Incidence trends of squamous cell carcinoma of the head and neck (SCCHN) in the aging population: A SEER based analysis from 2000-2016.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e18522-e18522
Author(s):  
Melissa Taylor ◽  
Mihir Patel ◽  
Jeffrey M. Switchenko ◽  
Mark William McDonald ◽  
Conor Ernst Steuer ◽  
...  
Keyword(s):  
The Elderly ◽  
The United States ◽  
Population Based ◽  
Annual Percent Change ◽  
Incidence Trends ◽  
Percent Change ◽  
United States Population ◽  
Study Population ◽  
Male Patients ◽  
Using Data

e18522 Background: SCCHN is more prevalent in the elderly. As the United States population ages, it is increasingly important to evaluate the change in the incidence of SCCHN in this population. Methods: This was a retrospective study using data from a population-based cancer registry (Surveillance, Epidemiology, and End Results) to identify patients ≥65 years old with the diagnosis of SCCHN between the years 2000-2016. The subgroups of oral cavity (OCC)and oropharynx cancer (OPC) were also analyzed independently. The incidence per year was calculated and joinpoint detection was used to identity significant changes in incidence trends. Annual percent change (APC) was detected to determine if the incidence trend was statistically significant. The study population was further stratified by sex. Results: For all sites, a joinpoint was found in 2003 with a statistically significant decrease in APC in incidence for males from 2000-2003 of -2.45%. For OCC, there was a joinpoint in 2005 with a statistically significant increase in APC in incidence for male patients of 1.41%. For (OPC), no joinpoint was found, but there was a statistically significant increase in APC in incidence for males of 3.41%. For females no joinpoint was found, but for OCC there was a statistically significant decrease in APC in incidence of -0.40%. Conclusions: In patients ≥ 65 years old the trend in incidence rate for all SCCHN sites stratified by sex has decreased between 2000-2016. However, for males the annual percent change in incidence has increased for OCC from 2005-2016 and for OPC from 2000-2016. [Table: see text]

scholarly journals Melanoma Incidence Among Non-Hispanic Whites in All 50 US States From 2001 Through 2015

2019 ◽  
Vol 112 (5) ◽  
pp. 533-539 ◽  
Author(s):  
Aaron P Thrift ◽  
Franciska J Gudenkauf
Keyword(s):  
Incidence Rate ◽  
Birth Cohort ◽  
Sun Exposure ◽  
The United States ◽  
Incidence Rates ◽  
Birth Cohorts ◽  
Annual Percent Change ◽  
Incidence Trends ◽  
Percent Change ◽  
Melanoma Incidence

Abstract Background The United States has large regional variation in primary prevention campaigns for skin cancer. We collected data from all 50 states to examine changes in melanoma incidence and performed age-period-cohort analyses to describe the simultaneous effects of age, period, and cohort on incidence rates. Methods Annual melanoma incidence rates for non-Hispanic whites from 2001 to 2015 were extracted from the US Cancer Statistics registry. Secular trends were examined overall and by sex and state. We used joinpoint regression to compute annual percent change and average annual percent change and corresponding 95% confidence intervals (CIs). We also analyzed incidence trends by 5-year age group and birth cohort using incidence rate ratios and age-period-cohort modeling. Results Melanoma incidence increased from 20.7 per 100 000 (95% CI = 20.5 to 20.9) in 2001 to 28.2 per 100 000 (95% CI = 28.0 to 28.5) in 2015, increasing by 3.90% (95% CI = 2.36% to 5.48%) annually between 2001 and 2005 and 1.68% (95% CI = 1.37% to 1.99%) annually from 2005 through 2015. The average annual percent change in melanoma incidence rates were similar for men (2.34%, 95% CI = 1.91 to 2.78) and women (2.25%, 95% CI = 1.60 to 2.91). Age-specific relative risk by birth cohort increased from circa 1921 to 1981 before decreasing. Compared with adults born circa 1956, those born circa 1991 had lower melanoma risk (incidence rate ratio  = 0.85; 95% CI = 0.77 to 0.94). Geographic variation was observed; some states still have melanoma rates trending upwards in all birth cohorts. Conclusions The continued increase in melanoma incidence among non-Hispanic whites, particularly in states where rates continue to rise among recent and current birth cohorts, underscores the need for increased public health campaigns aimed at reducing sun exposure.

scholarly journals Incidence trends, rates, and ethnic variations of primary CNS tumors in Texas from 1995 to 2013

2017 ◽  
Vol 5 (3) ◽  
pp. 154-160 ◽  
Author(s):  
Solomon N Ambe ◽  
Kristopher A Lyon ◽  
Damir Nizamutdinov ◽  
Ekokobe Fonkem
Keyword(s):  
United States ◽  
American Indians ◽  
Large Population ◽  
Ethnic Disparities ◽  
The United States ◽  
Incidence Rates ◽  
Cns Tumors ◽  
Annual Percent Change ◽  
Incidence Trends ◽  
Percent Change

Abstract Background Although rare, primary central nervous system (CNS) tumors are associated with significant morbidity and mortality. Texas is a representative sample of the United States population given its large population, ethnic disparities, geographic variations, and socio-economic differences. This study used Texas data to determine if variations in incidence trends and rates exist among different ethnicities in Texas. Methods Data from the Texas Cancer Registry from 1995 to 2013 were examined. Joinpoint Regression Program software was used to obtain the incidence trends and SEER*Stat software was used to produce average annual age-adjusted incidence rates for both nonmalignant and malignant tumors in Texas from 2009 to 2013. Results The incidence trend of malignant primary CNS tumors in whites was stable from 1995 to 2002, after which the annual percent change decreased by 0.99% through 2013 (95% CI, -1.4, -0.5; P = .04). Blacks and Asian/Pacific Islanders showed unchanged incidence trends from 1995 to 2013. Hispanics had an annual percent change of -0.83 (95% CI, -1.4, -0.2; P = .009) per year from 1995 through 2013. From 2009 to 2013, the incidence rates of nonmalignant and malignant primary CNS tumors were highest among blacks, followed by whites, Hispanics, Asians, and American Indians/Alaskan Natives. Conclusions Consistent with the 2016 Central Brain Tumor Registry of the United States report, the black population in Texas showed the highest total incidence of CNS tumors of any other race studied. Many factors have been proposed to account for the observed differences in incidence rate including geography, socioeconomic factors, and poverty factors, although the evidence for these external factors is lacking.

scholarly journals Trends in Incidence and Mortality of Skin Melanoma in Lithuania 1991–2015

2021 ◽  
Vol 18 (8) ◽  
pp. 4165
Author(s):  
Audrius Dulskas ◽  
Dovile Cerkauskaite ◽  
Ieva Vincerževskiene ◽  
Vincas Urbonas
Keyword(s):  
Age Groups ◽  
Population Based ◽  
Incidence Rates ◽  
Skin Melanoma ◽  
Annual Percent Change ◽  
Incidence Trends ◽  
Percent Change ◽  
Incidence And Mortality ◽  
European Standard Population ◽  
Age Adjusted Rates

Background. We aimed to investigate age-specific and sex-specific incidence trends of melanoma in Lithuania from 1991 to 2015. Methods. Analysis was based on data from the population-based Lithuanian Cancer Registry database for 1991–2015, and 6024 cases of skin melanoma were identified. Age-adjusted rates (ASRs) by sex and age group were calculated. Adjustment for ASRs was done using the old European standard population, where a total of three age groups were considered: 0–39, 40–59 and 60+. Additionally, the annual percent change (APC) was calculated, and 95% confidence intervals for APC were calculated. Results. Between 1991 and 2015, the overall melanoma rates increased by an annual percent change (APC) of 3.9% in men (95% CI, 3.6–4.1%) and 2.3% in women (95% CI, 2.1–2.5%). The highest incidences of new cutaneous melanoma cases were observed between old adults (60+) of both sexes, while the lowest incidence rates were observed in the young adult group (up to 39 years old), with the lowest APC (1.6% in males and 0.4% in females). The overall number of melanoma deaths during 1991 and 2015 increased from 64 to 103 deaths per year, and the age-standardized rate (ASR) increased 1.3 times (from 1.8 to 2.4). Conclusions. The incidence and mortality of skin melanoma seem to be increased in all age groups. These trends indicate that skin protection behavior is not sufficient in our population and more efforts need to be taken in order to decrease incidence and mortality rates.

Incidence trends of gastroenteropancreatic neuroendocrine tumors in the United States from 1975 to 2012.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 231-231
Author(s):  
Mi Ri Lee ◽  
Cynthia Harris ◽  
Kiwoon Joshua Baeg ◽  
Juan P. Wisnivesky ◽  
Michelle Kang Kim
Keyword(s):  
The United States ◽  
Population Based ◽  
Incidence Rates ◽  
Birth Cohorts ◽  
Annual Percent Change ◽  
Gastroenteropancreatic Neuroendocrine Tumors ◽  
Incidence Trends ◽  
The Us ◽  
Population Based Registry ◽  
Adjusted Incidence

231 Background: Although multiple studies document a rise in gastroenteropancreatic neuroendocrine tumor (GEP-NET) incidence over the past several decades, there are limited national data regarding recent trends. Using a population-based registry, we evaluated GEP-NET incidence trends in the US population from 1975-2012 by age and calendar year at diagnosis and year of birth. Methods: GEP-NET cases between 1975-2012 were identified from the most recent version of the Surveillance, Epidemiology, and End Results (SEER) registry based on histologic and site codes. We calculated overall annual incidence, age-adjusted incidence (number of cases per 100,000), annual percent change (APC), and average APC by 5 year age intervals. We also evaluated the incidence rates by age, period, and birth year cohorts. Results: We identified 22,744 patients with GEP-NETs. In adults age 25-39 years, GEP-NET incidence rates declined from the mid 1970s to early 1980s, then increased until 2012 (Table 1). In adults age 40 and older and between ages 15-24 years, incidence rates generally increased continuously from 1975 to 2012. Adults age 40-69 years demonstrated the most rapid increases in average APC, approximately 4-6% per year. Overall incidence rates were highest in adults age 70-84 years. Since the late 1880s, GEP-NET incidence has increased in consecutive birth cohorts. Conclusions: Our study demonstrates that more recent generations have had higher incidence rates than more distant generations. In addition, GEP-NETs are more common among older adults and the number of GEP NETs has increased in past decades. [Table: see text]

The influence of prescriber and patient gender on the prescription of benzodiazepines: results from the Florida Medicaid Dataset

CNS Spectrums ◽  
2021 ◽  
pp. 1-5
Author(s):  
Leanna M. W. Lui ◽  
Yena Lee ◽  
Orly Lipsitz ◽  
Nelson B. Rodrigues ◽  
Hartej Gill ◽  
...  
Keyword(s):  
The United States ◽  
Sociodemographic Factors ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Assistance Program ◽  
Patient Gender ◽  
Prescription Rates ◽  
Male Patients ◽  
Using Data ◽  
Main Effects

Abstract Background Benzodiazepine (BZD) prescription rates have increased over the past decade in the United States. Available literature indicates that sociodemographic factors may influence diagnostic patterns and/or prescription behaviour. Herein, the aim of this study is to determine whether the gender of the prescriber and/or patient influences BZD prescription. Methods Cross-sectional study using data from the Florida Medicaid Managed Medical Assistance Program from January 1, 2018 to December 31, 2018. Eligible recipients ages 18 to 64, inclusive, enrolled in the Florida Medicaid plan for at least 1 day, and were dually eligible. Recipients either had a serious mental illness (SMI), or non-SMI and anxiety. Results Total 125 463 cases were identified (i.e., received BZD or non-BZD prescription). Main effect of patient and prescriber gender was significant F(1, 125 459) = 0.105, P = 0 .745, partial η2 < 0.001. Relative risk (RR) of male prescribers prescribing a BZD compared to female prescribers was 1.540, 95% confidence intervals (CI) [1.513, 1.567], whereas the RR of male patients being prescribed a BZD compared to female patients was 1.16, 95% CI [1.14, 1.18]. Main effects of patient and prescriber gender were statistically significant F(1, 125 459) = 188.232, P < 0.001, partial η2 = 0.001 and F(1, 125 459) = 349.704, P < 0.001, partial η2 = 0.013, respectively. Conclusions Male prescribers are more likely to prescribe BZDs, and male patients are more likely to receive BZDs. Further studies are required to characterize factors that influence this gender-by-gender interaction.

scholarly journals Acculturative status, age, and hypertension among African American women

2021 ◽  
Vol 8 (5) ◽  
pp. 2083
Author(s):  
Fern J. Webb ◽  
Christina Jones ◽  
Ross Jones ◽  
Kristen Morga ◽  
Lori Bilello ◽  
...  
Keyword(s):  
African American ◽  
African American Women ◽  
Cultural Beliefs ◽  
The United States ◽  
Population Based ◽  
Health Interventions ◽  
Traditional Values ◽  
American Women ◽  
Using Data ◽  
Research Assistants

Background: Understanding culture’s impact on hypertension (HTN) is important since its prevalence in African American women (AAW) in the United States is among the highest. It is therefore important to know if younger AAW have similar acculturation status as older AAW when developing culturally relevant interventions.  The objective of this study was to examine the association between acculturation status and age, determining whether acculturation status and age are significantly associated with hypertension among AAW.Methods: Acculturation status, age, and HTN were analyzed using data from the listening to our voices study (LOVS), a population-based observational study of 294 AAW conducted throughout Florida. LOVS was promoted via African American women research assistants trained to inform and recruit AAW living in Ft. Lauderdale, Jacksonville, Miami, and Tampa.Results: Findings demonstrate that AAW held traditional values regardless of age. Moreover, AAW of younger ages had higher average acculturation scores compared with older AAW indicating stronger agreement with traditional values, practices and beliefs. Acculturation subscale scores were not associated with HTN. AAW with HTN scored higher on the traditional food subscale compared to AAW without HTN.Conclusions: These findings indicate the significance of considering the beliefs, values, and practices of AAW when developing health interventions. Health interventions developed should be tailored toward AAW of varying ages to incorporate activities relevant to their cultural beliefs, values and practices.

scholarly journals Trends in International Incidence of Pediatric Cancers in Children Under 5 Years of Age: 1988–2012

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Aubrey K Hubbard ◽  
Logan G Spector ◽  
Giulio Fortuna ◽  
Erin L Marcotte ◽  
Jenny N Poynter
Keyword(s):  
Cancer Incidence ◽  
Pediatric Cancer ◽  
Myeloid Leukemia ◽  
Lymphoblastic Leukemia ◽  
Annual Percent Change ◽  
Incidence Trends ◽  
Time Period ◽  
Multiple Regions ◽  
Using Data ◽  
Children Under 5

AbstractBackgroundPediatric cancer incidence has been steadily increasing over the last several decades with the largest increases reported in infants. Few evaluations have looked at international pediatric cancer incidence trends in the youngest children. The aim of this analysis was to evaluate trends in cancer incidence in children under 5 years of age, overall and by type, using data from Cancer Incidence in 5 Continents (CI5) from 1988 to 2012 (CI5 volumes VII–XI).MethodsRates of cancers in children ages 0–4 years were extracted from registries available in CI5 from 1988 to 2012. To overcome small numbers in individual registries, numerators and denominators were aggregated within regions corresponding to the United Nations’ geoscheme. Average annual percent change (AAPC) was estimated using Poisson regression.  Robust standard errors were used in all models to correct for overdispersion in some regions, and 95% Wald confidence intervals and P values were reported. The top five cancers by increasing AAPC were ranked within each region.ResultsOverall, in children under 5 years, increasing incidence was seen in multiple regions for acute lymphoblastic leukemia, acute myeloid leukemia, ependymal tumors, neuroblastoma, and hepatoblastoma. Hepatoblastoma had the largest AAPC in 11 out of 15 regions and showed an increase in all regions except southern Asia. Astrocytic tumors were the only cancer that decreased over the time period.ConclusionsWe evaluated 25 years of cancer incidence in children ages 0–4 years and observed increases in incidence for hepatoblastoma, leukemia, neuroblastoma, and ependymal tumors. Further etiologic evaluation will be required to explain these increases in incidence.

scholarly journals Serum caeruloplasmin as a coronary risk factor in the elderly: the Rotterdam Study

1999 ◽  
Vol 81 (2) ◽  
pp. 139-144 ◽  
Author(s):  
Kerstin Klipstein-Grobusch ◽  
Diederick E. Grobbee ◽  
J. F. Koster ◽  
J. Lindemans ◽  
Heiner Boeing ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
The Elderly ◽  
Population Based ◽  
Oxidative Modification ◽  
Substantial Part ◽  
Rotterdam Study ◽  
Reactive Protein ◽  
Study Population ◽  
Independent Risk Factors ◽  
First Myocardial Infarction

Serum Cu and caeruloplasmin levels have been suggested to be independent risk factors for CHD operating through oxidative modification of LDL. However, given its function as an acute-phase protein, the question has been raised whether an elevated caeruloplasmin level is not merely an indicator of inflammation. In the current study, we investigated whether serum caeruloplasmin was associated with subsequent myocardial infarction, taking into account indices of inflammation. The study population consisted of 210 cases of first myocardial infarction and controls, frequency-matched on age (5-year categories) and sex, selected from the population-based cohort of the Rotterdam Study. Serum caeruloplasmin levels were significantly elevated in cases of myocardial infarction compared with controls (510 (sd 110) v. 470 (sd 100) mg/1; P = 0·007). Risk of myocardial infarction for the highest compared with the lowest quartile of caeruloplasmin was 2·46 (95 % CI 1·04, 6·00; Ptrend = 0·043) after adjustment for age, sex, BMI, pack-years smoked, serum cholesterol, systolic blood pressure, and income. The relative risk was most evident in current smokers. Adjustment for C-reactive protein and leucocyte count reduced the excess risk by 33 %. This suggests that a substantial part of the observed association between serum caeruloplasmin and CHD may be attributed to inflammation processes rather than to the pro-oxidant activity of caeruloplasmin.

Spatial Context of Residential Moves by Elderly Persons

1978 ◽  
Vol 8 (3) ◽  
pp. 279-289 ◽  
Author(s):  
Stephen M. Golant
Keyword(s):  
United States ◽  
Residential Mobility ◽  
Descriptive Analysis ◽  
The Elderly ◽  
The United States ◽  
Spatial Context ◽  
Elderly Persons ◽  
United States Population ◽  
Residential Moves ◽  
Cent Sample

This is a descriptive analysis of the spatial context of residential moves by the over age forty-five population in the United States. It utilizes residential mobility and state of birth statistics calculated from a 15 per cent sample of the United States population drawn for the U. S. Census. It specifically focuses on the likelihood that the age sixty-five and over white and black mover will relocate within his same county or state of residence. The paper reveals that the preponderance of residential moves by the elderly (whether black or white) are within the same county. Only a relatively small percentage make interstate moves. The majority of elderly live in the state of their birth. However, there is no evidence that as a consequence of aging moves become more spatially restricted until after age seventy-five. It is argued that greater emphasis be placed on not why elderly persons move, but why when they do, their residential relocations occur within varying spatial contexts.

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