The Impact of Lithium in South-West Scotland III. The Discontinuation of Lithium

1985 ◽  
Vol 146 (1) ◽  
pp. 77-80 ◽  
Author(s):  
R. G. McCreadie ◽  
M. McCormick ◽  
D. P. Morrison
Keyword(s):  
Side Effects ◽  
General Population ◽  
Common Reason ◽  
South West ◽  
One Year ◽  
The Impact ◽  
First Time

SummaryA review in South-West Scotland of all patients prescribed lithium for the first time during the years 1972–82 showed that on average, 12 per 100,000 of the general population start this drug each year. By the end of the period, lithium had been stopped in 58% of patients; the most common reason for discontinuation was the development of side-effects, of which tremor was the most frequent. In only 15% was lithium stopped as it was considered no longer necessary; 44% of patients discontinued lithium within one year of starting it.

scholarly journals Impact of immunogenicity on clinical efficacy and toxicity profile of biologic agents used for treatment of inflammatory arthritis in children compared to adults

2021 ◽  
Vol 13 ◽  
pp. 1759720X2110026
Author(s):  
Chinar R. Parikh ◽  
Jaya K. Ponnampalam ◽  
George Seligmann ◽  
Leda Coelewij ◽  
Ines Pineda-Torra ◽  
...  
Keyword(s):  
Side Effects ◽  
Clinical Efficacy ◽  
Inflammatory Arthritis ◽  
Biologic Agents ◽  
Adult Patients ◽  
Therapeutic Drug ◽  
Biologic Drugs ◽  
Therapeutic Implications ◽  
The Impact ◽  
First Time

The treatment of inflammatory arthritis has been revolutionised by the introduction of biologic treatments. Many biologic agents are currently licensed for use in both paediatric and adult patients with inflammatory arthritis and contribute to improved disease outcomes compared with the pre-biologic era. However, immunogenicity to biologic agents, characterised by an immune reaction leading to the production of anti-drug antibodies (ADAs), can negatively impact the therapeutic efficacy of biologic drugs and induce side effects to treatment. This review explores for the first time the impact of immunogenicity against all licensed biologic treatments currently used in inflammatory arthritis across age, and will examine any significant differences between ADA prevalence, titres and timing of development, as well as ADA impact on therapeutic drug levels, clinical efficacy and side effects between paediatric and adult patients. In addition, we will investigate factors associated with differences in immunogenicity across biologic agents used in inflammatory arthritis, and their potential therapeutic implications.

scholarly journals 1628 Vaccination for Safe Surgery During The SARS-Cov-2 Pandemic: Modelling Study

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
Keyword(s):  
General Population ◽  
Elective Surgery ◽  
Risk Difference ◽  
Cancer Surgery ◽  
Number Needed To Treat ◽  
Worst Case ◽  
Registration Data ◽  
Increased Risk ◽  
One Year ◽  
The Impact

Abstract Introduction Compared to the general population, in the postoperative period, surgical patients are both at increased risk of SARS-CoV-2 infection and increased mortality in the event of SARS-CoV-2 infection. This study modelled the impact of preoperative vaccination of patients aged ≥70 years having elective inpatient surgery. Method The primary outcome was the number needed to treat (NNT) to prevent one death over one year following SARS-CoV-2 vaccination. Postoperative SARS-CoV-2 incidence and adjusted mortality risk difference for SARS-CoV-2 infection were estimated from the prospective GlobalSurg-CovidSurg Week study (90,146 elective surgery patients across 1,595 hospitals in 115 countries), were used to estimate lives saved by vaccination in the first 30 postoperative days. SARS-CoV-2 case and death registration data from the Office for National Statistics was used to estimate NNTs for the general population. Best and worst-case scenarios were used to describe uncertainty around estimates. Results Among patients aged ≥70 years undergoing any type of surgery, NNT was estimated to be 332 (best case: 213; worst case: 690). NNT was lower in the cancer surgery subgroup (245 [150-545]). This was more favourable than the NNT for vaccination of the general population aged ≥70 (588 [403-1032]). Globally, vaccinating elective surgery patients aged ≥70 years preoperatively was projected to save 27,356 lives in one year compared to vaccinating the same patients after surgery. Conclusions Preoperative pathways should be set up for the vaccination of patients aged ≥70. In settings with limited vaccine availability, elective cancer surgery patients should be prioritised for vaccination.

scholarly journals SARS-CoV-2 Infection: New Molecular, Phylogenetic, and Pathogenetic Insights. Efficacy of Current Vaccines and the Potential Risk of Variants

Viruses ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1687 ◽  
Author(s):  
John Charles Rotondo ◽  
Fernanda Martini ◽  
Martina Maritati ◽  
Chiara Mazziotta ◽  
Giulia Di Mauro ◽  
...  
Keyword(s):  
Viral Vector ◽  
Current Knowledge ◽  
Vaccination Campaign ◽  
Positive Effects ◽  
Molecular Phylogenetic ◽  
History Of ◽  
One Year ◽  
Novel Coronavirus ◽  
The Impact ◽  
First Time

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered coronavirus responsible for the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 has rapidly become a public health emergency of international concern. Although remarkable scientific achievements have been reached since the beginning of the pandemic, the knowledge behind this novel coronavirus, in terms of molecular and pathogenic characteristics and zoonotic potential, is still relatively limited. Today, there is a vaccine, or rather several vaccines, which, for the first time in the history of highly contagious infectious diseases that have plagued mankind, has been manufactured in just one year. Currently, four vaccines are licensed by regulatory agencies, and they use RNA or viral vector technologies. The positive effects of the vaccination campaign are being felt in many parts of the world, but the disappearance of this new infection is still far from being a reality, as it is also threatened by the presence of novel SARS-CoV-2 variants that could undermine the effectiveness of the vaccine, hampering the immunization control efforts. Indeed, the current findings indicate that SARS-CoV-2 is adapting to transmission in humans more efficiently, while further divergence from the initial archetype should be considered. In this review, we aimed to provide a collection of the current knowledge regarding the molecular, phylogenetic, and pathogenetic insights into SARS-CoV-2. The most recent findings obtained with respect to the impact of novel emerging SARS-CoV-2 variants as well as the development and implementation of vaccines are highlighted.

A Study of the Relationship between a Going Concern Opinion and Its Financial Distress Metrics

2017 ◽  
Vol 14 (2) ◽  
pp. 17-28 ◽  
Author(s):  
Vikram Desai ◽  
Joung W. Kim ◽  
Rajendra P. Srivastava ◽  
Renu V. Desai
Keyword(s):  
Search Engine ◽  
Financial Distress ◽  
Primary Objective ◽  
Financial Viability ◽  
Going Concern ◽  
Going Concern Opinion ◽  
One Year ◽  
The Impact ◽  
First Time ◽  
The Relationship

ABSTRACT The primary objective of this paper is to employ search engine technology to investigate the relationship between first-time going concern opinions (GCOs) and the financial viability of the GCO recipients using delisting as a criterion rather than bankruptcy. The paper also investigates the impact of client distress factors on auditors' propensity to issue GCOs. The search engine enables us to examine the entire population of 10-K filings from 1995 to 2015 and also to obtain delisting data, which are not readily available in commercial databases. Contrary to prior research, we find that the survival rate of first-time GCOs is much lower when we use delisting as a measure of financial viability. Around 26 percent of the companies that receive their first GCOs are delisted within a period of one year of the audit opinion date, and 50 percent of the companies that receive their first GCOs are delisted within a period of three years. The bankruptcy rate of first-time GCO companies within one year is around 9 percent. Such evidence may prove useful to the PCAOB's effort to expeditiously assess the intended benefit of GCOs. In addition, we find that the propensity of auditors to issue GCOs varies for each distress factor.

Abstract P194: A Prospective Study of the Association of Flushing Bother, Impact, Treatment Satisfaction and Discontinuation of Niacin Therapy

2011 ◽  
Vol 4 (suppl_1) ◽  
Author(s):  
Josephine M Norquist ◽  
Jane Liao ◽  
Tiffany B Miller ◽  
Lori D Bash ◽  
Douglas J Watson ◽  
...  
Keyword(s):  
Side Effects ◽  
Real World ◽  
Treatment Satisfaction ◽  
Patient Adherence ◽  
Alternative Methods ◽  
Cross Sectional ◽  
Niacin Therapy ◽  
One Year ◽  
A Prospective Study ◽  
The Impact

Background: Niacin has proven lipid-modifying efficacy and cardiovascular benefit. Previous cross-sectional and retrospective studies have suggested that niacin-induced flushing (NIF) significantly limits patient adherence to therapy. We conducted a one-year ‘real-world’ prospective observational study to characterize the impact and severity of NIF symptoms in subjects newly prescribed extended-release (ER) niacin. Methods: Subjects were surveyed daily during week 1 of therapy and thereafter via telephone at weeks 5, 9, 13 and months 6, 9 and 13. Surveys included the Global Flushing Symptom Score (GFSS), Flushing Impact Questionnaire (FIQ), and Treatment Satisfaction Questionnaire for Medication (TSQM). Results: A total of 306 subjects were recruited of which 43.5% (n=133) discontinued ER niacin by the end the study. Among those who discontinued, the median duration of ER niacin use was 95 days (range 2-402 days). At discontinuation, 3 (2.3%) subjects were on 250mg, 71 (54%) on 500mg, 1 (0.8%) on 750mg, 27 (20.3%) on 1000mg, 6 (4.5%) on 1500mg, and 4 (3.1%) on 2000mg. Dose was not available for 21 subjects. Over half of the discontinuers experienced flushing symptoms; 82% reported moderate to extreme flushing (GFSS≥4) and 68% reported severe to extreme (GFSS≥7) prior to discontinuation. About 74% of the discontinuers reported that moderate was the greatest degree of flushing they could tolerate before discontinuation. Those who discontinued and reported experiencing flushing side effects reported high degrees of impact in the FIQ Irritation/Frustration domain: mean (SD) 3.0 (1.3) (0=not at all, 4=extremely) and high dissatisfaction due to side effects as measured by the TSQM Side Effect domain: mean (SD) 63.3 (33.8) (0=extremely dissatisfied, 100=extremely satisfied). In addition, subjects who reported moderate or greater flushing bother during week 1 were 3.3 times more likely to discontinue due to flushing than those who reported less bother (95% CI: 1.01-10, p<0.05). Conclusion: Results from this study suggest that in a “real-world” setting, flushing side effects are bothersome and have an impact on continuation of ER niacin therapy. Further research is needed into alternative methods for increasing ER niacin acceptability.

scholarly journals Mortality and causes of death in a total national sample of patients with affective disorders admitted for the first time between 1973 and 1993

2000 ◽  
Vol 176 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Eyd Hansen Høyer ◽  
Preben Bo Mortensen ◽  
Anne V. Olesen
Keyword(s):  
Mortality Rate ◽  
General Population ◽  
Affective Disorder ◽  
Affective Disorders ◽  
Causes Of Death ◽  
National Sample ◽  
Causes Of Mortality ◽  
One Year ◽  
First Time ◽  
First Admission

BackgroundThe high mortality from suicide in patients admitted to hospital with an affective disorder is well documented, although specific causes of mortality and changes in mortality are less well studied.AimsTo describe the pattern of mortality in patients with affective disorder and to study changes in suicide riskduring the study period.MethodAll patients (n=54 103) admitted for the first time to a psychiatric hospital in Denmarkduring the period 1973–1993 because of affective disorder were included in this study. The mortality rate was compared with that of the general population.ResultsMortality from natural and unnatural causes was elevated in all subgroups of affective disorder. The risk of suicide among patients ill for one year or less after first admission increased during the period 1973–1993.ConclusionsMore attention should be paid to the risk of suicide and to physical illness in patients with affective disorders.

scholarly journals SIDE EFFECTS OF INJECTABLE AND ORAL CONTRACEPTIVE AND UNINTENDED PREGNANCY AMONG REPRODUCTIVE WOMEN IN INDONESIA

2021 ◽  
Vol 10 (2) ◽  
pp. 162
Author(s):  
Maria Gayatri ◽  
Dian Kristiani Irawaty
Keyword(s):  
Side Effects ◽  
Unintended Pregnancy ◽  
Unplanned Pregnancy ◽  
Health Problems ◽  
Counseling Services ◽  
Comprehensive Information ◽  
Contraceptive Discontinuation ◽  
Provider Knowledge ◽  
One Year ◽  
The Impact

Using contraception is essential for protecting women from the risk of unintended pregnancy. However, contraceptive discontinuation, caused by side effects of contraceptives or health problems, is still high. This study aimed to assess the impact of injectable and pill contraception discontinuation due to side effects or health problems on unintended pregnancy among women aged 15-49 years in Indonesia. This study is based on the 2017 Indonesia Demographic and Health Survey. As many as 1,613 women who discontinued their oral contraceptives and 5,022 women who discontinued their injectables were followed retrospectively. Pregnancy rates were tested for differences between categories using survival analysis. It was found that one year after stopping contraceptives due to side effects, almost 16-17% of oral/injectable contraceptive users were already pregnant. The pregnancy rate was higher among women aged less than 25 years. Unplanned pregnancy occurred more frequently among women who were not working than women who were working. Counseling services need to be strengthened by improving provider knowledge and skills to give comprehensive information including contraceptives’ side effects.

Long-term non-cancer mortality among 39,657 one-year testicular cancer survivors (TCSs)

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 4508-4508 ◽  
Author(s):  
S. D. Fosså ◽  
J. Chen ◽  
G. M. Dores ◽  
K. A. McGlynn ◽  
S. J. Schonfeld ◽  
...  
Keyword(s):  
General Population ◽  
Cancer Registries ◽  
Population Based ◽  
Duodenal Ulcers ◽  
Digestive Diseases ◽  
One Year ◽  
Few Data ◽  
The Impact ◽  
Circulatory Diseases

4508 Background: Multiple reports address the incidence of second cancer (SC) and long-term morbidity in TCSs, yet few data analyze the impact of non-malignant late sequelae on mortality. Methods: 39,657 one-year TCSs were identified in 14 population-based cancer registries in North America and Europe, with 17,856, 13,084 and 6,298 men followed for 10, 20 and 30 years, respectively. Standardized mortality ratios (SMRs), comparing TCSs to the general population, were calculated for deaths due to all non-cancer causes (n = 2,942) and specific sites. Further, absolute mortality due to TC, non-TC SC and all non-cancer disorders was estimated. Results: The SMR for all non-malignant diseases combined was 0.99 (95% CI: 0.95–1.02), with a significant reduction of deaths due to circulatory diseases (SMR: 0.92, n = 1,117). However, following initial treatment with chemotherapy and radiotherapy, the SMR for circulatory diseases was significantly elevated (SMR: 1.76), with a non-significant 29% excess after chemotherapy alone. Mortality due to digestive diseases was significantly increased (SMR: 1.32, n = 222), including gastric and duodenal ulcers (SMR = 1.52; excess deaths were observed between 10 and 25 years after initial radiotherapy). For the first 20 years after TC diagnosis, deaths due to infection were significantly elevated (SMR: 1.52, n=211). Absolute mortality due to non-cancer disorders always exceeded that due to SC, and was 15% after 30 years in a TCS diagnosed at age 35 compared with about 11% for SC. Conclusions: Compared with the general population, the overall risk of mortality due to all non-cancer causes combined does not appear to be increased in TCSs. However, they experience excess non-cancer deaths due to infection and digestive diseases, but not circulatory diseases. Additional analytic studies with detailed data on treatment and co-morbidities are required to further evaluate associations with specific causes of death. No significant financial relationships to disclose.

Post-fire recolonisation of a montado area by the endangered Cabrera vole (Microtus cabrerae)

2007 ◽  
Vol 16 (4) ◽  
pp. 450 ◽  
Author(s):  
Inês T. do Rosário ◽  
Maria da Luz Mathias
Keyword(s):  
Habitat Type ◽  
Fire Intensity ◽  
Bare Ground ◽  
Vegetation Height ◽  
Ecological Features ◽  
Cabrera Vole ◽  
Plant Families ◽  
One Year ◽  
The Impact ◽  
First Time

The Cabrera vole is an endangered species frequently found in the montado, a savannah-like ecosystem well adapted to fire. Although it is assumed that regular burning is not very prejudicial to this vole, the impact of fire is unknown. This research studied, for the first time, recolonisation by the Cabrera vole after wildfire. Colonies were monitored over one year after a wildfire and the most relevant ecological features in their reestablishment were identified. During the first eight months, all the 18 surveyed colonies remained unoccupied. However, after one year, 11 were recolonised. Vegetation structure and composition in the colonies (vegetation height, plant families diversity, percentage of bare ground and cover of shrubs before the fire), which are important features in offering protection and nutrition, were closely related to reoccupation of the colonies. Surprisingly, fire intensity did not influence recolonisation. Distance from unburned areas proved to be a factor that delayed recolonisation. The importance of the montado for this species was reinforced by the evidence that recolonisation occurred preferentially in colonies surrounded by this habitat type.

A Study of Attempted Suicides in Prisons

1987 ◽  
Vol 27 (4) ◽  
pp. 297-301 ◽  
Author(s):  
Rosemary J. Wool ◽  
Enda Dooley
Keyword(s):  
High Risk ◽  
General Population ◽  
Emotional Stress ◽  
Attempted Suicide ◽  
Physical Illness ◽  
Young Offender ◽  
South West ◽  
History Of ◽  
One Year

To date there have been very few studies of attempted suicide occurring in prison. This study analyses 111 reports of attempted suicide occurring in a one-year period in the prisons of the Midlands and South West regions of England. Unlike the general population, where there are marked differences (age, sex, etc.) between those attempting and those completing suicide, the characteristics for both groups in prison are similar, high risk being associated with youth, with being on remand or recently sentenced, and with a history of mental or physical illness. There is some indication that those in Young Offender Establishments may be more likely to attempt suicide by hanging. The motivation given by the inmates most commonly stated some form of emotional stress relating to poor communication with family or friends, and in this respect they are similar to attempters outside prison.

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