Serum Proteins in Huntington's Chorea

Huntington's chorea is transmitted by a rare autosomal Mendelian dominant gene. Its hereditary transmission is facilitated by a late onset of the condition in many cases. Often the first signs are not seen until late in the reproductive period, so that it is not uncommon for a patient already to have produced a number of children before the diagnosis is made. On a theoretical basis, 50 per cent. of these offspring are at risk for carrying the gene and consequently for developing the condition themselves.

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A controlled family study of late-onset non-affective psychosis (late paraphrenia)

The British Journal of Psychiatry ◽

10.1192/bjp.170.6.511 ◽

1997 ◽

Vol 170 (6) ◽

pp. 511-514 ◽

Cited By ~ 42

Author(s):

R. J. Howard ◽

C. Graham ◽

P. Sham ◽

J. Dennehey ◽

D. J. Castle ◽

...

Keyword(s):

At Risk ◽

Late Onset ◽

Psychiatric Morbidity ◽

Late Life ◽

Lifetime Risk ◽

First Degree Relatives ◽

Healthy Elderly ◽

Increased Risk ◽

Age Range ◽

The Relationship

BackgroundThe relationship between those schizophrenia-like conditions that have their onset in late life and early-onset schizophrenia is unclear. Very few family history studies of patients with late-onset psychosis have been reported, and it is not known whether their relatives have an increased risk of psychosis.MethodInformation was collected on the psychiatric morbidity of 269 first-degree relatives of patients with schizophrenia or delusional disorder with an onset after the age of 60 (late paraphrenia), and 272 first-degree relatives of healthy elderly control subjects, using a research diagnostic instrument.ResultsWith a narrow age range (15–50 years) at risk, the estimated lifetime risk of schizophrenia was 1.3% in the relatives of both cases and controls. With a wider age range (15–90 years) at risk, estimated lifetime risk of schizophrenia was 2.3% for the relatives of cases, and 2.2% for the relatives of controls. However, depression was significantly more common among the relatives of cases than controls.ConclusionThose schizophrenia-like psychoses with onset in late life are not genetically associated with schizophrenia.

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Huntington's Chorea: General Practitioners' Knowledge about Individuals' At-risk Status

Scandinavian Journal of Primary Health Care ◽

10.3109/02813438909103671 ◽

1989 ◽

Vol 7 (1) ◽

pp. 49-52 ◽

Cited By ~ 2

Author(s):

Sven Asger Sørensen ◽

Kirsten Fenger

Keyword(s):

At Risk ◽

General Practitioners ◽

Huntington's Chorea ◽

Risk Status

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Subjects at Risk for Genetic Late-Onset Neurological Diseases: Objective Knowledge

Public Health Genomics ◽

10.1159/000479292 ◽

2017 ◽

Vol 20 (3) ◽

pp. 158-165

Author(s):

Ângela Leite ◽

Fernanda Leite ◽

Maria Alzira P. Dinis

Keyword(s):

At Risk ◽

Late Onset ◽

Neurological Diseases ◽

Objective Knowledge

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Selective Prevention for Anxiety and Resilience Promotion: Outcomes of an Anxiety Prevention and Resilience Program with Girls at Risk

Pensando Psicología ◽

10.16925/pe.v11i18.1001 ◽

2015 ◽

Vol 11 (18) ◽

pp. 11-23 ◽

Cited By ~ 2

Author(s):

Julia Gallegos-Guajardo ◽

Norma Ruvalcaba-Romero ◽

Audra Langley ◽

Diana Villegas-Guinea

Keyword(s):

At Risk ◽

Low Socioeconomic Status ◽

Coping Skills ◽

Anxiety Symptoms ◽

Self Concept ◽

Social Emotional ◽

Number Of Children ◽

Anxiety Prevention ◽

Post Test ◽

Psychosocial Difficulties

Introduction: Research has shown that the number of children and adolescents experiencing emotional difficulties such as anxiety is escalating, especially for those groups at risk. Living in an orphanage has been considered a risk factor for delays in an individuals’ social, emotional and behavioral development. Objective: The aim of this study was to evaluate the effectiveness of the Spanish version of the FRIENDS program, a CBT-based resilience program, with 57 girls from low socioeconomic status (SES) background that were living in an orphanage. Method: Participants received the program for 10 consecutive weeks, and pre- and post-test measures were collected. Measures evaluated participants’ anxiety symptoms, level of self-concept, hope, coping skills, and psychosocial difficulties. Social validity was also assessed. Results: Results showed positive changes, including a decrease in anxiety symptoms and psychosocial difficulties, as well as an increase in their proactive coping skills. Several subscales and items of the self-concept and hope outcome measures also reported statistically significant improvements. Conclusions: Participants and parents/caregivers reported that the program was both enjoyable and useful. Implications of the findings and directions for further research are discussed.

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The phenomenon of social risk families and its dynamics in Lithuania

SHS Web of Conferences ◽

10.1051/shsconf/20185103001 ◽

2018 ◽

Vol 51 ◽

pp. 03001

Author(s):

Vide Gudzinskiene ◽

Rimvydas Augutavicius

Keyword(s):

Risk Factors ◽

At Risk ◽

Physical Environment ◽

Social Risk ◽

Public Concern ◽

Social Risk Factors ◽

Scientific Problem ◽

Number Of Children ◽

Social And Physical Environment ◽

The Impact

Families at risk are definitely the urgent public concern that requires immediate solutions in Lithuania. It is important to mention that the children growing within the families at risk are in the centre of concern as their social and physical environment is not stimulating enough, leading to a number of different problems the families and children themselves are facing. In general, the number of such children makes about 4 percent of the total number of children in the country and this rate has remained stable for many years. Scientific problem – the problems experienced by children growing within social risk families and the impact of social risk factors on children's socialization and integration. Object – phenomenon of families at risk in Lithuania. Task of the article – to analyze the phenomenon of social risk families and its trends in Lithuania.

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Huntington's Chorea and the Young Person at Risk

The British Journal of Social Work ◽

10.1093/oxfordjournals.bjsw.a055371 ◽

1987 ◽

Cited By ~ 1

Keyword(s):

At Risk ◽

Young Person ◽

Huntington's Chorea

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Dopamine Uptake Capacity of Platelets From People At Risk For Huntington’s Chorea

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100043110 ◽

1981 ◽

Vol 8 (2) ◽

pp. 167-168 ◽

Cited By ~ 2

Author(s):

Donald R. McLean ◽

Taichi Nihei

Keyword(s):

At Risk ◽

Risk Group ◽

Dopamine Uptake ◽

Huntington's Chorea ◽

Uptake Capacity ◽

Patients At Risk

SUMMARY:Dopamine (DA) uptake by platelets from 41 patients at risk to develop Huntington’s chorea was assayed and compared to controls. The DA uptake was significantly higher in the at risk group. However, the at risk group did not separate into two distinct subgroups. which reduces the usefulness of the assay as a disease prognosticator.

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Huntington's disease: prediction and prevention

Philosophical Transactions of the Royal Society of London Series B Biological Sciences ◽

10.1098/rstb.1988.0050 ◽

1988 ◽

Vol 319 (1194) ◽

pp. 285-298 ◽

Cited By ~ 7

Keyword(s):

At Risk ◽

Huntington's Disease ◽

Huntington’S Disease ◽

Late Onset ◽

Predictive Test ◽

Prediction And Prevention ◽

Feasible Alternative ◽

Dna Restriction ◽

The Individual ◽

First Time

The identification of a DNA restriction fragment length polymorphism closely linked to Huntington’s disease on the short arm of chromosome 4 has for the first time allowed presymptomatic prediction to be undertaken in first-degree relatives at risk. The late and variable onset of this dominantly inherited disorder makes such prediction a powerful and potentially valuable aid in genetic counselling, but in the absence of effective therapy there are serious ethical reservations concerning such a predictive test. The new developments have stimulated an active and informative debate among professionals and family members on whether and how predictive tests should be used. Guidelines have emerged which should be useful not only for Huntington’s disease, but for other serious late-onset neurogenetic disorders. Meanwhile, studies in Wales and elsewhere have not only confirmed the original linkage but have excluded multi-locus heterogeneity as a significant problem. Genetic prediction for the individual at risk remains critically dependent on a suitable family structure, present in only a minority of families in Wales. A more feasible alternative for most families is prenatal exclusion, which can allow risk prediction for a pregnancy without altering the situation for the person at risk. This approach has already been applied in Wales; the experience gained will be useful in full prediction, which is currently being introduced.

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