated with an increased incidence of bilateral HL. Our findings indicate smoking is an independent risk factor for HL.

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