scholarly journals An analysis of orphan medicine expenditure in Europe: is it sustainable?

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Jorge Mestre-Ferrandiz ◽  
Christina Palaska ◽  
Tom Kelly ◽  
Adam Hutchings ◽  
Adam Parnaby
Keyword(s):  
Pharmaceutical Expenditure ◽  
Pharmaceutical Market ◽  
Annual Growth Rate ◽  
List Type ◽  
Orphan Medicinal Product ◽  
Aggregated Data ◽  
Compound Annual Growth Rate ◽  
Country Level ◽  
Lower Volume ◽  
Pharmaceutical Spending

Abstract Background Orphan medicinal product (OMP) prices are considered by some to be a challenge to the sustainability of healthcare expenditure. These concerns are compounded by the increasing number of OMPs receiving marketing authorisation (MA) annually. The aim of this study was to explore the sustainability of OMP expenditure within the context of total European pharmaceutical expenditure. Methods Using historical IQVIA data, an analysis was conducted on total pharmaceutical and OMP expenditure in eight countries (using values / volumes) in the branded, non-branded and overall pharmaceutical market. Country level and aggregated data was considered for EU5 countries, Austria, Belgium and Ireland. Three key analyses were conducted: The OMP share of total pharmaceutical expenditure was calculated from 2000 to 2017, to assess its evolution over time.The results of this analysis were compared with a 2011 forecast of OMP budget impact.The evolution of the total pharmaceutical market and its different segments (branded OMPs, non-OMP branded and unbranded) were assessed by estimating the compound annual growth rate (CAGR) and percentage of pharmaceutical expenditure for each market segment from 2010 to 2017. Results Across countries, OMP share of total pharmaceutical expenditure has increased each year since 2000, rising to 7.2% of total pharmaceutical expenditure in 2017. OMP expenditure has increased at a CAGR of 16% since 2010. The number of OMPs receiving MA each year showed a CAGR of 11% since 2001, four percentage points greater than the CAGR for all medicines receiving MA over the same period. OMP share of total pharmaceutical expenditure is higher than forecasted in 2011 due to slower than expected growth in the non-OMP market. OMP growth has been offset by reduced expenditure in the general market and increased use of generics and biosimilars. Conclusions Relative spending on OMPs has increased over the last 20 years, but this has been largely compensated for within the current allocation of total pharmaceutical spending by flat expenditure for non-OMPs and increased volumes of (lower-priced) generics/biosimilars, reflecting a shift towards expenditure in higher cost, lower volume patient populations and a shift in drug development towards more specialised targeting of diseases.

scholarly journals Trends in lipid-modifying agent use in 83 countries

2021 ◽  
Author(s):  
Joseph E Blais ◽  
Yue Wei ◽  
Kevin KW Yap ◽  
Hassan Alwafi ◽  
Tian-Tian Ma ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Annual Growth Rate ◽  
Pcsk9 Inhibitors ◽  
Cross Sectional ◽  
Global Trends ◽  
Compound Annual Growth Rate ◽  
Country Level ◽  
Data Analysis System

ABSTRACTAimsLipid-modifying agents (LMAs) are increasingly used to reduce lipid levels and prevent cardiovascular events, but the magnitude of their consumption in different world regions is unknown. We aimed to describe recent global trends in LMA consumption and to explore the relationship between country-level LMA consumption and cholesterol concentrations.Methods and resultsThis cross-sectional and ecological study used monthly pharmaceutical sales data from January 2008 to December 2018, for 83 countries from the IQVIA Multinational Integrated Data Analysis System, and total and non–high-density lipoprotein (non– HDL) cholesterol concentrations from the NCD Risk Factor Collaboration. The compound annual growth rate (CAGR) was used to assess changes in LMA consumption over time. From 2008 to 2018, the use of LMAs increased from 7,468 to 11,197 standard units per 1000 inhabitants per year (CAGR 4.13%). Statins were the most used class of LMA and their market share increased in 75% of countries between 2008 and 2018. Fibrates were the most consumed nonstatin drugs. From 2013 to 2018, consumption of low-density lipoprotein lowering therapies increased (statins 3.99%; ezetimibe 4.01%; proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors 104.47%). Limited evidence supports a clear relationship between country-level changes in LMA consumption and total and non–HDL cholesterol concentrations in 2008 versus 2018.ConclusionSince 2008, global access to LMAs, especially statins, has improved. In line with international lipid guideline recommendations, recent trends indicate growth in the use of statins, ezetimibe, and PCSK9 inhibitors. Country-level patterns of LMA use and total and non–HDL cholesterol varied considerably.

scholarly journals Camel Research of Selected Pharmaceutical Industries

2020 ◽  
Vol 8 (6S4) ◽  
pp. 9-18
Keyword(s):  
Pharmaceutical Industry ◽  
Pharmaceutical Expenditure ◽  
Annual Growth Rate ◽  
Tier 2 ◽  
Geriatric Population ◽  
Compound Annual Growth Rate ◽  
Developed Economies ◽  
Pharmaceutical Industries ◽  
Tier 3 ◽  
European Markets

The pharmaceutical industry is observed to have an unhampered growth and is anticipated to grow supplemental a compound annual growth rate (CAGR) of 3-6% over the next five years. The worldwide expenditure on medicines has crossed US $1.2 Trillion in 2018 and is expected to go over US $ 1.5 Trillion by 2023. The new product lift-offs, particularly the specialty range have been the major contributor in the growth accomplishment. However, reforming per capita income, accelerating consciousness towards health, geriatric population, elevated chronic ailments along with technological magnifications are significantly pitching towards the growth accomplishment. The following economies have majorly pitched in towards the pharmaceuticals expenditure in 2018: US (US $ 486 Billion), top five European markets (US $ 178 Billion), China (US $ 137 Billion), Japan (US $ 86 Billion).Looking at the trend it seems that the growth of the world-wide pharmaceutical expenditure will majorly be moved by developed economies through innovatory products created using latest technology. United States appears to remain a fairy godmother in the pharmaceutical industry. However, emerging economies like Brazil, India, Russia (Tier 2 markets) and Tier 3 markets shall also confer to the growth process. Their CAGR is projected to grow 5-8% through 2023 to reach US $ 355 – 385 Billion.

Assessment of Gaming Practices and its effect on scholastic performance of medical students in India: A Case Control study. (Preprint)

2020 ◽  
Author(s):  
Deodatt Madhav Suryawanshi ◽  
Divya Rajaseharan 2nd ◽  
Raghuram Venugopal 3rd ◽  
Ramchandra Goyal 4th ◽  
Anju Joy 5th
Keyword(s):  
Medical Students ◽  
Case Control ◽  
Annual Growth Rate ◽  
Gaming Addiction ◽  
Gaming Disorder ◽  
Compound Annual Growth Rate ◽  
Internal Assessment ◽  
Assessment Scores ◽  
Scholastic Performance ◽  
Excessive Gaming

BACKGROUND Introduction: Gaming is a billion-dollar industry growing at a Compound annual growth rate (CAGR) of 9 %- 14.3% with biggest market in South East Asian countries. Availability of Low-cost smart phones, ease of internet access has made gaming popular among youth who enjoy it as a leisure activity. According to the WHO excessive indulgence in Gaming can lead to Gaming disorder. Medical students indulging in excessive gaming can succumb to gaming disorder which can affect their scholastic performance. Hence this study was done to assess the gaming practices and its effect on scholastic performance. OBJECTIVE Objective: 1. To assess the various Gaming practices and the Prevalence of Gaming addiction among medical students. 2. To study the effect of Gaming practices on Scholastic performance of medical students. METHODS Methods: The present study used a case control design where the 448(N) study participants were recruited using non probability sampling technique.91 (Nc) cases who were Gaming for past 6 months were identified using rapid preliminary survey .91 controls (Nco) who never played games were selected and matched for age and sex. Internal Assessment scores (%) of cases and controls were compared. Snedecor F test and Student t test were used to find out the association between the hours of gaming and internal assessment scores (%) and difference of Internal assessment scores between cases and controls respectively. Odds ratio was calculated to identify the risk of Poor scholastic performance. Prevalence of Gaming addiction was assessed using Lemmen’s Gaming addiction scale (GAS). RESULTS Results: Frequency of gaming (hrs) was not associated with the Mean internal assessment scores (p>0.05). Male students (cases) showed significant reduction in both their internal assessment scores (p<0.001,<0.01) whereas no reduction was observed in Female cases. A negative correlation was observed between GAS and internal assessment scores (r=-0.02). Prevalence of Gaming addiction using GAS was found to be 6.2% among the study population(N=448) and 31% among Cases (Nc=91).The risk of low scores was (OR =1.80-1.89) times more in cases than controls. CONCLUSIONS Conclusions: Excessive Gaming adversely affects scholastic performance in males than females.Awareness about Gaming addiction needs to be created among students, parents and teachers. Institutionalized De-addiction services should be made available to medical students. CLINICALTRIAL No

Australian Biotechnology: A 10-Year Study of Investor Performance

2021 ◽  
Vol 26 (4) ◽  
Author(s):  
Peter L. Molloy ◽  
Lester W. Johnson ◽  
Michael Gilding
Keyword(s):  
Drug Development ◽  
Global Financial Crisis ◽  
Critical Mass ◽  
Share Price ◽  
Annual Growth Rate ◽  
Compound Annual Growth Rate ◽  
Listed Firms ◽  
Investor Returns ◽  
The Global Financial Crisis ◽  
The Impact

A recent study assessed the investor performance of the Australian drug development biotech (DDB) sector over a 15-year period from 2003 to 2018. The current study builds on that research and extends the analysis to 2020, using a 10-year period starting 2010, to exclude the impact of the global financial crisis in 2008/09. Based on a value-weighted portfolio of all 41 DDB firms, the overall sector delivered a negative annualized return of -4.1%. Individual firm performance was also assessed using the compound annual growth rate (CAGR) in share price over the period as a measure of investor outcomes. On this basis 68% of firms produced negative CAGRs over the period, and of the 32% of firms that produced positive CAGRs, six firms produced CAGRs greater than 20% per annum and in three cases of recently-listed firms, the CAGR’s were greater than 50%. Overall however, the sector overall delivered very poor investor returns and despite a relatively large number of listed biotech firms, Australian biotechnology continues to be small and weak in terms of its contribution to global biotechnology industrialization. As such it lacks the critical mass to grow a robust bioeconomy based on drug development, which remains the standard-bearer of biotechnology industrialization.

A Study of E-Book Industry’s Cooperation in Taiwan

2012 ◽  
Vol 262 ◽  
pp. 223-226
Author(s):  
Tsung Yu Hao ◽  
Li Yi Ma ◽  
Hsiang Jung Lee
Keyword(s):  
Research Method ◽  
Penetration Rate ◽  
Book Industry ◽  
Annual Growth Rate ◽  
Digital Products ◽  
Internet Service ◽  
Compound Annual Growth Rate ◽  
On Line ◽  
Internet Penetration ◽  
Hardware Industry

Purchasing the E-books from the on-line bookstore is the trend that Amazon created this business model successfully. Miniwatts Marketing Group (2010) pointed that the internet penetration rate in Taiwan has been reached 70%. Amazon and Barnes and Nobel both claimed the revenue of e-books exceeded the books in 2010. The compound annual growth rate is nearly 72% in year 2008–2013. Therefore, there is a great need to investigate the cross-industry of publisher industry, hardware industry, and internet service platforms to integrate the picture of E-book industry in Taiwan. The qualitative research method will be used to interview the managers in the related leading companies in order to understand the “how to do and what to do” between each other to promote the digital products. By gathering the information to gain the knowledge for the reference to the related industries to work closely to benefit each other and expand the business scope. It is absolutely helpful to create a comfortable reading environment to satisfy the readers’ various needs.

scholarly journals IMPACT OF COVID-19 ON MALAYSIAN E-COMMERCE

2021 ◽  
Vol 5 (4) ◽  
Author(s):  
Vinesh Raj S. ◽  
Meghna Gohain
Keyword(s):  
Small And Medium Enterprises ◽  
Annual Growth Rate ◽  
Potential Growth ◽  
Compound Annual Growth Rate ◽  
Market Outlook ◽  
Customer Services ◽  
The Government ◽  
Medium Enterprises ◽  
Almost All ◽  
Tremendous Impact

COVID-19 pandemic has made a tremendous impact all across the globe. It is clearly reflected in the ongoing lockdowns, closing down of almost all shops, restaurants and public transportations, surge of unemployment etc. all culminating into severe economic depression. Malaysia, also, has faced this hit of recession, depreciation, and unemployment to a great extent with the current pandemic situation. However, when everything seems to be crumbling, e-commerce appears to have found its golden break in raising its profit and contributing to the overall GDP growth of Malaysia. There are various factors that played into the booming of e-commerce owing to the current pandemic situation. Needless to say, the value of e-commerce in helping the depleting economy and just plain convenience for people to purchase essential commodities during lockdown cannot be denied. Even the government of Malaysia has been showing support by encouraging local Micro, Small and Medium Enterprises (MSMEs). E-commerce has the potential to become a major source of contribution to the country’s economy. However, it needs to ramp up their infrastructure regarding security, delivery, and customer services. Additionally, importance should be given to local businesses in order to empower the local e-commerce sector. This article aims to give an overview of the trend in the growth of e-commerce during the COVID era and its potential growth in the next four years based on Compound Annual Growth Rate (CAGR) and Statista Digital Market Outlook and the factors that have led to the boom in e-commerce in Malaysia.

scholarly journals Characteristics and Challenges of the Internet of Things in Entrepreneurship

2020 ◽  
Vol 43 (338) ◽  
pp. 27-34
Author(s):  
Lasma Licite-Kurbe ◽  
Athul Chandramohan
Keyword(s):  
Internet Of Things ◽  
Smart Cities ◽  
Health Sector ◽  
The Internet ◽  
Annual Growth Rate ◽  
Privacy And Security ◽  
Compound Annual Growth Rate ◽  
Industrial Iot ◽  
Analysis And Synthesis ◽  
The Internet Of Things

AbstractThe Internet of Things (IoT) is a computing concept that describes the idea of everyday physical objects being connected to the Internet and being able to identify themselves to other devices, and day by day it becomes popular in everyday life as well as in entrepreneurship. The IoT covers broad areas, including manufacturing, the health sector, agriculture, smart cities, security and emergencies among many others. The market for the industrial IoT is estimated to surpass 107 billion euros by 2021 and reach a compound annual growth rate of 7.3% as of 2020. The IoT makes an impact on all industries and provides benefits for various areas of business; however, business may be faced with some risks as well. The research aim is to analyse the benefits and risks of the IoT in entrepreneurship. The descriptive method, analysis and synthesis, the induction and deduction methods were used to achieve the aim. The research has revealed that the IoT can provide several opportunities for business in all fields of operations – marketing, logistics, accounting and human resource management. However, businesses may be faced with some challenges related to privacy and security, processing, analysis and management of data, as well as monitoring and sensing.

Authorship Pattern and Collaboration Coefficient of Library Professional’s Competency on Research Publications During 1999-2018: A Scientometric Analysis

2019 ◽  
Vol 9 (1) ◽  
pp. 85-89
Author(s):  
Nutan Gaud ◽  
M. P. Singh ◽  
Bhoopendra Singh
Keyword(s):  
Growth Rate ◽  
Doubling Time ◽  
The United States ◽  
Annual Growth ◽  
Scientometric Analysis ◽  
Annual Growth Rate ◽  
Authorship Pattern ◽  
Relative Growth ◽  
Compound Annual Growth Rate ◽  
Scopus Database

The present study aims to analysis authorship pattern and collaboration coefficient of library professional’s competency publications research from 1999-2018. The data has been downloaded by Scopus database. A total number of published articles during the period of study was 433 in the particular database on the topic of ‘professional’s competency’. The study examine various scientometric parameter such as authorship pattern, year wise distribution of publication, determine the annual growth rate and compound annual growth rate of publication, relative growth rate and doubling time of publication and so many. After the analysis, it is found that the highest 11.78% of an article published in the year 2015. The highest growth rate in 2000 and the lowest in 1999. The United States published highest 174 article and secured first place in top five countries wish distribution of the publication. Majority of the article is published by single authors is 171 articles during the period of study.

scholarly journals Can a Different Formulation of Vitamin D3 Allow Savings? An Analysis From an Italian Regional Perspective

2019 ◽  
Vol 6 ◽  
pp. 233339281986188
Author(s):  
Mario Sanò ◽  
Patrizia Dutto ◽  
Stefano D’Anna ◽  
Carla Rognoni
Keyword(s):  
Health Care ◽  
Vitamin D3 ◽  
Pharmaceutical Expenditure ◽  
Local Health Authority ◽  
Local Health ◽  
Pharmaceutical Spending ◽  
Reducing Costs ◽  
New Formulation ◽  
Average Expenditure ◽  
Piedmont Region

Vitamin D3 reported in Italy in 2017 the net expenditure of almost €180 million, reaching the first place for consumption and the third place for conventional pharmaceutical spending. The aim of the study was to evaluate whether a shift of vitamin D3 prescriptions toward 100 000 IU formulation, less costly, could allow savings from the health-care perspective. An approach promoting the prescription of this formulation has been applied in a local health authority (ASL CN2) in Piedmont Region (Italy) starting from 2015. The retail pharmaceutical market and the consumption of vitamin D3 has been analyzed from year 2014 to 2017 in order to evaluate differences in expenditures. Despite an increase in consumption, the introduction of the new formulation enabled ASL CN2 to save about €280 000 in 2017 considering the regional average expenditure per 1000 inhabitants as a reference. If Piedmont Region had presented an average expenditure in line with that of ASL CN2, the annual regional savings would have exceeded €7 million in 2017 alone. A shift of vitamin D3 prescriptions toward 100 000 IU formulations would allow reducing costs from the payer perspective. Savings may be used to contain public pharmaceutical expenditure or can be allocated to fund other health-care technologies and services.

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