scholarly journals European headache federation consensus on the definition of resistant and refractory migraine

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Simona Sacco ◽  
Mark Braschinsky ◽  
Anne Ducros ◽  
Christian Lampl ◽  
Patrick Little ◽  
...  
Keyword(s):  
Pain Relief ◽  
Delphi Method ◽  
Main Body ◽  
Consensus Process ◽  
The Past ◽  
Adequate Pain Relief ◽  
Refractory Migraine ◽  
Definition Of ◽  
European Headache Federation ◽  
The Impact

Abstract Introduction Despite advances in the management of headache disorders, some patients with migraine do not experience adequate pain relief with acute and preventive treatments. It is the aim of the present document to provide a definition of those migraines which are difficult-to-treat, to create awareness of existence of this group of patients, to help Healthcare Authorities in understanding the implications, and to create a basis to develop a better pathophysiological understanding and to support further therapeutic advances. Main body Definitions were established with a consensus process using the Delphi method. Patients with migraine with or without aura or with chronic migraine can be defined as having resistant migraine and refractory migraine according to previous preventative failures. Resistant migraine is defined by having failed at least 3 classes of migraine preventatives and suffer from at least 8 debilitating headache days per month for at least 3 consecutive months without improvement; definition can be based on review of medical charts. Refractory migraine is defined by having failed all of the available preventatives and suffer from at least 8 debilitating headache days per month for at least 6 consecutive months. Drug failure may include lack of efficacy or lack of tolerability. Debilitating headache is defined as headache causing serious impairment to conduct activities of daily living despite the use of pain-relief drugs with established efficacy at the recommended dose and taken early during the attack; failure of at least two different triptans is required. Conclusions We hope, that the updated EHF definition will be able to solve the conflicts that have limited the use of definitions which have been put forward in the past. Only with a widely accepted definition, progresses in difficult-to-treat migraine can be achieved. This new definition has also the aim to increase the understanding of the impact of the migraine as a disease with all of its social, legal and healthcare implications. It is the hope of the EHF Expert Consensus Group that the proposed criteria will stimulate further clinical, scientific and social attention to patients who suffer from migraine which is difficult-to-treat.

scholarly journals The impact of the institutional environment on the development of the rural economy in the Belgorod region of Russia

2014 ◽  
Vol 3 (1) ◽  
pp. 13-19
Author(s):  
Andrei Dorofeev ◽  
Sergei Sazonov ◽  
Wim Heijman
Keyword(s):  
Rural Economy ◽  
Institutional Environment ◽  
Institutional Changes ◽  
Main Body ◽  
Institutional Conditions ◽  
The Past ◽  
Commodity Money ◽  
The Status ◽  
The Impact ◽  
Means Of Production

Abstract This article deals with the problems in the development of agriculture in Russia caused by an imperfect institutional environment. The characteristics of institutional conditions and their influence on the development of agriculture is discussed. The main institutional changes which have taken place in Russia over the past 20 years are described, including the ownership of the means of production, commodity-money relations, access to and distribution of profits and competition. The main body of the article presents an analysis of the development of agriculture in the Belgorod region in relation to the status of the institutional environment.

scholarly journals ENDOMETRIAL RECEPTIVITY AS THE KEY TO THE SUCCESS OF ART PROGRAMS: A LITERATURE REVIEW

2021 ◽  
pp. 17-26
Author(s):  
G.Zh. Anartaeva ◽  
A.M. Kurmanova ◽  
N.M. Mamedalieva ◽  
S.B. Baikoshkarova
Keyword(s):  
Risk Factors ◽  
Pain Relief ◽  
Reproductive Function ◽  
Endometrial Receptivity ◽  
Art Programs ◽  
Vitro Fertilization ◽  
The Past ◽  
Adequate Pain Relief ◽  
Vitamin Therapy

Relevance: To date, the success of in vitro fertilization (IVF) programs in Kazakhstan is 38%. The purpose of the study was to evaluate the mechanisms of influence of various risk factors on endometrial receptivity in women in IVF programs. Materials and Methods: This review was based on a search conducted for domestic and foreign publications available in Russian and international search systems (PubMed, eLibrary) for the past 25 years. Results: Chronic endometritis is a verified cause of impaired receptivity. Many studies have proven the beneficial effect of complex empirical treatment using antibacterial, anti-inflammatory, hormonal therapy with transdermal forms of estrogens and vitamin therapy on the outcome of IVF. Conclusion: The problem of recurrent implantation disorders in IVF programs is multifactorial. Women with unrealized reproductive function require rehabilitation after an unsuccessful fertilization attempt to prevent disorders of homeostasis and ensure adequate pain relief during transvaginal puncture of ovarian follicles. In addition to hormone therapy with transdermal forms of estradiol, complex rehabilitation measures shall include immunomodulatory therapy, psychotherapy, and vitamin therapy.

The impact of tax policy on the implementation of the regulatory function of tax law

2021 ◽  
Author(s):  
Dmytro Kobylnik
Keyword(s):  
Public Relations ◽  
Tax Policy ◽  
Legal Regulation ◽  
Regulatory Function ◽  
Tax Law ◽  
Main Body ◽  
Special Role ◽  
Tax Legislation ◽  
Definition Of ◽  
The Impact

Problem setting. The social value, role and purpose of tax law are revealed in its functions as the main directions of its impact on public life. At the same time, the value potential of law is revealed by both general social and special legal functions. It is obvious that the implementation of the regulatory function of law is influenced by a number of factors, among which tax policy is important. Therefore, the purpose of the article is to characterize the impact of tax policy on the implementation of the regulatory function of tax law. Analysis of recent researches and publications. Note that the question of the functions of tax law, tax policy and their interaction is not entirely new to the science of tax law, because to some extent to their consideration resorted to O. S. Yemelyanov, А. А. Kovalenko, M. P. Kucheryavenko, Yu. L. Smirnikova, V. V. Chaika and others. However, so far it is impossible to say that they have received a proper scientific analysis, as financial scientists have not resorted to a comprehensive examination of them, and conducted a fragmentary study. Thus, the purpose of the article is to consider the impact of tax policy on the implementation of the regulatory function of tax law. Article`s main body. The article focuses on clarifying the impact of tax policy on the implementation of the regulatory function of tax law in modern conditions. The presence of a corresponding dialectical relationship between tax and legal regulation and tax policy is emphasized, which is reflected in two planes: (1) through the definition of goals, objectives, results of tax policy, the directions of regulation of tax relations, its subject matter, limits and methods are determined, by which rules of conduct are established for subjects of tax relations, that is, we are talking about the impact on lawmaking activities in the field of taxation, the implementation of the regulatory function of tax law; (2) by determining the quality and effectiveness of tax legislation, the extent to which the tax policy has been implemented is assessed. Conclusions and prospects for the development. As we have shown, tax policy has its own meaning, it is organically linked to tax law, which by implementing the regulatory function implements the vectors indicated by the policy. Given the profound transformation of public relations that has taken place in our country in recent years, tax policy should be given a special role as a strong foundation for ensuring the effectiveness of tax and legal regulation.

The role of sports diplomacy in recognition of newly created states

2020 ◽  
pp. 92-98
Author(s):  
Marina Okladnaya ◽  
Ivan Shchehlakov
Keyword(s):  
Ad Hoc ◽  
Main Body ◽  
Sports Diplomacy ◽  
Football Match ◽  
The Government ◽  
Sport Events ◽  
Definition Of ◽  
The Impact ◽  
Problem Setting

Problem setting. Sport becomes an important part of modern life. Nowadays there are many international sports competitions and events, where unrecognized states take part. In connect with this, such cases have an impact on society and social media. Consequently, there is a question of the impact of sports diplomacy on recognition of states and its importance on this procedure. Target research. To identify the impact of sport diplomacy on the recognition of newly created states. Analysis of recent researches and publications. The object of research was recognition in international law of a large number of both domestic and foreign scientists, among which, Telipko V.E., Ovcharenko A.S., Feldman D.І., Janatayev H.M., whose doctrinal developments provide an important theoretical basis for studying the issue of the impact of sports diplomacy on recognition of states. Article’s main body. Forms of recognition of states were identified in the article. It was determined that there are three form of recognition: de jure, de facto and ad hoc. Definition of sports diplomacy was given. It was proposed that in ad hoc recognition as the representative of the state should be considered not only a representative of the Government, but also other persons with official powers given by authorities. Cases of using sports diplomacy were analyzed. Usually a platform of sports diplomacy is different sport events where unrecognized states take part. The examples of such events are participation of Kosovo Republic in Olimpic Games in Brazil, Kosovo’s entry into FIFA, the football match between Kosovo Republic and Ukraine and others. In this way, sports representatives of the states enter into the negotiations and establish relationships between the states, which don’t recognize each other. It was found that sports diplomacy can be a way of ad hoc recognition. Conclusions and prospects of development. Sports diplomacy is a type of diplomacy, which purpose is to provide state foreign policy in the field of sports. However, sports diplomacy doesn’t cause de jure or de facto recognition of states; it can influence on recognition of the states by helping to build relationships between them.

Board Certification in Forensic Psychiatry and Psychology: Separating the Chaff from the Wheat

2003 ◽  
Vol 31 (1) ◽  
pp. 5-19 ◽  
Author(s):  
Frank M. Dattilio ◽  
Robert L. Sadoff ◽  
Thomas G. Gutheil
Keyword(s):  
Forensic Psychiatry ◽  
Board Certification ◽  
The Past ◽  
Rules Of Evidence ◽  
Basic Need ◽  
Federal Rules Of Evidence ◽  
Definition Of ◽  
The Impact

Psychiatrists and psychologists are under increasing pressure to obtain board certification in their areas of specialization. While this has been the norm for psychiatrists, it is less true for psychologists as of this writing. Regardless, both professionals have been permitted to testify in court without board certification, particularly since the Federal Rules of Evidence 702 tend to be somewhat broad-based in their definition of what constitutes an expert. This article reviews the basic need for board certification and reasons why it should become a requirement for those who practice forensic psychiatry and psychology. The article considers some of the reasons why individuals in both professions may have been reluctant to pursue board certification in the past, as well as some of the pitfalls encountered in the process of becoming certified. Further discussion illuminates the need for psychiatrists and psychologists to adhere to rigid requirements for credentialing and to avoid dubious alternatives such as so-called “vanity” boards that offer ongoing grandfathering periods without rigorous credentials reviews and examination. The impact of such questionable credentials on the forensic field is also discussed.

scholarly journals Evolution of Concepts Related to the Term «Brand Reputation» and Their Relationship

2021 ◽  
Vol 9 (SPE2) ◽  
Author(s):  
Kurbangalieva Dinara Lenarovna
Keyword(s):  
Large Scale ◽  
Previous Analysis ◽  
The Past ◽  
Brand Reputation ◽  
Market Transformation ◽  
Definition Of ◽  
Work Done ◽  
The Impact ◽  
Corporate Business ◽  
Modern Technologies

Throughout the past decade, the theme of reputation has attracted growing interest in the world of corporate business. This interest is primarily due to the fact that reputation is beginning to have an increasing impact on the capitalization of brands. In addition, the accelerated development of information technology and the subsequent large-scale expansion of the organization into digital markets, with a new force, expanded the scientific field of research on the impact of intangible factors on the activities of brands. In numerous publications devoted to the study of the term reputation, both domestic and foreign researchers, there are different approaches to its definition. Previous analysis of works has shown that the reputation of an organization is often confused with the categories «brand», «brand image», «intangible assets», «goodwill» or «business reputation» (Malakhov, 2009), which have other nature and meaning. This article analyzes the views of various researchers of the above terms and, based on the work done, attempts to systematize these terms and offers the author's definition of the definition of «brand reputation». This research will provide a theoretical basis for further research, namely, quantitative assessment of reputation in the era of market transformation and the spread of modern technologies.

Immunoferritin localization of intracellular antigens in positively stained frozen sections

1978 ◽  
Vol 36 (2) ◽  
pp. 168-169
Author(s):  
K. T. Tokuyasu
Keyword(s):  
Surface Tension ◽  
Water Surface ◽  
Thin Layers ◽  
The Other ◽  
Positive Staining ◽  
Frozen Sections ◽  
The Past ◽  
Ultrathin Frozen Sections ◽  
Definition Of

During the past investigations of immunoferritin localization of intracellular antigens in ultrathin frozen sections, we found that the degree of negative staining required to delineate u1trastructural details was often too dense for the recognition of ferritin particles. The quality of positive staining of ultrathin frozen sections, on the other hand, has generally been far inferior to that attainable in conventional plastic embedded sections, particularly in the definition of membranes. As we discussed before, a main cause of this difficulty seemed to be the vulnerability of frozen sections to the damaging effects of air-water surface tension at the time of drying of the sections.Indeed, we found that the quality of positive staining is greatly improved when positively stained frozen sections are protected against the effects of surface tension by embedding them in thin layers of mechanically stable materials at the time of drying (unpublished).

Fluorescent potentiometric dyes for membrane-potential imaging

1994 ◽  
Vol 52 ◽  
pp. 166-167
Author(s):  
Leslie M. Loew
Keyword(s):  
Membrane Potential ◽  
Single Cells ◽  
Quantitative Imaging ◽  
Optical Recording ◽  
Biological Processes ◽  
Major Focus ◽  
The Past ◽  
Excitable Systems ◽  
Major Application ◽  
The Impact

A major application of potentiometric dyes has been the multisite optical recording of electrical activity in excitable systems. After being championed by L.B. Cohen and his colleagues for the past 20 years, the impact of this technology is rapidly being felt and is spreading to an increasing number of neuroscience laboratories. A second class of experiments involves using dyes to image membrane potential distributions in single cells by digital imaging microscopy - a major focus of this lab. These studies usually do not require the temporal resolution of multisite optical recording, being primarily focussed on slow cell biological processes, and therefore can achieve much higher spatial resolution. We have developed 2 methods for quantitative imaging of membrane potential. One method uses dual wavelength imaging of membrane-staining dyes and the other uses quantitative 3D imaging of a fluorescent lipophilic cation; the dyes used in each case were synthesized for this purpose in this laboratory.

Perceived Burden of Informal Caregivers of a Chronically Ill Older Family Member

GeroPsych ◽  
2011 ◽  
Vol 24 (3) ◽  
pp. 143-154 ◽  
Author(s):  
Elmar Gräßel ◽  
Raffaela Adabbo
Keyword(s):  
Family Member ◽  
Informal Caregiver ◽  
Chronically Ill ◽  
Stress Model ◽  
The Past ◽  
Perceived Burden ◽  
Hypothetical Construct ◽  
Care Situation ◽  
The Impact ◽  
Further Development

The burden of caregivers has been intensively researched for the past 30 years and has resulted in a multitude of individual findings. This review illustrates the significance of the hypothetical construct of perceived burden for the further development and design of the homecare situation. Following explanations regarding the term informal caregiver, we derive the construct burden from its conceptual association with the transactional stress model of Lazarus and Folkman. Once the extent and characteristics of burden have been set forth, we then present the impact of perceived burden as the care situation. The question of predictors of burden will lead into the last section from which implications can be derived for homecare and relief of caregivers.

Soziale Disziplinierung im flexiblen Kapitalismus

2004 ◽  
Vol 34 (136) ◽  
pp. 339-356
Author(s):  
Tobias Wölfle ◽  
Oliver Schöller
Keyword(s):  
Social Welfare ◽  
Second Step ◽  
Social Rights ◽  
Federal Law ◽  
Capitalist Development ◽  
The Core ◽  
The Past ◽  
The Impact ◽  
Municipal Level

Under the term “Hilfe zur Arbeit” (aid for work) the federal law of social welfare subsumes all kinds of labour disciplining instruments. First, the paper shows the historical connection of welfare and labour disciplining mechanisms in the context of different periods within capitalist development. In a second step, against the background of historical experiences, we will analyse the trends of “Hilfe zur Arbeit” during the past two decades. It will be shown that by the rise of unemployment, the impact of labour disciplining aspects of “Hilfe zur Arbeit” has increased both on the federal and on the municipal level. For this reason the leverage of the liberal paradigm would take place even in the core of social rights.

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