scholarly journals Intake of n-3 LCPUFA and trans-fatty acids is unrelated to development in body mass index and body fat among children

BMC Nutrition ◽  
2022 ◽  
Vol 8 (1) ◽  
Author(s):  
Xuan Ren ◽  
Sofus Christian Larsen ◽  
Lotte Lauritzen ◽  
Jeanett Friis Rohde ◽  
Lars Bo Andersen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Fatty Acids ◽  
Body Mass ◽  
Body Fat ◽  
Regression Models ◽  
Trans Fatty Acids ◽  
Saturated Fatty Acids ◽  
Chain Polyunsaturated Fatty Acid ◽  
Substitution Effects ◽  
Linear Regression Models

Abstract Background The number of children and adolescents with obesity has increased worldwide. Some studies have found an increase in the intake of n-3 long-chain polyunsaturated fatty acid (LCPUFA) to be beneficial for weight and obesity status. The objectives of this study were to examine if intake of trans-fatty acids (TFA) and n-3 LCPUFA at school start was associated with weight and body fat development in the following 3 and 7 years, and if substituting other fats for n-3 LCPUFA in regression models influenced weight and body fat development. Methods A total of 285 children (boys:130, girls:155) were included in this study. Weight, height and skinfold thickness (SF) of children were measured at age 6, 9 and 13 years by trained research personnel. Multivariate linear regression models were used to investigate the associations between n-3 LCPUFA or TFA intake and subsequent changes in body mass index (BMI) or SF. To investigate substitution effects, we constructed regression models including information on n-3 LCPUFA and all other energy given components of the diet, except for the nutrient to be substituted (all other fats and specific subgroups; saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and other polyunsaturated fatty acids (PUFAs)). Results No significant associations were observed between intake of TFA or n-3 LCPUFA and changes in BMI and SF. Also, results from regression analysis showed substituting other fats for n-3 LCPUFA did not associate with BMI or SF development. Conclusion The lack of associations between n-3 LCPUFA and TFA and adiposity suggests that fat composition in the diet does not play a major role in obesity development among school-aged children.

scholarly journals Anthropometric Variables as Mediators of the Association of Changes in Diet and Physical Activity With Inflammatory Profile

2021 ◽  
Author(s):  
Gabriela Cárdenas-Fuentes ◽  
Camille Lassale ◽  
Miguel Ángel Martínez-González ◽  
María Grau ◽  
Jordi Salas-Salvadó ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Mass ◽  
Body Fat ◽  
Controlled Trial ◽  
High Sensitivity ◽  
Linear Regression Models ◽  
Mediating Role ◽  
Inflammatory Score ◽  
Inflammatory Profile

Abstract Background Mechanisms underlying the associations of high levels of physical activity (PA) and adherence to the Mediterranean diet (MedDiet) with a better inflammatory profile remain unclear. Our objective was to assess the mediating role of changes in body mass index (BMI) and waist circumference (WC), as markers of body fat in the association of changes in PA and adherence to the MedDiet, with changes in the inflammatory profile. Method This study included 489 adults, aged 55–75 years, from the PREDIMED-Plus multicenter lifestyle intervention trial. An inflammatory score was calculated, based on 8 blood biomarkers: high-sensitivity C-reactive protein, interleukin 6, interleukin 8, interleukin 18, monocyte chemo-attractant protein-1, C-peptide, leptin, and regulated on activation, normal T-cell–expressed and secreted chemokine. Biomarkers, levels of PA, score of MedDiet adherence, BMI, and WC were measured at baseline and at 1-year follow-up. Linear regression models were fitted according to the Baron and Kenny framework for mediation analysis. Results Changes in BMI and WC mediated the association of both changes in PA and changes in the MedDiet adherence with the inflammatory score. Body mass index mediated 26% of the association of changes in total PA with the inflammatory profile, and 27% of the association of changes in the MedDiet, while WC mediated 13% and 12% of these associations, respectively. Conclusion In older adults at high cardiovascular risk, increasing PA levels and adherence to a MedDiet during 1 year were associated with a lower inflammatory score, which was partly mediated by a reduction in body fat. Clinical Trials Registration Number International Standard Randomized Controlled Trial Number: ISRCTN89898870; registration date July 24, 2014, retrospectively registered.

scholarly journals Role of Gut Microbiota and Short Chain Fatty Acids in Modulating Energy Harvest and Fat Partitioning in Youth

2016 ◽  
Vol 101 (11) ◽  
pp. 4367-4376 ◽  
Author(s):  
Martina Goffredo ◽  
Kendra Mass ◽  
Elizabeth J. Parks ◽  
David A. Wagner ◽  
Emily Ann McClure ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Fatty Acids ◽  
Gut Microbiota ◽  
Body Mass ◽  
Body Fat ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Gut Flora ◽  
Obese Youth ◽  
Chain Fatty Acids

Objective: We aimed at determining the relationship of the gut microbiota and short chain fatty acids with obesity and fat partitioning and at testing potential differences in the ability of gut microbiota to ferment equal amounts of carbohydrates (CHO) between lean and obese youth. Research Design and Methods: We analyzed the gut microbiota of 84 youth in whom body fat distribution was measured by fast-magnetic resonance imaging, de novo lipogenesis (DNL) quantitated using deuterated water, and the capability of gut flora to ferment CHO was assessed by 13C-fructose treatment in vitro. Results: A significant association was found between the Firmicutes to Bacteroidetes ratio, and the abundance of Bacteroidetes and Actinobacteria with body mass index, visceral and SC fat (all P < .05). Plasma acetate, propionate, and butyrate were associated with body mass index and visceral and SC fat (all P < .05) and with hepatic DNL (P = .01, P = .09, P = .04, respectively). Moreover, the rate of CHO fermentation from the gut flora was higher in obese than in lean subjects (P = .018). Conclusions: These data demonstrate that obese youth show a different gut flora composition than lean and that short chain fatty acids are associated with body fat partitioning and DNL. Also, the gut microbiota of obese youth have a higher capability than the gut flora of lean to oxidize CHO.

scholarly journals Association of body mass index with morbidity in patients hospitalised with COVID-19

2021 ◽  
Vol 8 (1) ◽  
pp. e000970
Author(s):  
Maria Plataki ◽  
Di Pan ◽  
Parag Goyal ◽  
Katherine Hoffman ◽  
Jacky Man Kwan Choi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
New York ◽  
Body Mass ◽  
Regression Models ◽  
Hospital Length ◽  
Hospital Length Of Stay ◽  
Linear Regression Models ◽  
Discharge Disposition ◽  
Home Discharge ◽  
Significant Difference

PurposeTo evaluate the association between body mass index (BMI) and clinical outcomes other than death in patients hospitalised and intubated with COVID-19.MethodsThis is a single-centre cohort study of adults with COVID-19 admitted to New York Presbyterian Hospital-Weill Cornell Medicine from 3 March 2020 through 15 May 2020. Baseline and outcome variables, as well as lab and ventilatory parameters, were generated for the admitted and intubated cohorts after stratifying by BMI category. Linear regression models were used for continuous, and logistic regression models were used for categorical outcomes.ResultsThe study included 1337 admitted patients with a subset of 407 intubated patients. Among admitted patients, hospital length of stay (LOS) and home discharge was not significantly different across BMI categories independent of demographic characteristics and comorbidities. In the intubated cohort, there was no difference in in-hospital events and treatments, including renal replacement therapy, neuromuscular blockade and prone positioning. Ventilatory ratio was higher with increasing BMI on days 1, 3 and 7. There was no significant difference in ventilator free days (VFD) at 28 or 60 days, need for tracheostomy, hospital LOS, and discharge disposition based on BMI in the intubated cohort after adjustment.ConclusionsIn our COVID-19 population, there was no association between obesity and morbidity outcomes, such as hospital LOS, home discharge or VFD. Further research is needed to clarify the mechanisms underlying the reported effects of BMI on outcomes, which may be population dependent.

scholarly journals QUALITY MACRONUTRIENT DIET СOMPARISON OF THE RECOMMENDED DAILY INTAKE DIABETES TYPE II PATIENTS AND HEALTHY PERSONS

2016 ◽  
Vol 10 (3) ◽  
Author(s):  
J. Kozonova ◽  
L. Telegenko
Keyword(s):  
Body Mass Index ◽  
Fatty Acids ◽  
Body Mass ◽  
Saturated Fatty Acids ◽  
Daily Intake ◽  
Caloric Intake ◽  
The Body ◽  
Omega 3 ◽  
Diabetes Type Ii ◽  
Patients With Diabetes

The article states that the development of insulin resistance is influenced by many parameters, however, one of the first is the increased weight. The main parameter that characterizes the degree of obesity is the body mass index. There is a direct correlation between body mass index and the probability of diabetes developing. Diabetes is a part of symptoms, metabolic syndrome. The comparative analysis of makronutrient composition of diabetic patient’s diets and healthy individuals were made. Thus, for patients with diabetes it is necessary to reduce overall caloric intake by fat and carbohydrates. It is recommended to reduce total fats by reducing saturated fatty acids at the same time to increase the content of omega-3 fatty acids. It is shown that the consumption of foods with dietary fiber (30 grams per day), reduces the need for insulin by 25 ... 50 %, and has a positive effect on blood glucose and lipids in the blood.

Overweight and erythrocyte polyunsaturated fatty acid changes in menopause

2020 ◽  
Vol 4 (3) ◽  
pp. 144-149
Author(s):  
Giulia D’Alberti ◽  
Carla Ferreri ◽  
Anna Vita Larocca ◽  
Pierangelo Torquato ◽  
Antonio Boccuto ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Body Mass ◽  
Saturated Fatty Acids ◽  
Monounsaturated Fatty Acids ◽  
The Body ◽  
Control Group ◽  
Menopausal Women ◽  
And Control

AbstractLipid disorders have been implicated in overweight and menopause. However, evidence on lipidomic analysis of fatty acids in erythrocytes of menopausal women is scarce. The aim of this study was to investigate the relationship between the body mass index within or beyond 5 years of menopause and erythrocyte fatty acid profile. This case-control study was conducted on out of 37 menopausal women total patients, 22 with body mass index ≥ 25 and 12 matched controls (body mass index <25). Experimental procedures were performed on the blood through robotic equipment for isolation of erythrocyte and cell membrane fatty acids were analyzed by using gas-liquid chromatography. Results showed that erythrocyte membranes did not change significantly in lipid composition between case and control group. However, the percentage of women who had a physiological content of saturated fatty acids was lower in case than in control group, and the percentage of women who had a physiological content of monounsaturated fatty acids and polyunsaturated fatty acids was lower in control than in case group. Woman with BMI>25 and non-physiological content of fatty acids, were richer in percentage of saturated fatty acids and poorer of monounsaturated fatty acids and polyunsaturated fatty acids than women with BMI<25. The percentage of physiological n-6/n-3 polyunsaturated ratio was lower in women with BMI>25 than in women with BMI<25. Interestingly, the percentage of patients that had physiological values of lipids beyond 5 years of menopause increased in comparison patients within 5 years of menopause. Notably, n-6/n-3 polyunsaturated fatty acids physiological ratio beyond 5 years of menopause increased in both case and control patients, indicating normalization over time. In conclusion erythrocytes fatty acids composition may be related to the body mass index and to the time from menopause.

scholarly journals Association of plasma phospholipid polyunsaturated and trans fatty acids with body mass index: results from the Multi-Ethnic Study of Atherosclerosis

2017 ◽  
Vol 42 (3) ◽  
pp. 433-440 ◽  
Author(s):  
T A Hastert ◽  
M C de Oliveira Otto ◽  
F Lê-Scherban ◽  
B T Steffen ◽  
L M Steffen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Fatty Acids ◽  
Body Mass ◽  
Trans Fatty Acids ◽  
Plasma Phospholipid ◽  
Ethnic Study

scholarly journals Factors Associated With the Outcome of a First-Line Intervention for Patients With Hip or Knee Osteoarthritis or Both: Data From the BOA Register

2020 ◽  
Vol 100 (10) ◽  
pp. 1771-1781
Author(s):  
Andrea Dell’Isola ◽  
Therese Jönsson ◽  
Håkan Nero ◽  
Frida Eek ◽  
Leif Dahlberg
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Regression Models ◽  
Negative Impact ◽  
Psychological Status ◽  
Linear Regression Models ◽  
First Line ◽  
Factors Associated ◽  
Independent Variables ◽  
Knee Oa

Abstract Objective This study explored the association of patients’ demographics, health status, symptom severity, previous osteoarthritis (OA) care, and psychological status with the change in pain severity following a first-line intervention including education and exercise for OA provided nationwide in Swedish primary care. Methods This register-based cohort study included 23,309 people with knee or hip OA from the Better Management of Patients with OA register. Linear regression models were used to assess the association of independent variables with the change in pain from baseline to 3 and 12 months. All the analyses were stratified based on the affected joint (hip vs knee). Results In people with hip and people with knee OA, high levels of baseline pain were associated with decreased pain at both follow-ups (3 months: knee B = −.67; hip B = −.64; 12 months: knee B = −.70; hip B = −.66), whereas being older, overweight, or female had a weak or no association. Finally, at both follow-ups, bilateral OA was associated with increased pain only in people with knee OA, whereas comorbidities and the willingness to undergo surgery were associated with increased pain regardless of the affected joint. Conclusions Baseline pain showed the strongest association among the analyzed variables, whereas sex, age, and body mass index appear to be weakly associated with the pain change after a first-line intervention. Comorbidities and willingness to undergo surgery showed a potentially important association and may have a negative impact on the pain change following a first-line intervention. Impact In people with hip or knee OA, age, sex, body mass index, and previous surgery are only weakly associated with the change in pain after a first-line intervention supporting the evidence recommending exercise and education as a foundation for all OA therapy. Having comorbidities and being willing to undergo surgery is associated with a worse outcome from a first-line intervention, including exercise and education. Individualized treatments addressing the disease perception and the specific comorbidity profile may improve the outcomes.

scholarly journals Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011-18: population based study

BMJ ◽  
2021 ◽  
pp. n365
Author(s):  
Buyun Liu ◽  
Yang Du ◽  
Yuxiao Wu ◽  
Linda G Snetselaar ◽  
Robert B Wallace ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Waist Circumference ◽  
Ethnic Groups ◽  
Body Mass ◽  
Body Fat ◽  
Lean Mass ◽  
The United States ◽  
Population Based ◽  
Body Fat Percentage ◽  
Fat Percentage

AbstractObjectiveTo examine the trends in obesity and adiposity measures, including body mass index, waist circumference, body fat percentage, and lean mass, by race or ethnicity among adults in the United States from 2011 to 2018.DesignPopulation based study.SettingNational Health and Nutrition Examination Survey (NHANES), 2011-18.ParticipantsA nationally representative sample of US adults aged 20 years or older.Main outcome measuresWeight, height, and waist circumference among adults aged 20 years or older were measured by trained technicians using standardized protocols. Obesity was defined as body mass index of 30 or higher for non-Asians and 27.5 or higher for Asians. Abdominal obesity was defined as a waist circumference of 102 cm or larger for men and 88 cm or larger for women. Body fat percentage and lean mass were measured among adults aged 20-59 years by using dual energy x ray absorptiometry.ResultsThis study included 21 399 adults from NHANES 2011-18. Body mass index was measured for 21 093 adults, waist circumference for 20 080 adults, and body fat percentage for 10 864 adults. For the overall population, age adjusted prevalence of general obesity increased from 35.4% (95% confidence interval 32.5% to 38.3%) in 2011-12 to 43.4% (39.8% to 47.0%) in 2017-18 (P for trend<0.001), and age adjusted prevalence of abdominal obesity increased from 54.5% (51.2% to 57.8%) in 2011-12 to 59.1% (55.6% to 62.7%) in 2017-18 (P for trend=0.02). Age adjusted mean body mass index increased from 28.7 (28.2 to 29.1) in 2011-12 to 29.8 (29.2 to 30.4) in 2017-18 (P for trend=0.001), and age adjusted mean waist circumference increased from 98.4 cm (97.4 to 99.5 cm) in 2011-12 to 100.5 cm (98.9 to 102.1 cm) in 2017-18 (P for trend=0.01). Significant increases were observed in body mass index and waist circumference among the Hispanic, non-Hispanic white, and non-Hispanic Asian groups (all P for trend<0.05), but not for the non-Hispanic black group. For body fat percentage, a significant increase was observed among non-Hispanic Asians (30.6%, 29.8% to 31.4% in 2011-12; 32.7%, 32.0% to 33.4% in 2017-18; P for trend=0.001), but not among other racial or ethnic groups. The age adjusted mean lean mass decreased in the non-Hispanic black group and increased in the non-Hispanic Asian group, but no statistically significant changes were found in other racial or ethnic groups.ConclusionsAmong US adults, an increasing trend was found in obesity and adiposity measures from 2011 to 2018, although disparities exist among racial or ethnic groups.

scholarly journals Prepubertal Dietary and Plasma Phospholipid Fatty Acids Related to Puberty Timing: Longitudinal Cohort and Mendelian Randomization Analyses

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1868
Author(s):  
Tuck Seng Cheng ◽  
Felix R. Day ◽  
John R. B. Perry ◽  
Jian’an Luan ◽  
Claudia Langenberg ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Linolenic Acid ◽  
Mendelian Randomization ◽  
Saturated Fatty Acids ◽  
Plasma Phospholipid ◽  
Height Velocity ◽  
Breast Development ◽  
Dietary Intakes ◽  
Linear Regression Models ◽  
Peak Height Velocity

Dietary intakes of polyunsaturated, monounsaturated and saturated fatty acids (FAs) have been inconsistently associated with puberty timing. We examined longitudinal associations of prepubertal dietary and plasma phospholipid FAs with several puberty timing traits in boys and girls. In the Avon Longitudinal Study of Parents and Children, prepubertal fat intakes at 3–7.5 years and plasma phospholipid FAs at 7.5 years were measured. Timings of Tanner stage 2 genital or breast development and voice breaking or menarche from repeated reports at 8–17 years, and age at peak height velocity (PHV) from repeated height measurements at 5–20 years were estimated. In linear regression models with adjustment for maternal and infant characteristics, dietary substitution of polyunsaturated FAs for saturated FAs, and higher concentrations of dihomo-γ-linolenic acid (20:3n6) and palmitoleic acid (16:1n7) were associated with earlier timing of puberty traits in girls (n = 3872) but not boys (n = 3654). In Mendelian Randomization models, higher genetically predicted circulating dihomo-γ-linolenic acid was associated with earlier menarche in girls. Based on repeated dietary intake data, objectively measured FAs and genetic causal inference, these findings suggest that dietary and endogenous metabolic pathways that increase plasma dihomo-γ-linolenic acid, an intermediate metabolite of n-6 polyunsaturated FAs, may promote earlier puberty timing in girls.

Sign in / Sign up

Export Citation Format

Share Document