Diaphragmatic ultrasound and pulmonary functions evaluation in thyroid patients: a case-control study

Abstract Background Dyspnea is a frequent symptom among patients with thyroid disorders. However, its actual causative mechanism is not clear. The diaphragm is the main inspiratory muscle and contraction of the diaphragm is essential for breathing, so any disorder that interferes with contractile muscle function can cause diaphragm dysfunction which is associated with dyspnea. The objective of study is to assess the effect of thyroid disorders on diaphragm excursion and thickness. Results Diaphragmatic excursion during tidal, deep, and sniff respiration were significantly decreased in patients with thyroid disorder in comparison to control and significantly decreased in hypothyroid patients (right tidal 1.42 ± 0.29, right deep respiration 5.07 ± 0.72, and sniff 2.15 ± 0.26 cm) than hyperthyroid patients (right tidal 1.61 ± 0.34, right deep respiration 5.63 ± 0.50, and sniff 2.67 ± 0.27 cm) and than the control group (right tidal 2.17 ± 0.27, right deep respiration 6.63 ± 0.33, right sniff 2.89 ± 0.19 cm). Diaphragmatic thickness at end tidal inspiration was significantly decreased in patients with thyroid disorder in comparison to control (p value < 0.05). There was negative correlation between diaphragmatic excursion and duration of disease. Conclusion Diaphragmatic excursion and thickness are affected in hypothyroidism compared to hyperthyroidism and control groups. There is significant negative correlation between diaphragmatic excursion and duration of disease in patients’ group. Respiratory symptoms are more frequent in hypothyroid patients.

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Role of insulin during the development of oligofructose (OF)-induced equine laminitis

Bulletin of the Veterinary Institute in Pulawy ◽

10.1515/bvip-2015-0044 ◽

2015 ◽

Vol 59 (2) ◽

pp. 303-309

Author(s):

Renli Jiang ◽

Li Gao ◽

Guanying Wang ◽

Xinran Li ◽

Yue Li ◽

...

Keyword(s):

Nitric Oxide ◽

Glucose Oxidase ◽

Negative Correlation ◽

Significant Negative Correlation ◽

Control Group ◽

Endothelin 1 ◽

Limulus Amoebocyte Lysate ◽

And Control ◽

Over Time

Abstract Horses (n = 20) were divided into 2 groups: oligofructose (OF)-induced equine laminitis group (group OF; n = 11) which received 10 g/kg b.w. of OF dissolved in 4 L water via nasogastric intubation, and control group (NS; n = 9) which received 4 L of saline. Blood was collected at 4 h intervals over 72 h study period and analysed by ELISA, kinetic limulus amoebocyte lysate assay, and glucose-oxidase methods. The level of insulin changed significantly in horses which received OF (P < 0.01); there was a significant negative correlation between the level of adiponectin and insulin over time. The results suggested that insulin may play an important role in the development of OF-induced equine laminitis by altering the level of endothelin-1 and nitric oxide.

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The Status of Thyroid Hormones in Iron Deficient Patients in Bangladesh

Medicine Today ◽

10.3329/medtoday.v24i1.13941 ◽

2013 ◽

Vol 24 (1) ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Shaheen Akhter ◽

Zeba-un Naher ◽

Shamima Pervin ◽

Kamrun Nahar ◽

Muktar Ali ◽

...

Keyword(s):

Serum Ferritin ◽

Negative Correlation ◽

Hemoglobin Concentration ◽

Significant Negative Correlation ◽

Control Group ◽

Free T4 ◽

Iron Deficient ◽

The Status ◽

And Control ◽

Serum Tsh

To determine the relation between iron deficiency and the status of thyroid hormones in iron deficient patients. This case control study was done in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU), during July 2006 to the June, 2007. Iron deficiency patient was considered as case a healthy control subject was considered as control. A total of 80 subjects were selected for study from those who were attended in out patient department of the above mentioned hospital were enrolled in this study. The mean (±SD) age of case and control were 33.48±11.03 years and 35.40±12.30 years with the range of 16-60 years and 15-60 years respectively. Male female ratio was 1:1.6 in the whole study subjects. Hemoglobin concentration, serum ferritin concentration were significantly (p<0.05) higher in control group but serum TSH level was significantly (p<0.05) higher in case group, however, serum FT3 was almost similar between case and control groups. In iron deficient patients, serum ferritin had no significant negative correlation (r=-0212; p>0.05) with serum TSH and no correlation with serum FT4 concentrations and serum FT3 concentration which were (r=0.055; p>0.05) and (r=0.147; p>0.05) respectively. In control subjects, serum ferritin revealed that there was significant negative correlation (r=-0.337; p<0.05) serum TSH. However, serum ferritin with serum FT4 concentration and serum ferritin with serum FT3 level showed no statistically significant correlation which were (r=0.283; p>0.05) and (r=0.145; p>0.05) respectively. On the other hand, there were no significant (p>0.05) correlation of hemoglobin concentration and serum ferritin with serum TSH, free T3 and free T4 concentrations both in case and control group. There were no significant (p>0.05) difference among serum TSH, free T3 and free T4 concentrations between male and female in both groups. Serum TSH level was significantly (p<0.05) higher in iron deficient patients and no significant negative correlation, serum ferritin level. DOI: http://dx.doi.org/10.3329/medtoday.v24i1.13941 Medicine TODAY Vol.24(1) 2012 pp.1-4

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Evaluating empathy in adolescents with conduct disorders

Vojnosanitetski pregled ◽

10.2298/vsp150121031k ◽

2016 ◽

Vol 73 (5) ◽

pp. 429-434 ◽

Cited By ~ 1

Author(s):

Jelena Kostic ◽

Milkica Nesic ◽

Miodrag Stankovic ◽

Olivera Zikic ◽

Jasminka Markovic

Keyword(s):

Conduct Disorder ◽

Negative Correlation ◽

Behavioral Problems ◽

Perspective Taking ◽

Significant Negative Correlation ◽

Conduct Disorders ◽

Self Report ◽

Reactivity Index ◽

Control Group ◽

Affective Empathy

Background/Aim. According to currently available data, there is no research dealing with evaluating empathy in adolescents with conduct disorders in our region. The aim of the research was to examine the differences in the severity of cognitive and affective empathy in adolescents with and with no conduct disorder, as well as to examine the relationship between cognitive and affective empathy and the level of externalization in adolescents with conduct disorder. Methods. This research was conducted on 171 adolescents, aged 15 to 18, using the Interpersonal Reactivity Index, Youth Self- Report and a Questionnaire constructed for the purpose of this research. Results. The results showed that adolescents with conduct disorder had significantly lower scores for Perspective Taking (t = 3.255, p = 0.001), Fantasy (t = 2.133, p = 0.034) and Empathic Concern (t = 2.479, p = 0.014) compared to the adolescents in the control group, while the values for Personal Distress (t = 1.818, p = 0.071) were higher compared to the control group, but the difference was not statistically significant. The study showed a statistically significant negative correlation between Perspective Taking and aggression (r = - 0.318, p = 0.003) and a negative correlation between Perspective Taking and the overall level of externalizing problems (r = -0.310, p = 0.004) in the group of adolescents with conduct disorder. Conclusion. This research contributes to better understanding of behavioral disorders in terms of individual factors, especially empathic reactivity. Preventive work with young people who have behavioral problems associated with empathy deficit disorder proved to be an important tool in preventing the development, or at least relieving the symptoms, of this ever more common disorder.

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The effect of obesity and Insulin Resistance on Liver Enzymes in Type2 Diabetes Mellitus

Baghdad Science Journal ◽

10.21123/bsj.12.3.536-545 ◽

2015 ◽

Vol 12 (3) ◽

pp. 536-545

Author(s):

Baghdad Science Journal

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Alkaline Phosphatase ◽

Negative Correlation ◽

Liver Enzymes ◽

Alanine Transaminase ◽

Obese Group ◽

Control Group ◽

Diabetic Patients ◽

And Control

Diabetes mellitus (DM) has been defined as a clinical syndrome that is characterized by abnormal carbohydrate metabolism. The chronic hyperglycemia of diabetes is associated with long term damage, dysfunction, and failure of different organs, especially the liver .This study was conducted to assess the effect obesity and insulin resistance on liver enzymes in diabetic Iraqi patients.A comparative study of (90) Iraqi adults divided to three subgroup(30) obese ,(30) nonobese diabetic patients and(30)person had used as control. The analysis included Liver enzyme ALP,ALT,AST,GGT ,Fasting Plasma Glucose (FBG) , Lipid Profile , Hemoglobin A1C , insulin and homeostasis model assessment of insulin resistance (HOMA IR) were measured. Subjects were excluded from this study if they had liver disease, alcohol intake, medications for lowering lipid, insulin treatment, pregnant women and women taking contraceptive pills . The study shows significantly higher of liver enzymes level ( gamma glutamyl transpeptidase (GGT), alkaline phosphatase, Aspartate Amino Transferase , Alanine Transaminase) in obese diabetic patients compared with non-obese diabetic patients and control subject and HOMA IR showed significantly higher in obese diabetic patients compared with non-obese with diabetic patients and control (P < 0.05). The lipids level showed significantly higher in obese diabetic patients compared with non-obese diabetic patients and control.The HbA1c level showed higher significantly in obese diabetic patients compared with control and ther is a posative correlation between insulin and HOMA IR , ALP in obeses diabetic patients while there was negative correlation between ALT and cholesterol in obese group and with HbA1c in control group. The liver enzymes level of(alkaline phosphatase, alanine transaminase, aspartate transaminase gama glutaminase transferase ) is significantly higher in obese diabetic patients than non –obese diabetic patients and control group , also There was posative correlation between ALP and HOMA IR while there was negative correlation between ALT and cholesterol in obese group and with HbA1c in control group .

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Job stress and resilience in Iranian nurses during the COVID-19 pandemic: A case-control study

Work ◽

10.3233/wor-210476 ◽

2021 ◽

pp. 1-10

Author(s):

Gholam-Abbas Shirali ◽

Arman Amiri ◽

Khalil Taherzadeh Chanani ◽

Maryam Silavi ◽

Sanaz Mohipoor ◽

...

Keyword(s):

Job Stress ◽

Negative Correlation ◽

Case Control Study ◽

Case Control ◽

Target Group ◽

Control Group ◽

Wide Range ◽

The Face ◽

And Control ◽

Control Study

BACKGROUND: The COVID-19 pandemic has created a wide range of sociocultural pressures on nurses. Resilience is defined as one’s ability to adapt to an unpredictable situation and it can be a factor in accepting an undesirable psychosocial situation. OBJECTIVE: The aim of the present study was to examine resilience in nurses in the face of job stress during the COVID-19 pandemic. METHODS: The study was carried out as a case-control study with participation of 400 nurses as the target group (nurses exposed to COVID-19 patients) and the control group (nurses not exposed to COVID-19 patients). To examine resilience and job stress, Conor and Davidson’s questionnaire and OSIPOW questionnaire were used respectively. RESULTS: The mean scores of job stress and resilience were significantly different between the target and control groups (p < 0.05). So that resilience in the target group was less than that in the control group. In addition, job stress in the target group was higher than that of the control group (p < 0.05). There was a significant and negative correlation between resilience and job stress and the correlation was stronger in the target group (p < 0.05). CONCLUSIONS: Given the high job stress score in the participants and its negative correlation with resilience, there is need to provide the health personnel with efficient preventive and treatment approaches, improve and educate the principles of resilience, improve mental health services system, and introduce programs to control some of demographical factors in job stress such as physical activity, and employment status of nurses.

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Biochemical Study of Gonad Hormones in Sera of Iraqi Patients with Thyroid Disorder

Baghdad Science Journal ◽

10.21123/bsj.10.3.907-914 ◽

2013 ◽

Vol 10 (3) ◽

pp. 907-914

Author(s):

Baghdad Science Journal

Keyword(s):

Biochemical Study ◽

Binding Study ◽

Control Group ◽

Thyroid Disorders ◽

Thyroid Disorder ◽

Healthy Individuals ◽

Molecular Binding ◽

Specialized Center ◽

The Mean ◽

Age Range

The objective of this study was to evaluate the alteration in levels of gonado trophins hormones i.e.,Leutizing (LH),Follicular(FSH) in sera of patients with thyroid disorders and molecular binding study of (LH ,FSH) with their antibodies The study was conducted at the specialized center for endocrinology and diabetes from January / 2009 to March / 2010.Two hundreds and twenty three Iraqi subjects, 109 patients with thyroid disorders at age range between (40-50) years and 114 healthy individuals as control group were included in this study.The majority of patients were female with hyperthyroidism and (49.54 % ) were at age range between(40 - 50) years. The levels of hormones(LH,FSH.tri iodothyronine(T3).thyroxine(T4), thyroid stimulating hormoneTSH) were measured by using Enzyme Linked Flourscent Assay( ELFA, while residual studies used Immuno Raido Metric Assay(IRMA) method only.It was found that production of TSH was increased with about (15-20) fold in hyperthyroidism over that in control.Sixty percent of patients with hyperthyroidism were underweight BMI?20.0 (kg/m2) while (44.5%) of patients with hypothyroidism were overweight BMI( 25.0-29.9)kg/m2 . The mean level of LH and FSH had increased significantly (p

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Study and Determination of Aryl Hydrocarbon Receptor with Some Trace Elements in Fuel Filling Station Workers

Journal of Petroleum Research and Studies ◽

10.52716/jprs.v10i4.380 ◽

2020 ◽

Vol 10 (4) ◽

pp. 233-251

Author(s):

Bassem Abd Al-Raheem Twaij ◽

Dr. Muthana Salam Mashkour ◽

Dr.Hussein Kadhem Al-Hakeim

Keyword(s):

Trace Elements ◽

Serum Concentration ◽

Aryl Hydrocarbon Receptor ◽

Negative Correlation ◽

Aromatic Hydrocarbons ◽

Significant Negative Correlation ◽

Correlation Study ◽

Control Group ◽

Aryl Hydrocarbon ◽

Filling Station

PollutiOn is the intrOduction Of contaminantsʹ intO the natural envirOnment that cause adverseʹ change. Gasoline is a toxic and highly flammable liquid consists of various types of aliphatic hydrocarbons, olefins, benzenes and aromatic hydrocarbons including toluene, xylene and a large number of volatile compounds in addition to tetraethyl lead. Gasoline consists of different types of aliphatic hydrocarbons, aryl compounds and some trace elements. Trace elements are several important roles in human bodies, some are essential for enzymes reactions where they attract and facilitate conversion of substrate molecules to specific end products. Aryl hydrocarbon receptor (AHR) is a receptor involved in the regulation of biological responses to planar aromatic hydrocarbons. The aim of the present study is to compare the serum AHR level in the fuel station workers (FSW) with the non-workers as a control group. The other aim is to find out a possible correlation between AHR with trace elements. Sixty male FSW and 30 controls, from ten fuel stations at Al-Najaf City-Iraq, were participated in the present study. The AHR level in serum was measured using ELISA technique. Determine the following metal ions Zn2+, Cu2+, Fe3+, Mg2+, Na+ and K+ level in filling station workers (FSW) and control group were measured spectrophotometrically by using ready for use kits. Serum Pb level was carried out using Atomic absorption spectroscopy. The results serum concentration of AHR in FSW group revealed a significant increase (p<0.001) as compared with the control group. No significant difference was noticed in AHR as compered in exposure ≥12years with exposure <12years in FWS. Smoking has no significant correlation with other parameters. Correlation study indicated a correlation between AHR and Age. Serum concentration of Cu2+, Zn2+, K+ and Pb in FSW group revealed a significant increase (p<0.001) as compared with the control group. While Fe3+, Na+ and Mg2+ in FSW group revealed a significant decrease (p<0.001) as compared with the control group. Correlation study indicated a significant negative correlation between serum Pb and AHR while other trace elements showed no significant correlation with AHR in FSW group. There is a significant negative correlation between serum Cu2+ with age while there is significant increase correlation between Zn2+, Mg2+ and Pb with age in FWS group. Conclusion of study is The role of increase AHR on the health in FSW group, attention to use safety gloves and face mask is recommended for FSW and a long follow-up to the studied group is necessary to explore the prognosis of increase AHR in FSW.

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P0299EVALUATION OF THE CORRELATION BETWEEN VITAMIN D LEVELS AND THROMBOCYTE MARKERS IN PATIENTS WITH DİALYSİS, CHRONIC RENAL DISEASE AND RENAL TRANSPLANTATION PATIENTS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0299 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

KÖNÜL AHMEDOVA ◽

Garip SAHIN ◽

Cengiz Bal ◽

Rüya Mutluay

Keyword(s):

Vitamin D ◽

Renal Transplantation ◽

Renal Disease ◽

Negative Correlation ◽

Chronic Renal Disease ◽

Significant Negative Correlation ◽

Vitamin D Supplementation ◽

Control Group ◽

Before And After ◽

Grade 3

Abstract Background and Aims 25(OH)D3 levels are known to be lower in patients with chronic renal disease (CRD). Vitamin D supplementation has been shown to have beneficial effects on mortality in these patients. In our study, we have evaluated the pleiotropic effect of vitamin D on thrombocyte markers, which is known very little by most. Method The main thrombocyte function markers (MPV, PDW and PCT) were obtained in patients which underwent dialysis, renal transplantation and patients with grade 3-4 CRD before and after vitamin D supplementation. 40 healthy individuals were chosen as control group and 24 patients underwent renal transplantation, 25 patients underwent dialysis for at least 3 months, 32 patients were diagnosed as Grade 3-4 CRD. All of the patients above had 25(OH)D3 levels <20ng/mL (<50nmol/L). Thrombocyte markers were evaluated before and after vitamin D supplementation (which was given 50.000 IU orally once a week for 8 weeks). Results Statistically no significant difference were found between MPV values in- and across- group comparison before and after vitamin D supplementation. After the correlation analyses were reviewed, statistically significant negative correlation was found (r=-0,422 p<0.05) between ΔMPV and ΔVitamin D in renal transplantation group. Also statistically significant positive correlation was found between ΔPDW and ΔVitamin D. In the control group with healty participants, a statistically significant negative correlation was found (r=-0,493 p<0.05) between ΔVitamin D and ΔThrombocyte count. In the dialysis group a statistically significant negative correlation was found (r=-0,422 p<0.05) between ΔVitamin D and ΔMPV. Conclusion A significant correlation was found particularly between Vitamin D and MPV in dialysis and renal transplantation patients. In order to prevent cardiovascular events due to thrombosis caused by Vitamin D deficiency which increases MPV, it has been thought that Vitamin D supplementation and antiaggregant therapy might be beneficial.

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POST HEPARIN PLASMA LIPOPROTEIN LIPASE ACTIVITY IN THYROID DISEASE

Acta Endocrinologica ◽

10.1530/acta.0.0590555 ◽

1968 ◽

Vol 59 (4) ◽

pp. 555-563 ◽

Cited By ~ 18

Author(s):

Knut Kirkeby ◽

Inger Bjerkedal

Keyword(s):

Lipoprotein Lipase ◽

Lipase Activity ◽

Significant Negative Correlation ◽

Control Group ◽

Lipoprotein Lipase Activity ◽

Heparin Plasma ◽

Hypothyroid Patients ◽

Hyperthyroid Patients ◽

High Triglyceride ◽

Synthesis And Degradation

ABSTRACT Plasma post heparin lipoprotein lipase activity (LLA) has been studied in patients with hyper- and hypothyroidism and in rabbits made thyrotoxic with thyroxine. The hypothyroid patients had high triglyceride and low LLA values as compared with a control group of healthy subjects. Statistically highly significant negative correlation was found between the triglycerides in fasting patients and the post heparin LLA, indicating a causal relationship, possibly with disturbance of chylomicron degradation due to low LLA in the arterial wall. However, relatively low LLA values were also demonstrated in hyperthyroid patients as well as in rabbits following treatment with thyroxine for 3 weeks. A stimulating effect of the thyroid hormones on the synthesis and degradation of lipoprotein lipase may be a possible explanation for these apparently contradictory findings.

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INCREASED URINARY 8-OXO-7,8-DIHYDRO-2′-DEOXYGUANOSINE EXCRETION IN A SAMPLE OF EGYPTIAN CHILDREN WITH BETA THALASSEMIA MAJOR: MARKER FOR LIPID PEROXIDATION-INDUCED DNA DAMAGE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i12.21045 ◽

2017 ◽

Vol 10 (12) ◽

pp. 171

Author(s):

Mona A Elabd ◽

Dina Abu Zeid ◽

Marwa A Elhady ◽

Maged A El Wakeel ◽

Ghada M El-kassas ◽

...

Keyword(s):

Lipid Peroxidation ◽

Dna Damage ◽

Urinary Excretion ◽

Serum Ferritin ◽

Negative Correlation ◽

Significant Negative Correlation ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Increased Risk ◽

Egyptian Children

Objective: The objective of this research was to evaluate oxidative stress status in children with β-thalassemia major.Methods: Our study was conducted in children with β-thalassemia aged from 5 to 15 years. Investigate the urinary excretion of human 8-oxo-7,8- dihydro-2′-deoxyguanosine, which will be analyzed by enzyme-linked immunosorbent assay. To investigate serum levels of antioxidant enzymes include glutathione s-transferase (GST) and catalase (CAT).Results: We found a significant elevation of the urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine level with p=0.001 compared to control group, a significant reduction of both GST and CAT p=0.05 and 0.03, respectively, compared to control group. There was a significant negative correlation between urinary 8-oxo-7,8-dihydro-2′-deoxyguanisine and CAT level, r=−0.378, p=0.016, hemoglobin - r=−0.610, p=0.001, hematocrit (%) - r=−0.478, p=0.002, while a significant positive correlation between urinary 8-oxo-7,8-dihydro-2′-deoxyguanisine and alanine aminotransferase - r=0.547, p=0.001, and serum ferritin - r=0.391, p=0.013. There was a significant negative correlation between CAT and serum ferritin - r=−0.320, p=0.44.Conclusion: We conclude that the strongly increased urinary excretion 8-oxo-7,8=dihydro-2′-deoxyguanisine indicates elevated lipid peroxidation induced DNA damage in internal organs such as the liver. These highly pro mutagenic lesions may contribute to the increased risk of thalassemia patients to develop hepatocellular carcinoma.

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