scholarly journals Comprehensive framework between environment and genomic stability: the open symposium of the Japanese Environmental Mutagen Society (JEMS) in 2019

2019 ◽  
Vol 41 (1) ◽  
Author(s):  
Katsuyoshi Horibata ◽  
Masashi Sekimoto ◽  
Kei-ichi Sugiyama
Keyword(s):  
Cancer Research ◽  
Genomic Stability ◽  
Environmental Mutagen ◽  
Conference Room ◽  
Current Trends ◽  
Research Activities ◽  
Comprehensive Framework ◽  
The Relationship

Abstract The open symposium of the Japanese Environmental Mutagen Society (JEMS), under the title of “Comprehensive framework between environment and genomic stability,” was held in the Main Conference Room of the Foundation for Promotion of Cancer Research, Tokyo, on June 8, 2019. To understand the relationship between genes and environmental mutagens, the symposium highlights the research activities in the fields of cancer, carcinogenesis and related diseases caused by genomic instabilities, including epigenetic and metabolomic alterations. The symposium was planned to help familiarize attendees with the current trends in research on genome safety. The organizers herein present a summary of the symposium.

scholarly journals Autophagy Modulators in Cancer Therapy

2021 ◽  
Vol 22 (11) ◽  
pp. 5804
Author(s):  
Kamila Buzun ◽  
Agnieszka Gornowicz ◽  
Roman Lesyk ◽  
Krzysztof Bielawski ◽  
Anna Bielawska
Keyword(s):  
Cancer Research ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Nutrient Deficiency ◽  
Molecular Regulation ◽  
Regulatory Pathways ◽  
Selective Autophagy ◽  
Atg Proteins ◽  
Different Types ◽  
The Relationship

Autophagy is a process of self-degradation that plays an important role in removing damaged proteins, organelles or cellular fragments from the cell. Under stressful conditions such as hypoxia, nutrient deficiency or chemotherapy, this process can also become the strategy for cell survival. Autophagy can be nonselective or selective in removing specific organelles, ribosomes, and protein aggregates, although the complete mechanisms that regulate aspects of selective autophagy are not fully understood. This review summarizes the most recent research into understanding the different types and mechanisms of autophagy. The relationship between apoptosis and autophagy on the level of molecular regulation of the expression of selected proteins such as p53, Bcl-2/Beclin 1, p62, Atg proteins, and caspases was discussed. Intensive studies have revealed a whole range of novel compounds with an anticancer activity that inhibit or activate regulatory pathways involved in autophagy. We focused on the presentation of compounds strongly affecting the autophagy process, with particular emphasis on those that are undergoing clinical and preclinical cancer research. Moreover, the target points, adverse effects and therapeutic schemes of autophagy inhibitors and activators are presented.

scholarly journals When and How Does Sustainable HRM Improve Customer Orientation of Frontline Employees? Satisfaction, Empowerment, and Communication

2021 ◽  
Vol 13 (7) ◽  
pp. 3693
Author(s):  
Youngsam Cho ◽  
Yongduk Choi
Keyword(s):  
Social Exchange ◽  
Social Exchange Theory ◽  
Customer Orientation ◽  
Frontline Employees ◽  
Hrm Practices ◽  
Employees Satisfaction ◽  
Organizational Empowerment ◽  
Research Findings ◽  
Comprehensive Framework ◽  
The Relationship

This study investigated the relationship between sustainable human resource management (HRM) practices, employee satisfaction, and customer orientation of frontline employees (FLEs) in the hotel industry from the perspective of internal marketing. Specifically, the study focused on three facets of sustainable HRM practices (i.e., training, reward, and benefit) as well as organizational empowerment and communication as FLE-supportive contexts. Although some studies have examined the relationship between HRM practices and customer orientation, they overlooked the importance of service context in facilitating FLE customer orientation. Thus, this study developed a comprehensive framework based on social exchange theory and self-determination theory. The results show that all three facets of the sustainable HRM practices were positively related to FLEs’ satisfaction. FLEs’ satisfaction was also positively related to their customer orientation. Furthermore, both organizational empowerment and communication moderated the relationship between FLEs’ satisfaction and customer orientation, which showed a positive relationship only when FLEs perceived high organizational empowerment or communication. The research findings provide beneficial theoretical and practical implications.

Perceptions of Ward Atmosphere on an Oncology Unit

1982 ◽  
Vol 11 (4) ◽  
pp. 331-340 ◽  
Author(s):  
William D. Alexy
Keyword(s):  
Cancer Research ◽  
Family Member ◽  
Multivariate Statistics ◽  
Treatment Program ◽  
Psychosocial Needs ◽  
Cancer Research Institute ◽  
Ward Atmosphere ◽  
Systems Maintenance ◽  
Oncology Unit ◽  
The Relationship

This study examined perceptions of ward atmosphere and ideal ward atmosphere by twenty patients, twenty-four staff, and fifteen family members on an oncology unit at a major cancer research institute. Specified preferences for an ideal ward atmosphere were assumed to reflect psychosocial needs of the three groups. Data were analyzed with multivariate statistics where it was found that perceptions of ward atmosphere differed for the three groups as did their perceptions of the amount of change needed to form an ideal ward atmosphere. This study was viewed as an initial and promising approach to assessing the compatibility of patient, family member, and staff needs along relationship, treatment program, and systems maintenance dimensions. It was believed that further studies of this type will increase the professional's understanding of the relationship between psychosocial needs and reponse to treatment.

Tolstoy in a recipe

2014 ◽  
Vol 44 (4) ◽  
pp. 310-323 ◽  
Author(s):  
Ana Tominc
Keyword(s):  
Design Methodology ◽  
The Other ◽  
Food Culture ◽  
Content Type ◽  
Current Trends ◽  
New Middle Class ◽  
Cooking Shows ◽  
Local Construction ◽  
The Impact ◽  
The Relationship

Purpose – The purpose of this study is to demonstrate the impact of global celebrity chefs and their discourse about food on the genre of cookbooks in Slovenia. Design/methodology/approach – Focusing this discourse study on cookbook topics only, the analysis demonstrates the relationship between the aspirations of local celebrity chefs for the food culture represented globally by global celebrity chefs, such as Oliver, and the necessity for a local construction of specific tastes. While the central genre of TV celebrity chefs remains TV cooking shows, their businesses include a number of side products, such as cookbooks, which can be seen as recontexualisations of TV food discourse. Findings – Hence, despite this study being limited to analysis of cookbooks only, it can be claimed that the findings extend to other genres. The analysis shows that local chefs aspire to follow current trends, such as an emphasis on the local and sustainable production of food as well as enjoyment and pleasure in the form of a postmodern hybrid genre, while, on the other hand, they strive to include topics that will resonate locally, as they aim to represent themselves as the “new middle class”. Originality/value – Such an analysis brings new insights into the relationship between discourse and globalisation as well as discourse and food.

Current trends in Greek puppet theatre. An informal form of education?

2021 ◽  
Author(s):  
Αντιγόνη Παρούση ◽  
Αντώνης Λενακάκης
Keyword(s):  
General Public ◽  
Digital Edition ◽  
Current Trends ◽  
Puppet Theatre ◽  
Stereotypical Image ◽  
The Relationship

When social and political upheavals are testing the art of puppetry, education, and most importantly, the relationship between theater and education, the digital edition of this volume aspires to present to the general public its "today". Greek puppetry, which is very different from the stereotypical image that circulates in much of the educational world. The volume aspires to capture, as much as possible, the dynamics of its existence and its history, a story that convinces that no matter how much it was underestimated as a theatrical genre, no matter how many exclusions it accepted, it is here and continues to entertain and "erode"» with its special characteristics both the fields of education and those of other arts

scholarly journals Cancer Health Literacy and Willingness to Participate in Cancer Research and Donate Bio-Specimens

2018 ◽  
Vol 15 (10) ◽  
pp. 2091 ◽  
Author(s):  
Margarita Echeverri ◽  
David Anderson ◽  
Anna Nápoles ◽  
Jacqueline Haas ◽  
Marc Johnson ◽  
...  
Keyword(s):  
Cancer Research ◽  
Health Literacy ◽  
Healthcare Providers ◽  
Internal Consistency Reliability ◽  
Diverse Populations ◽  
Willingness To Participate ◽  
Limited Participation ◽  
Non Invasive ◽  
Bonferroni Procedure ◽  
The Relationship

Although it has been well documented that poor health literacy is associated with limited participation in cancer clinical trials, studies assessing the relationships between cancer health literacy (CHL) and participation in research among diverse populations are lacking. In this study, we examined the relationship between CHL and willingness to participate in cancer research and/or donate bio-specimens (WPRDB) among African Americans, Latinos, and Whites. Participants completed the Cancer Health Literacy Test and the Multidimensional Cancer Literacy Questionnaire. Total-scale and subscale scores, frequencies, means, and distributions were computed. Analyses of variance, the Bonferroni procedure, and the Holm method were used to examine significant differences among groups. Cronbach’s alphas estimated scales’ internal consistency reliability. Significant interactions were found between race/ethnicity, gender, and CHL on WPRDB scales and subscale scores, even after education and age were taken into account. Our study confirms that CHL plays an important role that should be considered and researched further. The majority of participants were more willing to participate in non-invasive research studies (surveys, interviews, and training) or collection of bio-specimens (saliva, check cells, urine, and blood) and in studies led by their own healthcare providers, and local hospitals and universities. However, participants were less willing to participate in more-invasive studies requiring them to take medications, undergo medical procedures or donate skin/tissues. We conclude that addressing low levels of CHL and using community-based participatory approaches to address the lack of knowledge and trust about cancer research among diverse populations may increase not only their willingness to participate in research and donate bio-specimens, but may also have a positive effect on actual participation rates.

scholarly journals Interaksi Pesantren dengan Sains dan Teknologi

2021 ◽  
Vol 4 (1) ◽  
pp. 53
Author(s):  
Muhammad Abror Rosyidin
Keyword(s):  
Public Schools ◽  
Participant Observation ◽  
Science And Technology ◽  
Boarding School ◽  
Research Activities ◽  
Qualitative Descriptive ◽  
Islamic Science ◽  
The Times ◽  
The Relationship ◽  
Descriptive Method

However, along with the times, pesantren have not only opened religious-based schools, but also public schools that provide general knowledge (natural, social, and language) to their students. Educational formalities in pesantren were also proposed so that pesantren alumni could continue their education to public schools. There are three main problems in this paper by reconstructing the pesantren education system, as follows; (1) the relationship between pesantren and the outside world, (2) the relationship between pesantren and science and technology, and (3) the epistemology of Islamic Science in Pesantren Sains (Trensains).�The qualitative�descriptive method is the choice in this study. This research is a qualitative field study with case studies. In order to obtain comprehensive data and pay attention to the relationship between the data and the focus and objectives of the research, data collection in this study used three techniques, namely (1) interviews, (2) participant observation: (3) research documentation. Research activities in data analysis include data reduction, data presentation, and drawing conclusions. From this research, it can be found that the interaction of science and technology with science cannot be denied. So pesantren must be prepared to deal with it. There are several Islamic boarding schools that have interacted with science and technology, both of which have greatly influenced the style of education, one of which is the Tebuireng Science Boarding School (Trensains). Santri are invited to study religion (Qur'an) as well as to study the verses of Kauniyah contained in it.Keywords: Interaction, Pesantren, Science, Technology

scholarly journals Towards a Comprehensive Framework of the Relationships between Resource Footprints, Quality of Life, and Economic Development

2020 ◽  
Vol 12 (11) ◽  
pp. 4734 ◽  
Author(s):  
Stefan Cibulka ◽  
Stefan Giljum
Keyword(s):  
Quality Of Life ◽  
Sustainable Development ◽  
Economic Development ◽  
Social Boundaries ◽  
Gdp Per Capita ◽  
Environmental Implications ◽  
Per Capita ◽  
Comprehensive Framework ◽  
The Relationship

The relationship between economic affluence, quality of life, and environmental implications of production and consumption activities is a recurring issue in sustainability discussions. A number of studies examined selected relationships, but the general implications for future development options to achieve environmentally and socially sustainable development of countries at different levels of per capita resource footprints, quality of life, and income have not yet been investigated in detail. In this study, we use a global dataset with 173 countries to assess the overall relationship between resource footprints, quality of life, and economic development over the period of 1990–2015. We select the material footprint and carbon footprint and contrast them with the Human Development Index, the Happiness Index, and GDP per capita. Regression analyses show that the relationship between various resource footprints and quality of life generally follows a logarithmic path of development, while resource footprints and GDP per capita are linearly connected. From the empirical results, we derive a generalized path of development and cluster countries along this path. Within this comprehensive framework, we discuss options to change the path to respect planetary and social boundaries through a combination of resource efficiency increases, substitution of industries and sufficiency of consumption. We conclude that decoupling and green growth will not realize sustainable development if planetary boundaries have already been transgressed.

Customer disloyalty in retail banking services: attitudinal and behavioural dimensions

2019 ◽  
Vol 11 (1) ◽  
pp. 46-67
Author(s):  
Shakti Bodh Bhatnagar ◽  
Jitendra Kumar Mishra ◽  
Asif Ali Syed
Keyword(s):  
Retail Banking ◽  
Banking Services ◽  
Negative Image ◽  
Content Type ◽  
Customer Behaviour ◽  
Customer Switching ◽  
Comprehensive Framework ◽  
The Relationship ◽  
Relevant Factors ◽  
Structured Questionnaire

Purpose The literature on customer behaviour has attracted significant attention towards customer loyalty; however, customer disloyalty has not been adequately studied. The purpose of this paper is to identify factors leading to customer disloyalty and develop a comprehensive framework for understanding various dimensions of customer disloyalty in retail banking services. Design/methodology/approach The study is descriptive in nature. Variables associated with customer disloyalty were identified from literature and subsequently factor analysis has been applied to derive the significant factors leading to customer disloyalty. Data were collected through a structured questionnaire administered to 357 retail banking customers. EFA and CFA have been employed to determine relevant factors. Findings This study found that customer disloyalty comprises of, both, attitudinal and behavioural components. Further, the study revealed three factors – unfair practices, unfulfilled services and poor interaction leading to behavioural disloyalty and negative image leading to attitudinal disloyalty. Surprisingly, the study found that pricing and competitor’s attraction do not affect, both, attitudinal disloyalty and behavioural disloyalty. Research limitations/implications The study contributes to customer behaviour literature by understanding customer disloyalty as a distinct concept in comparison to much prevalent customer switching. It addition, this study empirically identified factors leading to behavioural disloyalty and attitudinal disloyalty. Originality/value The originality lies in that fact that it is the only empirical study which has studied customer disloyalty through attitudinal disloyalty lenses. Subsequently, it has also attempted to fill the gap in available literature by studying the relationship between attitudinal disloyalty and behavioural disloyalty.

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