scholarly journals EQ-5D-5L in Schizophrenia: differences between patients and nurses’ reports

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Fredrick Dermawan Purba ◽  
Yusi Anggriani ◽  
Tri Murtini

Abstract Purpose To examine the differences between patient-reports and proxy-reports by nurses of EQ-5D-5L responses among patients with schizophrenia. Methods This study was conducted in June–September 2019 in Duren Sawit Regional Public Hospital in Jakarta, Indonesia. The self-report data were obtained by interviewing the patients and the proxy-report data were obtained from the psychiatric nurses. The patients’ Positive and Negative Syndrome Scale (PANSS) scores were obtained from their medical records. The data were collected in two time points: (1) when the patients moved from the acute to the quiet rooms (first-test) and (2) when they were discharged from the hospital (second-test). The self and proxy report scores were analysed by the Wilcoxon matched-pairs signed-ranks test and their relationship with the PANSS scores using Spearman's rank correlation coefficient. Results There were 206 patients in the final sample. The majority are male (56.8%) with a mean age of 37.5 years (SD = 12.05). Significant differences between the two reports were found in three domains (i.e., self-care, usual activities, and pain/discomfort) in the first-test and two domains (i.e., usual activities and pain/discomfort) in the second-test. Concerning the relationship with the PANSS scores, only three significant correlations were found, all in the proxy-version and in the second-test: mobility (r = 0.139), anxiety/depression (r = 0.2523), and utility scores (r = − 0.176). Conclusions The poor-to-fair agreement between patients and nurses reports and the poor correlation with the PANSS scores suggested that it is difficult to decide which report best represents the patients’ health status.

2017 ◽  
Vol 39 (1) ◽  
pp. 51
Author(s):  
Daniel Vicentini de Oliveira ◽  
José Roberto Andrade do Nascimento Júnior ◽  
Renan Codonhato ◽  
Thayna Da Silva Zamboni ◽  
Adriele Tarini dos Santos ◽  
...  

This study aimed at investigating the impact of the quality of life perception on the self-esteem of physically active adults. A total of 63 male and female swimming practitioners (38.13 ± 11.72) were evaluated. A socio-demographic questionnaire, WHOQOL-Bref Scale, and the Rosenberg Self-Esteem Scale were used as tools. For data analysis the descriptive statistics, Kolmogorov-Smirnov Test, Mann-Whitney U Test, Spearman’s Rank Correlation Coefficient, and the Univariate Multiple Regression were used. No significant differences were found either for the quality of life or the self-esteem between sexes; there was a significant positive correlation (p < 0.05) among the physical (r = 0.37), psychological (r = 0.36) and environmental (r = 0.30) domains with self-esteem. The regression model explained 20% of the self-esteem variability, with moderate and significant pathways of the physical (β = 0.23) and psychological (β = 0.23) domains, whereas the environmental domain did not show a significant predictive relation (p = 0.988) with self-esteem. It is concluded that a higher quality of life perception may result in a higher self-esteem for physically active adults. 


2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Hui Jiang ◽  
Peian Lou ◽  
Xiaoluo Chen ◽  
Chenguang Wu ◽  
Shihe Shao

Abstract Background Type 2 diabetes mellitus (T2DM) is mainly affected by genetic and environmental factors; however, the correlation of long noncoding RNAs (lncRNAs) with T2DM remains largely unknown. Methods Microarray analysis was performed to identify the differentially expressed lncRNAs and messenger RNAs (mRNAs) in patients with T2DM and healthy controls, and the expression of two candidate lncRNAs (lnc-HIST1H2AG-6 and lnc-AIM1-3) were further validated using quantitative real-time polymerase chain reaction (qRT-PCR). Spearman’s rank correlation coefficient was used to measure the degree of association between the two candidate lncRNAs and differentially expressed mRNAs. Furthermore, the KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway and GO (Gene Ontology) enrichment analysis were used to reveal the biological functions of the two candidate lncRNAs. Additionally, multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were performed. Results The microarray analysis revealed that there were 55 lncRNAs and 36 mRNAs differentially expressed in patients with T2DM compared with healthy controls. Notably, lnc-HIST1H2AG-6 was significantly upregulated and lnc-AIM1-3 was significantly downregulated in patients with T2DM, which was validated in a large-scale qRT-PCR examination (90 controls and 100 patients with T2DM). Spearman’s rank correlation coefficient revealed that both lncRNAs were correlated with 36 differentially expressed mRNAs. Furthermore, functional enrichment (KEGG and GO) analysis demonstrated that the two lncRNA-related mRNAs might be involved in multiple biological functions, including cell programmed death, negative regulation of insulin receptor signal, and starch and sucrose metabolism. Multivariate logistic regression analysis revealed that lnc-HIST1H2AG-6 and lnc-AIM1-3 were significantly correlated with T2DM (OR = 5.791 and 0.071, respectively, both P = 0.000). Furthermore, the ROC curve showed that the expression of lnc-HIST1H2AG-6 and lnc-AIM1-3 might be used to differentiate patients with T2DM from healthy controls (area under the ROC curve = 0.664 and 0.769, respectively). Conclusion The profiles of lncRNA and mRNA were significantly changed in patients with T2DM. The expression levels of lnc-HIST1H2AG-6 and lnc-AIM1-3 genes were significantly correlated with some features of T2DM, which may be used to distinguish patients with T2DM from healthy controls and may serve as potential novel biomarkers for diagnosis in the future.


Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 769
Author(s):  
Yuko Hara ◽  
Kenichi Goda ◽  
Shinichi Hirooka ◽  
Takehiro Mitsuishi ◽  
Masahiro Ikegami ◽  
...  

We previously reported that superficial non-ampullary duodenal tumors (SNADETs) commonly had a whitish mucosal surface, named milk-white mucosa (MWM). The aim of this study was to evaluate the association of MWM with epithelial intracellular lipid droplets (immunohistochemically stained by adipose differentiation-related protein (ADRP)) and histological tumor grades. We reviewed endoscopic images and the histopathology of SNADETs resected en bloc endoscopically. We analyzed the correlation between the positive rates of endoscopic MWM in preoperative endoscopy and resected specimens, and ADRP-positive rates in the resected specimens. Associations between the MWM-positive rates and tumor grades, high-grade intraepithelial neoplasia (HGIN)/intramucosal carcinoma (IC), and low-grade intraepithelial neoplasia (LGIN) were analyzed. All the 92 SNADETs analyzed were <20 mm and histologically classified into 39 HGIN/IC and 53 LGIN. Spearman’s rank correlation coefficient showed a significant correlation between MWM-positive and ADRP-positive rates (p < 0.001). MWM-positive rates were significantly lower in the HGIN/IC than in the LGIN in preoperative endoscopy (p < 0.001) and resected specimens (p = 0.02). Our results suggest that endoscopic MWM is closely associated with epithelial intracellular lipid droplets and that the MWM-positive rate may be a predictor of histological grade in small SNADETs.


2012 ◽  
Vol 16 (02) ◽  
pp. 209-216 ◽  
Author(s):  
Luana Berwig ◽  
Ana da Silva ◽  
Eliane Corrêa ◽  
Eliane Serpa ◽  
Rodrigo Ritzel

Summary Introduction: Hyperplasia of the pharyngeal tonsil is one of the main causes of mouth breathing, and accurate diagnosis of this alteration is important for proper therapeutic planning. Therefore, studies have been conducted in order to provide information regarding the procedures that can be used for the diagnosis of pharyngeal obstruction. Objective: To verify the correlation between nasopharyngoscopy and cephalometric examinations in the diagnosis of pharyngeal tonsil hyperplasia. Method: This was a cross-sectional, clinical, experimental, and quantitative study. Fifty-five children took part in this study, 30 girls and 25 boys, aged between 7 and 11 years. The children underwent nasofibropharyngoscopic and cephalometric evaluation to determine the grade of nasopharyngeal obstruction. The Spearman's rank correlation coefficient at the 5% significance level was used to verify the correlation between these exams. Results: In the nasopharyngoscopy evaluation, most children showed grade 2 and 3 hyperplasia of the pharyngeal tonsil, which was followed by grade 1. In the cephalometry assessment, most children showed grade 1 hyperplasia of the pharyngeal tonsil, which was followed by grade 2. A statistically significant regular positive correlation was observed between the exams. Conclusion: It was concluded that the evaluation of the pharyngeal tonsil hyperplasia could be carried out by fiber optic nasopharyngoscopy and cephalometry, as these examinations were regularly correlated. However, it was found that cephalometry tended to underestimate the size of the pharyngeal tonsil relative to nasopharyngoscopy.


2018 ◽  
Vol 23 (3) ◽  
Author(s):  
Urszula Kaczmarek ◽  
Wojciech Kowalczyk ◽  
Dariusz Gozdowski ◽  
Dorota Olczak-Kowalczyk

Introduction. The use of age- and risk-adjusted caries prevention requires up-to-date knowledge on the cariostatic effects of fluoride, as well as the methods and safety of fluoride prophylaxis. Aim. The aim of the study was to assess dentists’ knowledge of the safety and mechanism of anticaries effects of fluoride. Material and methods. An anonymous questionnaire was conducted among 212 dentists participating in dental training. The questions included in the questionnaire related to knowledge about water fluoridation, fluoride cariostatic mechanisms and the safety of fluoride prophylaxis. The chi-square test and the Spearman’s rank correlation coefficient were used for statistical analysis. A significance level of 0.05 was used. Results. Incorrect knowledge about water fluoridation was demonstrated by 26.9% of respondents in the country and 16.0% of respondents in Europe. Most respondents (80.7%) reported higher efficacy of exogenous vs endogenous anticaries approaches, and more than half of respondents (59.0%) considered the processes of remineralisation and demineralisation as the most important anticaries activity. Almost all respondents (95.7%) agreed that the use of fluoride for caries prevention is controversial, mainly due to its dose-dependent therapeutic or toxic effects (85.4%). According to about 20% of respondents, cariostatic fluoride doses have adverse effects on the general health, mainly in the form of bone fragility (10.4%). Conclusions. Lack of correct knowledge about the dominant cariostatic effects of fluoride may result in the choice of an inappropriate preventive method or avoiding local application of fluoride preparations for fear of adverse systemic effects, which may in turn lead to increased caries prevalence in a given population.


2018 ◽  
Vol 30 (4) ◽  
pp. 419-428
Author(s):  
Danwen Bao ◽  
Xiaoling Zhang ◽  
Jiayu Gu

To scientifically and accurately evaluate the status of the development of green airports in China, evaluation methods of green, ecological airports are established in this paper. To address the shortcomings in subjective and objective weighting methods, we propose a combination weighting method based on Spearman’s rank correlation coefficient and evaluation grades based on interval approximation. At the same time, by taking into account resource conservation, environmental friendliness, operation efficiency, and people-oriented service, we propose an evaluation index system and an interval number for each index. Lastly, the theory is applied to five large airports in different regions of China. Analysis of the evaluation results shows that Shanghai Pudong International Airport (PVG) and Guangzhou Baiyun International Airport (CAN) have the highest scores for the resource conservation and environmental friendliness indexes, thus indicating that the development of a green ecological airport is closely related to its passenger transportation scale and economic strength. All considered airports showed the need for upgrading public  service facilities and constructing intelligent equipment. The method proposed in this paper is reasonable  and reliable; therefore, it can provide guidance for the evaluation and construction of green, ecological  airports.


2017 ◽  
Vol 41 (4) ◽  
pp. 451-464 ◽  
Author(s):  
Sara I. McClelland

In research using self-report measures, there is little attention paid to how participants interpret concepts; instead, researchers often assume definitions are shared, universal, or easily understood. I discuss the self-anchored ladder, adapted from Cantril’s ladder, which is a procedure that simultaneously collects a participant’s self-reported rating and their interpretation of that rating. Drawing from a study about sexual satisfaction that included a self-anchored ladder, four analyses are presented and discussed in relation to one another: (1) comparisons of sexual satisfaction scores, (2) variations of structures participants applied to the ladder, (3) frequency of terms used to describe sexual satisfaction, and (4) thematic analysis of “best” and “worst” sexual satisfaction. These analytic strategies offer researchers a model for how to incorporate self-anchored ladder items into research designs as a means to draw out layers of meaning in quantitative, qualitative, and mixed methods data. I argue that the ladder invites the potential for conceptual disruption by prioritizing skepticism in survey research and bringing greater attention to how social locations, histories, economic structures, and other factors shape self-report data. I also address issues related to the multiple epistemological positions that the ladder demands. Finally, I argue for the centrality of epistemological self-reflexivity in critical feminist psychological research. Additional online materials for this article are available on PWQ’s website at http://journals.sagepub.com/doi/suppl/10.1177/0361684317725985


2021 ◽  
Vol 7 (4) ◽  
pp. 58-68
Author(s):  
T. Chernykh ◽  
V. Mulyk ◽  
K. Mulyk ◽  
А. Skaliy ◽  
А. Ostrowski ◽  
...  

Purpose: to determine the relationship between the performance of basic elements and indicators of static and dynamic balance in the training process of young acrobats 6-7 years. Material and methods. The study involved 16 young acrobats at the stage of initial training (age 6-7 years). All parents of the participants gave written consent for the participation of children in the study. The study involved testing the technique of performing basic elements of sports acrobatics and assessing the static and dynamic balance of young athletes. The relationship between (swallow, shoulder blade, forward squat, wheel (sideways overturning), bridges) and static and dynamic equilibrium tests was determined. Spearman's rank correlation coefficient method was used as a method of statistical analysis. Results. It is established that the largest relationship between the performance of basic elements and static balance in the basic exercises of young acrobats have: Romberg's test with the elements "Swallow", "Stand on the shoulders", "Bridge"; Biryuk test with elements "Swallow", "Wheel", "Bridge"; balance "Swallow" with elements "Swallow", "Wheel"; static equilibrium test with the elements "Swallow", "Rack on the shoulders", "Rolling forward with a squat", "Wheel". Reliable values ​​of the correlation coefficient were established between the tests of dynamic balance and the basic elements of sports acrobatics in young athletes 6-7 years, namely: "Swallow", "Flip forward with a squat", "Wheel" and "Bridge". The analysis of special tests of static and dynamic balance in mastering the basic elements of acrobatics at the first stage of long-term training makes it possible to use them to determine the level of coordination capabilities of young athletes and further improve the use of acrobatic exercises. Conclusions. A reliable relationship between the performance of basic exercises and indicators of static and dynamic balance in young acrobats at the initial stage of training. It is shown that the level of static and dynamic balance is of great importance for the assimilation and improvement of basic elements of technology by young acrobats 6-7 years. Static and dynamic balance tests can be used to individually build training programs and young acrobats. It is shown that sports acrobatics is a significant means of developing the balance of children 6-7 years.


Author(s):  
Satyanand Sathi ◽  
Richa Tiwari ◽  
Savita Verma ◽  
Anil Kumar Garg ◽  
Virendra Singh Saini ◽  
...  

Recent literature has reported that radiological features of coronavirus disease (COVID-19) patients are influenced by computed tomography. This study aimed to assess the characteristic chest X-ray features of COVID-19 and correlate them with clinical outcomes of patients. This retrospective study included 120 COVID-19 patients. Baseline chest X-rays and serial chest X-rays were reviewed. A severity index in the form of maximum radiological assessment of lung edema (RALE) score was calculated for each lung, and scores of both the lungs were summed to obtain a final score. The mean ± standard deviation (SD) and frequency (%) were determined, and an unpaired t test, Spearman’s rank correlation coefficient, and logistic regression analyses were performed for statistical analyses. Among 120 COVID-19 patients, 74 (61.67%) and 46 (38.33%) were males and females, respectively; 64 patients (53.33%) had ground-glass opacities (GGO), 55 (45.83%) had consolidation, and 38 (31.67%) had reticular-nodular opacities, with lower zone distribution (50%) and peripheral distribution (41.67%). Baseline chest X-ray showed a sensitivity of 63.3% in diagnosing typical findings of SARS-CoV-2 pneumonia. The maximum RALE score was 2.13 ± 1.9 in hospitalized patients and 0.57 ± 0.77 in discharged patients ( p value <0.0001). Spearman’s rank correlation coefficient between maximum RALE score and clinical outcome parameters was as follows: age, 0.721 ( p value <0.00001); >10 days of hospital stay, 0.5478 ( p value <0.05); ≤10 days of hospital stay, 0.5384 ( p value <0.0001); discharged patients, 0.5433 ( p value <0.0001); and death, 0.6182 ( p value = 0.0568). The logistic regression analysis revealed that maximum RALE scores (0.0932 [0.024–0.367]), (10.730 [2.727–42.206]), (1.258 [0.990–1.598]), and (0.794 [0.625–1.009]) predicted discharge, death, >10 days of hospital stay, and ≤10 days of hospital stay, respectively. The study findings suggested that the RALE score can quantify the extent of COVID-19 and can predict the prognosis of patients.


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