scholarly journals Hepatoprotective effect of Moringa oleifera extract on TNF-α and TGF-β expression in acetaminophen-induced liver fibrosis in rats

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Omnia Aly ◽  
Dalia M. Abouelfadl ◽  
Olfat G. Shaker ◽  
Gehan A. Hegazy ◽  
Ahmed M. Fayez ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Liver Tissue ◽  
Moringa Oleifera ◽  
Hepatoprotective Effect ◽  
Tissue Homogenate ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Albino Rats ◽  
Group I ◽  
Tnf Α

Abstract Background It has been reported that Moringa oleifera (MO) has different medicinal properties. The aim of this study was to evaluate the hepatoprotective role of Moringa oleifera extract on acetaminophen-induced liver fibrosis in albino rats on a biochemical and histological basis. Forty male albino rats were divided into four groups: group I (control group), healthy rates; group II (acetaminophen group), rates received acetaminophen for induction of liver fibrosis; group III (treated group), liver fibrosis of rates treated with Moringa oleifera extract; and group IV (prophylactic group), rates treated with Moringa oleifera extract before and after induction of liver fibrosis. Serum liver function parameters were quantified using a spectrophotometer, while tumor necrosis factor α (TNF-α) and transformed growth factor beta (TGF- β) in liver tissue homogenate by means of enzyme-linked immunosorbent assay (ELISA), and expression of liver tissue TNF-α and TGF-genes was measured by real-time PCR after extraction and purification. Hepatic tissue was also evaluated under a microscope for histopathological changes. Results Our results showed a significant decrease in liver enzymes, TNF-α, and TGF-β in the treated and prophylactic groups compared to the acetaminophen group, and our biochemical data were consistent with the histopathological findings confirming the hepatoprotective effect of Moringa oleifera extract. Conclusions Biochemical parameters and histopathology results provide evidence that Moringa oleifera ethanolic extract has a great potential to prevent and improve liver damage due to its protective activity.

scholarly journals Ameliorating Effect of Combined Cinnamon and Ginger Oils against the Neurotoxicity of Nicotine Administration on the Prefrontal Cortex of Adult Albino Rats: Immunohistochemical and Ultrastructural Study

2021 ◽  
Vol 89 (3) ◽  
pp. 41
Author(s):  
Medhat Taha ◽  
Mohie Mahmoud Ibrahim ◽  
Mamdouh Eldesoqui ◽  
Mohamed A. M. Iesa ◽  
Tourki A. S. Baokbah ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prefrontal Cortex ◽  
Group Iv ◽  
Tissue Homogenate ◽  
Control Group ◽  
Albino Rats ◽  
Group Iii ◽  
Group I ◽  
Tnf Α ◽  
Group Ii

Background: Nicotine is the active alkaloid in cigarettes. It was reported that tobacco smoking has many hazards; one of these hazards is the effect on the cognitive function of the prefrontal cortex. The aim of our study is to investigate the antioxidant effects of ginger, cinnamon oils, and their combination on morphological changes in the prefrontal cortex that were induced by nicotine. Materials and methods: Fifty adult male albino rats were divided into five groups: group I (control group), group II (nicotine), group III (nicotine + cinnamon), group IV (nicotine + ginger), and group V (nicotine + cinnamon + ginger). The coronal sections from the anterior part of the rat brain at the site of prefrontal cortex were examined by light microscope for (H&E and immunohistochemical staining with TNF-α and GFAP), while the ultrastructure morphology was examined by transmission electron microscopy. Levels of the oxidative stress markers (MDA, GSH) in the rats’ brain tissue homogenate were biochemically assessed. Results: Compared to the control group, the rats that were treated with nicotine (group II) showed a significant oxidative stress in the form of marked elevation of MDA and decrease in GSH, apoptotic changes especially in the pyramidal cells in the form of neuronal cell degeneration and pyknosis, and an elevation in the inflammatory marker TNF-α and GFAP expressions. These changes were observed to a lesser degree in rat group (III) and group (IV), while there was a marked improvement achieved by the combined usage of cinnamon and ginger oils, together compared to the nicotine group. Conclusions: Ginger and cinnamon are powerful antioxidants which ameliorate the degenerative and oxidative effects produced by nicotine on a rat’s prefrontal cortex.

scholarly journals A Novel Role of SIRT1/ FGF-21 in Taurine Protection Against Cafeteria Diet-Induced Steatohepatitis in Rats

2017 ◽  
Vol 43 (2) ◽  
pp. 644-659 ◽  
Author(s):  
Azza H. Abd Elwahab ◽  
Basma K. Ramadan ◽  
Mona F. Schaalan  ◽  
Amina M. Tolba
Keyword(s):  
Caspase 3 ◽  
B Cell Lymphoma ◽  
Cafeteria Diet ◽  
Control Group ◽  
Albino Rats ◽  
Protective Mechanism ◽  
Alcoholic Fatty Liver ◽  
Group I ◽  
Tnf Α

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the alarmingly rising clinical problems in the 21st century with no effective drug treatment until now. Taurine is an essential amino acid in humans that proved efficacy as a non-pharmacological therapy in a plethora of diseases; however, its impact on NAFLD remains elusive. The aim of the current study is to evaluate the protective mechanism of taurine in experimental steatohepatitis induced by junk food given as cafeteria-diet (CAF-D) in male albino rats. Methods: Forty adult male albino rats of local strain between 8-10 weeks old, weighing 150 ± 20 g, were divided into four equal groups: Group I (control group), Group II (Taurine group), Group III (CAF-D for 12 weeks) and Group IV (CAF-D +Taurine). CAF-D was given in addition to the standard chow for 12 weeks, where each rat was given one piece of beef burger fried in 15 g of sunflower oil, one teaspoonful of mayonnaise, and one piece of petit pan bread, weighing 60g/ piece. In the serum, liver function tests; ALT, AST, ALP, GGT and the lipid profile; TG, TC, HDL-C added to reduced glutathione (GSH) were assessed colorimetrically, while fibroblast growth factor (FGF)-21, adiponectin & interleukin (IL)-6 via ELISA. The same technique was used for the assays of the hepatic levels of FGF-21, silent information regulator (SIRT1), malondialdehyde (MDA),IL-10, tumor necrosis factor-α (TNF-α) as well as the apoptotic markers; caspase-3 and B-cell lymphoma (Bcl-2). Results: The cafeteria-diet induced steatohepatitis was reflected by significantly increased body and liver weight gain, elevation of liver enzymes; ALT, AST, ALP and GGT added to the dyslipidemic panel, presented as increased TC, TG, LDL-C and decreased HDL-C levels. The steatosis-induced inflammatory milieu, marked by elevated serum levels of FGF-21, IL-6, hepatic TNF-α, as well as reduced IL-10 and adiponectin, was associated with steatosis- induced hepatic oxidative stress, reflected by increased hepatic MDA and decreased GSH levels, along with stimulated caspase-3 and decline in BcL-2 hepatic levels. These pathological disturbances were significantly ameliorated by taurine supplementation and evidenced histopathologically. The cross talk between hepatic FGF-21 and SIRT1 and their association to the induced perturbations are novel findings in this study. Taurine's efficacy in restoration of hepatic structure and function is partially via the increase in SIRT1 and associated reduction of FGF-21. Conclusion: The findings of the current study prove the protective role of taurine in NAFLD via a novel role in the amelioration of FGF-21/ SIRT1 axis, which could be considered a new therapeutic target.

scholarly journals Differential Expression of CD3, TNF-α, and VEGF Induced by Olanzapine on the Spleen of Adult Male Albino Rats and the Possible Protective Role of Vitamin C

Biomedicines ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 39
Author(s):  
Sahar Youssef ◽  
Marwa Salah
Keyword(s):  
Body Weight ◽  
Vitamin C ◽  
Adult Male ◽  
Control Group ◽  
Albino Rats ◽  
White Pulp ◽  
Group Iii ◽  
Group I ◽  
Tnf Α ◽  
Group Ii

Olanzapine is an antipsychotic drug effective in the treatment of stress-associated psychiatric illnesses, but its effect on the spleen remains unclear. Vitamin C is essential for the optimum function of the immune system. We aim to investigate the effect of Olanzapine on spleen structures and to assess the protective effect of vitamin C. Forty adult male albino rats were divided into four groups: group (I), a control; group (II), rats were given vitamin C at 40 mg/kg body weight; group (III), rats were given Olanzapine at 2 mg/kg body weight; and group (IV), rats were given vitamin C and Olanzapine at the same dose of group (II) and group (III) for one month. The hematoxylin and eosin (H&E) of the olanzapine treated group showed focal areas of cellular depletion and a decrease in the size of the white pulp. The red pulp was expanded and showed marked congestion and dilatation of blood sinusoids. Cluster of differentiation 3 (CD3) was significantly reduced, however both tumor necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF) were significantly higher. The administration of vitamin C repaired structural and immunohistochemical changes via increased CD3 and decreased TNF-α and VEGF. Therefore, the oxidative and the inflammatory pathways may be the possible mechanisms underlying olanzapine immunotoxicity. Vitamin C exerted immune modulator and antioxidant effects against olanzapine.

scholarly journals Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?

2021 ◽  
Vol 55 (3) ◽  
pp. 131-141
Author(s):  
Vitaliy Shcherba ◽  
Inna Krynytska ◽  
Mariya Marushchak ◽  
Mykhaylo Korda
Keyword(s):  
Inflammatory Cytokines ◽  
Inflammatory Mediators ◽  
Thyroid Dysfunction ◽  
Solid Phase ◽  
White Male ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Tnf Α

Abstract Objective. The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. Methods. White male 12–14 weeks old inbred rats (n=48) weighing 180–200 g were employed in the experiment. They were randomly divided into the following groups: Group I – control group, Group II – group with a model of periodontitis, Group III – group with a periodontitis in a setting of hyperthyroidism, and Group IV – group with periodontitis in a setting of hypothyroidism. The presence of tumor-necrosis factor-α (TNF-α) and interleukins IL-1β and IL-10 in the periodontal homogenate supernatant was studied by a solid-phase enzyme-linked immunosorbent assay. Results. It was shown that experimental lipopolysaccharide (LPS)-induced periodontitis is accompanied by hyperproduction of pro-inflammatory cytokines (TNF-α, IL-1β) and reduction of anti-inflammatory cytokines (IL-10), whereas TNF-α underwent to maximum changes. Thyroid dysfunction exacerbates cytokine imbalance and severity of inflammation in experimental LPS-induced periodontitis, especially pronounced at hyperthyroidism, as evidenced by the predominance of TNF-α and IL-1β levels in the periodontal homogenate supernatant by 38.5% (р<0.01) and 75.6% (p<0.001), respectively, hyperthyroid over the euthyroid, and by 20.1% (p<0.05) and 24.1% (p<0.05), respectively, over the hypothyroid rats. Conclusions. Thyroid dysfunction, especially hyperthyroidism, may play an important role in the pro-inflammatory response in periodontitis. Hyperproduction of inflammatory mediators in thyroid dysfunction can induce a noticeable damage in the whole apparatus of the periodontium, thereby causing progression of periodontitis.

Astaxanthin Reduces the Severity of Intestinal Damage in a Neonatal Rat Model of Necrotizing Enterocolitis

2021 ◽  
Author(s):  
Hasan Akduman ◽  
Cuneyt Tayman ◽  
Veli Korkmaz ◽  
Filiz Akduman ◽  
Nurdan D. Fettah ◽  
...  
Keyword(s):  
Placebo Group ◽  
Necrotizing Enterocolitis ◽  
Caspase 3 ◽  
Neonatal Rat ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Albino Rats ◽  
Related Factor ◽  
Intestinal Damage ◽  
Tnf Α

Objective This study aimed to ascertain the effects of astaxanthin (ASX) in an experimental necrotizing enterocolitis (NEC) model using rat pups. Study Design Forty-two pups born from five Wistar albino rats were randomly divided into three groups as the control group, NEC + placebo (saline), and NEC + ASX. Pups in the NEC + ASX group were given 100 mg/kg/day oral ASX from day 1 to day 4 of the study. Saline of 2 mL/kg was given to the NEC + placebo group. Histopathological, immunohistochemical (caspase-3), and biochemical evaluations including the total antioxidant status (TAS), total oxidant status (TOS), superoxide dismutase (SOD), glutathione (GSH), lipid hydroperoxide (LPO), 8-hydroxydeoxyguanosine (8-OHdG), advanced oxidation protein products (AOPP), myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nuclear factor erythroid 2–related factor 2 (Nfr-2) activities were all performed. Results A better survival rate and weight gain were demonstrated in the NEC + ASX group (p < 0.05). In the histopathological evaluation, the severity of intestinal damage was significantly reduced in the NEC + ASX group, as well as decreased apoptosis (enzyme-linked immunosorbent assay [ELISA] for caspase-3; p = 0.001). The biochemical analyses of intestinal tissue TOS, oxidative stress index (OSI; TOS/TAS), IL-1β, LPO, 8-OHdG, AOPP, caspase-3 (p < 0.001 for all), and TNF-α and MPO (p = 0.001 for both parameters) levels were lower in the NEC + ASX group than in the NEC + placebo group. Nrf-2, TAS, GSH, and SOD levels were higher in the NEC + ASX group than in the NEC + placebo group (p = 0.001, 0.001, <0.001, and 0.01, respectively). Conclusion ASX treatment has been shown to effectively reduce the severity of intestinal damage in NEC due to its antioxidant, anti-inflammatory, and antiapoptotic properties. Key Points

scholarly journals Efficacy of Combined Crude Extract of Curcuma longa and Moringa oleifera in the Prevention of Peptic Ulcer in Albino Rats

2019 ◽  
pp. 1-9
Author(s):  
Augustine I. Airaodion ◽  
Olukunle A. Adekale ◽  
Edith O. Airaodion ◽  
Emmanuel O. Ogbuagu ◽  
Uloaku Ogbuagu ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Moringa Oleifera ◽  
Curcuma Longa ◽  
Control Group ◽  
Albino Rats ◽  
Reference Drug ◽  
Prophylactic Efficacy ◽  
Ulcer Disease ◽  
Group I ◽  
Significant Difference

Aim: This study is aimed at investigating the prophylactic efficacy of combined extract of Curcuma longa and Moringa oleifera leaf against indomethacin–induced ulcer in albino rats. Place and Duration of Study: This research was carried out in Ibadan Nigeria between November 2017 and January, 2018. Methods: Fifty (50) healthy male albino rats with body weights between 150 and 200 g were used for this study. They were randomly divided into ten groups of five rats each. Group I was administered omeprazole for seven days, group II was administered Moringa oleifera leaf solution for seven days, group III was administered Curcuma longa solution for seven days, group IV was administered Curcuma longa + Moringa oleifera leaf solution for seven days and group V was administered distilled water for seven days. This group served as the control group. Groups VI, VII, VIII, IX and X were treated similarly as groups I, II, III, IV and V respectively but were treated for fourteen days. At the end of the administration, the animals were fasted for 18 hours and 50 mg/kg of indomethacin was administered orally (p.o) to the rats. After 8 hours of indomethacin administration, the animals were anesthetized by chloroform anesthesia and sacrificed and the stomach removed and opened along the greater curvature, rinsed with copious volume of normal saline and pinned on a board to expose the stomach clearly. Results: Animals treated with combined extracts of Curcuma longa + Moringa oleifera leaf showed significantly increased ulcer inhibition (71.64%, 75.57%) when compared with those of Curcuma longa (44.10%, 46.53%) and Moringa oleifera leaf (53.43%, 57.58) respectively but showed no significant difference when compared with that of omeprazole (72.60%, 74.29%), the reference drug after 7 and 14 days pre-treatment respectively. Conclusion: The combined extract has a greater prophylactic efficacy against indomethacin-induced ulcer than individual extracts and gave similar result as omeprazole. The combined extract of Curcuma longa + Moringa oleifera leaf could be used as a prophylaxis against peptic ulcer disease.

scholarly journals Study on the Hepatoprotective Effect of Oyster Mushroom (Pleurotus Florida) Against Paracetamol Induced Liver Damage in Wistar Albino Rats

1970 ◽  
Vol 5 (2) ◽  
pp. 46-52 ◽  
Author(s):  
Afroza Khanam Sumy ◽  
Nasim Jahan ◽  
Nayma Sultana
Keyword(s):  
Liver Damage ◽  
Liver Tissue ◽  
Treated Group ◽  
Oyster Mushroom ◽  
Tissue Homogenate ◽  
Control Group ◽  
Albino Rats ◽  
Pleurotus Florida ◽  
Wistar Albino Rats ◽  
Group B

Background: Liver damage can be occurred due to prolonged use of higher doses of some drugs, exposure to some chemicals or infectious agents. But liver protective drugs are not available in modern medicine. Some hepatoprotective herbal medicines are often used in the treatment of liver damage. Objective: This experimental study was carried out to observe the hepatoprotective effect of Oyster mushroom (Pleurotus florida) against paracetamol induced liver damage in Wistar albino rats. Method: This experimental study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka from 1st July 2009 to 30th June 2010. A total number of 34 Wistar albino rats, age ranged from 90 to 120 days, weighing between 150 to 210 grams were selected for the study. After acclimatization for 14 days, they were divided into two groups, control group (Group A) and experimental group (Group B- mushroom pretreated and paracetamol treated group). Control group again subdivided into group A1 (baseline control) and group A2 (paracetamol treated control group). All groups of animals received basal diet for 30 consecutive days. Group A1 consisted of 10 rats, received propylene glycol (2 ml/kg bw, orally) only on 30th day. Group A2 consisted of 14 rats, received single dose of paracetamol suspension (750 mg/ kg bw, orally) only on 30th day. Group B consisted of 10 rats, received mushroom extract (200 mg/ kg bw, orally) for 30 consecutive days and paracetamol suspension (750 mg/ kg bw, orally) only on 30th day. All the animals were sacrificed on 31st day. Then blood and liver samples were collected. Initial body weight, final body weight and liver weight were measured. Then measurement of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and assessment of malondialdehyde (MDA) concentration in liver tissue homogenate were done by using standard laboratory kits. The statistical analysis was done by one way ANOVA and Bonferroni test as applicable. Result: The mean serum AST, ALT levels and in the liver tissue MDA concentration were significantly (p<0.001) higher in paracetamol treated group in comparison to those of baseline control group. Again, the mean serum AST (p<0.05), ALT (p<0.05) levels and in the liver tissue homogenate MDA concentration (p<0.001) were significantly lower in mushroom pretreated and paracetamol treated group (experimental group) when compared to those of only paracetamol treated group (control). Conclusion: This study reveals that Oyster mushroom (Pleurotus florida) which is excellently edible and nutritious, may have some hepatoprotective role. Key words: hepatoprotective; oyster mushroom; malondialdehyde; tissue homogenate DOI: 10.3329/jbsp.v5i2.6776J Bangladesh Soc Physiol. 2010 December; 5(2): 46-52

scholarly journals Hepatoprotective Effect of Eriobotrya japonica Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Abdelaaty A. Shahat ◽  
Riaz Ullah ◽  
Ali S. Alqahtani ◽  
Mansour S. Alsaid ◽  
Husseiny A. Husseiny ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Leaf Extract ◽  
Hepatoprotective Effect ◽  
Eriobotrya Japonica ◽  
Control Group ◽  
Albino Rats ◽  
Aqueous Fraction ◽  
Group I ◽  
Glutamyl Transferase ◽  
Control Group Group

Eriobotrya japonica is traditionally used as an antipyretic, digestive, and diuretic agent. Its flowers possess free radical–scavenging, antioxidative, and hepatoprotective effects. We investigated the hepatoprotective potential of E. japonica leaf extract and its various fractions against hepatotoxicity in rats. Liver injury was stimulated by the oral administration of carbon tetrachloride (CCl4; 2.5 mL/kg b.wt.). Male albino rats (n = 55) were distributed arbitrarily into 11 groups: Group I, normal control group; Group II, CCl4 (positive control group); Group III, CCl4 + silymarin; Groups IV and V, CCl4 + two doses of 250 and 500 mg/kg of the 80% methanolic extract of E. japonica leaves, respectively; Groups VI and VII, CCl4 + 250 mg/kg and 500 mg/kg of the ethyl acetate fraction, respectively; Groups VIII and IX, CCl4 + 250 and 500 mg/kg of the butanol fraction, respectively; and Groups X and XI, CCl4 + 250 and 500 mg/kg of the aqueous fraction of E. Japonica leaves, respectively. CCl4-treated rats that were given 250 or 500 mg/kg of the methanol extract of E. Japonica leaves, or its ethyl acetate, butanol, or aqueous fractions, had significantly lower levels of biochemical parameters such as alanine aminotransferase, aspartate transaminase, alkaline phosphate, total protein, gamma-glutamyl transferase, and bilirubin levels than those of the CCl4 positive group. However, the extract and fractions did not significantly affect lipid profiles. Thus, we conclude that Eriobotrya leaf extract and its fractions have a hepatoprotective effect against CCl4-induced hepatotoxicity in rats.

scholarly journals Concomitant using of topical carrageenan-kappa and oral vitamin D against 7, 12-dimethylbenz[a]anthracene induced-oral cancer in rats: A synergism or an antagonism effects

2020 ◽  
Vol 23 (3) ◽  
Author(s):  
Aseel J Ali ◽  
Jamal N.A. Al-Juboori ◽  
Marwan Al-Nimer
Keyword(s):  
Vitamin D ◽  
Oral Cancer ◽  
Treated Group ◽  
Group Iv ◽  
Antiproliferative Effect ◽  
Lower Percentage ◽  
Control Group ◽  
Albino Rats ◽  
Group I ◽  
Tnf Α

Objective: κ-carrageenan is a food stabilizer agent which has an antiproliferative effect, while vitamin D is a prohormone acts on the nuclear receptor and has a cytotoxic against cancer. This study aimed to show the synergistic effect of using topical κ-carrageenan and oral administration of the vitamin D on the 7, 12-dimethylbenz[a] anthracene (DMBA)-induced oral cancer. Material and Methods: fifty four male albino rats were randomly divided into seven groups: Acetone-treated served as control (Group I), vitamin D (5000UI)-treated (Group II), κ-carrageenan (1%)- treated (Group III), DMBA (0.5%)-treated (Group IV), Acetone, κ-carrageenan and DMBA were administered topically on both cheeks and palate, five times weekly for 12 weeks, while the vitamin D was  administered orally twice weekly for 12 weeks. Groups V, VI, and VII were animals treated with vitamin D, κ-carrageenan, and both vitamin D and κ-carrageenan for 8 weeks after induction of oral cancer. At the end of the study, blood samples were obtained by cardiac puncture for determination of TNF-α and EGFR. Results: In the groups III and IV, serum EGFR showed significant low levels compared with Group I. In the Group VII, serum EGFR showed a significantly (p=0.014) low level compared with Group IV (614.3±69.7 pg/ml versus 882.4±45.6 pg/ml, respectively). Higher percentages of high levels of TNF-α were observed in the Groups VI and VII, while a lower percentage of EGFR was observed in the Group VI. Conclusion: both κ-carrageenan and vitamin D have antiproliferative effect against DMBA-inducing oral cancer by increasing the levels of TNF-α and suppressing the signaling pathway of EGFR. Concomitant using κ-carrageenan and vitamin D reduces the antiproliferative effect of each other. KeywordsOral cancer; 7, 12-dimethylbenz[a] anthracene; Vitamin D; κ-carrageenan; Epidermal growth factor receptor; Tumor necrosis factor-α. 

scholarly journals Histopathologic Changes in Liver Tissues From Male Albino Rats Treated with Croton tiglium Mixed With Animals Diet.

2021 ◽  
pp. 152-156
Author(s):  
Awatif M.E Omran ◽  
Salah A.M Ali ◽  
Elkamali H H
Keyword(s):  
Liver Tissue ◽  
Control Group ◽  
Albino Rats ◽  
Bioactive Constituents ◽  
African Countries ◽  
Group I ◽  
Croton Tiglium ◽  
Histopathologic Changes ◽  
Group Ii ◽  
Liver Tissues

Croton tiglium is commonly used to treat constipation in African countries including Sudan. This study aim to evaluate histopathologic changes in Liver tissue after treated with Croton tiglium mixed with animals diet in male albino rats. The rats were divided into three groups containing of 6 rats per group for each , and they treated as follow : Group I serve as control, Group II & III: Were given a mixture of animals diet with Croton tiglium diet at concentrations of 10% and 20% respectively. Treatment of rats with 10% of Croton tiglium showed no remarkable damages or signs of lesions on specimens taken from animals for histopathological examinations ,but rats under 20% treatment showed some abnormal (alterations) .Therefore, the fruits of Croton tiglium at 20% are toxic to rats .Further studies are necessary to isolate and characterize the bioactive constituents in the fruits and to elucidate modes of compound actions and interactions.

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